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https://www.readbyqxmd.com/read/29766010/single-stage-endovascular-treatment-of-a-penetrating-aortic-ulcer-with-a-concomitant-isolated-iliac-aneurysm
#1
Haidi Hu, Jianming Guo, Hualong Bai, Alan Dardik
Penetrating aortic ulcer (PAU) is an acute aortic syndrome that can proceed to life-threatening aortic dissection or even aortic rupture. Isolated iliac aneurysms are relatively rare and often asymptomatic due to their deep pelvic location but are frequently associated with high mortality with rupture. We report a case of a 68-year-old man with a symptomatic penetrating ulcer in the descending aorta and an asymptomatic right iliac aneurysm involving the common and internal iliac arteries. The patient was successfully treated by endovascular repair in a single-stage manner using stent grafts in the descending aorta and right common iliac artery after coil embolization of the right internal iliac artery...
December 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29765449/effects-of-single-and-combined-low-frequency-electromagnetic-fields-and-simulated-microgravity-on-gene-expression-of-human-mesenchymal-stem-cells-during-chondrogenesis
#2
Susanne Mayer-Wagner, Florian Hammerschmid, Helmut Blum, Stefan Krebs, Julia I Redeker, Boris M Holzapfel, Volkmar Jansson, Peter E Müller
Introduction: Low frequency electromagnetic fields (LF-EMF) and simulated microgravity (SMG) have been observed to affect chondrogenesis. A controlled bioreactor system was developed to apply LF-EMF and SMG singly or combined during chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in 3D culture. Material and methods: An external motor gear SMG bioreactor was combined with magnetic Helmholtz coils for EMF (5 mT; 15 Hz). Pellets of hMSCs (±TGF-β3) were cultured (P5) under SMG, LF-EMF, LF-EMF/SMG and control (1 g) conditions for 3 weeks...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29764123/the-folding-pathways-and-thermodynamics-of-semiflexible-polymers
#3
Jing Wu, Chenqian Cheng, Gaoyuan Liu, Ping Zhang, Tao Chen
Inspired by the protein folding and DNA packing, we have systematically studied the thermodynamic and kinetic behaviors of single semiflexible homopolymers by Langevin dynamics simulations. In line with experiments, a rich variety of folding products, such as rod-like bundles, hairpins, toroids, and a mixture of them, are observed in the complete diagram of states. Moreover, knotted structures with a significant population are found in a certain range of bending stiffness in thermal equilibrium. As the solvent quality becomes poorer, the population of the intermediate occurring in the folding process increases, which leads to a severe chevron rollover for the folding arm...
May 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29761210/biochemical-properties-of-bacterial-reverse-transcriptase-related-rvt-gene-products-multimerization-protein-priming-and-nucleotide-preference
#4
Irina A Yushenova, Irina R Arkhipova
Cellular reverse transcriptase-related (rvt) genes represent a novel class of reverse transcriptases (RTs), which are only distantly related to RTs of retrotransposons and retroviruses, but, similarly to telomerase RTs, are immobilized in the genome as single-copy genes. They have been preserved by natural selection throughout the evolutionary history of large taxonomic groups, including most fungi, a few plants and invertebrates, and even certain bacteria, being the only RTs present across different domains of life...
May 14, 2018: Current Genetics
https://www.readbyqxmd.com/read/29759788/novel-extravascular-defibrillation-configuration-with-a-coil-in-the-substernal-space-the-asd-clinical-study
#5
Joseph Y S Chan, Jacek Lelakowski, Francis D Murgatroyd, Lucas V Boersma, Jian Cao, Vladimir Nikolski, Griet Wouters, Mark C S Hall
OBJECTIVES: This study assessed the defibrillation efficacy of the substernal-lateral electrode configuration. BACKGROUND: Subcutaneous implantable cardioverter-defibrillators (ICDs) are regarded as alternatives to transvenous ICDs in certain subjects. However, substantially higher shock energy of up to 80 J may be required. Proposed is a new defibrillation method of placing the shock coil into the substernal space. METHODS: This prospective, nonrandomized, feasibility study was conducted in subjects scheduled for midline sternotomy or implant of ICD...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759436/single-and-dual-coil-defibrillator-leads-the-electrophysiology-social-network-in-action
#6
EDITORIAL
Fred Kusumoto
No abstract text is available yet for this article.
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759435/temporal-trends-in-and-factors-associated-with-use-of-single-versus-dual-coil-implantable-cardioverter-defibrillator-leads-data-from-the-ncdr-icd-registry
#7
Sean D Pokorney, Craig S Parzynski, James P Daubert, Donald D Hegland, Paul D Varosy, Jeptha P Curtis, Sana M Al-Khatib
OBJECTIVES: This analysis evaluated temporal trends and factors associated with the use of dual-coil implantable cardioverter-defibrillator (ICD) leads. BACKGROUND: Data suggest that dual-coil ICD leads are not associated with lower mortality and can be more difficult to extract than single-coil leads. METHODS: A total of 435,772 patients at 1,690 hospitals underwent ICD lead insertion in the National Cardiovascular Data Registry's ICD Registry between April 2010 and December 2015...
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29751179/treatment-of-small-and-tiny-aneurysms-before-and-after-flow-diversion-era-a-single-center-experience-of-409-aneurysms
#8
Yuxiang Zhang, Yupeng Zhang, Feng Guo, Fei Liang, Peng Yan, Shikai Liang, Chuhan Jiang
OBJECT: To explore whether we should use PED as primary treatment modality for small and tiny aneurysms at anterior circulation. METHOD: This retrospective study included 409 cases of small and tiny aneurysms including aneurysms treated by PED (n=77), coiling (n=51) and SAC (n=281). We also made a comparison regarding the safety and efficacy among these treatment modality. RESULTS: A total of 55 patients with 77 small aneurysms was treated with PEDs...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29749066/direct-nano-spectroscopic-verification-of-the-amyloid-aggregation-pathway
#9
Ewelina Lipiec, David Perez-Guaita, Janina Kaderli, Bayden Wood, Renato Zenobi
The aggregation pathways of neurodegenerative peptides determine the disease etiology and their better understanding can lead to strategies for early disease treatment. Previous research has allowed modelling of hypothetic aggregation pathways. However, their direct experimental observation has been elusive due to methodological limitations. Here we demonstrate that nanoscale chemical mapping by Tip-Enhanced Raman Spectroscopy of single amyloid fibrils at various stages of aggregation captures the fibril formation process...
May 11, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29748820/trans-arterial-embolization-of-non-variceal-upper-gastrointestinal-bleeding-is-the-use-of-ethylene-vinyl-alcohol-copolymer-as-safe-as-coils
#10
Marcello Andrea Tipaldi, Gianluigi Orgera, Miltiadis Krokidis, Alberto Rebonato, Daniele Maiettini, Simone Vagnarelli, Cesare Ambrogi, Michele Rossi
PURPOSE: The safety of liquid embolics over the conventional coils for the treatment of non-variceal upper gastrointestinal bleeding (UGIB) approach is still unclear. Purpose of this study is to assess the safety of ethylene-vinyl alcohol copolymer (EVOH 6%) over coils in the treatment of UGIB. MATERIALS AND METHODS: All the upper gastrointestinal tract embolization procedures performed in a single center in a 6-year period were reviewed. Patients embolised with coils (Group A) versus those embolised with EVOH 6% (Group B) were compared...
May 10, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29736426/stent-assisted-treatment-of-ruptured-intracranial-aneurysms-in-the-acute-phase-a-single-center-experience
#11
Michael J Ho, Sophia L Göricke, Petra Mummel, Christoph Mönninghoff, Karsten Wrede, Isabel Wanke
Introduction: The purpose of this study was to analyze the results of patients with ruptured aneurysms who were treated with a specific microstent in the acute phase of subarachnoid hemorrhage. Methods: Data from patients with acutely-ruptured intracranial aneurysm treated with the Neuroform stent in the period between 2003 and 2016 were retrospectively assessed, addressing aneurysm occlusion and clinical outcome with a focus on periprocedural complications. Results: Twenty-nine consecutive patients with ruptured intracranial aneurysms were included in the analysis...
March 2018: ENeurologicalSci
https://www.readbyqxmd.com/read/29729833/compaction-of-single-molecule-megabase-long-chromatin-under-the-influence-of-macromolecular-crowding
#12
Anatoly Zinchenko, Nikolay V Berezhnoy, Qinming Chen, Lars Nordenskiöld
The megabase-sized length of chromatin is highly relevant to the state of chromatin in vivo, where it is subject to a highly crowded environment and is organized in topologically associating domains of similar dimension. We developed an in vitro experimental chromatin model system reconstituted from T4 DNA (approximately 166 kbp) and histone octamers and studied the monomolecular compaction of this megabase-sized chromatin fiber under the influence of macromolecular crowding. We used single-molecule fluorescence microscopy and observed compaction in aqueous solutions containing poly(ethylene glycol) in the presence of monovalent (Na+ and K+ ) and divalent (Mg2+ ) cations...
May 2, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29724762/endovascular-treatment-of-dural-arteriovenous-fistulas-using-transarterial-liquid-embolization-in-combination-with-transvenous-balloon-assisted-protection-of-the-venous-sinus
#13
D F Vollherbst, C Ulfert, U Neuberger, C Herweh, M Laible, S Nagel, M Bendszus, M A Möhlenbruch
BACKGROUND AND PURPOSE: Sinus-preserving endovascular embolization was described as a promising treatment technique for dural arteriovenous fistulas. Our aim was to report our single-center experience in patients with dural arteriovenous fistulas who were treated with transarterial liquid embolization in combination with transvenous balloon-assisted protection of the affected venous sinus. MATERIALS AND METHODS: A retrospective analysis of a prospectively collected data base was performed...
May 3, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29723614/the-effect-of-jet-speed-on-large-volume-jet-injection
#14
James W Mckeage, Bryan P Ruddy, Poul M F Nielsen, Andrew J Taberner
Jet injection presents a promising alternative to needle and syringe injection for transdermal drug delivery. The controllability of recently-developed jet injection devices now allows jet speed to be modulated during delivery, and has enabled efficient and accurate delivery of volumes up to 0.3 mL. However, recent attempts to inject larger volumes of up to 1 mL using the same methods have highlighted the different requirements for successful delivery at these larger volumes. This study aims to establish the jet speed requirements for delivery of 1 mL of liquid using a controllable, voice coil driven injection device...
April 30, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29716712/contemporary-outcomes-of-percutaneous-closure-of-patent-ductus-arteriosus-in-adolescents-and-adults
#15
Sudhakar P, John Jose, Oommen K George
BACKGROUND: Catheter based treatment has gained wide acceptance for management of patent ductus arteriosus (PDA) ever since its introduction. Percutaneous closure in adults can be challenging because of anatomical factors including large sizes, associated pulmonary arterial hypertension (PAH) and co-morbidities. This study aimed to provide comprehensive contemporary data on the safety and efficacy of percutaneous device closure of PDA in adult and adolescent population at a large referral center...
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29716351/modeling-and-design-of-a-two-axis-elliptical-notch-flexure-hinge
#16
Jianwei Wu, Yin Zhang, Yunfeng Lu, Zhongpu Wen, Deer Bin, Jiubin Tan
As an important part of the joule balance system, the two-axis elliptical notch flexure hinge (TENFH) which typically consists of two single-axis elliptical notch flexure hinges was studied. First, a 6 degrees of freedom (6-DOF) compliance model was established based on the coordinate transformation method. In addition, the maximum stress of the TENFH was derived. The compliance and maximum stress model was verified using finite element analysis simulation. To decouple the attitude of the suspended coil system and reduce the offset between the centroid of the suspended coil mechanism and the mass comparator in the joule balance system, a new mechanical structure of TENFH was designed based on the compliance model and stress model proposed in this paper...
April 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29704561/oral-carcinoma-clinical-evaluation-using-diffusion-kurtosis-imaging-and-its-correlation-with-histopathologic-findings
#17
Ichiro Yamada, Norio Yoshino, Keigo Hikishima, Junichiro Sakamoto, Misaki Yokokawa, Yu Oikawa, Hiroyuki Harada, Tohru Kurabayashi, Yukihisa Saida, Ukihide Tateishi, Akane Yukimori, Toshiyuki Izumo, Shun Asahina
PURPOSE: In this study, we aimed to determine the usefulness of diffusion kurtosis imaging (DKI) as a noninvasive method for evaluation of the histologic grade and lymph node metastasis in patients with oral carcinoma. MATERIALS AND METHODS: Twenty-seven patients with oral carcinoma were examined with a 3-T MR system and 16-channel coil. DKI data were obtained by a single-shot echo-planar imaging sequence with repetition time, 10,000 ms; echo time, 94 ms; field of view, 250 × 204...
April 25, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29703978/time-efficient-whole-brain-coverage-with-mr-fingerprinting-using-slice-interleaved-echo-planar-imaging
#18
Benedikt Rieger, Mehmet Akçakaya, José C Pariente, Sara Llufriu, Eloy Martinez-Heras, Sebastian Weingärtner, Lothar R Schad
Magnetic resonance fingerprinting (MRF) is a promising method for fast simultaneous quantification of multiple tissue parameters. The objective of this study is to improve the coverage of MRF based on echo-planar imaging (MRF-EPI) by using a slice-interleaved acquisition scheme. For this, the MRF-EPI is modified to acquire several slices in a randomized interleaved manner, increasing the effective repetition time of the spoiled gradient echo readout acquisition in each slice. Per-slice matching of the signal-trace to a precomputed dictionary allows the generation of T1 and T2 * maps with integrated B1 + correction...
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29700422/structure-of-the-receptor-activated-human-trpc6-and-trpc3-ion-channels
#19
Qinglin Tang, Wenjun Guo, Li Zheng, Jing-Xiang Wu, Meng Liu, Xindi Zhou, Xiaolin Zhang, Lei Chen
TRPC6 and TRPC3 are receptor-activated nonselective cation channels that belong to the family of canonical transient receptor potential (TRPC) channels. They are activated by diacylglycerol, a lipid second messenger. TRPC6 and TRPC3 are involved in many physiological processes and implicated in human genetic diseases. Here we present the structure of human TRPC6 homotetramer in complex with a newly identified high-affinity inhibitor BTDM solved by single-particle cryo-electron microscopy to 3.8 Å resolution...
April 26, 2018: Cell Research
https://www.readbyqxmd.com/read/29698850/structural-elements-of-stromal-interaction-molecule-function
#20
REVIEW
Matthew J Novello, Jinhui Zhu, Qingping Feng, Mitsuhiko Ikura, Peter B Stathopulos
Stromal interaction molecule (STIM)-1 and -2 are multi-domain, single-pass transmembrane proteins involved in sensing changes in compartmentalized calcium (Ca2+ ) levels and transducing this cellular signal to Orai1 channel proteins. Our understanding of the molecular mechanisms underlying STIM signaling has been dramatically improved through available X-ray crystal and solution NMR structures. This high-resolution structural data has revealed that intricate intramolecular and intermolecular protein-protein interactions are involved in converting STIMs from the quiescent to activation-competent states...
April 18, 2018: Cell Calcium
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