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https://www.readbyqxmd.com/read/28230348/nmr-structures-of-gcn4p-are-largely-conserved-when-ion-pairs-are-disrupted-at-acidic-ph-but-show-a-relaxation-of-the-coiled-coil-superhelix
#1
Anne R Kaplan, Megan R Brady, Mark W Maciejewski, Richard A Kammerer, Andrei T Alexandrescu
To understand the roles ion pairs play in stabilizing coiled coils we determined NMR structures of GCN4p at three pH values. At pH 6.6 all acidic residues are fully charged, at pH 4.4 they are half-charged, and at pH 1.5 they are protonated and uncharged. The α-helix monomer and coiled coil structures of GCN4p are largely conserved, except for a loosening of the coiled coil quaternary structure with decreasing pH. Differences going from neutral to acidic pH include (i) an unwinding of the coiled coil superhelix due to the loss of inter-chain ion pair contacts, (ii) a small increase in the separation of the monomers in the dimer, (iii) a loosening of knobs-into-holes packing motifs, and (iv) an increased separation between oppositely charged residues that participate in ion pairs at neutral pH...
February 23, 2017: Biochemistry
https://www.readbyqxmd.com/read/28229334/specific-amyloid-binding-of-polybasic-peptides-in-vivo-is-retained-by-%C3%AE-sheet-conformers-but-lost-in-the-disrupted-coil-and-all-d-amino-acid-variants
#2
Jonathan S Wall, Angela Williams, Tina Richey, Alan Stuckey, Craig Wooliver, J Christopher Scott, Robert Donnell, Emily B Martin, Stephen J Kennel
PURPOSE: The heparin-reactive, helical peptide p5 is an effective amyloid imaging agent in mice with systemic amyloidosis. Analogs of p5 with modified secondary structure characteristics exhibited altered binding to heparin, synthetic amyloid fibrils, and amyloid extracts in vitro. Herein, we further study the effects of peptide helicity and chirality on specific amyloid binding using a mouse model of systemic inflammation-associated (AA) amyloidosis. PROCEDURES: Peptides with disrupted helical structure [p5(coil) and p5(Pro3)], with an extended sheet conformation [p5(sheet)] or an all-D enantiomer [p5(D)], were chemically synthesized, radioiodinated, and their biodistribution studied in WT mice as well as transgenic animals with severe systemic AA amyloidosis...
February 22, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28227941/a-three-element-1-h-31-p-dual-tuned-array-for-magnetic-resonance-spectroscopy-at-4-7-t
#3
Matthew D Wilcox, Romina Del Bosque, Kurt Parizek, Jeremy Sia, Edwin D Eigenbrodt, Mary P McDougall, Matthew D Wilcox, Romina Del Bosque, Kurt Parizek, Jeremy Sia, Edwin D Eigenbrodt, Mary P McDougall, Jeremy Sia, Romina Del Bosque, Kurt Parizek, Mary P McDougall, Matthew D Wilcox, Edwin D Eigenbrodt
This work describes the construction and testing of a three-element, double-tuned receive array and transmit coils for (31)P-(1)H spectroscopy and imaging. The receive coils were geometrically-decoupled, single-loop surface coils and the transmit coils were concentric saddle coils. The coils were used to examine a physiologically-modeled CNC-milled phantom. The receive coil array was able to improve SNR while also providing gross localization of the (1)H and (31)P signals.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227511/toward-a-distributed-free-floating-wireless-implantable-neural-recording-system
#4
Pyungwoo Yeon, Xingyuan Tong, Byunghun Lee, Abdollah Mirbozorgi, Bruce Ash, Helmut Eckhardt, Maysam Ghovanloo, Pyungwoo Yeon, Xingyuan Tong, Byunghun Lee, Abdollah Mirbozorgi, Bruce Ash, Helmut Eckhardt, Maysam Ghovanloo, Maysam Ghovanloo, Byunghun Lee, Bruce Ash, Xingyuan Tong, Pyungwoo Yeon, Abdollah Mirbozorgi, Helmut Eckhardt
To understand the complex correlations between neural networks across different regions in the brain and their functions at high spatiotemporal resolution, a tool is needed for obtaining long-term single unit activity (SUA) across the entire brain area. The concept and preliminary design of a distributed free-floating wireless implantable neural recording (FF-WINeR) system are presented, which can enabling SUA acquisition by dispersedly implanting tens to hundreds of untethered 1 mm(3) neural recording probes, floating with the brain and operating wirelessly across the cortical surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227237/fusion-of-inertial-and-magnetic-sensors-for-3d-position-and-orientation-estimation
#5
P Tadayon, T Felderhoff, A Knopp, G Staude, P Tadayon, T Felderhoff, A Knopp, G Staude, G Staude, P Tadayon, T Felderhoff, A Knopp
This paper presents a new method for 3D position and orientation estimation based on the magnetic field generated by a single coil and the fusion of low power magnetometers and inertial sensors. The fixed spatial relationship between the sensors is exploited to solve the ambiguity problem that occurs when only a single coil is employed. In this context a new positioning algorithm is developed and verified by simulations. Using a single coil instead of three coils as common in conventional magnetic field based systems brings a benefit both regarding power consumption and construction size...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226904/optimal-wireless-receiver-structure-for-omnidirectional-inductive-power-transmission-to-biomedical-implants
#6
Hesam Sadeghi Gougheri, Mehdi Kiani, Hesam Sadeghi Gougheri, Mehdi Kiani, Hesam Sadeghi Gougheri, Mehdi Kiani
In order to achieve omnidirectional inductive power transmission to biomedical implants, the use of several orthogonal coils in the receiver side (Rx) has been proposed in the past. In this paper, the optimal Rx structure for connecting three orthogonal Rx coils and the power management is found to achieve the maximum power delivered to the load (PDL) in the presence of any Rx coil tilting. Unlike previous works, in which a separate power management has been used for each coil to deliver power to the load, different resonant Rx structures for connecting three Rx coils to a single power management are studied...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224171/assessment-of-liver-iron-overload-by-3%C3%A2-t-mri
#7
A Paisant, A Boulic, E Bardou-Jacquet, E Bannier, G d'Assignies, F Lainé, B Turlin, Y Gandon
PURPOSE: To evaluate the performance and limitations of the signal intensity ratio method for quantifying liver iron overload at 3 T. METHODS: Institutional review board approval and written informed consent from all participants were obtained. One hundred and five patients were included prospectively. All patients underwent a liver biopsy with biochemical assessment of hepatic iron concentration and a 3 T MRI scan with 5 breath-hold single-echo gradient-echo sequences...
February 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28216791/molecular-processes-leading-to-necking-in-extensional-flow-of-polymer-solutions-using-microfluidics-and-single-dna-imaging
#8
Shaurya Sachdev, Aswin Muralidharan, Pouyan E Boukany
We study the necking and pinch-off dynamics of liquid droplets that contain a semidilute polymer solution of polyacrylamide close to overlap concentration by combining microfluidics and single DNA observation. Polymeric droplets are stretched by passing them through the stagnation point of a T-shaped microfluidic junction. In contrast with the sudden breakup of Newtonian droplets, a stable neck is formed between the separating ends of the droplet which delays the breakup process. Initially, polymeric filaments experience exponential thinning by forming a stable neck with extensional flow within the filament...
December 27, 2016: Macromolecules
https://www.readbyqxmd.com/read/28213604/efficacy-and-safety-of-super-selective-bronchial-artery-coil-embolisation-for-haemoptysis-a-single-centre-retrospective-observational-study
#9
Hideo Ishikawa, Masahiko Hara, Misaki Ryuge, Jun Takafuji, Mihoko Youmoto, Masanori Akira, Yukio Nagasaka, Daijiro Kabata, Kouji Yamamoto, Ayumi Shintani
OBJECTIVES: Evidence on the safety and long-term efficacy of super selective bronchial artery embolisation (ssBAE) using platinum coils in patients with haemoptysis is insufficient. The objective of the present study was to evaluate the safety and the 3-year postprocedure haemoptysis-free survival rate of de novo elective ssBAE using platinum coils rather than particles for the treatment of haemoptysis. DESIGN: A single-centre retrospective observational study. SETTING: Hemoptysis and Pulmonary Circulation Center in Japan...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28188183/variants-of-the-sir4-coiled-coil-domain-improve-binding-to-sir3-for-heterochromatin-formation-in-saccharomyces-cerevisiae
#10
Anke Samel, Adam Rudner, Ann E Ehrenhofer-Murray
Heterochromatin formation in the yeast Saccharomyces cerevisiae is characterized by the assembly of the Silent Information Regulator (SIR) complex, which consists of the histone deacetylase Sir2 and the structural components Sir3 and Sir4 and binds to unmodified nucleosomes to provide gene silencing. Sir3 contains an AAA(+) ATPase-like domain, and mutations in an exposed loop on the surface of this domain abrogate Sir3 silencing function in vivo as well in vitro binding to the Sir2/ Sir4 subcomplex. Here, we found that the removal of a single methyl group in the C-terminal coiled-coil domain (mutation T1314S) of Sir4 was sufficient to restore silencing at the silent mating-type loci HMR and HML to a Sir3 version with a mutation in this loop...
February 10, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28185841/varicocele-embolization-with-glue-and-coils-a-single-center-experience
#11
C Bilreiro, P Donato, J F Costa, A Agostinho, V Carvalheiro, F Caseiro-Alves
PURPOSE: The purpose of this study was to compare metallic coils and glue (n-butyl-2 cyanoacrylate) for varicocele embolization, regarding immediate technical and clinical success, procedure time, complications and recurrence rates. MATERIALS AND METHODS: A retrospective analysis of a consecutive series of varicocele embolization procedures performed between July 2012 and July 2015 was undertaken. A total of 129 procedures were performed, 26 using glue (20.2%; 26 men with a mean age of 32...
February 6, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28185433/model-based-iterative-reconstruction-for-single-shot-epi-at-7t
#12
Uten Yarach, Myung-Ho In, Itthi Chatnuntawech, Berkin Bilgic, Frank Godenschweger, Hendrik Mattern, Alessandro Sciarra, Oliver Speck
PURPOSE: To describe a model-based reconstruction strategy for single-shot echo planar imaging (EPI) that intrinsically accounts for k-space nonuniformity, Nyquist ghosting, and geometric distortions during rather than before or after image reconstruction. METHODS: Ramp sampling and inhomogeneous B0 field-induced distortion cause the EPI samples to lie on a non-Cartesian grid, thus requiring the nonuniform fast Fourier transform. Additionally, a 2D Nyquist ghost phase correction without the need for extra navigator acquisition is included in the proposed reconstruction...
February 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28185321/a-2-in-1-single-element-coil-design-for-transcranial-magnetic-stimulation-and-magnetic-resonance-imaging
#13
Hai Lu, Shumin Wang
PURPOSE: To demonstrate the feasibility of turning transcranial magnetic stimulation (TMS) coil for MRI signal reception. METHODS: A critically coupled network was formed by using a resonated turn of TMS coil as the secondary and a regular radiofrequency (RF) coil as the primary. A third coil was positioned between the two coils for detuning during RF transmission. Bench measurement, numerical simulation, and MRI experiment were performed for validation. RESULTS: The signal-to-noise ratio of the proposed 2-in-1 coil is 35% higher in its field of view, compared with a MRI-only reference coil of the same size, made by the same material, and backed up by an untuned TMS coil, but lower than a RF surface coil of the same size without any TMS coil nearby...
February 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28185301/feasibility-of-through-time-spiral-generalized-autocalibrating-partial-parallel-acquisition-for-low-latency-accelerated-real-time-mri-of-speech
#14
Sajan Goud Lingala, Yinghua Zhu, Yongwan Lim, Asterios Toutios, Yunhua Ji, Wei-Ching Lo, Nicole Seiberlich, Shrikanth Narayanan, Krishna S Nayak
PURPOSE: To evaluate the feasibility of through-time spiral generalized autocalibrating partial parallel acquisition (GRAPPA) for low-latency accelerated real-time MRI of speech. METHODS: Through-time spiral GRAPPA (spiral GRAPPA), a fast linear reconstruction method, is applied to spiral (k-t) data acquired from an eight-channel custom upper-airway coil. Fully sampled data were retrospectively down-sampled to evaluate spiral GRAPPA at undersampling factors R = 2 to 6...
February 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28185113/monte-carlo-studies-of-two-dimensional-polymer-solvent-systems
#15
Piotr Polanowski, Jeremiasz K Jeszka, Andrzej Sikorski
The static properties of two-dimensional athermal polymer solutions were studied by performing Monte Carlo lattice simulations using the cooperative motion algorithm (CMA) and taking into account the presence of explicit solvent molecules. The simulations were performed for a wide range of polymer chain lengths N (16-1024) and concentrations φ (0.0156-1). The results obtained for short chains (N < 256) were in good agreement with those given by previous simulations. For the longest chains (512 or 1024 beads), some unexpected behavior was observed in the dilute and semidilute regimes...
February 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28177620/transforming-the-energy-landscape-of-a-coiled-coil-peptide-via-point-mutations
#16
Konstantin Röder, David J Wales
We analyze the effect of point mutations on the energy landscape of a coiled-coil peptide, GCN4-pLI, where the native state is a parallel tetrameric configuration formed from two identical dimers. Experimentally, a single mutation, E20S, supports both antiparallel and parallel structures. Here, we analyze the potential energy landscapes of the dimeric units for the parent sequence and four mutants, namely E20S, E20A, E20P, and E20G. Despite sharing characteristic funnels containing the parallel and antiparallel structures, the point mutations change some parts of the landscape quite dramatically, and we predict new intermediate structures and characterize the associated heat capacities...
February 8, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28176954/coil-therapy-for-patients-with-severe-emphysema-and-bilateral-incomplete-fissures-effectiveness-and-complications-after-1-year-follow-up-a-single-center-experience
#17
Konstantina Kontogianni, Vasiliki Gerovasili, Daniela Gompelmann, Maren Schuhmann, Hans Hoffmann, Claus Peter Heussel, Felix Jf Herth, Ralf Eberhardt
BACKGROUND: Lung volume reduction coil (LVRC) treatment is established in daily endoscopic lung volume reduction routine. The aim of this study was to evaluate the safety and efficacy of LVRC treatment. PATIENTS AND METHODS: This was a retrospective analysis of 86 patients (male/female: 40/46, mean age: 64±7 years) with severe COPD and bilateral incomplete fissures. A total of 10 coils were unilaterally implanted in a single lobe, and 28 out of 86 patients were treated bilaterally...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28175367/114%C3%A2-treatment-of-bifurcation-aneurysms-using-single-stent-coiling-with-relation-to-aneurysm-configuration-a-cohort-study-of-two-academic-institutions-in-the-united-states
#18
Nimer Adeeb, Apar S Patel, Christoph Johannes Griessenauer, Justin M Moore, Paul M Foreman, Raghav Gupta, Mark R Harrigan, Christopher S Ogilvy, Ajith J Thomas
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28173691/characterization-of-the-wild-type-and-truncated-form-of-a-neutral-gh10-xylanase-from-coprinus-cinereus-roles-of-c-terminal-basic-amino-acid-rich-extension-in-its-sds-resistance-thermostability-and-activity
#19
Hang Hu, Kaixiang Chen, Lulu Li, Liangkun Long, Shaojun Ding
A neutral xylanase (Ccxyn) was identified from Coprinus cinereus. It has a single GH10 catalytic domain with a basic amino acid-rich extension (PVRRK) at C-terminus. In this study, the wild-type (Ccxyn) and C-terminus truncated xylanase (CcXynΔ5C) were heterologously expressed in Pichia pastoris and their characteristics were comparatively analyzed with aims to examine the effect of this extension on the enzyme function. The circular dichorism (CD) analysis indicated that both enzymes in general had a similar structure, but CcXynΔ5C contained less α-helices (42...
February 7, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28165427/developing-and-evaluating-a-flexible-wireless-microcoil-array-based-integrated-interface-for-epidural-cortical-stimulation
#20
Xing Wang, Sharjeel A Chaudhry, Wensheng Hou, Xiaofeng Jia
Stroke leads to serious long-term disability. Electrical epidural cortical stimulation has made significant improvements in stroke rehabilitation therapy. We developed a preliminary wireless implantable passive interface, which consists of a stimulating surface electrode, receiving coil, and single flexible passive demodulated circuit printed by flexible printed circuit (FPC) technique and output pulse voltage stimulus by inductively coupling an external circuit. The wireless implantable board was implanted in cats' unilateral epidural space for electrical stimulation of the primary visual cortex (V1) while the evoked responses were recorded on the contralateral V1 using a needle electrode...
February 5, 2017: International Journal of Molecular Sciences
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