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https://www.readbyqxmd.com/read/28733225/microneurosurgical-clip-ligation-of-acutely-ruptured-cerebral-aneurysm-immediately-preceded-by-intentional-subtotal-endovascular-coil-embolization-under-a-single-anesthesia-observations-using-a-deliberate-combined-sequential-treatment-strategy-in-13-cases
#1
Jeffrey E Thomas, Jack C Rose
BACKGROUND: Endovascular coil embolization and craniotomy with clip ligation are the two most commonly used treatments for ruptured cerebral aneurysm. While coiling maintains the advantages of brevity and complete avoidance of brain retraction and manipulation, clipping offers the benefits of decompression of the injured brain and lower aneurysm recurrence rates. A combined, immediately sequential treatment strategy for acutely ruptured cerebral aneurysm that simultaneously maximizes the advantages of both techniques, while minimizing their respective disadvantages, may be a useful paradigm...
July 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28731402/twenty-four-hour-emergency-intervention-versus-early-intervention-in-aneurysmal-subarachnoid-hemorrhage
#2
Joseph R Linzey, Craig Williamson, Venkatakrishna Rajajee, Kyle Sheehan, B Gregory Thompson, Aditya S Pandey
OBJECTIVE Recent observational data suggest that ultra-early treatment of ruptured aneurysms prevents rebleeding, thus improving clinical outcomes. However, advances in critical care management of patients with ruptured aneurysms may reduce the rate of rebleeding in comparison with earlier trials, such as the International Cooperative Study on the Timing of Aneurysm Surgery. The objective of the present study was to determine if an ultra-early aneurysm repair protocol will or will not significantly reduce the number of incidents of rebleeding following aneurysmal subarachnoid hemorrhage (SAH)...
July 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28727829/functional-differentiation-and-spatial-temporal-co-expression-networks-of-the-nbs-encoding-gene-family-in-jilin-ginseng-panax-ginseng-c-a-meyer
#3
Rui Yin, Mingzhu Zhao, Kangyu Wang, Yanping Lin, Yanfang Wang, Chunyu Sun, Yi Wang, Meiping Zhang
Ginseng, Panax ginseng C.A. Meyer, is one of the most important medicinal plants for human health and medicine. It has been documented that over 80% of genes conferring resistance to bacteria, viruses, fungi and nematodes are contributed by the nucleotide binding site (NBS)-encoding gene family. Therefore, identification and characterization of NBS genes expressed in ginseng are paramount to its genetic improvement and breeding. However, little is known about the NBS-encoding genes in ginseng. Here we report genome-wide identification and systems analysis of the NBS genes actively expressed in ginseng (PgNBS genes)...
2017: PloS One
https://www.readbyqxmd.com/read/28727544/abbreviated-biparametric-prostate-mr-imaging-in-men-with-elevated-prostate-specific-antigen
#4
Christiane K Kuhl, Robin Bruhn, Nils Krämer, Sven Nebelung, Axel Heidenreich, Simone Schrading
Purpose To determine the diagnostic accuracy for clinically significant prostate cancer achieved with abbreviated biparametric prostate magnetic resonance (MR) imaging in comparison with full multiparametric contrast material-enhanced prostate MR imaging in men with elevated prostate-specific antigen (PSA) and negative transrectal ultrasonography (US)-guided biopsy findings; to determine the significant cancer detection rate of biparametric versus full multiparametric contrast-enhanced MR imaging and between-reader agreement for interpretation of biparametric MR imaging...
July 20, 2017: Radiology
https://www.readbyqxmd.com/read/28722314/prospective-motion-correction-using-coil-mounted-cameras-cross-calibration-considerations
#5
Julian Maclaren, Murat Aksoy, Melvyn B Ooi, Benjamin Zahneisen, Roland Bammer
PURPOSE: Optical prospective motion correction substantially reduces sensitivity to motion in neuroimaging of human subjects. However, a major barrier to clinical deployment has been the time-consuming cross-calibration between the camera and MRI scanner reference frames. This work addresses this challenge. METHODS: A single camera was mounted onto the head coil for tracking head motion. Two new methods were developed: (1) a rapid calibration method for camera-to-scanner cross-calibration using a custom-made tool incorporating wireless active markers, and (2) a calibration adjustment method to compensate for table motion between scans...
July 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28718776/coil-geometry-effects-on-scanning-single-coil-magnetic-induction-tomography
#6
Joe R Feldkamp, Stephen Quirk
Alternative coil designs for single coil MIT (magnetic induction tomography) are considered in this work, with the intention of improving upon the standard design used previously. In particular, we note that the blind spot associated with this coil type, a portion of space along its axis where eddy current generation can be very weak, has an important effect on performance. The seven designs tested here vary considerably in the size of their blind spot. To provide the most discerning test possible, we use laboratory phantoms containing feature dimensions similar to blind spot size...
July 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28700894/preparation-of-an-au-pt-alloy-free-from-artifacts-in-magnetic-resonance-imaging
#7
Tomonobu Kodama, Ryusuke Nakai, Kenji Goto, Kunihiro Shima, Hiroo Iwata
PURPOSE: When magnetic resonance imaging (MRI) is performed on patients carrying metallic implants, artifacts can disturb the images around the implants, often making it difficult to interpret them appropriately. However, metallic materials are and will be indispensable as raw materials for medical devices because of their electric conductivity, visibility under X-ray fluoroscopy, and other favorable features. What is now desired is to develop a metallic material which causes no artifacts during MRI...
July 9, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28700714/genome-wide-re-sequencing-of-newly-developed-rice-lines-from-common-wild-rice-oryza-rufipogon-griff-for-the-identification-of-nbs-lrr-genes
#8
Wen Liu, Fozia Ghouri, Hang Yu, Xiang Li, Shuhong Yu, Muhammad Qasim Shahid, Xiangdong Liu
Common wild rice (Oryza rufipogon Griff.) is an important germplasm for rice breeding, which contains many resistance genes. Re-sequencing provides an unprecedented opportunity to explore the abundant useful genes at whole genome level. Here, we identified the nucleotide-binding site leucine-rich repeat (NBS-LRR) encoding genes by re-sequencing of two wild rice lines (i.e. Huaye 1 and Huaye 2) that were developed from common wild rice. We obtained 128 to 147 million reads with approximately 32.5-fold coverage depth, and uniquely covered more than 89...
2017: PloS One
https://www.readbyqxmd.com/read/28699424/endovascular-repair-of-subclavian-artery-aneurysms-results-from-a-single-center-experience
#9
XiXiang Gao, LiQiang Li, YongQuan Gu, LianRui Guo, ShiJun Cui, LiXing Qi, JianXin Li, Jian Zhang
OBJECTIVE: To present our experience of the endovascular treatment of subclavian artery aneurysms (SAAs) and analyze the clinical manifestations, imaging findings and treatment outcomes. METHODS: In this retrospective study, nine patients with SAAs underwent endovascular stent placement in our center between July 2011 and June 2016. Clinical features, imaging findings, treatment outcomes and follow-up results of these SAA patients were retrospectively analyzed. RESULTS: Nine patients were diagnosed with SAAs by computer tomography angiography (CTA)...
July 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28697942/outcomes-for-concomitant-common-iliac-artery-aneurysms-after-endovascular-abdominal-aortic-aneurysm-repair
#10
Mohsen Bannazadeh, Christina Jenkins, Andrew Forsyth, Jason Kramer, Ankur Aggarwal, Amy E Somerset, Paul G Bove, Graham W Long
OBJECTIVE: This study evaluated the morbidity of endovascular abdominal aortic aneurysm repair (EVAR) in patients with concomitant common iliac artery aneurysm (CCIAA). METHODS: This was a retrospective review of all patients who underwent elective EVAR from June 2006 through June 2012 at a single institution. Demographics, comorbidities, preoperative presentation, intraoperative details, and postoperative complications were tabulated. Patients with CCIAA were categorized into three groups according to the distal extent of their iliac limb: iliac limb extension into the external iliac artery with internal iliac artery coil embolization (EE); flared iliac limb ≥20 mm in diameter to the iliac bifurcation (FL); and iliac limb ≤20 mm ending proximal to the CCIAA (no-FL)...
July 8, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28690870/spinal-dural-arteriovenous-fistula-a-case-series-and-review-of-imaging-findings
#11
Shandy Fox, Luke Hnenny, Uzair Ahmed, Kotoo Meguro, Michael E Kelly
INTRODUCTION: Spinal dural arteriovenous fistulae (sdAVF) are rare lesions. Patients typically present with slowly progressive myelopathy that is often mistaken for degenerative cervical or lumbar stenosis. On spinal magnetic resonance imaging (MRI), multisegmental T2 hyperintensities along with associated flow voids are pathognomonic of sdAVF. However, diagnosis can be difficult. Definitive diagnosis and localization is achieved with complete spinal angiography. Treatment options include open surgical ligation, endovascular embolization or multimodality treatment...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28669554/a-randomized-controlled-trial-on-the-effect-of-a%C3%A2-double-check-on-the-detection-of-medication%C3%A2-errors
#12
Amy M Douglass, Joshua Elder, Robin Watson, Tom Kallay, David Kirsh, William G Robb, Amy H Kaji, Clinton J Coil
STUDY OBJECTIVE: The use of a double check by 2 nurses has been advocated as a key error-prevention strategy. This study aims to determine how often a double check is used for high-alert medications and whether it increases error detection. METHODS: Emergency department and ICU nurses worked in pairs to care for a simulated patient. Nurses were randomized into single- and double-check groups. Errors intentionally introduced into the simulation included weight-based dosage errors and wrong medication vial errors...
June 29, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28667981/full-area-covered-3d-profile-measurement-of-special-shaped-optics-based-on-a-new-prototype-non-contact-profiler
#13
Hui-Lin Du, Zhao-Zhong Zhou, Ze-Qing Sun, Bing-Feng Ju, Shaoning Xu, Anyu Sun
A new prototype non-contact profiler based on surface tracking has been specially developed. Surface tracking is carried out by a specially designed dual stage probe system with the aid of a four-Degree Of Freedom high-precision motion platform. The dual stage probe system keeps a short-range optical probe constantly tracking the surface by a self-developed voice coil motor servo, by which a wide measuring range of up to 10 mm is realized. The system performance evaluation including resolution, repeatability, and scanning speed proved the good capability of the new prototype non-contact profiler...
June 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28664353/adopting-reciprocity-theorem-in-deep-transcranial-magnetic-stimulation-problem-to-design-an-efficient-single-source-coil-array-based-on-nerve-cell-direction
#14
Ali Mohtadi Jafari, Ali Abdolali
Deep transcranial magnetic stimulation (dTMS) plays an important role in the treatment of many diseases. Previous designs rarely considered the direction of the induced electric field (E) with respect to nerve fibers. However, it can be observed from related formulae that the tangential component of E (E effective) has a more significant role in the stimulation of nerve cells. In this paper, a new approach is proposed for designing a single-source coil array (CA) by combining tractography and the reciprocity theorem (RT)...
June 29, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28663758/lmna-sequences-of-60-706-unrelated-individuals-reveal-132-novel-missense-variants-in-a-type-lamins-and-suggest-a-link-between-variant-p-g602s-and-type-2-diabetes
#15
Alyssa Florwick, Tejas Dharmaraj, Julie Jurgens, David Valle, Katherine L Wilson
Mutations in LMNA, encoding nuclear intermediate filament proteins lamins A and C, cause multiple diseases ('laminopathies') including muscular dystrophy, dilated cardiomyopathy, familial partial lipodystrophy (FPLD2), insulin resistance syndrome and progeria. To assess the prevalence of LMNA missense mutations ('variants') in a broad, ethnically diverse population, we compared missense alleles found among 60,706 unrelated individuals in the ExAC cohort to those identified in 1,404 individuals in the laminopathy database (UMD-LMNA)...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28660339/a-multifunctional-fluorescent-aptamer-probe-for-highly-sensitive-and-selective-detection-of-cadmium-ii
#16
Yu-Feng Zhu, Yong-Sheng Wang, Bin Zhou, Jun-Hui Yu, Li-Lan Peng, Yan-Qin Huang, Xue-Jiao Li, Si-Han Chen, Xian Tang, Xiao-Feng Wang
We report a highly sensitive and selective strategy for Cd(II) assay using a singly labeled multifunctional probe consisting of a Cd(II)-specific aptamer (CAP), which acted as a recognition element for Cd(II) and a signal reporter. The presence of Cd(II) can induce the conformational switching of the CAP, accompanied by a change in fluorescence intensity. Thereby, a fluorescence strategy for Cd(II) assay was established. The proposed method has a detection limit of 2.15 nM, which is much lower than the detection limits reported in related literature...
June 29, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28653193/effects-of-ripasudil-hydrochloride-hydrate-k-115-a-rho-kinase-inhibitor-on-ocular-blood-flow-and-ciliary-artery-smooth-muscle-contraction-in-rabbits
#17
Yusuke Ohta, Sanae Takaseki, Takeshi Yoshitomi
PURPOSE: Ripasudil, a Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor, is a novel drug for glaucoma in Japan. ROCK inhibition not only reduces intraocular pressure (IOP) but also increases ocular blood flow. We investigated the effects of ripasudil on optic disc blood flow (ODBF) in rabbit eyes and in isolated rabbit ciliary arteries. METHODS: We measured IOP by tonometry and ODBF by laser speckle flowgraphy (LSFG) in male Dutch rabbits. A single drop (20 μL) of 0...
June 26, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28653012/optically-tracked-single-coil-scanning-magnetic-induction-tomography
#18
Joe R Feldkamp, Stephen Quirk
Recent work has shown that single-coil, magnetic induction tomography (MIT) is useful for visualizing three-dimensional electrical conductivity distributions within biological targets. Coil-induced eddy currents and the associated secondary field are detected as an inductive loss while the coil is relocated to several unique positions and orientations near a target. Image reconstruction is then accomplished by inversion of a convolution integral that quantitatively maps inductive loss with conductivity. Previously, coil position and orientation had to be established by a template, which required assignment of fixed locations for the coil to visit...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28649224/the-video-head-impulse-test
#19
REVIEW
G M Halmagyi, Luke Chen, Hamish G MacDougall, Konrad P Weber, Leigh A McGarvie, Ian S Curthoys
In 1988, we introduced impulsive testing of semicircular canal (SCC) function measured with scleral search coils and showed that it could accurately and reliably detect impaired function even of a single lateral canal. Later we showed that it was also possible to test individual vertical canal function in peripheral and also in central vestibular disorders and proposed a physiological mechanism for why this might be so. For the next 20 years, between 1988 and 2008, impulsive testing of individual SCC function could only be accurately done by a few aficionados with the time and money to support scleral search-coil systems-an expensive, complicated and cumbersome, semi-invasive technique that never made the transition from the research lab to the dizzy clinic...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28648883/molecular-cloning-and-functional-analysis-of-tumor-necrosis-factor-receptor-associated-factor-6-traf6-in-crossastrea-gigas
#20
Fan Mao, Jun Li, Yuehuan Zhang, Zhiming Xiang, Yang Zhang, Ziniu Yu
Tumor necrosis factor receptor-associated factor 6 (TRAF6) has been demonstrated to be a key signaling molecule involved in adaptive and innate immunity. In this study, we obtained the full length CgTRAF6 cDNA and analyzed the characteristics of the ORF and the peptide sequence in Crassostrea gigas. The deduced protein sequence of CgTRAF6 includes a conserved C-terminal TRAF domain following the RING and the zinc finger domain. The TRAF domain is composed of coiled-coil TRAF-N and MATH (meprin and TRAF-C homology) subdomains...
June 23, 2017: Fish & Shellfish Immunology
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