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https://www.readbyqxmd.com/read/28544880/systems-wide-studies-uncover-commander-a-multiprotein-complex-essential-to-human-development
#1
REVIEW
Anna L Mallam, Edward M Marcotte
Recent mass spectrometry maps of the human interactome independently support the existence of a large multiprotein complex, dubbed "Commander." Broadly conserved across animals and ubiquitously expressed in nearly every human cell type examined thus far, Commander likely plays a fundamental cellular function, akin to other ubiquitous machines involved in expression, proteostasis, and trafficking. Experiments on individual subunits support roles in endosomal protein sorting, including the trafficking of Notch proteins, copper transporters, and lipoprotein receptors...
May 24, 2017: Cell Systems
https://www.readbyqxmd.com/read/28542609/potent-and-selective-inhibition-of-pathogenic-viruses-by-engineered-ubiquitin-variants
#2
Wei Zhang, Ben A Bailey-Elkin, Robert C M Knaap, Baldeep Khare, Tim J Dalebout, Garrett G Johnson, Puck B van Kasteren, Nigel J McLeish, Jun Gu, Wenguang He, Marjolein Kikkert, Brian L Mark, Sachdev S Sidhu
The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to human health, and our inability to rapidly develop effective therapeutic countermeasures. Many viruses, including MERS-CoV and the Crimean-Congo hemorrhagic fever virus (CCHFV) encode deubiquitinating (DUB) enzymes that are critical for viral replication and pathogenicity. They bind and remove ubiquitin (Ub) and interferon stimulated gene 15 (ISG15) from cellular proteins to suppress host antiviral innate immune responses...
May 18, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28529069/cholinergic-modulation-of-the-immune-system-presents-new-approaches-for-treating-inflammation
#3
REVIEW
Donald B Hoover
The nervous system and immune system have broad and overlapping distributions in the body, and interactions of these ubiquitous systems are central to the field of neuroimmunology. Over the past two decades, there has been explosive growth in our understanding of neuroanatomical, cellular, and molecular mechanisms that mediate central modulation of immune functions through the autonomic nervous system. A major catalyst for growth in this field was the discovery that vagal nerve stimulation (VNS) caused a prominent attenuation of the systemic inflammatory response evoked by endotoxin in experimental animals...
May 18, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28526314/efficacy-of-the-world-health-organization-recommended-handwashing-technique-and-a-modified-washing-technique-to-remove-clostridium-difficile-from-hands
#4
Philippe Deschênes, Frédéric Chano, Léa-Laurence Dionne, Didier Pittet, Yves Longtin
BACKGROUND: The efficacy of the World Health Organization (WHO)-recommended handwashing technique against Clostridium difficile is uncertain, and whether it could be improved remains unknown. Also, the benefit of using a structured technique instead of an unstructured technique remains unclear. METHODS: This study was a prospective comparison of 3 techniques (unstructured, WHO, and a novel technique dubbed WHO shortened repeated [WHO-SR] technique) to remove C difficile...
May 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28516294/does-seeing-an-asian-face-make-speech-sound-more-accented
#5
Yi Zheng, Arthur G Samuel
Prior studies have reported that seeing an Asian face makes American English sound more accented. The current study investigates whether this effect is perceptual, or if it instead occurs at a later decision stage. We first replicated the finding that showing static Asian and Caucasian faces can shift people's reports about the accentedness of speech accompanying the pictures. When we changed the static pictures to dubbed videos, reducing the demand characteristics, the shift in reported accentedness largely disappeared...
May 17, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28514228/outcomes-for-2-children-after-peripartum-acquisition-of-zika-virus-infection-french-polynesia-2013-2014
#6
Marianne Besnard, Timothée Dub, Patrick Gérardin
Congenital Zika virus infection is associated with severe brain anomalies and impaired function. To determine outcomes, we followed 2 affected children for ≈30 months. For 1 who was symptomatic at birth, transient hepatitis developed. However, neurodevelopment for both children was age appropriate.
August 17, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28507986/more-than-just-a-simple-cardiac-envelope-cellular-contributions-of-the-epicardium
#7
REVIEW
Angel Dueñas, Amelia E Aranega, Diego Franco
The adult pumping heart is formed by distinct tissue layers. From inside to outside, the heart is composed by an internal endothelial layer, dubbed the endocardium, a thick myocardial component which supports the pumping capacity of the heart and exteriorly covered by a thin mesothelial layer named the epicardium. Cardiac insults such as coronary artery obstruction lead to ischemia and thus to an irreversible damage of the myocardial layer, provoking in many cases heart failure and death. Thus, searching for new pathways to regenerate the myocardium is an urgent biomedical need...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28506875/deubiquitinase-usp33-is-negatively-regulated-by-%C3%AE-trcp-through-ubiquitin-dependent-proteolysis
#8
Qiao Cheng, Yukang Yuan, Lemin Li, Tingting Guo, Ying Miao, Ying Ren, Jin Liu, Qian Feng, Xiaofang Wang, Peng Zhao, Yibo Zuo, Liping Qian, Liting Zhang, Hui Zheng
Ubiquitin-mediated proteolysis regulates cellular levels of various proteins, and therefore plays important roles in controlling cell signaling and disease progression. The Skp1-Cul1-F-box ubiquitin ligase β-TrCP is recognized as an important negative regulator for numerous key signaling proteins. Recently, the deubiquitinases (DUBs) have turned out to be essential to regulate signaling pathways related to human diseases. However, whether β-TrCP is able to regulate the deubiquitinase family members remains largely unexplored...
May 13, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28498721/mechanisms-of-deubiquitinase-specificity-and-regulation
#9
Tycho E T Mevissen, David Komander
Protein ubiquitination is one of the most powerful posttranslational modifications of proteins, as it regulates a plethora of cellular processes in distinct manners. Simple monoubiquitination events coexist with more complex forms of polyubiquitination, the latter featuring many different chain architectures. Ubiquitin can be subjected to further posttranslational modifications (e.g., phosphorylation and acetylation) and can also be part of mixed polymers with ubiquitin-like modifiers such as SUMO (small ubiquitinrelated modifier) or NEDD8 (neural precursor cell expressed, developmentally downregulated 8)...
May 12, 2017: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/28498477/identification-of-candidate-substrates-of-ubiquitin-specific-protease-13-using-2d-dige
#10
Jianmin Wang, Yingli Liu, Lijuan Tang, Sufen Qi, Yingjun Mi, Dianwu Liu, Qingbao Tian
The present study aimed to identify candidate substrates of ubiquitin-specific protease (USP)13 using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE). USP13 is a well-characterized member of the USP family, which regulates diverse cellular functions by cleaving ubiquitin from ubiquitinated protein substrates. However, existing studies indicate that USP13 has no detectable hydrolytic activity in vitro. This finding implies that USP13 likely has different substrate specificity. In this study, a USP cleavage assay was performed using two different types of model substrates (glutathione S-transferase-Ub52 and ubiquitin-β-galactosidase) to detect the deubiquitinating enzyme (DUB) activity of USP13...
May 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28483947/regulation-of-usp37-expression-by-rest-associated-g9a-dependent-histone-methylation
#11
Tara Dobson, Rashieda J Hatcher, Jyothismathi Swaminathan, Chandra M Das, Shavali Shaik, Rong-Hua Tao, Ciro Milite, Sabrina Castellano, Pete Taylor, Gianluca Sbardella, Vidya Gopalakrishnan
The deubiquitylase (DUB) USP37 is a component of the ubiquitin system and controls cell proliferation by regulating the stability of the cyclin-dependent kinase inhibitor 1B, (CDKN1B/p27Kip1). The expression of USP37 is down-regulated in human medulloblastoma tumor specimens. In the current study we show that USP37 prevents medulloblastoma growth in mouse orthotopic models, suggesting that it has tumor suppressive properties in this neural cancer. Here, we also report on the mechanism underlying USP37 loss in medulloblastoma...
May 8, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28483520/pppde1-is-a-novel-deubiquitinase-belonging-to-a-cysteine-isopeptidase-family
#12
Xingwang Xie, Xueyan Wang, Dong Jiang, Jianghua Wang, Ran Fei, Xu Cong, Lai Wei, Yu Wang, Hongsong Chen
Ubiquitinlation of proteins is prevalent and important in both normal and pathological cellular processes. Deubiquitinating enzymes (DUBs) can remove the ubiquitin tags on substrate proteins and dynamically regulate the ubiquitination process. The PPPDE family proteins were predicted to be a novel class of deubiquitinating peptidase, but this has not yet been experimentally proved. Here we validated the deubiquitinating activity of PPPDE1 and revealed its isopeptidase activity against ubiquitin conjugated through Lys 48 and Lys 63...
May 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28483386/zika-virus-and-guillain-barr%C3%A3-syndrome
#13
EDITORIAL
T Dub, A Fontanet
No abstract text is available yet for this article.
May 5, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28476940/mechanisms-of-regulation-and-diversification-of-deubiquitylating-enzyme-function
#14
REVIEW
Pawel Leznicki, Yogesh Kulathu
Deubiquitylating (or deubiquitinating) enzymes (DUBs) are proteases that reverse protein ubiquitylation and therefore modulate the outcome of this post-translational modification. DUBs regulate a variety of intracellular processes, including protein turnover, signalling pathways and the DNA damage response. They have also been linked to a number of human diseases, such as cancer, and inflammatory and neurodegenerative disorders. Although we are beginning to better appreciate the role of DUBs in basic cell biology and their importance for human health, there are still many unknowns...
May 5, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28476333/identification-of-4-arylidene-curcumin-analogues-as-novel-proteasome-inhibitors-for-potential-anticancer-agents-targeting-19s-regulatory-particle-associated-deubiquitinase
#15
Xin Yue, Yinglin Zuo, Hongpeng Ke, Jiaming Luo, Lanlan Lou, Wenjing Qin, Youqiao Wang, Ziyi Liu, Daoyuan Chen, Haixia Sun, Weichao Zheng, Cuige Zhu, Ruimin Wang, Gesi Wen, Jun Du, Binhua Zhou, Xianzhang Bu
The proteasomal 19S regulatory particle (RP) associated deubiquitinases (DUBs) have attracted much attention owing to its potential as a therapeutic target for cancer therapy. Identification of new entities against 19S RP associated DUBs and illustration of the underlying mechanisms is crucial for discovery of novel proteasome blockers. In this study, a series of 4-arylidene curcumin analogues were identified as potent proteasome inhibitor by preferentially blocking deubiquitinase function of proteasomal 19S RP with moderate 20S CP inhibition...
May 2, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28474909/new-relations-for-gauge-theory-and-gravity-amplitudes-at-loop-level
#16
Song He, Oliver Schlotterer
In this Letter, we extend the tree-level Kawai-Lewellen-Tye (KLT) and Bern-Carrasco-Johansson (BCJ) amplitude relations to loop integrands of gauge theory and gravity. By rearranging the propagators of gauge and gravity loop integrands, we propose the first manifestly gauge- and diffeomorphism-invariant formulation of their double-copy relations. The one-loop KLT formula expresses gravity integrands in terms of more basic gauge invariant building blocks for gauge-theory amplitudes, dubbed partial integrands...
April 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28472782/identification-of-deubiquitinase-targets-of-isothiocyanates-using-silac-assisted-quantitative-mass-spectrometry
#17
Ann P Lawson, Daniel W Bak, D Alexander Shannon, Marcus J C Long, Tushara Vijaykumar, Runhan Yu, Farid El Oualid, Eranthie Weerapana, Lizbeth Hedstrom
Cruciferous vegetables such as broccoli and kale have well documented chemopreventative and anticancer effects that are attributed to the presence of isothiocyanates (ITCs). ITCs modulate the levels of many oncogenic proteins, but the molecular mechanisms of ITC action are not understood. We previously reported that phenethyl isothiocyanate (PEITC) inhibits two deubiquitinases (DUBs), USP9x and UCH37. DUBs regulate many cellular processes and DUB dysregulation is linked to the pathogenesis of human diseases including cancer, neurodegeneration, and inflammation...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28468120/trace-element-concentrations-along-a-gradient-of-urban-pressure-in-forest-and-lawn-soils-of-the-paris-region-france
#18
Ludovic Foti, Florence Dubs, Jacques Gignoux, Jean-Christophe Lata, Thomas Z Lerch, Jérôme Mathieu, François Nold, Naoise Nunan, Xavier Raynaud, Luc Abbadie, Sébastien Barot
The concentration, degree of contamination and pollution of 7 trace elements (TEs) along an urban pressure gradient were measured in 180 lawn and wood soils of the Paris region (France). Iron (Fe), a major element, was used as reference element. Copper (Cu), cadmium (Cd), lead (Pb) and zinc (Zn) were of anthropogenic origin, while arsenic (As), chromium (Cr) and nickel (Ni) were of natural origin. Road traffic was identified as the main source of anthropogenic TEs. In addition, the industrial activity of the Paris region, especially cement plants, was identified as secondary source of Cd...
April 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28457867/brain-to-brain-synchrony-tracks-real-world-dynamic-group-interactions-in-the-classroom
#19
Suzanne Dikker, Lu Wan, Ido Davidesco, Lisa Kaggen, Matthias Oostrik, James McClintock, Jess Rowland, Georgios Michalareas, Jay J Van Bavel, Mingzhou Ding, David Poeppel
The human brain has evolved for group living [1]. Yet we know so little about how it supports dynamic group interactions that the study of real-world social exchanges has been dubbed the "dark matter of social neuroscience" [2]. Recently, various studies have begun to approach this question by comparing brain responses of multiple individuals during a variety of (semi-naturalistic) tasks [3-15]. These experiments reveal how stimulus properties [13], individual differences [14], and contextual factors [15] may underpin similarities and differences in neural activity across people...
May 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28450118/importance-of-deubiquitinases-in-zebrafish-craniofacial-development
#20
William Ka Fai Tse
Deconjugation of ubiquitin and/or ubiqutin-like modified substrates is essential to maintain a sufficient free ubiquitin within the cell. Deubiquitinases (DUBs) play a key role in the process. Besides, DUBs also play several important regulatory roles in cellular processes. However, our knowledge of their developmental roles are limited. The report here aims to study their potential roles in craniofacial development. Based on the previous genome-wide study in 2009, we selected 36 DUBs to perform the morpholino (MO) knockdown in this study, followed by the Alcian blue cartilage staining at 5 days post-fertilization (dpf) larvae to investigate the facial development...
June 10, 2017: Biochemical and Biophysical Research Communications
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