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https://www.readbyqxmd.com/read/29040580/cohort-profile-the-mother-child-cohort-in-crete-greece-rhea-study
#1
Leda Chatzi, Vasiliki Leventakou, Marina Vafeiadi, Katerina Koutra, Theano Roumeliotaki, Georgia Chalkiadaki, Marianna Karachaliou, Vasiliki Daraki, Andriani Kyriklaki, Mariza Kampouri, Eleni Fthenou, Katerina Sarri, Maria Vassilaki, Maria Fasoulaki, Panos Bitsios, Antonis Koutis, Euripides G Stephanou, Manolis Kogevinas
No abstract text is available yet for this article.
June 21, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29039968/characteristics-biological-properties-and-analytical-methods-of-ursolic-acid-a-review
#2
Andressa Maria Pironi, Patricia Rocha de Araújo, Mariza Aires Fernandes, Hérida Regina Nunes Salgado, Marlus Chorilli
Ursolic acid (UA) is a naturally occurring triterpenoid which is a promising candidate for the development of new therapeutic approaches and for the prevention and treatment of several diseases owing to its pharmacological importance. However, its low solubility in aqueous medium affects its therapeutic application. Several strategies have been used to overcome this obstacle. In this study, the incorporation of UA in to different drug delivery systems was found to be highly efficient. In addition, important investigations were performed about methods for qualitative and quantitative analyses of UA in various raw materials, including plants, biological fluids, and drug delivery systems, were investigated...
October 17, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/29036934/identification-of-genetic-interaction-with-risk-factors-using-a-time-to-event-model
#3
Mariza de Andrade, Sebastian M Armasu, Bryan M McCauley, Tanya M Petterson, John A Heit
BACKGROUND: Certain diseases can occur with and without a trigger. We use Venous Thromboembolism (VTE) as our example to identify genetic interaction with pregnancy in women with VTE during pre- or postpartum. Pregnancy is one of the major risk factors for VTE as it accounts for 10% of maternal deaths. METHODS: We performed a whole genome association analysis using the Cox Proportional Hazard (CoxPH) model adjusted for covariates to identify genetic variants associated with the time-to-event of VTE related to pre- or postpartum during the childbearing age of 18-45 years using a case-only design in a cohort of women with VTE...
October 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28977089/pregnancy-recurrence-in-adolescents-in-southern-brazil
#4
Mariza Zanchi, Raúl Andrés Mendoza-Sassi, Marilyn Rita da Silva, Sheylla Gorges de Almeida, Lisiane Ortiz Teixeira, Carla Vitola Gonçalves
OBJECTIVE: To determine the pregnancy recurrence among adolescents and young people in a city located in the extreme south of Brazil and to identify associated factors. METHOD: One hundred and twelve (112) women participated, having delivered their children in 2010, while adolescents. The sample was stratified in two stages, being the first a census of the whole population of the city and the second a convenience sample. For statistical analysis, Pearson Chi-square test was used, with a significance level of 5%...
July 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28967586/correlation-between-voice-and-auditory-processing
#5
Janine Santos Ramos, Mariza Ribeiro Feniman, Ingrid Gielow, Kelly Cristina Alves Silverio
PURPOSE: To compare and to correlate the performance of women with behavioral dysphonia and without voice disorders in auditory processing tests and in the Voice Tone Reproduction Test (VTRT). METHODS: Forty women aged from 18 to 44 years participated and were divided in two groups: dysphonic (DG) and non-dysphonic (NDG). The participants underwent interview, hearing, otorhinolaryngology and voice assessments (voice record, VTRT through phonetography), and auditory processing assessment-using the Pitch Pattern Sequence (PPS) test and the Duration Pattern Sequence (DPS) test...
September 26, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28953253/an-efficient-test-for-gene-environment-interaction-in-generalized-linear-mixed-models-with-family-data
#6
Mauricio A Mazo Lopera, Brandon J Coombes, Mariza de Andrade
Gene-environment (GE) interaction has important implications in the etiology of complex diseases that are caused by a combination of genetic factors and environment variables. Several authors have developed GE analysis in the context of independent subjects or longitudinal data using a gene-set. In this paper, we propose to analyze GE interaction for discrete and continuous phenotypes in family studies by incorporating the relatedness among the relatives for each family into a generalized linear mixed model (GLMM) and by using a gene-based variance component test...
September 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28940498/twice-weekly-pulse-and-daily-continuous-dose-erlotinib-as-initial-treatment-for-patients-with-epidermal-growth-factor-receptor-mutant-lung-cancers-and-brain-metastases
#7
Kathryn C Arbour, Mark G Kris, Gregory J Riely, Ai Ni, Kathryn Beal, Mariza Daras, Sara A Hayes, Robert J Young, Christopher R Rodriguez, Linda Ahn, William Pao, Helena A Yu
BACKGROUND: In a phase 1 study of pulse/continuous-dose erlotinib, no patient had disease progression in the central nervous system (CNS). This expansion cohort of the phase 1 study tested the same regimen in a cohort of individuals with epidermal growth factor receptor (EGFR)-mutant lung cancers with untreated brain metastases. METHODS: Patients had not received EGFR tyrosine kinase inhibitors or radiation for brain metastases. All received 1200 mg of erlotinib on days 1 and 2 and 50 mg on days 3 to 7 weekly...
September 21, 2017: Cancer
https://www.readbyqxmd.com/read/28927293/antileishmanial-and-antioxidant-potential-of-fractions-and-isolated-compounds-from-nectandra-cuspidata
#8
Lilian Dos Anjos Oliveira Ferreira, Mariana Maciel de Oliveira, Flávia Lais Faleiro, Débora Botura Scariot, Joana Schuelter Boeing, Jesuí Vergílio Visentainer, Mariza Barion Romagnolo, Celso Vataru Nakamura, Maria da Conceição Torrado Truiti
The effects on the viability of promastigote and amastigote forms of Leishmania (Leishmania) amazonensis and citotoxicity in J774.A1 macrophages of ethanolic extract, fractions and isolated compounds that were obtained from the leaves of Nectandra cuspidata were determined. The total phenolics content (TP) and antioxidant activity were assessed using different assays. The ethyl acetate fraction (EAF) had the best antiproliferative activity (amastigote IC50: 4.42 ± 0.60 μg/mL, promastigote IC50: 33.33 ± 0...
September 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28914079/co-infection-of-human-herpesvirus-type-2-hhv-2-and-human-immunodeficiency-virus-hiv-among-pregnant-women-in-rio-de-janeiro-brazil
#9
Lyana Rodrigues Pinto Lima, Luis Eduardo Barros Costa Fernandes, Daniel A M Villela, Mariza Gonçalves Morgado, José Henrique Pilotto, Vanessa Salete de Paula
Pregnant women who are infected with the Human Immunodeficiency Virus (HIV) are particularly vulnerable to severe and recurrent infections with Human Herpesvirus 2 (HHV-2). Neonatal transmission of HHV-2 has been associated with malformations and neurological sequelae in infants, which makes it very important to perform antenatal monitoring for genital herpes. In the study, 134 pregnant women infected with HIV were tested for HHV-2 IgM and IgG using an enzyme-linked immunosorbent assay (ELISA) and had HHV-2 DNA analyzed by Real Time Polymerase Chain Reaction (qPCR)...
September 15, 2017: AIDS Care
https://www.readbyqxmd.com/read/28902298/nursing-infant-with-acquired-toxoplasmosis-in-the-first-months-of-life-a-case-report
#10
Hanstter Hallison Alves Rezende, Heloísa Ribeiro Storchilo, Jaqueline Ataíde Silva Lima, Antônio Roberto Gomes, Taynara Cristina Gomes, Jéssica Yonara de Souza, Mariza Martins Avelino, Waldemar Naves do Amaral, Marina Clare Vinaud, Ana Maria de Castro
Toxoplasmosis is caused by Toxoplasma gondii and the probability of this infection occurring in the first months of life is usually low because its transmission is related to eating habits. A 6-month-old nursing infant was diagnosed with acute toxoplasmosis, which was identified through anti- T. gondii IgA, IgM and low-avidity IgG serologic assays, polymerase chain reaction (PCR) and mouse bioassay test although its mother was seronegative. This serological divergence between mother and child led us to interview the mother regarding epidemiological factors...
August 24, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28878856/-68-gallium-arginine-glycine-aspartic-acid-and-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-chondroblastic-osteosarcoma-of-the-skull
#11
Akintunde Orunmuyi, Moshe Modiselle, Thabo Lengana, Thomas Ebenhan, Mariza Vorster, Mike Sathekge
We report the case of a 32 year-old male with Chondroblastic Osteosarcoma of the skull, which was imaged with both (18)[F]fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) and (68)Gallium-arginine-glycine-aspartic acid ((68)Ga-RGD) PET/CT. The (18)F-FDG PET/CT did not demonstrate the tumour, whereas the (68)Ga-RGD PET/CT clearly depicted a left-sided frontal tumour. (68)Ga-RGD PET/CT may be a clinically useful imaging modality for early detection of recurrent osteosarcoma, considering the limitations of (18)F-FDG PET in a setting of low glycolytic activity...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28878686/comparative-analysis-of-3d-bladder-tumor-spheroids-obtained-by-forced-floating-and-hanging-drop-methods-for-drug-screening
#12
Robson L F Amaral, Mariza Miranda, Priscyla D Marcato, Kamilla Swiech
Introduction: Cell-based assays using three-dimensional (3D) cell cultures may reflect the antitumor activity of compounds more accurately, since these models reproduce the tumor microenvironment better. Methods: Here, we report a comparative analysis of cell behavior in the two most widely employed methods for 3D spheroid culture, forced floating (Ultra-low Attachment, ULA, plates), and hanging drop (HD) methods, using the RT4 human bladder cancer cell line as a model. The morphology parameters and growth/metabolism of the spheroids generated were first characterized, using four different cell-seeding concentrations (0...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28874142/risk-factors-for-increased-immune-reconstitution-in-response-to-mycobacterium-tuberculosis-antigens-in-tuberculosis-hiv-infected-antiretroviral-na%C3%A3-ve-patients
#13
Tatiana Pereira da Silva, Carmem Beatriz Wagner Giacoia-Gripp, Carolina A Schmaltz, Flavia Marinho Sant'Anna, Maria Helena Saad, Juliana Arruda de Matos, Julio Castro Alves de Lima E Silva, Valeria Cavalcanti Rolla, Mariza Gonçalves Morgado
BACKGROUND: Little is known regarding the restoration of the specific immune response after combined antiretroviral therapy (cART) and anti-tuberculosis (TB) therapy introduction among TB-HIV patients. In this study, we examined the immune response of TB-HIV patients to Mycobacterium tuberculosis (Mtb) antigens to evaluate the response dynamics to different antigens over time. Moreover, we also evaluated the influence of two different doses of efavirenz and the factors associated with immune reconstitution...
September 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28818989/metabolic-imaging-of-infection
#14
Ismaheel Lawal, Jan Rijn Zeevaart, Thomas Ebenhan, Alfred Ankrah, Mariza Vorster, Hendrick Kruger, Thavendran Govender, Mike Sathekge
Metabolic imaging of infection has come to occupy a prominent place in the diagnosis and management of microbial infection. Molecular probes available for infection imaging have undergone a rapid evolution starting with the use of non-specific agents that accumulate similarly in infection, sterile inflammation and neoplastic tissue to more targeted probes that seek to identify specific microbial species. This focus review describes the metabolic and molecular imaging techniques currently available for clinical use in infection imaging and those that have demonstrated promising results in preclinical studies with the potential for clinical applications...
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28817824/parametric-linkage-analysis-identifies-five-novel-genome-wide-significant-loci-for-familial-lung-cancer
#15
Anthony M Musolf, Claire L Simpson, Mariza de Andrade, Diptasri Mandal, Colette Gaba, Ping Yang, Yafang Li, Ming You, Elena Y Kupert, Marshall W Anderson, Ann G Schwartz, Susan M Pinney, Christopher I Amos, Joan E Bailey-Wilson
OBJECTIVE: One of four American cancer patients dies of lung cancer. Environmental factors such as tobacco smoking are known to affect lung cancer risk. However, there is a genetic factor to lung cancer risk as well. Here, we perform parametric linkage analysis on family-based genotype data in an effort to find genetic loci linked to the disease. METHODS: 197 individuals from families with a high-risk history of lung cancer were recruited and genotyped using an Illumina array...
2016: Human Heredity
https://www.readbyqxmd.com/read/28807297/cutaneous-leishmaniosis-in-naturally-infected-dogs-in-paran%C3%A3-brazil-and-the-epidemiological-implications-of-leishmania-viannia-braziliensis-detection-in-internal-organs-and-intact-skin
#16
Ellen de Souza Marquez, Edilene Alcântara de Castro, Luciene Biazono Nabut, Magda Clara Vieira da Costa-Ribeiro, Ludmilla Dela Coletta Troiano Araújo, Saloe Bispo Poubel, André Luiz Gonçalves, Mariza Fordellone Rosa Cruz, Ana Paula Millet Evangelista Dos Santos Trad, Rafael Andre Ferreira Dias, Italmar Teodorico Navarro, Vanete Thomaz-Soccol
Environmental changes have occurred over the years, altering the eco-epidemiological pattern of leishmaniosis in the State of Paraná, Brazil, involving the pillars of the cycle (parasite, vectors, reservoir, and environment) and their interaction. Much has been discussed about the dog's role as a reservoir of the Leishmania (Viannia) braziliensis Vianna, 1911 transmission cycle. However, this question remains unanswered. The purpose of this study was to investigate, using parasitological and molecular methods, different samples in eight naturally infected dogs from an endemic rural locality where only L...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28802387/sleep-quality-and-communication-aspects-in-children
#17
Camila de Castro Corrêa, Maria Renata José, Eduardo Carvalho Andrade, Mariza Ribeiro Feniman, Ana Paula Fukushiro, Giédre Berretin-Felix, Luciana Paula Maximino
OBJECTIVES: To correlate quality of life of children in terms of sleep, with their oral language skills, auditory processing and orofacial myofunctional aspects. METHODS: Nineteen children (12 males and seven females, in the mean age 9.26) undergoing otorhinolaryngological and speech evaluations participated in this study. The OSA-18 questionnaire was applied, followed by verbal and nonverbal sequential memory tests, dichotic digit test, nonverbal dichotic test and Sustained Auditory Attention Ability Test, related to auditory processing...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28709425/erratum-to-metabolic-syndrome-and-its-predictors-in-an-urban-population-in-kenya-a-cross-sectional-study
#18
Geoffrey Omuse, Daniel Maina, Mariza Hoffman, Jane Mwangi, Caroline Wambua, Elizabeth Kagotho, Angela Amayo, Peter Ojwang, Zulfiqarali Premji, Kiyoshi Ichihara, Rajiv Erasmus
No abstract text is available yet for this article.
July 14, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28697189/gallium-68-dotatate-pet-ct-is-better-than-ct-in-the-management-of-somatostatin-expressing-tumors-first-experience-in-africa
#19
COMPARATIVE STUDY
Ismaheel O Lawal, Kehinde O Ololade, Thabo Lengana, Florette Reyneke, Alfred O Ankrah, Thomas Ebenhan, Mariza Vorster, Mike M Sathekge
OBJECTIVE: In this study we aimed to present our experience on the use of Gallium-68-dotatate with positron emission tomography, computed tomography ((68) Ga-dotatate PET/CT) in the management of neuroendocrine tumors (NET) and other somatostatin expressing tumors. SUBJECTS AND METHODS: We retrospectively reviewed patients with histologically confirmed or biochemically suspected NET and other somatostatin expressing (SSTR) tumors imaged at our department with (68)Ga-dotatate PET/CT...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28685401/high-maternal-vitamin-d-levels-in-early-pregnancy-may-protect-against-behavioral-difficulties-at-preschool-age-the-rhea-mother-child-cohort-crete-greece
#20
Vasiliki Daraki, Theano Roumeliotaki, Katerina Koutra, Georgia Chalkiadaki, Marianna Katrinaki, Andriani Kyriklaki, Mariza Kampouri, Katerina Margetaki, Marina Vafeiadi, Stathis Papavasiliou, Manolis Kogevinas, Leda Chatzi
Animal studies suggest that prenatal vitamin D status may affect fetal brain growth. However, human studies are scarce with conflicting results. We aimed to investigate the association of maternal 25-hydroxyvitamin D [25(OH) D] levels with multiple neurodevelopmental outcomes at 4 years of age. We included 487 mother-child pairs from the prospective pregnancy cohort, "Rhea" in Crete, Greece. Maternal serum 25(OH) D concentrations were measured at the first prenatal visit (13 ± 2.4 weeks). Cognitive functions at 4 years were assessed by means of the McCarthy Scales of Children's Abilities...
July 6, 2017: European Child & Adolescent Psychiatry
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