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https://www.readbyqxmd.com/read/29324920/technetium-99m-dimercaptosuccinic-acid-renal-scintigraphy-can-guide-clinical-management-in-congenital-hydronephrosis
#1
Biljana Bazić-Đorović, Marija Radulović, Marija Šišić, Ljiljana Jauković, Sanja Dugonjić, Dragan Pucar, Zoran Janković, Slobodanka Beatović, Milica Janković, Zoran Krstić, Boris Ajdinović
OBJECTIVE: The purpose of this study was to evaluate damage of the kidney with technetium-99m-dimercaptosuccinic acid (99mTc-DMSA) scintigraphy in children with congenital hydronephrosis (CH) and the influence of other postnatal associated diagnoses on abnormal 99mTc-DMSA findings. SUBJECTS AND METHODS: 99mTc-DMSA scintigraphy in 54 children (17 girls and 37 boys), aged from 2 months to 5 years (median 11 months) with 66 congenital hydronephrotic renal units (RU) (42 unilateral hydronephrosis-29 boys and 13 girls; 12 bilateral hydronephrosis-8 boys and 4 girls) was performed...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29306986/d-dimer-as-a-marker-of-acute-pyelonephritis-in-infants-younger-than-24%C3%A2-months-with-urinary-tract-infection
#2
Jung Won Lee, Sun Mi Her, Ji Hong Kim, Keum Hwa Lee, Michael Eisenhut, Se Jin Park, Jae Il Shin
BACKGROUND: D-dimer, as well as other biomarkers related to coagulation, is significantly increased during severe bacterial infection and sepsis. The aim of this study was to evaluate the usefulness of serum D-dimer as a biological marker in diagnosing acute pyelonephritis (APN) and in predicting vesicoureteric reflux (VUR) in infants with urinary tract infection (UTI). METHODS: We retrospectively analyzed the data of 177 young infants (<2 years) with febrile UTI between 2005 and 2014, grouped as APN and lower UTI groups...
January 6, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29271690/surgical-outcome-analysis-of-pneumovesicoscopic-ureteral-reimplantation-and-endoscopic-dextranomer-hyaluronic-acid-injection-for-primary-vesicoureteral-reflux-in-children-a-multicenter-12-year-review
#3
Kenneth L Y Chung, Jennifer Sihoe, Kelvin Liu, Nicholas Chao, Judy Hung, Clarence Liu, Felix Yam, Yvonne Leung, Peter Tam, Kim Hung Lee, Michael Leung
OBJECTIVE: Vesicoureteral reflux (VUR) is a common condition associated with childhood urinary tract infection (UTI), which may lead to chronic renal failure and hypertension. Different antireflux approaches were advocated with differences in morbidity and success. The aim of this study is to review and analyze the surgical outcomes of pneumovesicoscopic ureteral reimplantation and endoscopic injection of dextranomer/hyaluronic acid (Dx/HA) in three tertiary centers. MATERIALS AND METHODS: The medical records of 215 patients (159 boys and 56 girls) for a total of 323 ureters underwent surgical interventions for primary VUR from February 2002 to August 2014 were reviewed...
December 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29248949/robot-assisted-extravesical-ureteral-reimplantation-revur-for-unilateral-vesico-ureteral-reflux-in-children-results-of-a-multicentric-international-survey
#4
Ciro Esposito, Lorenzo Masieri, Henri Steyaert, Maria Escolino, Raffaele Cerchione, Angela La Manna, Chiara Cini, Thomas S Lendvay
PURPOSE: This multicentric international retrospective study aimed to report the outcome of robot-assisted extravesical ureteral reimplantation (REVUR) in patients with unilateral vesico-ureteral reflux (VUR). METHODS: The medical records of 55 patients (35 girls, 20 boys) underwent REVUR in four international centers of pediatric robotic surgery for primary unilateral VUR were retrospectively reviewed. Patients' average age was 4.9 years. The preoperative grade of reflux was III in 12...
December 16, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29243800/vesicoureteral-reflux-in-infants-what-do-we-know-about-the-gender-prevalence-by-age
#5
N Capozza, C Gulia, Z Heidari Bateni, A Zangari, S Gigli, V Briganti, S Tursini, C J Koh, M Gaffi, S Baldassarra, F Signore, A Porrello, R Piergentili
OBJECTIVE: Vesicoureteral reflux (VUR) affects up to 1% of Caucasian children. Primary VUR is characterized by failure of the ureterovesicular junction to prevent urine from traveling in a retrograde fashion from the bladder to the ureters and the kidneys. Several reports in the literature describe the prevalence of this condition in pediatric patients; overall, VUR affects more males during infancy and with higher grades. However, a thorough consideration of these articles reveals important contradictions regarding the prevalence by gender and age...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29226740/do-infants-in-the-neonatal-intensive-care-unit-diagnosed-with-urinary-tract-infection-need-a-routine-voiding-cystourethrogram
#6
Dustin D Flannery, Erik Brandsma, Judy Saslow, Amy B Mackley, David A Paul, Zubair H Aghai
OBJECTIVE: To determine if infants diagnosed with urinary tract infection (UTI) in the neonatal intensive care unit (NICU) require a routine voiding cystourethrogram (VCUG). STUDY DESIGN: Retrospective data analysis from three centers for infants admitted to the NICU born between 2000 and 2013 and diagnosed with UTI. RESULTS: One hundred twenty-six infants from three centers were diagnosed with UTI during their hospitalization. Renal ultrasound (RUS) was performed in 115 infants (91...
December 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29223546/sigmoidocolocystoplasty-for-neurogenic-bladder-reviewed-after-20-years
#7
Yutaka Hayashi, Emi Nishimura, Satoko Shimizu, Go Miyano, Manabu Okawada, Itsuro Nagae, Geoffrey J Lane, Kenji Katsumata, Atsuyuki Yamataka, Akihiko Tsuchida
BACKGROUND/PURPOSE: We report the current status of patients who underwent augmentation cystoplasty (AC) at least 20years previously. METHODS: Surgical history, incidence of urinary tract infection (UTI) and bladder stones, vesicoureteral reflux (VUR), urine cytology, renal function, a colon cancer tumor marker (carcinoembryonic antigen: CEA), and patient outcomes were assessed. RESULTS: Forty patients who underwent AC (mean age: 34.4years; mean follow-up time: 24...
December 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29217322/incidence-of-ureterovesical-obstruction-and-cohen-antireflux-surgery-after-deflux%C3%A2-treatment-for-vesicoureteric-reflux
#8
Manabu Okawada, Hiroshi Murakami, Nana Tanaka, Yuki Ogasawara, Geoffrey J Lane, Tadaharu Okazaki, Toshihiro Yanai, Masahiko Urao, Atsuyuki Yamataka
AIM: The purpose of this study was to determine the incidence of ureteric obstruction (UB) and requirement for Cohen antireflux surgery (CAS) after DefluxⓇ treatment (DT) for vesicoureteric reflux (VUR). METHODS: Between 2011 and 2017, 494 ureters (VUR severity ≤ grade III: N=291 or >grade IV: N=203) were treated by DT at a mean age of 4.5 (range: 0.2-24) years. Epidural Catheter Assistance (ECA) was used to exclude UB by injecting diluted indigo carmine solution (1-3mL) into an epidural catheter inserted into a ureter after DT and confirming dye flow within 15min...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29203188/congenital-segmental-megaureter-in-an-ectopic-kidney
#9
A Khanna, R S Mavuduru, G S Bora, S K Devana, A K Mandal
We describe the imaging findings of a 19 year female who presented with recurrent urinary tract infections and pain abdomen which was diagnosed to be due to a left sided focal segmental megaureter with a calculus. The highlights of the case are functioning moiety with no other associated anomalies like VUR, Duplex system etc.
December 1, 2017: Urology
https://www.readbyqxmd.com/read/29198997/a-reanalysis-of-the-rivur-trial-using-a-risk-classification-system
#10
Zhan Tao Wang, Elias Wehbi, Yasaman Alam, Antoine Khoury
PURPOSE: The RIVUR trial showed a 50% reduction in the risk for urinary tract infection (UTI) recurrence in children receiving continuous antibiotic prophylaxis (CAP). We reanalyzed the RIVUR data with the purpose of using a risk classification system to identify children who are more likely to benefit from CAP. METHODS: Data from 607 children enrolled in the RIVUR trial were obtained from the NIDDK central repository and were analyzed. We stratified these children into low and high-risk categories...
November 30, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29181582/contrast-enhanced-voiding-urosonography-cevus-with-the-intravesical-administration-of-the-ultrasound-contrast-agent-optison%C3%A2-for-vesicoureteral-reflux-detection-in-children-a-prospective-clinical-trial
#11
Aikaterini Ntoulia, Susan J Back, Sphoorti Shellikeri, Laura Poznick, Trudy Morgan, Joanne Kerwood, J Christopher Edgar, Richard D Bellah, Janet R Reid, Diego Jaramillo, Douglas A Canning, Kassa Darge
BACKGROUND: Contrast-enhanced voiding urosonography (ceVUS) is widely used outside the United States to diagnose vesicoureteral reflux (VUR) in children and is highly sensitive while avoiding exposure to ionizing radiation. At the onset of this study, two ultrasound (US) contrast agents were available in the United States. Pediatric safety data for intravenous administration was published for one, Optison™. OBJECTIVE: This study aimed to evaluate the diagnostic performance and safety of ceVUS using Optison™ and compare its diagnostic efficacy with voiding cystourethrogram (VCUG) for VUR detection and grading in children...
November 27, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29154987/positioning-the-instillation-of-contrast-cystography-does-it-provide-any-clinical-benefit
#12
Hakan Bahadir Haberal, Burak Çitamak, Mesut Altan, Ali Cansu Bozaci, Taner Ceylan, Hasan Serkan Doğan, Serdar Tekgül
OBJECTIVES: To outline positioning the instillation of contrast cystography (PICC)'s benefits in clinical practice. METHODS: 198 patients underwent PICC with the following indications: patients with positive preoperative conventional voiding cystourethrography (VCUG) for single ureteric side, patients with urinary tract infection, and negative VCUG for both ureteric sides. Patients with positive VCUG served as the control group. Preoperative, intraoperative, and postoperative features of all patients were compared...
November 15, 2017: Urology
https://www.readbyqxmd.com/read/29150195/anatomic-findings-associated-with-epispadias-in-boys-implications-for-surgical-management-and-urinary-continence
#13
M Cendron, P S Cho, M Pennison, I Rosoklija, D A Diamond, J G Borer
INTRODUCTION: Pre-operative physical examination of male epispadias allows for classification of epispadias level as glanular (GE), penile (PE) or penopubic (PPE), and for delineation of anatomic anomalies. The incidence of associated extragenital abnormalities, such as vesicoureteral reflux (VUR), bladder neck (BN) abnormality and abnormal pubic diastasis (PD), and their impact on urinary continence has not yet been systematically studied. OBJECTIVE: The goal of this study was to evaluate whether the more proximal level of epispadias correlated with associated extragenital anatomic anomalies seen on initial imaging or endoscopic evaluation, and whether these pre-operative findings contributed to subsequent surgical management and impacted on achieving urinary continence...
October 26, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29146303/comparison-of-intravesical-cohen-and-extravesical-lich-gregoir-ureteroneocystostomy-in-the-treatment-of-unilateral-primary-vesicoureteric-reflux-in-children
#14
Mesrur Selcuk Silay, Turgay Turan, Yunus Kayalı, İsmail Başıbüyük, Bilal Gunaydin, Turhan Caskurlu, M İhsan Karaman
INTRODUCTION: Various intravesical and extravesical techniques have been described for the surgical correction of vesicoureteral reflux (VUR). Among those techniques Cohen (intra-vesical) and Lich-Gregoir (extra-vesical) are the most commonly used ones. However, there are limited studies that compare those two surgical techniques in the literature. OBJECTIVE: In this study, we aim to compare the outcomes of the open intravesical and extravesical procedures for unilateral primary VUR in children...
October 14, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29135976/loss-of-peri-wolffian-duct-stromal-frs2%C3%AE-expression-in-mice-leads-to-abnormal-ureteric-bud-induction-and-vesicoureteral-reflux
#15
Deepti Narla, Stacey B Slagle, Caitlin M Schaefer, Daniel S Bushnell, Pawan Puri, Carlton M Bates
BackgroundFibroblast growth factor receptor 2 (Fgfr2) deletion from murine peri-Wolffian duct stroma (ST) results in aberrant ureteric bud induction, abnormal ureteral insertion into the bladder, and high rates of vesicoureteral reflux (VUR). It is unclear which receptor docking protein(s) is/are responsible for Fgfr2 actions in these tissues. We investigated whether the docking protein, fibroblast receptor substrate 2α (Frs2α), had a role in peri-Wolffian duct ST similar to Fgfr2.MethodsWe conditionally deleted Frs2α in peri-Wolffian duct ST with a Tbx18cre mouse line (Frs2α(ST-/-))...
December 2017: Pediatric Research
https://www.readbyqxmd.com/read/29133166/determination-of-threshold-value-for-follow-up-of-isolated-antenatal-hydronephrosis-detected-in-the-second-trimester
#16
Ravi de Roo, Bart J Voskamp, C Emily Kleinrouweler, Ben W Mol, Eva Pajkrt, Antonia H M Bouts
INTRODUCTION: Isolated antenatal hydronephrosis (ANH), defined as a dilation of the renal pelvis (≥5 mm), is one of the most common abnormalities detected on prenatal ultrasound. However, established cut-off values for postnatal follow-up differ between countries and are based on little evidence. The current protocol in the Netherlands for follow-up might be too conservative. OBJECTIVE: To assess the applicability of a higher threshold for follow-up of isolated antenatal hydronephrosis (ANH) than the current practice, without the risk of missing significant postnatal urinary tract obstruction...
June 21, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29127964/minimally-invasive-management-for-vesicoureteral-reflux-in-infants-and-young-children
#17
REVIEW
Chung-Kwong Yeung, Sujit K Chowdhary, Biji Sreedhar
Minimally invasive ureteral reimplantation is an attractive and useful tool in the armamentarium for the management of complicated vesicoureteral reflux (VUR). Subureteric dextranomer/hyaluronic acid injection, laparoscopic extravesical ureteric reimplantation and pneumovesicoscopic intravesical ureteral reimplantation with or without robotic assistance are established minimally invasive approaches to management of VUR. The high cost and the limited availability of robotics have restricted accessibility to these approaches...
December 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/29104797/endoscopic-correction-of-vesicoureteral-reflux-in-children-using-polyacrylate-polyalcohol-copolymer-vantris-5-years-of-prospective-follow-up
#18
Stanisław Warchoł, Grażyna Krzemień, Agnieszka Szmigielska, Przemysław Bombiński, Krzysztof Toth, Teresa Dudek-Warchoł
Introduction: The endoscopic correction of vesicoureteral reflux (VUR) in children is a currently well accepted therapy in many pediatric urology centers. Polyacrylate-polyalcohol copolymer (PPC), namely Vantris(®), is one of the tissue-augmenting substances used for endoscopic reflux therapy. The aim of this study was to evaluate the results with PPC in children. Material and methods: From 2012 to 2016, 125 children (73 girls and 52 boys) aged 0.6-17.9 years (mean 4...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/29097723/genome-wide-linkage-and-association-study-implicates-the-10q26-region-as-a-major-genetic-contributor-to-primary-nonsyndromic-vesicoureteric-reflux
#19
John M Darlow, Rebecca Darlay, Mark G Dobson, Aisling Stewart, Pimphen Charoen, Jennifer Southgate, Simon C Baker, Yaobo Xu, Manuela Hunziker, Heather J Lambert, Andrew J Green, Mauro Santibanez-Koref, John A Sayer, Timothy H J Goodship, Prem Puri, Adrian S Woolf, Rajko B Kenda, David E Barton, Heather J Cordell
Vesicoureteric reflux (VUR) is the commonest urological anomaly in children. Despite treatment improvements, associated renal lesions - congenital dysplasia, acquired scarring or both - are a common cause of childhood hypertension and renal failure. Primary VUR is familial, with transmission rate and sibling risk both approaching 50%, and appears highly genetically heterogeneous. It is often associated with other developmental anomalies of the urinary tract, emphasising its etiology as a disorder of urogenital tract development...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29087113/impact-of-using-an-evidence-based-clinical-guideline-for-the-management-of-primary-vesicoureteral-reflux-in-children
#20
Natalia Álvarez García, Reyes Delgado Alvira, Yurema González Ruiz, Alexander Siles Hinojosa, Rafael Fernández Atuán, Miguel A Rihuete Heras, Marisa Justa Roldán, Jesús Gracia Romero
OBJETIVE: To analyze changes in the therapeutic approach at a tertiary care hospital following the implementation of a clinical guideline for the treatment of primary vesicoureteral reflux (VUR) in children. POPULATION AND METHODS: Retrospective study conducted in a cohort of patients with primary VUR (1989-2015) aged 0-15 years at a tertiary care hospital. The therapeutic approach before and after the development of the clinical guideline (2008) was compared. RESULTS: A total of 297 patients (49...
December 1, 2017: Archivos Argentinos de Pediatría
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