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Cancer photothermal therapy nano

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https://www.readbyqxmd.com/read/28191450/remotely-triggered-nano-theranostics-for-cancer-applications
#1
Alexandra Sneider, Derek VanDyke, Shailee Paliwal, Prakash Rai
Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response, and, if required, initiate secondary treatments. Recent in vivo experiments demonstrate the promise of using theranostics in the clinic. In this paper, we review the use of remotely triggered theranostic nanoparticles for cancer applications, focusing heavily on advances in the past five years. Remote triggering mechanisms covered include photodynamic, photothermal, phototriggered chemotherapeutic release, ultrasound, electro-thermal, magneto-thermal, X-ray, and radiofrequency therapies...
2017: Nanotheranostics (Syd)
https://www.readbyqxmd.com/read/28187379/novel-doxorubicin-loaded-pegylated-cuprous-telluride-nanocrystals-for-combined-photothermal-chemo-cancer-treatment
#2
Xianwen Wang, Yan Ma, Huajian Chen, Xiaoyi Wu, Haisheng Qian, Xianzhu Yang, Zhengbao Zha
Recently, combined photothermal-chemo therapy has attracted great attention due to its enhanced anti-tumor efficiency via synergistic effects. Herein, PEGylated cuprous telluride nanocrystals (PEGylated Cu2Te NCs) were developed as novel drug nanocarriers for combined photothermal-chemo treatment of cancer cells. PEGylated Cu2Te NCs were fabricated through a simple two-step process, comprised of hot injection and thin-film hydration. The as-prepared PEGylated Cu2Te NCs (average diameter of 5.21±1.05nm) showed a noticeable photothermal conversion efficiency of 33...
February 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28128375/facile-fabrication-of-a-magnetically-smart-ptx-loaded-cys-fe3o4-cus-bsa-nano-drug-for-imaging-guided-chemo-photothermal-therapy
#3
Lanfang Ren, Xijian Liu, Qian Wang, Lijuan Zhang, Guoying Deng, Feng Zhou, Jie Lu
In this study, a multifunctional nano-drug (PTX-loaded Cys-Fe3O4/CuS@BSA nanocomposite), which performs well in hydrophobic drug delivery, magnetic resonance imaging (MRI) and chemo-photothermal combination therapy, has been successfully synthesized via a facile method with several biocompatible agents. The characterization verified that our as-obtained nanocarrier has a preferable average diameter of about 300 nm for cancer therapy, shows a great MRI ability and magnetism performance, and exhibits a favorable in vitro and in vivo photothermal therapeutic efficacy by introducing CuS, and the sustained release of chemotherapeutics could be controlled by pH value and near-infrared laser irradiation has further enhanced the therapeutic performance...
January 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28106955/cypate-mediated-thermosensitive-nanoliposome-for-tumor-imaging-and-photothermal-triggered-drug-release
#4
Zhihao Han, Liwei Lv, Yi Ma, Zhaohui Wang, Yuxi Liu, Min Zhang, Siwen Li, Yueqing Gu
It is an emerging focus to explore controlled release drug delivery systems for simultaneous cancer imaging and therapy. Herein, we synthesized a photothermal sensitive multifunctional nano-liposome drug delivery system, with doxorubicin wrapped in the hydropholic layer as the therapeutical agent and cypate doped in the hydrophobic layer as the diagnostic agent. A series of in vitro and in vivo characterization demonstrated the stability of synthesized liposome, as the DL% was 9 ± 1.5 and the EE% was 82.7 ± 2...
January 20, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28024382/gold-nanoclustered-hyaluronan-nano-assemblies-for-photothermally-maneuvered-photodynamic-tumor-ablation
#5
Hwa Seung Han, Ki Young Choi, Hansang Lee, Minchang Lee, Jae Yoon An, Sol Shin, Seunglee Kwon, Doo Sung Lee, Jae Hyung Park
Optically active nanomaterials have shown great promise as a nanomedicine platform for photothermal or photodynamic cancer therapies. Herein, we report a gold-nanoclustered hyaluronan nanoassembly (GNc-HyNA) for photothermally boosted photodynamic tumor ablation. Unlike other supramolecular gold constructs based on gold nanoparticle building blocks, this system utilizes the nanoassembly of amphiphilic hyaluronan conjugates as a drug carrier for a hydrophobic photodynamic therapy agent verteporfin, a polymeric reducing agent, and an organic nanoscaffold upon which gold can grow...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27992805/selective-ex%C3%A2-vivo-photothermal-nano-therapy-of-solid-liver-tumors-mediated-by-albumin-conjugated-gold-nanoparticles
#6
Lucian Mocan, Cristian Matea, Flaviu A Tabaran, Ofelia Mosteanu, Teodora Pop, Cosmin Puia, Lucia Agoston-Coldea, Gabriela Zaharie, Teodora Mocan, Anca Dana Buzoianu, Cornel Iancu
We have used albumin (BSA) bound to gold nanoparticles (GNPs) as active vectors to target liver cells. Our incentive to develop an original model of living liver cancer sprang from the ethical drawbacks that hindered the assessment of the selective character and the therapeutic capacity of these nano-biosystems in cancer patients. Ex vivo-perfused liver specimens were obtained from hepatocellular carcinoma patients similarly to the surgical technique of transplantation. Albumin bound to GNPs was inoculated intra-arterially onto the resulting specimen and determined the specific delivery of the nano-bioconjugate into the malignant tissue by means of the capillary bed...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/27987749/poly-acrylic-acid-conjugated-hollow-mesoporous-carbon-as-a-dual-stimuli-triggered-drug-delivery-system-for-chemo-photothermal-synergistic-therapy
#7
Xian Li, Chang Liu, Shengyu Wang, Jian Jiao, Donghua Di, Tongying Jiang, Qinfu Zhao, Siling Wang
In this work, we described the development of the redox and pH dual stimuli-responsive drug delivery system and combination of the chemotherapy and photothermal therapy for cancer treatment. The poly(acrylic acid) (PAA) was conjugated on the outlets of hollow mesoporous carbon (HMC) via disulfide bonds. PAA was used as a capping to block drug within the mesopores of HMC for its lots of favorable advantages, such as good biocompatibility, appropriate molecular weight to block the mesopores of HMC, extension of the blood circulation, and the improvement of the dispersity of the nano-carriers in physiological environment...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27758099/near-infrared-organic-dye-based-nanoagent-for-the-photothermal-therapy-of-cancer
#8
Bingjiang Zhou, Yunzheng Li, Guangle Niu, Minhuan Lan, Qingyan Jia, Qionglin Liang
Given their easy structural modification and good biocompatibility advantages, near-infrared (NIR) organic dyes with a large molar extinction coefficient, while a superlow fluorescence quantum yield shows considerable potential application in photothermal therapy (PTT). Herein, a new NIR-absorbing asymmetric cyanine dye, namely, RC, is designed and synthesized via the hybrid of rhodamine and hemicyanine derivatives. RC-BSA nanoparticles (NPs) are fabricated by using the bovine serum albumin (BSA) matrix. The NPs exhibit a strong NIR absorption peak at ∼868 nm and 28...
November 9, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27714072/dynamic-visualization-of-photothermal-heating-by-gold-nanocages-using-thermoresponsive-elastin-like-polypeptides
#9
Surya Cheemalapati, Mikhail Ladanov, Bo Pang, Yuan Yuan, Piyush Koria, Younan Xia, Anna Pyayt
Understanding how plasmonic nanoparticles collectively generate heat upon exposure to light and thus increase the local temperature of the surrounding medium is critical for many applications such as plasmon-assisted microfluidics, plasmonic tweezers, and photothermal cancer therapy. Reliable temperature manipulation requires the capability to spatially and dynamically analyze local temperature profiles as a function of nanoparticle concentration and laser intensity. In this work, we present a novel method for visualization of local temperature increase using elastin-like polypeptides (ELP)...
December 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27636008/photothermal-therapeutic-effect-of-pegylated-gold-nano-semicubes-in-chemically-induced-skin-cancer-in-mice
#10
Mahmoud T Abo-Elfadl, Amira M Gamal-Eldeen, Mostafa M Elshafey, Gamil M Abdalla, Shawkey S Ali, Moustafa R K Ali, Mahmoud F M Zawrah
BACKGROUND: The photothermal properties of gold nanoparticles (GNPs) are promising therapeutic modality for cancer. The study objective is to evaluate the therapeutic effect of the prepared PEGylated gold nano-semicubes (PEG-GNSCs) in skin cancer. The synthesized PEG-GNSCs were intermediate between cubic and rod shapes (low aspect ratio- rods). METHODS: In vitro toxicity was investigated in human skin melanoma Sk-Mel-28 cells, and skin squamous cell carcinoma was induced in CD1 mice by dimethylbenzanthracene (DMBA) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)...
November 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27503666/photosensitizer-cross-linked-nano-micelle-platform-for-multimodal-imaging-guided-synergistic-photothermal-photodynamic-therapy
#11
Xiaodong Liu, Guangbao Yang, Lifen Zhang, Zhuang Liu, Zhenping Cheng, Xiulin Zhu
The multifunctional nano-micelle platform holds great promise to enhance the accuracy and efficiency of cancer diagnosis and therapy. In this work, an amphiphilic poly[(poly(ethylene glycol) methyl ether methacrylate)-co-(3-aminopropyl methacrylate)]-block-poly(methyl methacrylate) (P(PEGMA-co-APMA)-b-PMMA) block copolymer was synthesized by successive RAFT polymerizations and subsequent chemical modification. Then the multifunctional micelles with high solubility in physiological environments were developed by a self-assembly and crosslinking processes...
August 18, 2016: Nanoscale
https://www.readbyqxmd.com/read/27481537/single-particle-and-pet-based-platform-for-identifying-optimal-plasmonic-nano-heaters-for-photothermal-cancer-therapy
#12
Jesper Tranekjær Jørgensen, Kamilla Norregaard, Pengfei Tian, Poul Martin Bendix, Andreas Kjaer, Lene B Oddershede
Plasmonic nanoparticle-based photothermal cancer therapy is a promising new tool to inflict localized and irreversible damage to tumor tissue by hyperthermia, without harming surrounding healthy tissue. We developed a single particle and positron emission tomography (PET)-based platform to quantitatively correlate the heat generation of plasmonic nanoparticles with their potential as cancer killing agents. In vitro, the heat generation and absorption cross-section of single irradiated nanoparticles were quantified using a temperature sensitive lipid-based assay and compared to their theoretically predicted photo-absorption...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27461058/ballistic-heat-transport-in-laser-generated-nano-bubbles
#13
Julien Lombard, Thierry Biben, Samy Merabia
Nanobubbles generated by laser heated plasmonic nanoparticles are of interest for biomedical and energy harvesting applications. Of utmost importance is the maximal size of these transient bubbles. Here, we report hydrodynamic phase field simulations of the dynamics of laser induced nanobubbles, with the aim to understand which physical processes govern their maximal size. We show that the nanobubble maximal size and lifetime are to a large extent controlled by the ballistic thermal flux which is present inside the bubble...
August 4, 2016: Nanoscale
https://www.readbyqxmd.com/read/27375782/hsp90-inhibitor-encapsulated-photo-theranostic-nanoparticles-for-synergistic-combination-cancer-therapy
#14
Tzu-Yin Lin, Wenchang Guo, Qilai Long, Aihong Ma, Qiangqiang Liu, Hongyong Zhang, Yee Huang, Siddarth Chandrasekaran, Chongxian Pan, Kit S Lam, Yuanpei Li
Photodynamic therapy (PDT) is a promising non-invasive therapeutic modality that has been proposed for treating prostate cancer, but the procedure is associated with limited efficacy, tumor recurrence and photo-toxicity. In the present study, we proposed to develop a novel multifunctional nano-platform for targeted delivery of heat, reactive oxygen species (ROS) and heat shock protein 90 (Hsp90) inhibitor simultaneously for combination therapy against prostate cancer. This new nano-platform combines two newly developed entities: 1) a unique organic and biocompatible nanoporphyrin-based drug delivery system that can generate efficient heat and ROS simultaneously with light activation at the tumor sites for dual-modal photothermal- and photodynamic- therapy (PTT/PDT), and 2) new nano-formulations of Hsp90 inhibitors that can decrease the levels of pro-survival and angiogenic signaling molecules induced by phototherapy, therefore, further sensitizing cancer cells to phototherapy...
2016: Theranostics
https://www.readbyqxmd.com/read/27333329/emerging-nanomedicine-approaches-fighting-tumor-metastasis-animal-models-metastasis-targeted-drug-delivery-phototherapy-and-immunotherapy
#15
Chao Liang, Ligeng Xu, Guosheng Song, Zhuang Liu
Metastasis is directly or indirectly responsible for the majority of cancer deaths. Anti-metastasis treatment is thus the key to cure cancer. Recent development in nanomedicine has shown great promise for tackling cancer metastasis. In recent years, nanoparticle-based drug delivery systems have been extensively explored for improving cancer treatment, showing the ability to reduce the risk of tumor metastasis compared with conventional chemotherapy. Photothermal therapy, by employing nano-theranostic agents, has also been found to be able to inhibit lymphatic tumor metastasis...
June 22, 2016: Chemical Society Reviews
https://www.readbyqxmd.com/read/27244649/somatostatin-receptor-mediated-tumor-targeting-nanocarriers-based-on-octreotide-peg-conjugated-nanographene-oxide-for-combined-chemo-and-photothermal-therapy
#16
Xuyuan Zhang, Chongyin Yang, Jianping Zhou, Meirong Huo
Nano-sized in vivo active targeting drug delivery systems have been developed to a high anti-tumor efficacy strategy against certain cancer-cells-specific. Graphene based nanocarriers with unique physical and chemical properties have shown significant potentials in this aspect. Here, octreotide (OCT), an efficient biotarget molecule, is conjugated to PEGylated nanographene oxide (NGO) drug carriers for the first time. The obtained NGO-PEG-OCT complex shows low toxicity and excellent stability in vivo and is able to achieve somatostatin receptor-mediated tumor-specific targeting delivery...
July 2016: Small
https://www.readbyqxmd.com/read/27217836/polydopamine-nanoparticles-as-a-versatile-molecular-loading-platform-to-enable-imaging-guided-cancer-combination-therapy
#17
Ziliang Dong, Hua Gong, Min Gao, Wenwen Zhu, Xiaoqi Sun, Liangzhu Feng, Tingting Fu, Yonggang Li, Zhuang Liu
Cancer combination therapy to treat tumors with different therapeutic approaches can efficiently improve treatment efficacy and reduce side effects. Herein, we develop a theranostic nano-platform based on polydopamine (PDA) nanoparticles, which then are exploited as a versatile carrier to allow simultaneous loading of indocyanine green (ICG), doxorubicin (DOX) and manganese ions (PDA-ICG-PEG/DOX(Mn)), to enable imaging-guided chemo & photothermal cancer therapy. In this system, ICG acts as a photothermal agent, which shows red-shifted near-infrared (NIR) absorbance and enhanced photostability compared with free ICG...
2016: Theranostics
https://www.readbyqxmd.com/read/27215899/versatile-molybdenum-disulfide-based-antibacterial-composites-for-in-vitro-enhanced-sterilization-and-in-vivo-focal-infection-therapy
#18
Wentao Zhang, Shuo Shi, Yanru Wang, Shaoxuan Yu, Wenxin Zhu, Xu Zhang, Daohong Zhang, Baowei Yang, Xin Wang, Jianlong Wang
Biologically, MoS2-based nanostructures have been intensely applied for the photothermal therapy of cancer, but rarely for antibacterial uses. In this contribution, a multifunctional chitosan (CS) functionalized magnetic MoS2 (abbreviated to CFM) was constructed to nonspecifically combat bacterial infection by integrating bacterial conjugation and enrichment, and NIR-triggered photothermal sterilization. Owing to the abundant introduced amino groups, the CFM complex offers a significantly enhanced conjugation efficiency without obvious specificity towards both Gram-positive and -negative bacteria compared to amino-free magnetic MoS2...
June 2, 2016: Nanoscale
https://www.readbyqxmd.com/read/27121639/monitoring-of-the-tumor-response-to-nano-graphene-oxide-mediated-photothermal-photodynamic-therapy-by-diffusion-weighted-and-bold-mri
#19
Jianbo Cao, Hengqing An, Xinglu Huang, Guifeng Fu, Rongqiang Zhuang, Lei Zhu, Jin Xie, Fan Zhang
Photothermal therapy (PTT) and photodynamic therapy (PDT) are promising cancer treatment modalities. Because each modality has its own set of advantages and limitations, there has been interest in developing methods that can co-deliver the two regimens for enhanced tumor treatment. Among the efforts, nano-graphene oxide-mediated phototherapies have recently attracted much attention. Nano-graphene oxide has a broad absorbance spectrum and can be loaded with photosensitizers, such as chlorin e6, with high efficiency...
May 21, 2016: Nanoscale
https://www.readbyqxmd.com/read/27110230/fese2-decorated-bi2se3-nanosheets-fabricated-via-cation-exchange-for-chelator-free-64-cu-labeling-and-multimodal-image-guided-photothermal-radiation-therapy
#20
Liang Cheng, Sida Shen, Sixiang Shi, Yuan Yi, Xiaoyong Wang, Guosheng Song, Kai Yang, Gang Liu, Todd E Barnhart, Weibo Cai, Zhuang Liu
Multifunctional theranostic agents have become rather attractive to realize image-guided combination cancer therapy. Herein, we develop a novel method to synthesize Bi2Se3 nanosheets decorated with mono-dispersed FeSe2 nanoparticles (FeSe2/Bi2Se3) for tetra-modal image-guided combined photothermal & radiation tumor therapy. Interestingly, upon addition of Bi(NO3)3, pre-made FeSe2 nanoparticles via cation exchange would be gradually converted into Bi2Se3 nanosheets, on which remaining FeSe2 nanoparticles are decorated...
April 5, 2016: Advanced Functional Materials
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