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https://www.readbyqxmd.com/read/29783247/predictors-of-thrombogenesis-by-the-state-of-pro-and-anticoagulant-components-of-hemostasis-in-the-patients-with-stage-vd-chronic-kidney-disease
#1
Olexiy B Storozhuk, Iryna B Seleznyova, Larisa O Storozhuk, Boris G Storozhuk, Tetyana V Dovgalyuk
OBJECTIVE: Introduction: One of the major complications of stage V chronic kidney disease (CKD), treated by program hemodialysis, are hemostatic system disturbances resulting in thrombosis development. To detect early predictors of potential thrombosis in study category of patients is rather difficult because of inflammatory process, accumulation of antibodies, continuous damage of blood elements. The aim: To estimate potential applicability of activators and inhibitors of thrombogenesis as thrombophilia markers in the patients with stage V CKD, treated by program hemodialysis...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782079/the-dipep-diagnosis-of-pe-in-pregnancy-study-an-observational-study-of-the-diagnostic-accuracy-of-clinical-assessment-d-dimer-and-chest-x-ray-for-suspected-pulmonary-embolism-in-pregnancy-and-postpartum
#2
Steve Goodacre, Kimberley Horspool, Catherine Nelson-Piercy, Marian Knight, Neil Shephard, Fiona Lecky, Steven Thomas, Beverley J Hunt, Gordon Fuller
OBJECTIVE: To identify clinical features associated with PE diagnosis and determine the accuracy of decision rules and D-dimer for diagnosing suspected PE in pregnant/postpartum women. DESIGN: Observational cohort study augmented with additional cases. SETTING: Emergency departments and maternity units at eleven prospectively recruiting sites and maternity units in the United Kingdom Obstetric Surveillance System (UKOSS). POPULATION: 324 pregnant/postpartum women with suspected PE and 198 pregnant/postpartum women with diagnosed PE...
May 21, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29780589/at-the-threshold-of-certainty-risk-stratification-and-clinical-assessment-incongruity-in-the-diagnosis-of-aortic-dissection
#3
Maxim Zlatopolsky, Daniel Brancheau, Marcel Zughaib
The use of D-dimer assay to screen for aortic dissection has become routine in clinical practice. Although an uncommon disease entity, aortic dissection is rapidly fatal without prompt diagnosis, and biochemical detection in the proper clinical context is crucial. We performed a retrospective chart review of all aortic dissections presenting to a community tertiary care center between 2000 and 2016 and identified three patients in whom laboratory D-dimer testing was positive and a diagnosis of Stanford Type A aortic dissection was confirmed with computed tomography angiography based on clinical assessment and a newly validated risk stratification tool...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29774166/hemostatic-state-augmented-with-platelet-indices-among-sudanese-diabetic-septic-foot
#4
Bashir Abdrhman Bashir, Mohamed Salih Ali
Background: Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Owing to the potential sequelae of coagulation and vascular abnormalities, this work aimed at studying the hemostatic state and platelet indices in diabetes type II patients with septic foot. Methods: A case-control study was conducted during the period from July to September 2017 at Dr...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29772969/case-control-study-of-plasma-mean-platelet-component-concentration-and-survival-analysis-for-dogs-with-immune-mediated-hemolytic-anemia
#5
Andrea Zoia, Magda Gerou-Ferriani, Michele Drigo, Marco Caldin
OBJECTIVE To determine whether dogs with immune-mediated hemolytic anemia (IMHA) had a low plasma mean platelet component (MPC) concentration and whether MPC was associated with outcome. DESIGN Retrospective case-control study and survival analysis. ANIMALS 95 dogs with IMHA (cases) as well as 95 healthy dogs and 95 sick dogs without IMHA (controls) matched to cases by age, reproductive status, and breed. PROCEDURES Plasma MPC concentration at initial examination was compared among groups. For dogs with IMHA only, sex, age, serum urea and bilirubin concentrations, Hct, platelet count, and plasma fibrinogen, D-dimer, and MPC concentrations were evaluated for associations with survival to 42 days after initial examination...
June 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29771870/hyperfibrinolysis-is-an-important-cause-of-early-hemorrhage-in-patients-with-acute-promyelocytic-leukemia
#6
Yu-Hua Song, Chun Qiao, Li-Chan Xiao, Run Zhang, Hua - Lu
BACKGROUND The objective of the current study was to guide the early clinical treatment strategies by assessing the recovery of abnormal coagulation in acute promyelocytic leukemia (APL) patients during induction therapy. MATERIAL AND METHODS Retrospective analysis was performed in 112 newly-diagnosed patients with APL during induction treatment. RESULTS The early death (ED) rate in our study was 5.36% and the main cause was fetal hemorrhage. The presence of bleeding symptoms was significantly correlated with low platelet and fibrinogen levels...
May 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29771476/questioning-the-use-of-an-age-adjusted-d-dimer-threshold-to-exclude-venous-thromboembolism-reply
#7
S Takach Lapner, Jim A Julian, Lori-Ann Linkins, Shannon Bates, Clive Kearon
In a recent analysis[1], we questioned the validity of using a progressively higher D-dimer to define a positive test as the age of patients with suspected venous thromboembolism (VTE) increased over 50 years (termed "age-adjusted D-dimer" interpretation). We hypothesized that the benefits of age-adjusted D-dimer interpretation compared with using a conventional threshold of 500 ug/L in patients of all ages were due to a non-specific increase in the average D-dimer threshold used to classify a test as positive...
May 17, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29769425/gender-differences-in-hemostatic-and-inflammatory-factors-in-patients-with-acute-coronary-syndromes-a-pilot-study
#8
A Siennicka, M Jastrzebska, K Smialkowska, S Oledzki, K Chelstowski, M Klysz, J Clark, Z Kornacewicz-Jach
Many studies have shown gender differences in the progress of acute coronary syndromes (ACS). These differences include, amongst others, processes involved in hemostasis and inflammation, and in the present study we put forward the hypothesis that these are the primary cause of other differences. The study included 66 ACS patients (27 women and 39 men) aged 43 - 83 years, 23 with non-ST-elevation myocardial infarction (NSTEMI) and 43 with ST-elevation myocardial infarction (STEMI). Blood samples were taken on day 3 (NSTEMI) or day 5 (STEMI) after hospitalization, and fibrinogen, D-dimers, von Willebrand factor, C-reactive protein and interleukin-6 levels measured...
February 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29769125/observational-study-of-coagulation-activation-in-early-breast-cancer-development-of-a-prognostic-model-based-on-data-from-the-real-world-setting
#9
Chiara Mandoj, Laura Pizzuti, Domenico Sergi, Isabella Sperduti, Marco Mazzotta, Luigi Di Lauro, Antonella Amodio, Silvia Carpano, Anna Di Benedetto, Claudio Botti, Francesca Ferranti, Anna Antenucci, Maria Gabriella D'Alessandro, Paolo Marchetti, Silverio Tomao, Giuseppe Sanguineti, Antonio Giordano, Marcello Maugeri-Saccà, Gennaro Ciliberto, Laura Conti, Patrizia Vici, Maddalena Barba
BACKGROUND: Cancer and coagulation activation are tightly related. The extent to which factors related to both these pathologic conditions concur to patient prognosis intensely animates the inherent research areas. The study herein presented aimed to the development of a tool for the assessment and stratification of risk of death and disease recurrence in early breast cancer. METHODS: Between 2008 and 2010, two hundreds thirty-five (N: 235) patients diagnosed with stage I-IIA breast cancer were included...
May 16, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29768369/pembrolizumab-induced-acute-thrombosis-a-case-report
#10
Kei Kunimasa, Kazumi Nishino, Madoka Kimura, Takako Inoue, Motohiro Tamiya, Toru Kumagai, Fumio Imamura
RATIONALE: Acute thrombosis has not been reported in the literature so far in lung cancer patients as an immune-related adverse event (irAE) associated with PD-1 pathway inhibitors. PATIENTS CONCERNS: Here, we for the first time present two NSCLC (non-small cell lung cancer) patients suffering from acute thrombosis as a pembrolizumab-induced irAE. Immediate treatment with continuous heparin infusion improved their symptoms and enabled them to continue pembrolizumab administration...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29764552/-construction-of-death-early-warning-model-for-patients-with-septic-myocardial-depression-a-retrospective-analysis-of-129-patients
#11
Jianping Huang, Yangqing Zhou, Haifen Liu
OBJECTIVE: To explore the death risk factors of septic myocardial depression (SMD) and their predictive effect, and to set up a death early-warning model. METHODS: A retrospective analysis was conducted. The patients with SMD admitted to emergency department and rescue room of Beilun Branch of the First Affiliated Hospital of Zhejiang University Medical College from January 2015 to November 2017 were enrolled. The patients were divided into survival group and non-survival group according to 28-day outcome, and the gender, age, and the initial examination parameters [white blood cell (WBC) count, neutrophil (Neut) count, activated partial thromboplastin time (APTT), procalcitonin (PCT), D-dimer, C-reactive protein (CRP), cardiac troponin I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), and left atrium diameter (LAD)] of both groups were compared...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29761335/-biomarkers-and-atrial-fibrillation-prediction-of-recurrences-and-thromboembolic-events-after-rhythm-control-management
#12
REVIEW
Jelena Kornej, Katja Schumacher, Daniela Husser, Gerhard Hindricks
Atrial fibrillation (AF) is the most common arrhythmia in clinical praxis and is associated with an increased risk for cardio- and cerebrovascular complications leading to an increased mortality. Catheter ablation represents one of the most important and efficient therapy strategies in AF patients. Nevertheless, the high incidence of arrhythmia recurrences after catheter ablation leads to repeated procedures and higher treatment costs. Recently, several scores had been developed to predict rhythm outcomes after catheter ablation...
May 14, 2018: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/29760845/ruling-out-pulmonary-embolism-in-patients-with-high-pretest-probability
#13
Murtaza Akhter, Jeffrey Kline, Bikash Bhattarai, Mark Courtney, Christopher Kabrhel
Introduction: The American College of Emergency Physicians guidelines recommend more aggressive workup beyond imaging alone in patients with a high pretest probability (PTP) of pulmonary embolism (PE). However, the ability of multiple tests to safely rule out PE in high PTP patients is not known. We sought to measure the ability of negative computed tomography pulmonary angiography (CTPA) along with negative D-dimer to rule out PE in these high-risk patients. Methods: We analyzed data from a previous prospective observational study conducted in 12 emergency departments (ED)...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29759857/multiple-dose-intravenous-tranexamic-acid-further-reduces-hidden-blood-loss-after-total-hip-arthroplasty-a-randomized-controlled-trial
#14
Yiting Lei, Qiang Huang, Zeyu Huang, Jinwei Xie, Guo Chen, Fuxing Pei
BACKGROUND: The most appropriate dose of tranexamic acid in total hip arthroplasty (THA) has not been decided. This study was conducted to evaluate the clinical effects of multiple-dose intravenous tranexamic acid (IV-TXA) in THA. METHODS: One hundred fifty patients were randomized to receive one dose of IV-TXA before incision, followed by 2 doses of IV-TXA (group A), or 3 doses of IV-TXA (group B), or 4 doses of IV-TXA (group C) at 3-hour intervals. The primary outcome was hidden blood loss (HBL)...
April 23, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29753834/age-adjusted-versus-clinical-probability-adjusted-d-dimer-to-exclude-pulmonary-embolism
#15
Sarah Takach Lapner, Scott M Stevens, Scott C Woller, Gregory Snow, Clive Kearon
INTRODUCTION: A low D-dimer can exclude suspected pulmonary embolism (PE) in cases with low or intermediate clinical probability of disease. Yet D-dimer is nonspecific, so many cases without PE require imaging. D-dimer's specificity is improved by increasing the threshold for a positive test with age (age × 10 ng/mL; age-adjusted D-dimer; AADD) or clinical probability of PE (1000 ng/mL if low and 500 ng/mL if intermediate clinical probability; clinical probability-adjusted D-dimer; CPADD)...
May 5, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29751131/d-dimer-levels-in-non-immune-travelers-with-malaria
#16
Meltzer Eyal, Keller Shlomit, Shmuel Stienlauf, Schwartz Eli
BACKGROUND: Elevated serum D-dimer levels may reflect endothelial activation, which in malaria may correlate with parasite biomass and disease severity. METHODS: We performed a retrospective chart review of all non-immune travelers hospitalized with malaria during 01/2000-12/2014 at the Sheba Medical Center, Israel. Admission and peak D-dimer levels were compared among malaria patients, according to Plasmodium species and severity. RESULTS: Complete laboratory data was available for 94/168 travelers hospitalized with malaria, with 68...
May 8, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29746945/activation-of-coagulation-and-endothelium-with-concurrent-impairment-of-anticoagulant-mechanisms-in-patients-with-typhoid-fever
#17
Hanna K de Jong, Chris M Parry, Thomas W van der Vaart, Liesbeth M Kager, Stannie J van den Ende, Rapeephan R Maude, Lalith Wijedoru, Aniruddha Ghose, Mohammed U Hasan, Mohammed A Hossain, Arjan M Dondorp, Steve Baker, M Abul Faiz, Joost C M Meijers, W Joost Wiersinga
OBJECTIVES: Typhoid fever caused by Salmonella Typhi remains a major burden worldwide. Gastrointestinal bleeding can be seen in up to 10 percent of patients and may be fatal. The coagulopathy, which may be the driver of this severe complication in patients with typhoid fever, however is ill defined. The aim of this study was to evaluate the activation of coagulation, anticoagulation, and fibrinolysis in patients with acute typhoid fever. METHODS: . Parameters of coagulation and fibrinolysis were measured in 28 hospitalized patients with culture-confirmed or PCR-confirmed typhoid fever and compared to 38 age- and sex-matched healthy volunteers...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29745767/a-proof-of-concept-for-epidemiological-research-using-structured-reporting-with-pulmonary-embolism-as-a-use-case
#18
Pinto Dos Santos Daniel, Scheibl Sonja, Arnhold Gordon, Maehringer-Kunz Aline, Düber Christoph, Mildenberger Peter, Kloeckner Roman
OBJECTIVE: This paper studies the possibilities of an integrated IT-based workflow for epidemiological research in pulmonary embolism using freely available tools and structured reporting. METHODS: We included a total of 521 consecutive cases which had been referred to the radiology department for computed tomography pulmonary angiography (CTPA) with suspected pulmonary embolism (PE). Free-text reports were transformed into structured reports using a freely available IHE-MRRT-compliant reporting platform...
May 10, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29742907/new-interfaces-of-thyroid-hormone-actions-with-blood-coagulation-and-thrombosis
#19
Paul J Davis, Shaker A Mousa, Geraldine P Schechter
Substantial clinical evidence indicates hyperthyroidism enhances coagulation and increases the risk of thrombosis. In vitro and clinical evidence implicate multiple mechanisms for this risk. Genomic actions of thyroid hormone as 3,5,3'-triiodo-L-thyronine (T3 ) via a nuclear thyroid hormone receptor have been implicated, but recent evidence shows that nongenomic mechanisms initiated at the receptor for L-thyroxine (T4 ) on platelet integrin αvβ3 are prothrombotic. The T4 -initiated mechanisms involve platelet activation and, in addition, cellular production of cytokines and chemokines such as CX3CL1 with procoagulatory activities...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29739066/basic-evaluation-of-the-newly-developed-lias-auto-p-fdp-assay-and-the-influence-of-plasmin-%C3%AE-2-plasmin-inhibitor-complex-values-on-discrepancy-in-the-comparison-with-lias-auto-d-dimer-neo-assay
#20
Osamu Kumano, Masahiro Ieko, Yutaka Komiyama, Sumiyoshi Naito, Mika Yoshida, Nobuhiko Takahashi, Kazumasa Ohmura, Junki Hayasaki, Mineji Hayakawa
BACKGROUND: Laboratory determination of fibrin/fibrinogen degradation products (FDP) levels, along with that of the D-dimer, is important for assessing the fibrinolytic situation. Recently, we developed a new FDP reagent "Lias Auto P-FDP", which can detect various FDP fragments. The purpose of this study was to evaluate the basic performance of the newly developed Lias Auto P-FDP and compare it with Lias Auto D-Dimer Neo assay. METHODS: The within-run precision of Lias Auto P-FDP and Lias Auto D-Dimer was determined 20 times in low and high value controls...
April 1, 2018: Clinical Laboratory
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