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https://www.readbyqxmd.com/read/29453580/neurosurgical-management-of-hydrocephalus-by-a-general-surgeon-in-an-extremely-low-resource-setting-initial-experience-in-north-kivu-province-of-eastern-democratic-republic-of-congo
#1
Sarah B Cairo, Justice Agyei, Kavira Nyavandu, David H Rothstein, Luc Malemo Kalisya
PURPOSE: Evaluate the management of hydrocephalus in pediatric patients in the Eastern Democratic Republic of Congo by a general surgeon. METHODS: Retrospective review of a single institution in the province of North Kivu. Patient charts and surgical notes were reviewed from 2003 to 2016. RESULTS: 116 procedures were performed for an average of 8.9 per year. 51.7% of surgeries were on female patients with an average age of 13.6 ± 22.7. The average distance traveled from home to hospital was 153...
February 16, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29442139/safety-profile-of-nivolumab-administered-as-30-min-infusion-analysis-of-data-from-checkmate-153
#2
David Waterhouse, Leora Horn, Craig Reynolds, David Spigel, Jason Chandler, Tarek Mekhail, Mohamed Mohamed, Ben Creelan, Kenneth B Blankstein, Petros Nikolinakos, Michael J McCleod, Ang Li, Abderrahim Oukessou, Shruti Agrawal, Nivedita Aanur
PURPOSE: Nivolumab has been administered using a 60-min infusion time. Reducing this time to 30 min would benefit both patients and infusion facilities. This analysis compared the safety of 30- and 60-min infusions of nivolumab in patients with previously treated advanced non-small cell lung cancer. METHODS: CheckMate 153 is an open-label, phase 3b/4, predominantly community-based study ongoing in the United States and Canada. Patients with stage IIIB/IV disease with progression/recurrence after at least one prior systemic therapy received nivolumab 3 mg/kg every 2 weeks over 30 or 60 min for 1 year or until disease progression...
February 13, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29439582/diversity-of-hiv-1-in-aquitaine-south-western-france-2012-2016
#3
Camille Tumiotto, Pantxika Bellecave, Patricia Recordon-Pinson, Alexi Groppi, Macha Nikolski, Herve J Fleury
We have estimated the prevalence of the different viral subtypes between January 2012 and December 2016 in HIV-1-infected patients of the Aquitaine region (south-west part of France) who had a routine HIV-1 genotype resistance testing (GRT) centralized at the Bordeaux University Hospital. GRT was performed on viral RNA (1784 samples) before treatment initiation or at failure whereas proviral DNA was used as template (1420 samples) in the event of a treatment switch in patients with viral load below 50 copies/mL...
February 14, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29435185/diagnostic-value-of-wif1-methylation-for-colorectal-cancer-a-meta-analysis
#4
Haochang Hu, Bin Li, Cong Zhou, Xiuru Ying, Min Chen, Tianyi Huang, Yuehong Chen, Huihui Ji, Ranran Pan, Tiangong Wang, Danjie Jiang, Yanfei Chen, Yong Yang, Shiwei Duan
As a common antagonist of Wnt/β-catenin signaling, Wnt inhibitory factor 1 (WIF1) plays an important role in the tumor progression. The aim of our meta-analysis was to summarize the diagnostic value of WIF1 methylation in colorectal cancer (CRC). Eligible studies were retrieved by a systemic search among PubMed, Embase, CNKI, and Wanfang literature databases. The diagnostic value of WIF1 methylation for CRC was assessed by the summary receiver operating characteristics (SROC) test. Our meta-analysis of 12 studies between 1420 CRC samples and 946 control samples showed that WIF1 hypermethylation was significantly associated with CRC (P < 0...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29429556/infection-with-gram-negative-bacteria-among-children-in-a-tertiary-pediatric-hospital-in-egypt
#5
John Rene Labib, Sally K Ibrahim, Marwa Rashad Salem, Meray Rene L Youssef, Basant Meligy
BACKGROUND: Patients in pediatric intensive care units (PICUs) are susceptible to infections with gram-negative bacteria (GNB). METHODS: A prospective observational study was conducted in 2 PICUs at Cairo University Hospitals to determine the incidence and outcome of GNB infections over 1 year. Variables of interest included age, gender, isolated organism, susceptibility to antibiotics, and final outcome. RESULTS: During the study period, 1420 patients were admitted to the PICU; of these, 291 developed GNB infections...
February 9, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29423656/rna-binding-protein-rbpms-is-represented-in-human-retinas-by-isoforms-a-and-c-and-its-transcriptional-regulation-involves-sp1-binding-site
#6
Linda Ye, Lei Gu, Joseph Caprioli, Natik Piri
Rbpms (RNA-binding protein with multiple splicing) is a member of the RRM (RNA Recognition Motif) family of RNA-binding proteins, which is expressed as multiple alternatively spliced transcripts encoding different protein isoforms. We have shown earlier that Rbpms expression in the retina is restricted to retinal ganglion cells (RGCs), and have characterized this gene as a marker for RGCs. The aim of this study was to identify isoforms representing Rbpms in human retinas and to analyze its transcriptional regulation...
February 8, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29414469/physico-chemical-characterization-and-biocompatibility-of-hydroxyapatite-derived-from-fish-waste
#7
Hirochi Yamamura, Victor Hugo Pereira da Silva, Pedro Luiz Menin Ruiz, Valter Ussui, Dolores Ribeiro Ricci Lazar, Ana Claudia Muniz Renno, Daniel Araki Ribeiro
The aim of this study was to synthesize hydroxyapatite (HAP) powder from fish waste. The powder was characterized through X-ray diffraction, Fourier transform infrared spectroscopy, ion exchange chromatography, scanning electron microscopy and plasma emission spectrometry. The cyto- and genotoxicity was carried out to demonstrate biocompatibility in vivo by means of rat subcutaneous tissue test. The results showed that the visible crystalline nature of typical apatite crystal structure when they were calcined at 800 °C...
January 31, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29365151/lack-of-evidence-for-transovarial-transmission-of-the-lyme-disease-spirochete-borrelia-mayonii-by-infected-female-ixodes-scapularis-acari-ixodidae-ticks
#8
Nicole E Breuner, Andrias Hojgaard, Lars Eisen
The recently described Lyme disease spirochete Borrelia mayonii is associated with human illness in the Upper Midwest of the United States. Experimental laboratory studies and field observations on natural infection indicate that B. mayonii is maintained by horizontal transmission between tick vectors and vertebrate reservoirs. While maintaining a colony of Ixodes scapularis Say (Acari: Ixodidae) ticks infected with the B. mayonii type strain (MN14-1420), we had an opportunity to examine whether infected females may pass this spirochete transovarially to their offspring...
January 20, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29363850/improving-image-quality-of-mid-trimester-fetal-sonography-in-obese-the-role-the-ultrasound-propagation-velocity
#9
B Chauveau, C Auclair, A Legrand, R Mangione, L Gerbaud, F Vendittelli, L Boyer, D Lémery
INTRODUCTION: Obesity impairs the quality of ultrasound images. All ultrasound scanners are calibrated for an ultrasound propagation velocity of 1540 m/s, although the propagation in fatty tissue is slower (1450 m/s). Our objective was to evaluate the quality of images obtained considering various ultrasound propagation velocities, in situation of mid-trimester fetal scans in obese women. MATERIALS AND METHODS: This cross-sectional study collected image triplets of four recommended scanning planes from 32 obese pregnant women at their mid-trimester fetal scan...
January 24, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29321192/transvenous-lead-extraction-in-chronic-kidney-disease-and-dialysis-patients-with-infected-cardiac-devices
#10
Amr F Barakat, Oussama M Wazni, Khaldoun G Tarakji, Thomas Callahan, Nayef Nimri, Walid I Saliba, Shailee Shah, Karim Abdur Rehman, John Rickard, Michael P Brunner, David O Martin, Mohamed Kanj, Bryan Baranowski, Daniel Cantillon, Mark Niebauer, Thomas Dresing, Bruce D Lindsay, Bruce L Wilkoff, Ayman A Hussein
BACKGROUND: Cardiac implantable electronic device infections have been on the rise. A high-risk population is that with renal disease, especially dialysis. We aimed to assess procedural profiles and clinical outcomes of transvenous lead extraction for cardiac implantable electronic device infection based on renal disease status. METHODS AND RESULTS: In 1420 consecutive patients undergoing transvenous lead extraction of infected cardiac implantable electronic devices (1996-2012), we assessed procedural profiles and clinical outcomes in 3 groups: normal renal function (group 1, n=1159), renal dysfunction not requiring dialysis (group 2, n=163), and dialysis (group 3, n=98)...
January 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29214243/intracellular-investigation-on-the-differential-effects-of-4-polyphenols-on-mcf-7-breast-cancer-cells-by-raman-imaging
#11
A Mignolet, B R Wood, E Goormaghtigh
The past decades have seen significant interest in the study of polyphenolic compounds as potential therapeutic agents in medicine because they display a vast array of cellular effects beneficial to treat or manage a plethora of chronic diseases including inflammatory diseases, cardiovascular abnormalities and several types of cancer. These compounds act at different stages of carcinogenesis but deciphering their mode of action is a complex task. Live MCF-7 breast cancer cells were investigated using Raman imaging to evaluate the perturbations induced after incubating cells with four different polyphenols: EGCG, gallic acid, resveratrol and tannic acid...
December 7, 2017: Analyst
https://www.readbyqxmd.com/read/29195172/exposure-to-school-violence-at-school-and-mental-health-of-victimized-adolescents-the-mediation-role-of-social-support
#12
Erdinc Duru, Murat Balkis
The purpose of the current study is to examine the mediation role of social support in the relationship between exposure to violence at school and mental health among adolescents within the framework of two structured models via structural equation model (SEM). The participants consist of a total of 1420 9th, 10th, and 11th grades high school students (54.5% girls and 45.5% boys). The students' ages ranged from 14 to 18 years with a mean of 16.11 (SD=0.91) for total sample. 38 percent of the participants are in the 9th grade, 34...
November 28, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29170303/6%C3%A2-prognostic-value-of-the-glasgow-admission-prediction-score-hospital-length-of-stay-mortality-and-hospital-readmission
#13
Dominic Jones, Allan Cameron, Suzanne Mason, Colin O'Keeffe, David Lowe
INTRODUCTION: As patient numbers presenting to emergency departments (ED) increase, with their myriad of comorbidities, early hospital admission prediction and demand modelling are crucial both in the ED and beyond. The Glasgow admission prediction score (GAPS) (figure 1)1 has already been shown to be accurate in predicting hospital admission from the ED at the point of triage.2 As demand on EDs increase, data driven models such as GAPS will become increasingly important for predicting patient course...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29162169/stress-exposure-and-psychopathology-alter-methylation-of-the-serotonin-receptor-2a-htr2a-gene-in-preschoolers
#14
Stephanie H Parade, Andrew M Novick, Justin Parent, Ronald Seifer, Samantha J Klaver, Carmen J Marsit, Asi Polly Gobin, Bao-Zhu Yang, Audrey R Tyrka
Serotonin signaling pathways play a key role in brain development, stress reactivity, and mental health. Epigenetic alterations in the serotonin system may underlie the effect of early life stress on psychopathology. The current study examined methylation of the serotonin receptor 2A (HTR2A) gene in a sample of 228 children including 119 with child welfare documentation of moderate to severe maltreatment within the last 6 months. Child protection records, semistructured interviews in the home, and parent reports were used to assess child stress exposure, psychiatric symptoms, and behavior...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29146401/neratinib-after-trastuzumab-based-adjuvant-therapy-in-her2-positive-breast-cancer-extenet-5-year-analysis-of-a-randomised-double-blind-placebo-controlled-phase-3-trial
#15
Miguel Martin, Frankie A Holmes, Bent Ejlertsen, Suzette Delaloge, Beverly Moy, Hiroji Iwata, Gunter von Minckwitz, Stephen K L Chia, Janine Mansi, Carlos H Barrios, Michael Gnant, Zorica Tomašević, Neelima Denduluri, Robert Šeparović, Erhan Gokmen, Anna Bashford, Manuel Ruiz Borrego, Sung-Bae Kim, Erik Hugger Jakobsen, Audrone Ciceniene, Kenichi Inoue, Friedrich Overkamp, Joan B Heijns, Anne C Armstrong, John S Link, Anil Abraham Joy, Richard Bryce, Alvin Wong, Susan Moran, Bin Yao, Feng Xu, Alan Auerbach, Marc Buyse, Arlene Chan
BACKGROUND: ExteNET showed that 1 year of neratinib, an irreversible pan-HER tyrosine kinase inhibitor, significantly improves 2-year invasive disease-free survival after trastuzumab-based adjuvant therapy in women with HER2-positive breast cancer. We report updated efficacy outcomes from a protocol-defined 5-year follow-up sensitivity analysis and long-term toxicity findings. METHODS: In this ongoing randomised, double-blind, placebo-controlled, phase 3 trial, eligible women aged 18 years or older (≥20 years in Japan) with stage 1-3c (modified to stage 2-3c in February, 2010) operable breast cancer, who had completed neoadjuvant and adjuvant chemotherapy plus trastuzumab with no evidence of disease recurrence or metastatic disease at study entry...
November 13, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29124397/long-term-glucocorticoid-treatment-in-patients-with-polymyalgia-rheumatica-giant-cell-arteritis-or-both-diseases-results-from-a-national-rheumatology-database
#16
Katinka Albrecht, Dörte Huscher, Frank Buttgereit, Martin Aringer, Guido Hoese, Wolfgang Ochs, Katja Thiele, Angela Zink
The objective of this study was to evaluate glucocorticoid (GC) use in patients with polymyalgia rheumatica (PMR), giant cell arteritis (GCA) or both diseases (PMR + GCA) under rheumatological care. Data from patients with PMR (n = 1420), GCA (n = 177) or PMR + GCA (n = 261) from the National Database of the German Collaborative Arthritis Centers were analyzed regarding GCs and related comorbidities (osteoporosis, diabetes and cardiovascular disease), stratified by disease duration (DD). Longitudinal data were analyzed for all patients with a DD ≤ 2 years at database entry (n = 1397)...
November 9, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29092979/aspirin-and-the-prevention-of-venous-thromboembolism-following-total-joint-arthroplasty-commonly-asked-questions
#17
REVIEW
I Azboy, R Barrack, A M Thomas, F S Haddad, J Parvizi
The number of arthroplasties being performed increases each year. Patients undergoing an arthroplasty are at risk of venous thromboembolism (VTE) and appropriate prophylaxis has been recommended. However, the optimal protocol and the best agent to minimise VTE under these circumstances are not known. Although many agents may be used, there is a difference in their efficacy and the risk of bleeding. Thus, the selection of a particular agent relies on the balance between the desire to minimise VTE and the attempt to reduce the risk of bleeding, with its undesirable, and occasionally fatal, consequences...
November 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29030074/a-survey-of-morcellator-preference-and-cost-comparison-of-the-lumenis-versacut-and-wolf-piranha-morcellators
#18
Marcelino E Rivera, James E Lingeman, Kevin Heinsimer, Nadya E York, Amy E Krambeck
OBJECTIVE: To evaluate operating room (OR) costs associated with the 2 available morcellators in the United States in a matched cohort and to determine benign prostatic hyperplasia surgeon's morcellator preference. MATERIALS AND METHODS: Patients from 2013, the last year our institution exclusively used the VersaCut device, were matched 1:1 with the most recent patient cohort, utilizing the Wolf Piranha morcellator. Cost of morcellation including the expense of OR time and disposable instrument costs were calculated...
October 10, 2017: Urology
https://www.readbyqxmd.com/read/28971511/relationship-between-speaking-english-as-a-second-language-and-agitation-in-people-with-dementia-living-in-care-homes-results-from-the-marque-managing-agitation-and-raising-quality-of-life-english-national-care-home-survey
#19
C Cooper, P Rapaport, S Robertson, L Marston, J Barber, M Manela, G Livingston
OBJECTIVE: As not speaking English as a first language may lead to increased difficulties in communication with staff and other residents, we (1) tested our primary hypotheses that care home residents with dementia speaking English as a second language experience more agitation and overall neuropsychiatric symptoms, and (2) explored qualitatively how staff consider that residents' language, ethnicity, and culture might impact on how they manage agitation. METHODS: We interviewed staff, residents with dementia, and their family carers from 86 care homes (2014-2015) about resident's neuropsychiatric symptoms, agitation, life quality, and dementia severity...
October 3, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28924563/functional-near-infrared-spectroscopy-in-movement-science-a-systematic-review-on-cortical-activity-in-postural-and-walking-tasks
#20
REVIEW
Fabian Herold, Patrick Wiegel, Felix Scholkmann, Angelina Thiers, Dennis Hamacher, Lutz Schega
Safe locomotion is a crucial aspect of human daily living that requires well-functioning motor control processes. The human neuromotor control of daily activities such as walking relies on the complex interaction of subcortical and cortical areas. Technical developments in neuroimaging systems allow the quantification of cortical activation during the execution of motor tasks. Functional near-infrared spectroscopy (fNIRS) seems to be a promising tool to monitor motor control processes in cortical areas in freely moving subjects...
October 2017: Neurophotonics
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