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https://www.readbyqxmd.com/read/28427972/endovascular-treatment-of-complex-distal-posterior-cerebral-artery-aneurysms-with-the-pipeline-embolization-device
#1
Paul Mazaris, Tapan Mehta, Mohammed Hussain, Violiza Inoa, Justin Singer, Gary Spiegel, Inam Kureshi, Martin Ollenschleger
INTRODUCTION: The purpose of our study is to assess the safety and efficacy of the Pipeline Embolization Device (PED) for endovascular treatment of complex, distal posterior cerebral artery (PCA) aneurysms. METHODS: We conducted a retrospective review of patients who underwent endovascular treatment of complex PCA aneurysms with PED from November 2012 to December 2015. A total of 4 patients were identified and treated. 12 month angiographic and clinical follow-up was available for all patients...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28419217/shock-efficacy-of-single-and-dual-coil-electrodes-new-insights-from-the-nordic-icd-trial
#2
Dietmar Bänsch, Hendrik Bonnemeier, Johan Brandt, Frank Bode, Jesper Hastrup Svendsen, Oliver Ritter, Johannes Aring, Klaus-Jürgen Gutleben, Ralph Schneider, Angelika Felk, Tino Hauser, Anika Buchholz, Gerhard Hindricks, Karl Wegscheider
Aims: Dual coil (DC) electrodes are preferred to single coil (SC) electrodes because of an assumed higher shock efficacy. However, DC-electrodes may be associated with an increased difficulty and risk of lead extraction. We aimed to compare SC- and DC-electrodes with respect to the first shock efficacy (FSE) after implantable cardioverter defibrillator (ICD) implantation. Methods and results: One thousand and seventy-seven patients of the NORDIC ICD trial were randomly assigned to first time ICD implantation with or without defibrillation (DF) testing...
April 13, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28416410/progressive-occlusion-and-recanalization-after-endovascular-treatment-for-287-unruptured-small-aneurysms-5mm-a-single-center-6-year-experience
#3
Xin Feng, Luyao Wang, Erkang Guo, Baorui Zhang, Zenghui Qian, Peng Liu, Xiaolong Wen, Wenjuan Xu, Youxiang Li, Chuhan Jiang, Zhongxue Wu, Aihua Liu
OBJECT: We aimed to investigate the effect of coiling for small unruptured intracranial aneurysms(UIAs)﹤5mm) on progressive occlusion and recanalization, and the dubious factors related to progressive occlusion and recanalization among UIAs without complete occlusion. METHODS: A total of 264 patients with 287 small UIAs were coiled in our institute between June 2009 and December 2014. All UIAs enrolled were divided into small (3-5mm) and very small (<3mm) groups, and UIAs without initial complete occlusion were divided into progressive, stable and recanalization groups...
April 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28414964/insights-into-the-short-term-effects-of-ceo2-nanoparticles-on-sludge-dewatering-and-related-mechanism
#4
Guoxiang You, Peifang Wang, Jun Hou, Chao Wang, Yi Xu, Lingzhan Miao, Bowen Lv, Yangyang Yang, Zhilin Liu, Fei Zhang
As CeO2 nanoparticles (NPs) are used in many applications, the released particles eventually enter wastewater treatment plants, influencing sludge dewatering and increasing the disposal costs. We conducted tests to gain insight into the sludge dewatering performance and the potential mechanism related to the distribution and production of extracellular polymeric substances (EPS). In addition, we conducted single-factor tests with six concentrations of CeO2 NPs in sequencing batch reactors containing matured activated sludge...
April 8, 2017: Water Research
https://www.readbyqxmd.com/read/28411437/design-and-construction-of-a-novel-1-h-19-f-double-tuned-coil-system-using-pin-diode-switches-at-9-4t
#5
Chang-Hoon Choi, Suk-Min Hong, YongHyun Ha, N Jon Shah
A double-tuned (1)H/(19)F coil using PIN-diode switches was developed and its performance evaluated. The is a key difference from the previous developments being that this design used a PIN-diode switch in series with an additionally inserted inductor in parallel to one of the capacitors on the loop. The probe was adjusted to (19)F when the reverse bias voltage was applied (PIN-diode OFF), whilst it was switched to (1)H when forward current was flowing (PIN-diode ON). S-parameters and Q-factors of single- and double-tuned coils were examined and compared with/without a phantom on the bench...
April 7, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28410370/a-systematic-screen-for-morphological-abnormalities-during-fission-yeast-sexual-reproduction-identifies-a-mechanism-of-actin-aster-formation-for-cell-fusion
#6
Omaya Dudin, Laura Merlini, Felipe O Bendezú, Raphaël Groux, Vincent Vincenzetti, Sophie G Martin
In non-motile fungi, sexual reproduction relies on strong morphogenetic changes in response to pheromone signaling. We report here on a systematic screen for morphological abnormalities of the mating process in fission yeast Schizosaccharomyces pombe. We derived a homothallic (self-fertile) collection of viable deletions, which, upon visual screening, revealed a plethora of phenotypes affecting all stages of the mating process, including cell polarization, cell fusion and sporulation. Cell fusion relies on the formation of the fusion focus, an aster-like F-actin structure that is marked by strong local accumulation of the myosin V Myo52, which concentrates secretion at the fusion site...
April 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28409727/clival-chordomas-considerations-after-16-years-of-endoscopic-endonasal-surgery
#7
Matteo Zoli, Laura Milanese, Rocco Bonfatti, Marco Faustini-Fustini, Gianluca Marucci, Giovanni Tallini, Corrado Zenesini, Carmelo Sturiale, Giorgio Frank, Ernesto Pasquini, Diego Mazzatenta
OBJECTIVE In the past decade, the role of the endoscopic endonasal approach (EEA) has relevantly evolved for skull base tumors. In this study, the authors review their surgical experience with using an EEA in the treatment of clival chordomas, which are deep and infiltrative skull base lesions, and they highlight the advantages and limitations of this ventral approach. METHODS All consecutive cases of chordoma treated with an EEA between 1998 and 2015 at a single institution are included in this study. Preoperative assessment consisted of neuroimaging (MRI and CT with angiography sequences) and endocrinological, neurological, and ophthalmological evaluations, which were repeated 3 months after surgery and annually thereafter...
April 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28408752/high-resolution-neutron-larmor-diffraction-using-superconducting-magnetic-wollaston-prisms
#8
Fankang Li, Hao Feng, Alexander N Thaler, Steven R Parnell, William A Hamilton, Lowell Crow, Wencao Yang, Amy B Jones, Hongyu Bai, Masaaki Matsuda, David V Baxter, Thomas Keller, Jaime A Fernandez-Baca, Roger Pynn
The neutron Larmor diffraction technique has been implemented using superconducting magnetic Wollaston prisms in both single-arm and double-arm configurations. Successful measurements of the coefficient of thermal expansion of a single-crystal copper sample demonstrates that the method works as expected. The experiment involves a new method of tuning by varying the magnetic field configurations in the device and the tuning results agree well with previous measurements. The difference between single-arm and double-arm configurations has been investigated experimentally...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28408264/single-session-hematoma-removal-and-transcranial-coil-embolization-for-a-cavernous-sinus-dural-arteriovenous-fistula-a-technical-case-report
#9
Yosuke Akamatsu, Kenichi Sato, Hidenori Endo, Yasushi Matsumoto, Teiji Tominaga
BACKGROUND: Patients with cavernous sinus dural arteriovenous fistulas (CS dAVFs) with cortical venous varix are indicated for aggressive treatment because of the associated risk for intracranial hemorrhage. CASE DESCRIPTION: We present a case of surgical transvenous embolization in an 84-year-old woman with CS dAVF who presented with massive intracerebral hematoma. Cerebral angiograms revealed the dural AVF drained only into the superficial middle cerebral vein...
April 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28388496/single-chip-electron-spin-resonance-detectors-operating-at-50ghz-92ghz-and-146ghz
#10
Alessandro V Matheoud, Gabriele Gualco, Minki Jeong, Ivica Zivkovic, Jürgen Brugger, Henrik M Rønnow, Jens Anders, Giovanni Boero
We report on the design and characterization of single-chip electron spin resonance (ESR) detectors operating at 50GHz, 92GHz, and 146GHz. The core of the single-chip ESR detectors is an integrated LC-oscillator, formed by a single turn aluminum planar coil, a metal-oxide-metal capacitor, and two metal-oxide semiconductor field effect transistors used as negative resistance network. On the same chip, a second, nominally identical, LC-oscillator together with a mixer and an output buffer are also integrated...
March 24, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28385886/preliminary-experience-with-stent-assisted-coiling-of-aneurysms-arising-from-small-2-5-mm-cerebral-vessels-using-the-low-profile-visualized-intraluminal-support-device
#11
C-C Wang, W Li, Z-Z Feng, B Hong, Y Xu, J-M Liu, Q-H Huang
BACKGROUND AND PURPOSE: The Low-Profile Visualized Intraluminal Support (LVIS) stent is a new device recently introduced for the treatment of wide-neck intracranial aneurysms. This single-center study presents the authors' preliminary experience using the LVIS stent to treat saccular aneurysms with parent arteries smaller than 2.5 mm. MATERIALS AND METHODS: Aneurysms with a LVIS stent used in a small parent vessel (<2.5 mm in diameter) between October 2014 and April 2016 were included...
April 6, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28384393/d-cysteine-ligands-control-metal-geometries-within-de-novo-designed-three-stranded-coiled-coils
#12
Vincent Louis Pecoraro, Leela Ruckthong, Anna F A Peacock, Cherilyn E Pascoe, Lars Hemmingsen, Jeanne A Stuckey
While metal ion binding to naturally occurring L-amino acid proteins is well documented, understanding the impact of the opposite chirality (D) amino acids on the structure and stereochemistry of metals is in its infancy. We examine the effect of a D-configuration cysteine within a designed L-amino acid three-stranded coiled coil in order to enforce a precise coordination number on a metal center. The D-chirality does not alter the native fold, but the side-chain reorientation modifies the sterics of the metal binding pocket...
April 6, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28381579/reverse-transcription-mechanically-initiates-hiv-1-capsid-disassembly
#13
Sanela Rankovic, Janani Varadarajan, Ruben Ramalho, Christopher Aiken, Itay Rousso
The HIV-1 core consists of the viral genomic RNA and several viral proteins encased within a conical capsid. Following cell entry, the core disassembles in a process termed uncoating. Although HIV-1 uncoating has been linked to reverse transcription of the viral genome in target cells, the mechanism by which uncoating is initiated is unknown. Using time-lapse atomic force microscopy, we analyzed the morphology and physical properties of isolated HIV-1 cores during the course of reverse transcription in vitro We find that, during an early stage of reverse transcription the pressure inside the capsid increases, reaching a maximum after 7 hours...
April 5, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28374941/characterizing-physical-properties-of-superparamagnetic-nanoparticles-in-liquid-phase-using-brownian-relaxation
#14
Kai Wu, Karl Schliep, Xiaowei Zhang, Jinming Liu, Bin Ma, Jian-Ping Wang
Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used as bioimaging contrast agents, heating sources for tumor therapy, and carriers for controlled drug delivery and release to target organs and tissues. These applications require elaborate tuning of the physical and magnetic properties of the SPIONs. The authors present here a search-coil-based method to characterize these properties. The nonlinear magnetic response of SPIONs to alternating current magnetic fields induces harmonic signals that contain information of these nanoparticles...
April 4, 2017: Small
https://www.readbyqxmd.com/read/28373927/non-invasive-brain-stimulation-for-essential-tremor
#15
REVIEW
Ludy C Shih, Alvaro Pascual-Leone
BACKGROUND: There is increasing interest in the use of non-invasive brain stimulation to characterize and potentially treat essential tremor (ET). Studies have used a variety of stimulation coils, paradigms, and target locations to make these observations. We reviewed the literature to compare prior studies and to evaluate the rationale and the methods used in these studies. METHODS: We performed a systematic literature search of the PubMed database using the terms "transcranial," "noninvasive," "brain stimulation," "transcranial magnetic stimulation (TMS)," "transcranial direct current stimulation (tDCS)," "transcranial alternating current stimulation (tACS)," and "essential tremor...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28369589/bivalent-formation-1-a-plant-conserved-gene-encodes-an-omph-coiled-coil-motif-containing-protein-required-for-meiotic-recombination-in-rice
#16
Lian Zhou, Jingluan Han, Yuanling Chen, Yingxiang Wang, Yao-Guang Liu
Meiosis is essential for eukaryotic sexual reproduction and plant fertility. In comparison with over 80 meiotic genes identified in Arabidopsis, there are only ~30 meiotic genes characterized in rice (Oryza sativa L.). Many genes involved in the regulation of meiotic progression remain to be determined. In this study, we identified a sterile rice mutant and cloned a new meiotic gene, OsBVF1 (Bivalent Formation 1) by map-based cloning. Molecular genetics and cytological approaches were carried out to address the function of OsBVF1 in meiosis...
March 24, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28365483/structural-transitions-in-torsionally-constrained-dna-and-their-dependence-on-solution-electrostatics
#17
Jaspreet Singh, Prashant K Purohit
Experimental studies on single molecules of DNA have reported a rich variety of structural transitions, including coexistence of three phases, in a torsionally constrained molecule. A comprehensive knowledge of these structural transitions is useful for unraveling the in vivo and in vitro behavior of DNA. Our objective is to understand the structural transitions in a torsionally constrained DNA molecule when it is pulled using optical or magnetic tweezers. We use foundational concepts from the Zimm-Bragg helix-coil transition theory and merge them with ideas from the theory of fluctuating elastic rods to model the mechanics of DNA...
March 29, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28360455/a-feasibility-study-of-high-strength-bi-2223-conductor-for-high-field-solenoids
#18
A Godeke, D V Abraimov, E Arroyo, N Barret, M D Bird, A Francis, J Jaroszynski, D V Kurteva, W D Markiewicz, E L Marks, W S Marshall, D M McRae, P D Noyes, R C P Pereira, Y L Viouchkov, R P Walsh, J M White
We performed a feasibility study on a high-strength Bi2-x Pb x Sr2Ca2Cu3O10-x (Bi-2223) tape conductor for high-field solenoid applications. The investigated conductor, DI-BSCCO Type HT-XX, is a pre-production version of Type HT-NX, which has recently become available from Sumitomo Electric Industries (SEI). It is based on their DI-BSCCO Type H tape, but laminated with a high-strength Ni-alloy. We used stress-strain characterizations, single- and double-bend tests, easy- and hard-way bent coil-turns at various radii, straight and helical samples in up to 31...
March 2017: Superconductor Science & Technology
https://www.readbyqxmd.com/read/28357169/low-profile-visualized-intraluminal-support-junior-device-for-the-treatment-of-intracranial-aneurysms
#19
Mihir Gupta, Vincent J Cheung, Peter Abraham, Arvin R Wali, David R Santiago-Dieppa, Brandon C Gabel, Abdulrahman Almansouri, J Scott Pannell, Alexander A Khalessi
OBJECTIVE: Early case series suggest that the recently introduced Low-profile Visualized Intraluminal Support Junior (LVIS Jr.) device (MicroVention-Terumo, Inc., Tustin, CA) may be used to treat wide-necked aneurysms that would otherwise require treatment with intrasaccular devices or open surgery. We report our single-center experience utilizing LVIS Jr. to treat intracranial aneurysms involving 1.8-2.5 mm parent arteries. METHODS: We retrospectively reviewed records of patients treated with the LVIS Jr...
February 17, 2017: Curēus
https://www.readbyqxmd.com/read/28351129/action-self-quenching-dimer-induced-fluorescence-quenching-of-chromophores-as-a-probe-for-biomolecular-structure
#20
Steven Daly, Chang Min Choi, Fabien Chirot, Luke MacAleese, Rodolphe Antoine, Philippe Dugourd
To obtain a more detailed understanding of how structure influences the function and interaction of biomolecules, it is important to develop structure sensitive techniques to probe these relationships. Alongside in vivo and in vitro techniques, it is instructive to consider in vacuo methodologies: for example native mass spectrometry, ion mobility mass spectrometry, and FRET. Here, we propose a novel technique for probing biomolecular structure based on the changes in photophysics of a chromophore upon dimer formation...
April 7, 2017: Analytical Chemistry
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