keyword
MENU ▼
Read by QxMD icon Read
search

insulin metabolism

keyword
https://www.readbyqxmd.com/read/29053995/effects-of-a-whey-protein-supplementation-on-oxidative-stress-body-composition-and-glucose-metabolism-among-overweight-people-affected-by-diabetes-mellitus-or-impaired-fasting-glucose-a-pilot-study
#1
Chiara Flaim, Michael Kob, Angela M Di Pierro, Markus Herrmann, Lucio Lucchin
Obesity and diabetes mellitus type 2 (DM2) are characterized by chronic inflammation and oxidative stress [Donath et al. 2013] and this leads to cardiovascular diseases [Hulsmans & Holvoet 2010]. Whey proteins (WP) have antioxidant [Chitapanarux et al. 2009], anti-inflammatory [Sugawara et al. 2012] and hypoglycemic activities [Mignone et al. 2015], while data on weight, body composition [Frestedt et al. 2008; Aldrich et al. 2011] and blood pressure are conflicting [Kawase et al. 2000; Lee et al. 2007]. WP have unpleasant taste and smell [Patel 2015], but a new WP isolate (ProLYOtin®) seems to be more palatable...
May 20, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29053815/insulin-immuno-neutralization-decreases-food-intake-in-chickens-without-altering-hypothalamic-transcripts-involved-in-food-intake-and-metabolism
#2
M Proszkowiec-Weglarz, J Dupont, N Rideau, C Gespach, J Simon, T E Porter
In mammals, insulin regulates blood glucose levels and plays a key regulatory role in appetite via the hypothalamus. In contrast, chickens are characterized by atypical glucose homeostasis, with relatively high blood glucose levels, reduced glucose sensitivity of pancreatic beta cells, and large resistance to exogenous insulin. The aim of the present study was to investigate in chickens the effects of 5 h fasting and 5 h insulin immuno-neutralization on hypothalamic mRNA levels of 23 genes associated with food intake, energy balance, and glucose metabolism...
September 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053802/docosahexaenoic-acid-supplementation-in-pregnancy-modulates-placental-cellular-signaling-and-nutrient-transport-capacity-in-obese-women
#3
Susanne Lager, Vanessa I Ramirez, Ometeotl Acosta, Christiane Meireles, Evelyn Miller, Francesca Gaccioli, Fredrick J Rosario, Jonathan A L Gelfond, Kevin Hakala, Susan T Weintraub, Debra A Krummel, Theresa L Powell
Context: Maternal obesity in pregnancy has profound impacts on maternal metabolism and promotes placental nutrient transport, which may contribute to fetal overgrowth in these pregnancies. The fatty acid docosahexaenoic acid (DHA) has bioactive properties that may improve outcomes in obese pregnant women by modulating placental function. Objective: To determine the effects of DHA supplementation in obese pregnant women on maternal metabolism and placental function...
October 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29053727/impaired-glucose-metabolism-in-subjects-with-the-williams-beuren-syndrome-a-five-year-follow-up-cohort-study
#4
Maria Elena Lunati, Maria Francesca Bedeschi, Veronica Resi, Valeria Grancini, Eva Palmieri, Simona Salera, Faustina Lalatta, Giuseppe Pugliese, Emanuela Orsi
OBJECTIVE: The Williams-Beuren syndrome (WS) is associated with impaired glucose metabolism (IGM) early in adulthood. However, the pathophysiology of IGM remains poorly defined, due to the lack of longitudinal studies investigating the contribution of β-cell dysfunction and impaired insulin sensitivity. This study aimed at assessing incidence of IGM and the underlying mechanisms in WS adults. METHODS: This observational, longitudinal (5-year), cohort study enrolled thirty-one consecutive WS subjects attending a tertiary referral center...
2017: PloS One
https://www.readbyqxmd.com/read/29053582/zinc-supplementation-improves-glucose-homeostasis-in-high-fat-fed-mice-by-enhancing-pancreatic-%C3%AE-cell-function
#5
Vinícius Cooper-Capetini, Diogo Antonio Alves de Vasconcelos, Amanda Roque Martins, Sandro Massao Hirabara, José Donato, Angelo Rafael Carpinelli, Fernando Abdulkader
Zinc is an essential component of the insulin granule and it possibly modulates insulin secretion and signaling. Since insulin resistance is a hallmark in the development of type 2 diabetes mellitus, this study aimed at investigating if zinc supplementation is able to improve glucose tolerance and β-cell function in a model of insulin resistance. Male C57BL/6 mice were distributed in four groups according to the diet: normal fat (NF); normal fat supplemented with ZnCl₂ (NFZ); high-fat (HF); and, high-fat chow supplemented with ZnCl₂ (HFZ)...
October 20, 2017: Nutrients
https://www.readbyqxmd.com/read/29053141/loss-of-bim-increases-mitochondrial-oxygen-consumption-and-lipid-oxidation-reduces-adiposity-and-improves-insulin-sensitivity-in-mice
#6
Jibran A Wali, Sandra Galic, Christina Yr Tan, Esteban N Gurzov, Ann E Frazier, Timothy Connor, Jingjing Ge, Evan G Pappas, David Stroud, L Chitra Varanasi, Claudia Selck, Michael T Ryan, David R Thorburn, Bruce E Kemp, Balasubramanian Krishnamurthy, Thomas Wh Kay, Sean L McGee, Helen E Thomas
BCL-2 proteins are known to engage each other to determine the fate of a cell after a death stimulus. However, their evolutionary conservation and the many other reported binding partners suggest an additional function not directly linked to apoptosis regulation. To identify such a function, we studied mice lacking the BH3-only protein BIM. BIM(-/-) cells had a higher mitochondrial oxygen consumption rate that was associated with higher mitochondrial complex IV activity. The consequences of increased oxygen consumption in BIM(-/-) mice were significantly lower body weights, reduced adiposity and lower hepatic lipid content...
October 20, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29052766/decreased-diabetes-risk-over-9%C3%A2-year-after-18-month-oral-l-arginine-treatment-in-middle-aged-subjects-with-impaired-glucose-tolerance-and-metabolic-syndrome-extension-evaluation-of-l-arginine-study
#7
Lucilla D Monti, Elena Galluccio, Valentina Villa, Barbara Fontana, Serena Spadoni, Pier Marco Piatti
PURPOSE: This study aimed to determine whether L-arginine supplementation lasting for 18 months maintained long-lasting effects on diabetes incidence, insulin secretion and sensitivity, oxidative stress, and endothelial function during 108 months among subjects at high risk of developing type 2 diabetes. METHODS: One hundred and forty-four middle-aged subjects with impaired glucose tolerance and metabolic syndrome were randomized in 2006 to an L-arginine supplementation (6...
October 20, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29052591/targeting-thermogenesis-in-brown-fat-and-muscle-to-treat-obesity-and-metabolic-disease
#8
REVIEW
Matthias J Betz, Sven Enerbäck
Brown fat is emerging as an interesting and promising target for therapeutic intervention in obesity and metabolic disease. Activation of brown fat in humans is associated with marked improvement in metabolic parameters such as levels of free fatty acids and insulin sensitivity. Skeletal muscle is another important organ for thermogenesis, with the capacity to induce energy-consuming futile cycles. In this Review, we focus on how these two major thermogenic organs - brown fat and muscle - act and cooperate to maintain normal body temperature...
October 23, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29052001/quail-coturnix-japonica-egg-yolk-bioactive-components-attenuate-streptozotocin-induced-testicular-damage-and-oxidative-stress-in-diabetic-rats
#9
Gideon Oludare Oladipo, Chidinma Martha Nlekerem, Emmanuel Oluwafemi Ibukun, Ayodele Oluseyi Kolawole
INTRODUCTION: The testicular milieu is the machinery for the metabolism of testosterone in the male reproductive system. PURPOSE: The dysfunction of this highly regenerating system is inevitable in the condition of glucose imbalance as a result of insulin machinery impairment. Therefore, it is imperative to recommend dietary intervention for attenuating the testicular dysfunction and oxidative stress resulting from STZ-induction of diabetes. METHODS: STZ-induced diabetes (65 mg/kg, ip) was treated with QEYEM (50, 100 and 200 mg/kg/day) and quercetin (50 mg/kg/day) for 7weeks...
October 19, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29051986/the-relationship-between-fatty-liver-index-and-bone-mineral-density-in-koreans-knhanes-2010-2011
#10
S H Ahn, D H Seo, S H Kim, M-S Nam, S Hong
Analyses using a nationally representative cohort have revealed that high fatty liver index (FLI) is associated with low bone mineral density (BMD) regardless of insulin resistance in men, thereby supporting the deteriorated bone metabolism in nonalcoholic fatty liver disease (NAFLD). INTRODUCTION: NAFLD is linked to deteriorated bone health. We investigated the association of FLI, a scoring model for NAFLD, with BMD. METHODS: This was a population-based, cross-sectional study from the Korea National Health and Nutrition Examination Surveys including 4264 Koreans (1908 men and 2356 women)...
October 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29051770/serum-alanine-aminotransferase-aspartate-aminotransferase-ratio-is-one-of-the-best-markers-of-insulin-resistance-in-the-chinese-population
#11
Li Zhao, Jing Cheng, Yingchao Chen, Qin Li, Bing Han, Yi Chen, Fangzhen Xia, Chi Chen, Dongping Lin, Xuemei Yu, Ningjian Wang, Yingli Lu
BACKGROUND: The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio is reportedly associated with insulin resistance (IR). However, few studies have explored the relationship between the ALT/AST ratio and IR in the Chinese population. Here, we aimed to explore whether the ALT/AST ratio is associated and, if so, to what extent, with IR in the Chinese population as categorized by waist circumference (WC). METHODS: Our data were obtained from the SPECT-China study, a cross-sectional survey on the prevalence of metabolic diseases and risk factors in East China from 2014 to 2015...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29051736/novel-peripherally-restricted-cannabinoid-1-receptor-selective-antagonist-txx-522-with-prominent-weight-loss-efficacy-in-diet-induced-obese-mice
#12
Wei Chen, Fengchun Shui, Cheng Liu, Xinbo Zhou, Wei Li, Zhibing Zheng, Wei Fu, Lili Wang
The clinical development of the first generation of globally active cannabinoid 1 receptor (CB1R) antagonists was suspended because of their adverse neuropsychiatric effects. Selective blockade of peripheral CB1Rs has the potential to provide a viable strategy for the treatment of severe obesity while avoiding these central nervous system side effects. In the current study, a novel compound (TXX-522) was rationally designed based on the parent nucleus of a classical CB1R-selective antagonist/inverse agonist, rimonabant (SR141716A)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29051554/recombinant-incretin-secreting-microbe-improves-metabolic-dysfunction-in-high-fat-diet-fed-rodents
#13
Paul M Ryan, Elaine Patterson, Robert M Kent, Helena Stack, Paula M O'Connor, Kiera Murphy, Veronica L Peterson, Rupasri Mandal, David S Wishart, Timothy G Dinan, John F Cryan, Randy J Seeley, Catherine Stanton, R Paul Ross
The gut hormone glucagon-like peptide (GLP)-1 and its analogues represent a new generation of anti-diabetic drugs, which have also demonstrated propensity to modulate host lipid metabolism. Despite this, drugs of this nature are currently limited to intramuscular administration routes due to intestinal degradation. The aim of this study was to design a recombinant microbial delivery vector for a GLP-1 analogue and assess the efficacy of the therapeutic in improving host glucose, lipid and cholesterol metabolism in diet induced obese rodents...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051084/high-fat-diet-reduces-the-hippocampal-content-level-of-lactate-which-is-correlated-with-the-expression-of-glial-glutamate-transporters
#14
Sheng-Feng Tsai, Yun-Wen Chen, Yu-Min Kuo
Metabolic disorders hamper the brain metabolism and functions. The astrocytic glucose-derived lactate is known to fill the increased energy needs of neurons during synaptic transmission. However, whether systemic metabolism dysregulation affects the astrocytic lactate metabolism in the brain remain unexamined. To address this question, we adopt a 12-week high-fat diet to induce metabolic disorders in adult mice, and the effects of high-fat diet on the lactate metabolism in the hippocampus were examined. Results showed that a 12-week high-fat diet induced obesity and insulin resistance in mice...
October 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29050649/obesity-status-influences-the-relationship-among-serum-osteocalcin-iron-stores-and-insulin-sensitivity
#15
Gemma Xifra, José María Moreno-Navarrete, María Moreno, Wifredo Ricart, José Manuel Fernández-Real
BACKGROUND & AIMS: Increased iron stores significantly influence the clinical course of several chronic metabolic diseases. Recent studies have shown that iron overload decreases osteocalcin. We aimed to explore the relationship among osteocalcin, iron stores and insulin sensitivity. METHODS: Extensive clinical and laboratory measurements, including serum ferritin, cross-linked C-telopeptide of type I collagen (CTX) and osteocalcin (OC) concentrations, were analyzed in 250 adult consecutive Caucasian men...
October 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29050587/hypoglycemic-effect-and-mechanism-of-a-pectic-polysaccharide-with-hexenuronic-acid-from-the-fruits-of-ficus-pumila-l-in-c57bl-ksj-db-db-mice
#16
Jianjun Wu, Miaomiao Chen, Songshan Shi, Huijun Wang, Ning Li, Juan Su, Ruimin Liu, Zhenlin Huang, Hong Jin, Xueqing Ji, Shunchun Wang
In this study, a particular pectic polysaccharide (FPLP) was extracted and purified from the fruits of Ficus pumila Linn. through boiling water extraction, alcohol precipitation, diethylaminoethyl-Sepharose Fast Flow chromatography and Superdex™ G-75 gel filtration chromatography. Analysis of high-performance gel permeation chromatography, FTIR, GC-MS, methylation and 1D/2D NMR spectroscopy revealed that FPLP (Mw: 34.69kDa) is a linear (1,4)-α-d-galacturonic acid binding 1.30% branched chain hexenuronic acid with 23...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29050364/lncrnas-key-players-and-novel-insights-into-diabetes-mellitus
#17
REVIEW
Xiaoyun He, Chunlin Ou, Yanhua Xiao, Qing Han, Hao Li, Suxian Zhou
Long non-coding RNAs (LncRNAs) are a class of endogenous RNA molecules, which have a transcribing length of over 200 nt, lack a complete functional open reading frame (ORF), and rarely encode a functional short peptide. Recent studies have revealed that disruption of LncRNAs levels correlates with several human diseases, including diabetes mellitus (DM), a complex multifactorial metabolic disorder affecting more than 400 million people worldwide. LncRNAs are emerging as pivotal regulators in various biological processes, in the progression of DM and its associated complications, involving pancreatic β-cell disorder, insulin resistance, and epigenetic regulation, etc...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050301/mir-377-promotes-white-adipose-tissue-inflammation-and-decreases-insulin-sensitivity-in-obesity-via-suppression-of-sirtuin-1-sirt1
#18
Jie Peng, Yinghui Wu, Zhao Deng, Yuanfei Zhou, Tongxing Song, Yang Yang, Xiaming Zhang, Tao Xu, Mao Xia, Anle Cai, Zuhong Liu, Jian Peng
Obesity is associated with a wide range of metabolic disorders including inflammation and insulin-resistance. Sirtuin-1 (SIRT1) is an important regulator of metabolic homeostasis and stress response pathways in white adipose tissue. However, involvement of microRNAs (miRNAs) in regulating SIRT1 during obesity-induced inflammation and insulin-resistance remains unclear. Here, we found that miR-377 was upregulated in adipose tissue and showed a negative correlation with SIRT1 in chronic high fat diet (HFD)-fed mice...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050221/pdgfra-hsd17b4-and-hmgb2-are-potential-therapeutic-targets-in-polycystic-ovarian-syndrome-and-breast-cancer
#19
Huiyu Xu, Yong Han, Jiaying Lou, Hongxian Zhang, Yue Zhao, Balázs Győrffy, Rong Li
To explore the key genes associated with both PCOS and breast cancer, we overlapped the synchronously differently expressed genes in two obese insulin-resistant GEO datasets in muscle tissue and genes exert essential roles in breast cancer prognosis together base on the following reasons: (1) Androgens excess is believed to contribute to the onset of both PCOS and breast cancer. (2) PCOS is usually complicated with metabolic symptoms, such as obesity and insulin-resistance. (3) Muscle is the main place where energy metabolism and material metabolism take place...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049981/angiotensin-receptor-blockade-improves-cardiac-mitochondrial-activity-in-response-to-an-acute-glucose-load-in-obese-insulin-resistant-rats
#20
Max Thorwald, Ruben Rodriguez, Andrew Lee, Bridget Martinez, Janos Peti-Peterdi, Daisuke Nakano, Akira Nishiyama, Rudy M Ortiz
Hyperglycemia increases the risk of oxidant overproduction in the heart through activation of a multitude of pathways. Oxidation of mitochondrial enzymes may impair their function resulting in accumulation of intermediates and reverse electron transfer, contributing to mitochondrial dysfunction. Furthermore, the renin-angiotensin system (RAS) becomes inappropriately activated during metabolic syndrome, increasing oxidant production. To combat excess oxidant production, the transcription factor, nuclear factor erythriod-2- related factor 2 (Nrf2), induces expression of many antioxidant genes...
October 7, 2017: Redox Biology
keyword
keyword
118802
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"