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Resting state functional MRI

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https://www.readbyqxmd.com/read/28223037/asymmetric-dopaminergic-degeneration-and-levodopa-alter-functional-corticostriatal-connectivity-bilaterally-in-experimental-parkinsonism
#1
Cyril Monnot, Xiaoqun Zhang, Sahar Nikkhou-Aski, Peter Damberg, Per Svenningsson
Asymmetric dopamine loss is commonly found in early Parkinson's disease (PD), but its effects on functional networks have been difficult to delineate in PD patients because of variations in age, disease duration and therapy. Here we used unilateral 6-hydroxydopamine-lesioned (6-OHDA) rats and controls and treated them with a single intraperitoneal injection of levodopa (L-DOPA) before performing diffusion weighted MRI and resting state functional MRI (rs-fMRI). In accordance with a neurodegeneration of the nigrostriatal dopaminergic pathway, diffusion tensor imaging showed increased radial diffusivity and decreased fractional anisotropy in the lesioned substantia nigra...
February 18, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28220377/altered-functional-connectivity-architecture-of-the-brain-in-medication-overuse-headache-using-resting-state-fmri
#2
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma, Shengyuan Yu
BACKGROUND: Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the altered functional network with the identified brain regions. This may be an effective assessment strategy for headache research. This study is to investigate the RSFC architecture changes of the brain in the patients with medication overuse headache (MOH) using FCD and RSFC methods...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28220083/risperidone-effects-on-brain-dynamic-connectivity-a-prospective-resting-state-fmri-study-in-schizophrenia
#3
Kristin K Lottman, Nina V Kraguljac, David M White, Charity J Morgan, Vince D Calhoun, Allison Butt, Adrienne C Lahti
Resting-state functional connectivity studies in schizophrenia evaluating average connectivity over the entire experiment have reported aberrant network integration, but findings are variable. Examining time-varying (dynamic) functional connectivity may help explain some inconsistencies. We assessed dynamic network connectivity using resting-state functional MRI in patients with schizophrenia, while unmedicated (n = 34), after 1 week (n = 29) and 6 weeks of treatment with risperidone (n = 24), as well as matched controls at baseline (n = 35) and after 6 weeks (n = 19)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28210922/resting-cerebral-blood-flow-alteration-in-severe-obstructive-sleep-apnoea-an-arterial-spin-labelling-perfusion-fmri-study
#4
Si Nie, De-Chang Peng, Hong-Han Gong, Hai-Jun Li, Li-Ting Chen, Cheng-Long Ye
STUDY OBJECTIVES: The aim of this study is to investigate changes in regional cerebral blood flow (rCBF) in awake people with untreated severe obstructive sleep apnoea (OSAs) compared with good sleepers (GSs). DESIGN: Arterial spin labelling perfusion imaging was used to quantify cerebral perfusion based on resting-state functional magnetic resonance imaging (MRI). SETTING: Lying supine in a 3.0-T magnetic resonance imaging scanner in the night was done...
February 16, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28199371/the-value-of-resting-state-functional-magnetic-resonance-imaging-for-detecting-epileptogenic-zones-in-patients-with-focal-epilepsy
#5
Zhijuan Chen, Yang An, Bofeng Zhao, Weidong Yang, Qing Yu, Li Cai, Hongyan Ni, Jianzhong Yin
OBJECTIVE: To determine the value of resting-state functional magnetic resonance imaging (RS-fMRI) based on the local analysis methods regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF), for detecting epileptogenic zones (EZs). METHODS: A total of 42 consecutive patients with focal epilepsy were enrolled. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of visually assessed RS-fMRI, MRI, magnetic resonance spectroscopy (MRS), video electroencephalography (VEEG), and positron-emission tomography computed tomography (PET-CT) in EZ localization were evaluated to assess their diagnostic abilities...
2017: PloS One
https://www.readbyqxmd.com/read/28197860/local-resting-state-functional-connectivity-in-autism-site-and-cohort-variability-and-the-effect-of-eye-status
#6
Sangeeta Nair, R Joanne Jao Keehn, Michael M Berkebile, José Omar Maximo, Natalia Witkowska, Ralph-Axel Müller
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with prominent impairments in sociocommunicative abilities, which have been linked to anomalous brain network organization. Despite ample evidence of atypical long-distance connectivity, the literature on local connectivity remains small and divergent. We used resting-state functional MRI regional homogeneity (ReHo) as a local connectivity measure in comparative analyses across several well-matched low-motion subsamples from the Autism Brain Imaging Data Exchange and in-house data, with a grand total of 147 ASD and 184 typically developing (TD) participants, ages 7-18 years...
February 14, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28195583/longitudinal-test-retest-neuroimaging-data-from-healthy-young-adults-in-southwest-china
#7
Wei Liu, Dongtao Wei, Qunlin Chen, Wenjing Yang, Jie Meng, Guorong Wu, Taiyong Bi, Qinglin Zhang, Xi-Nian Zuo, Jiang Qiu
Multimodal magnetic resonance imaging (mMRI) has been widely used to map the structure and function of the human brain, as well as its behavioral associations. However, to date, a large sample with a long-term longitudinal design and a narrow age-span has been lacking for the assessment of test-retest reliability and reproducibility of brain-behavior correlations, as well as the development of novel causal insights into these correlational findings. Here we describe the SLIM dataset, which includes brain and behavioral data across a long-term retest-duration within three and a half years, mMRI scans provided a set of structural, diffusion and resting-state functional MRI images, along with rich samples of behavioral assessments addressed-demographic, cognitive and emotional information...
February 14, 2017: Scientific Data
https://www.readbyqxmd.com/read/28191693/gene-expression-profiles-in-peripheral-blood-mononuclear-cells-correlate-with-salience-network-activity-in-chronic-visceral-pain-a-pilot-study
#8
A Gupta, S Cole, J S Labus, S Joshi, T J Nguyen, L A Kilpatrick, K Tillisch, B D Naliboff, L Chang, E A Mayer
BACKGROUND: Distinct gene expression profiles in peripheral blood mononuclear cells (PBMCs) consistent with increased sympathetic nervous system activity have been described in different populations under chronic stress. Neuroinflammatory brain changes, possibly related to the migration of primed monocytes to the brain, have been implicated in the pathophysiology of chronic pain. Irritable bowel syndrome (IBS) is a stress-sensitive gastrointestinal disorder associated with altered brain-gut interactions and increased sympathetic/vagal tone and anxiety...
February 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28191669/adaptive-testing-for-multiple-traits-in-a-proportional-odds-model-with-applications-to-detect-snp-brain-network-associations
#9
Junghi Kim, Wei Pan
There has been increasing interest in developing more powerful and flexible statistical tests to detect genetic associations with multiple traits, as arising from neuroimaging genetic studies. Most of existing methods treat a single trait or multiple traits as response while treating an SNP as a predictor coded under an additive inheritance mode. In this paper, we follow an earlier approach in treating an SNP as an ordinal response while treating traits as predictors in a proportional odds model (POM). In this way, it is not only easier to handle mixed types of traits, e...
February 13, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/28186667/thalamocortical-dysconnectivity-in-paroxysmal-kinesigenic-dyskinesia-combining-functional-magnetic-resonance-imaging-and-diffusion-tensor-imaging
#10
Zhiliang Long, Qiang Xu, Huan-Huan Miao, Yang Yu, Mei-Ping Ding, Huafu Chen, Zhi-Rong Liu, Wei Liao
BACKGROUND: Paroxysmal kinesigenic dyskinesia is associated with macrostructural and microstructural abnormalities in the thalamus. OBJECTIVES: To examine functional and structural connectivity of thalamocortical networks in paroxysmal kinesigenic dyskinesia and to further investigate the effect of mutation of the proline-rich transmembrane protein 2 on thalamocortical networks. METHODS: Patients with paroxysmal kinesigenic dyskinesia (n = 20), subdivided into proline-rich transmembrane protein 2-mutated (n = 8) and nonmutated patients (n = 12) and healthy controls (n = 20) underwent resting-state functional MRI and diffusion imaging scan...
February 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28183367/selective-functional-disconnection-of-the-orbitofrontal-subregions-in-schizophrenia
#11
Y Xu, W Qin, C Zhuo, L Xu, J Zhu, X Liu, C Yu
BACKGROUND: As a disconnection syndrome, schizophrenia has shown impaired resting-state functional connectivity (rsFC) in the orbitofrontal cortex (OFC); however, the OFC is a rather heterogeneous region and the rsFC changes in the OFC subregions remain unknown. METHOD: A total of 98 schizophrenia patients and 102 healthy controls underwent resting-state functional MRI using a sensitivity-encoded spiral-in imaging sequence (SENSE-SPIRAL) to reduce susceptibility-induced signal loss and distortion...
February 10, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28180077/multicenter-stability-of-resting-state-fmri-in-the-detection-of-alzheimer-s-disease-and-amnestic-mci
#12
Stefan J Teipel, Alexandra Wohlert, Coraline Metzger, Timo Grimmer, Christian Sorg, Michael Ewers, Eva Meisenzahl, Stefan Klöppel, Viola Borchardt, Michel J Grothe, Martin Walter, Martin Dyrba
BACKGROUND: In monocentric studies, patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia exhibited alterations of functional cortical connectivity in resting-state functional MRI (rs-fMRI) analyses. Multicenter studies provide access to large sample sizes, but rs-fMRI may be particularly sensitive to multiscanner effects. METHODS: We used data from five centers of the "German resting-state initiative for diagnostic biomarkers" (psymri...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28179464/increased-default-mode-network-centrality-in-cognitively-impaired-multiple-sclerosis-patients
#13
Anand J C Eijlers, Kim A Meijer, Thomas M Wassenaar, Martijn D Steenwijk, Bernard M J Uitdehaag, Frederik Barkhof, Alle M Wink, Jeroen J G Geurts, Menno M Schoonheim
OBJECTIVE: To investigate how changes in functional network hierarchy determine cognitive impairment in multiple sclerosis (MS). METHODS: A cohort consisting of 332 patients with MS (age 48.1 ± 11.0 years, symptom duration 14.6 ± 8.4 years) and 96 healthy controls (HCs; age 45.9 ± 10.4 years) underwent structural MRI, fMRI, and extensive neuropsychological testing. Patients were divided into 3 groups: cognitively impaired (CI; n = 87), mildly cognitively impaired (MCI; n = 65), and cognitively preserved (CP; n = 180)...
February 8, 2017: Neurology
https://www.readbyqxmd.com/read/28174532/resting-state-brain-abnormalities-in-chronic-subjective-tinnitus-a-meta-analysis
#14
Yu-Chen Chen, Fang Wang, Jie Wang, Fan Bo, Wenqing Xia, Jian-Ping Gu, Xindao Yin
Purpose: The neural mechanisms that give rise to the phantom sound of tinnitus have not been fully elucidated. Neuroimaging studies have revealed abnormalities in resting-state activity that could represent the neural signature of tinnitus, but there is considerable heterogeneity in the data. To address this issue, we conducted a meta-analysis of published neuroimaging studies aimed at identifying a common core of resting-state brain abnormalities in tinnitus patients. Methods: A systematic search was conducted for whole-brain resting-state neuroimaging studies with SPECT, PET and functional MRI that compared chronic tinnitus patients with healthy controls...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28174333/resting-state-network-topology-differentiates-task-signals-across-the-adult-lifespan
#15
Micaela Y Chan, Fahd H Alhazmi, Denise C Park, Neil K Savalia, Gagan S Wig
: Brain network connectivity differs across individuals. For example, older adults exhibit less segregated resting-state sub-networks relative to younger adults (e.g., Chan et al., 2014). It has been hypothesized that individual differences in network connectivity impact the recruitment of brain areas during task execution. While recent studies have described the spatial overlap between resting-state functional correlation (RSFC) sub-networks and task-evoked activity, it is unclear whether individual variations in the connectivity pattern of a brain area (topology) relates to its activity during task execution...
February 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28173729/structural-and-functional-abnormalities-in-children-with-adhd-a-focus-on-subgenual-anterior-cingulate-cortex
#16
Chenyang Zhan, Yuhong Liu, Kai Wu, Yu Gao, Xiaobo Li
Attention-Deficit/Hyperactivity Disorder (ADHD), characterized by developmentally inappropriate inattention, hyperactivity/impulsivity, or a combination of both, is a major public health problem. Neuroimaging studies have revealed associations of these cognitive impairments with structural and functional deficits all over the brain. Existing findings are not fully consistent due to the heterogeneity of study samples and diversity of research techniques. In the current study, we propose to utilize a multi-modal MRI approach to study the structural and functional brain networks in children with ADHD-combined type (ADHD-C) with a focus on the subgenual anterior cingulate cortex (sgACC)...
February 7, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28167076/brain-network-alterations-in-the-inflammatory-soup-animal-model-of-migraine
#17
Lino Becerra, James Bishop, Gabi Barmettler, Vanessa Kainz, Rami Burstein, David Borsook
Advances in our understanding of the human pain experience have shifted much of the focus of pain research from the periphery to the brain. Current hypotheses suggest that the progression of migraine depends on abnormal functioning of neurons in multiple brain regions. Accordingly, we sought to capture functional brain changes induced by the application of an inflammatory cocktail known as inflammatory soup (IS), to the dura mater across multiple brain networks. Specifically, we aimed to determine whether IS alters additional neural networks indirectly related to the primary nociceptive pathways via the spinal cord to the thalamus and cortex...
February 3, 2017: Brain Research
https://www.readbyqxmd.com/read/28162166/-difference-in-imaging-and-metal-metabolism-between-hepatic-and-cerebral-type-wilson-disease
#18
X X Zhou, X H Li, X Y Pu, H L Qin, X B Li, J P Chu, Z Y Yang, H W Huang, X L Liang
Objective: To evaluate the difference of metal metabolism, damage to structure and functional activity in brains between hepatic and cerebral type Wilson disease (WD). Methods: Forty patients with WD, including 20 with cerebral type and 20 with hepatic type, and 20 age-matched healthy controls in the First Affiliated Hospital, Sun Yat-sen University between Jul 2013 and May 2016 were enrolled.All study subjects underwent diffusion tensor imaging (DTI), resting state functional MRI (rs-fMRI) and susceptibility weighted imaging (SWI) of the brain...
January 17, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28161319/biophysical-and-neural-basis-of-resting-state-functional-connectivity-evidence-from-non-human-primates
#19
REVIEW
Li Min Chen, Pai-Feng Yang, Feng Wang, Arabinda Mishra, Zhaoyue Shi, Ruiqi Wu, Tung-Lin Wu, George H Wilson, Zhaohua Ding, John C Gore
Functional MRI (fMRI) has evolved from simple observations of regional changes in MRI signals caused by cortical activity induced by a task or stimulus, to task-free acquisitions of images in a resting state. Such resting state signals contain low frequency fluctuations which may be correlated between voxels, and strongly correlated regions are deemed to reflect functional connectivity within synchronized circuits. Resting state functional connectivity (rsFC) measures have been widely adopted by the neuroscience community, and are being used and interpreted as indicators of intrinsic neural circuits and their functional states in a broad range of applications, both basic and clinical...
February 2, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28161313/development-of-large-scale-functional-networks-from-birth-to-adulthood-a-guide-to-neuroimaging-literature
#20
David S Grayson, Damien A Fair
The development of human cognition results from the emergence of coordinated brain activity betweeen distant brain areas. Network science, combined with non-invasive functional imaging, has generated unprecedented insights regarding the adult brain's functional organization, and promises to help elucidate the development of functional architectures supporting complex behavior. Here we review what is known about functional network development from birth until adulthood, particularly as understood through the use of resting-state functional connectivity MRI (rs-fcMRI)...
February 1, 2017: NeuroImage
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