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https://www.readbyqxmd.com/read/27922627/blood-based-and-urinary-prostate-cancer-biomarkers-a-review-and-comparison-of-novel-biomarkers-for-detection-and-treatment-decisions
#1
REVIEW
R J Hendriks, I M van Oort, J A Schalken
BACKGROUND: The diagnosis of prostate cancer (PCa) is currently based on serum PSA testing and/or abnormal digital rectal examination and histopathologic evaluation of prostate biopsies. The main drawback of PSA testing is the lack of specificity for PCa. To improve early detection of PCa more specific biomarkers are needed. In the past few years, many new promising biomarkers have been identified; however, to date, only a few have reached clinical practice. METHODS: In this review, we discuss new blood-based and urinary biomarker models that are promising for usage in PCa detection, follow-up and treatment decision-making...
December 6, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27920851/zinner-syndrome-a-rare-developmental-anomaly-of-the-mesonephric-duct-diagnosed-on-magnetic-resonance-imaging
#2
Shibani Mehra, Rajeev Ranjan, Umesh Chandra Garga
Developmental anomalies of the urogenital tract are rare but often encountered. Zinner's syndrome is a rare congenital abnormality of mesonephric (Wolffian) duct consisting of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ipsilateral ejaculatory duct obstruction due to developmental arrest in early embryogenesis affecting the caudal end of Mullerian duct and only approximately a 100 cases have been reported so far. Radiologic modalities such as intravenous pyelography, ultrasonography, vasovesiculography, contrast enhanced computed tomography, and magnetic resonance imaging are all helpful in diagnosis of this unusual entity...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920841/wolffian-origin-of-vagina-unfolds-the-embryopathogenesis-of-ohvira-obstructed-hemivagina-and-ipsilateral-renal-anomaly-syndrome-and-places-ohvira-as-a-female-counterpart-of-zinner-syndrome-in-males
#3
Yashant Aswani, Ravi Varma, Pradeep Choudhary, Reeta B Gupta
BACKGROUND: The classical theory of Müllerian origin of upper vagina fails to explain complex urogenital malformations like OHVIRA syndrome; the Acien's hypothesis, however, unravels the hidden embryopathogenesis. As per Acien, Wolffian (mesonephric) ducts instead of Müllerian ducts and sinovaginal bulbs, give rise to the vagina. The new hypothesis, however, retains the concept of origin of the ureters (with ureters inducing renal development) by the former and the uterus by Müllerian ducts...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27919982/clinical-significance-of-the-apparent-diffusion-coefficient-ratio-in-prostate-cancer-treatment-with-intensity-modulated-radiotherapy
#4
Hiroko Yamaguchi, Masatoshi Hori, Osamu Suzuki, Yuji Seo, Fumiaki Isohashi, Yasuo Yoshioka, Iori Sumida, Motohide Uemura, Kazutoshi Fujita, Akira Nagahara, Takeshi Ujike, Atsunari Kawashima, Norio Nonomura, Noriyuki Tomiyama, Kazuhiko Ogawa
AIM: We aimed to investigate the correlation between biochemical recurrence (BCR) and the pretreatment apparent diffusion coefficient (ADC) ratio of tumor to normal prostate tissue in patients with prostate cancer who underwent intensity-modulated radiotherapy (IMRT). PATIENTS AND METHODS: Retrospective analyses were performed for 101 patients diagnosed with localized prostate cancer who underwent IMRT at a dose of 70-78 Gy to the prostate gland and medial part of the seminal vesicles...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27913152/development-and-validation-of-an-objective-scoring-tool-for-robot-assisted-radical-prostatectomy-prostatectomy-assessment-and-competency-evaluation-pace
#5
Ahmed A Hussein, Khurshid R Ghani, James Peabody, Richard Sarle, Ronney Abaza, Daniel Eun, Jim Hu, Michael Fumo, Brian Lane, Jeffrey Montgomery, Nobuyuki Hinata, Deborah Rooney, Bryan Comstock, Hei Kit Chan, Sridhar S Mane, James L Mohler, Gregory Wilding, David Miller, Khurshid A Guru
INTRODUCTION: and Background: Comprehensive training and skill acquisition by urologic surgeons are vital to optimize surgical outcomes and patient safety. We sought to develop and validate an objective and procedure specific tool to assess the quality of robot-assisted radical prostatectomy (RARP)-Prostatectomy Assessment and Competence Evaluation (PACE) METHODS: Development and content validation of PACE was performed by deconstruction of RARP into seven key domains utilizing the Delphi methodology...
November 29, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27906710/who-s-your-daddy-paternal-inheritance-of-metabolic-disease-risk
#6
Elvira Isganaitis, Harumi Suehiro, Connie Cardona
PURPOSE OF REVIEW: Although the importance of optimizing mothers' health prior to conception and during pregnancy is now well accepted, recent data also implicate health and nutritional status of fathers as contributors to chronic disease risk in their progeny. This brief review will highlight recent epidemiological and experimental studies linking paternal overnutrition, undernutrition, and other forms of stress, to metabolic disease in the offspring. RECENT FINDINGS: The past 2 years have brought tremendous insights into the mechanisms by which paternal exposures can contribute to disease susceptibility in the next generation...
November 30, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27905212/multicystic-seminal-vesicle-with-ipsilateral-renal-agenesis-two-cases-of-zinner-syndrome
#7
Pablo Naval-Baudin, Elena Carreño García, Ana Sanchez Marquez, Joana Valcárcel José, Natalia M Romero
The association of ipsilateral renal agenesis and cystic seminal vesicle is a rare congenital syndrome described by Zinner in 1914. The cases of two patients with this syndrome are presented, one of them associated with infertility, the other with cryptorchidism and testicular pain. A brief review of the literature is undertaken, regarding the main clinical and imaging implications, and the developmental anomalies that are involved in this unusual congenital anomaly are analyzed.
December 1, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27900799/tissue-sources-for-accurate-measurement-of-germline-dna-genotypes-in-prostate-cancer-patients-treated-with-radical-prostatectomy
#8
Nima C Emami, Lancelote Leong, Eunice Wan, Erin L Van Blarigan, Matthew R Cooperberg, Imelda Tenggara, Peter R Carroll, June M Chan, John S Witte, Jeffry P Simko
BACKGROUND: Benign tissue from a tumor-containing organ is commonly the only available source for obtaining a patient's unmutated genome for use in cancer research. While it is critical to identify histologically normal tissue that is independent of the tumor lineage, few additional considerations are applied to the choice of this material for such measurements. METHODS: Normal formalin-fixed, paraffin-embedded seminal vesicle, and urethral tissues, in addition to whole blood, were collected from 31 prostate cancer patients having undergone radical prostatectomy...
November 30, 2016: Prostate
https://www.readbyqxmd.com/read/27896239/prostate-specific-antigen-density-and-gleason-score-predict-adverse-pathologic-features-in-patients-with-clinically-localized-prostate-cancer
#9
Mohammad Reza Nowroozi, Seyed Ali Momeni, Solmaz Ohadian Moghadam, Elnaz Ayati, Afshin Mortazavi, Simin Arfae, Hassan Jamshidian, Mohsen Taherimahmoudi, Mohsen Ayati
BACKGROUND: According to recent studies, prostate cancer is the second most common cancer among Iranian men. Radical prostatectomy has been considered the gold standard treatment in patients with clinically localized prostate cancer. Gleason score, PSA density, and PSA velocity are some of the parameters used to predict adverse pathologic features. OBJECTIVES: The aim of this study was to evaluate the prognostic value of PSA density and Gleason score in predicting adverse pathologic features in patients with localized prostate cancer who undergo radical prostatectomy...
November 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27884405/zika-virus-causes-testis-damage-and-leads-to-male-infertility-in-mice
#10
Wenqiang Ma, Shihua Li, Shuoqian Ma, Lina Jia, Fuchun Zhang, Yong Zhang, Jingyuan Zhang, Gary Wong, Shanshan Zhang, Xuancheng Lu, Mei Liu, Jinghua Yan, Wei Li, Chuan Qin, Daishu Han, Chengfeng Qin, Na Wang, Xiangdong Li, George Fu Gao
Zika virus (ZIKV) persists in the semen of male patients, a first for flavivirus infection. Here, we demonstrate that ZIKV can induce inflammation in the testis and epididymidis, but not in the prostate or seminal vesicle, and can lead to damaged testes after 60 days post-infection in mice. ZIKV induces innate immune responses in Leydig, Sertoli, and epididymal epithelial cells, resulting in the production of pro-inflammatory cytokines/chemokines. However, ZIKV does not induce a rapid and abundant cytokine production in peritubular cell and spermatogonia, suggesting that these cells are vulnerable for ZIKV infection and could be the potential repositories for ZIKV...
December 1, 2016: Cell
https://www.readbyqxmd.com/read/27881345/-extraction-and-identification-of-semen-derived-exosomes-using-peg6000
#11
Cheng Yang, Wen-Bin Guo, Wan-Song Zhang, Jun Bian, Jian-Kun Yang, Tao Qi, Chun-Yan Wang, Cun-Dong Liu
OBJECTIVE: To extract and identify semen-derived exosome using PEG6000. METHODS: Exosomes were extracted from semen specimens from 6 healthy volunteers with step-by-step centrifugations and ultracentrifugation prior to 8% PEG6000 enrichment. The extracted exosomes were characterized by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA) and Western blotting. RESULTS: The pellets obtained were round or elliptic membrane vesicles 30 to 150 nm in diameter with intact double membranes and contained low electron density material...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27879490/intense-uptake-in-amyloidosis-of-the-seminal-vesicles-on-68ga-psma-pet-mimicking-locally-advanced-prostate-cancer
#12
Maximilian Stephens, David Insoo Kim, Benjamin Shepherd, Sonja Gustafson, Paul Thomas
We report a case of benign senile seminal vesicle amyloidosis demonstrating intense Ga-prostate-specific membrane antigen (PSMA) uptake on PET/CT. A 68-year-old man underwent staging PSMA PET/CT and MRI for biopsy-proven prostate adenocarcinoma. There was an intense focus of Ga-PSMA uptake in the primary malignancy, as well as symmetrical intense uptake in the seminal vesicles bilaterally that was reported as multifocal disease with local invasion. Final histology after radical prostatectomy showed amyloidosis of the seminal vesicles without any evidence of prostate cancer...
November 22, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27872787/synchronous-malignant-peripheral-nerve-sheath-tumor-and-adenocarcinoma-of-the-prostate-case-report-and-literature-review
#13
Nikolaos Ferakis, Antonios Katsimantas, Konstantinos Bouropoulos, Antonios Farmakis
Malignant Peripheral Nerve Sheath Tumors (MPNSTs) of the prostate are extremely rare. A very unusual case of simultaneous adenocarcinoma and MPNST of the prostate is reported. A 60-year-old Caucasian male presented for annual urologic examination. Digital rectal examination revealed a painless, toughish, and asymmetrically enlarged prostate. Serum prostate-specific antigen was 1 ng/mL. Radiologic examinations demonstrated a large mass, which was arising from the left peripheral lobe of the prostate. The patient underwent transrectal ultrasound-guided biopsy of the prostate which revealed a smooth muscle tumor of uncertain malignant potential...
2016: Case Reports in Urology
https://www.readbyqxmd.com/read/27866302/expression-analysis-of-dickkopf-related-protein-3-dkk3-suggests-its-pleiotropic-roles-for-a-secretory-glycoprotein-in-adult-mouse
#14
Junji Inoue, Hirofumi Fujita, Tetsuya Bando, Yoichi Kondo, Hiromi Kumon, Hideyo Ohuchi
Dickkopf-related protein 3 (Dkk3) is the third member of the Dkk gene family and identical to the gene, whose expression was reduced in immortalized cells. Therefore, its another name is reduced expression in immortalized cells. Since the intratumoral introduction of Dkk3 inhibits tumor growth in mouse models of cancers, Dkk3 is likely a tumor suppressor gene. However, the functions of Dkk3 in vivo remain unclear. As the first step to decipher the physiological roles of this gene, we examined the expression pattern of Dkk3 in various tissues from adult mice...
November 19, 2016: Journal of Molecular Histology
https://www.readbyqxmd.com/read/27846218/muc1-expression-by-immunohistochemistry-is-associated-with-adverse-pathologic-features-in-prostate-cancer-a-multi-institutional-study
#15
Okyaz Eminaga, Wei Wei, Sarah J Hawley, Heidi Auman, Lisa F Newcomb, Jeff Simko, Antonio Hurtado-Coll, Dean A Troyer, Peter R Carroll, Martin E Gleave, Daniel W Lin, Peter S Nelson, Ian M Thompson, Lawrence D True, Jesse K McKenney, Ziding Feng, Ladan Fazli, James D Brooks
BACKGROUND: The uncertainties inherent in clinical measures of prostate cancer (CaP) aggressiveness endorse the investigation of clinically validated tissue biomarkers. MUC1 expression has been previously reported to independently predict aggressive localized prostate cancer. We used a large cohort to validate whether MUC1 protein levels measured by immunohistochemistry (IHC) predict aggressive cancer, recurrence and survival outcomes after radical prostatectomy independent of clinical and pathological parameters...
2016: PloS One
https://www.readbyqxmd.com/read/27833937/external-validation-of-the-cancer-of-the-prostate-risk-assessment-postsurgical-score-for-prediction-of-disease-recurrence-after-radical-prostatectomy
#16
Taha Numan Yıkılmaz, Erdem Öztürk, Eşref Oğuz Güven, Halil Başar
Objective. The cancer of the prostate risk assessment (CAPRA-S) postsurgical score predicts recurrence, metastasis, and cancer-specific survival after radical prostatectomy (RP). We evaluated the relation between CAPRA-S score and biochemical recurrence (BCR) in prostate cancer after RP in our clinic. Materials and Methods. This study was performed on 203 patients with prostate carcinoma who underwent open RP and regional lymph node dissection in our clinic between 2008 and 2013. We calculated the CAPRA-S scores including prostate-specific antigen (PSA) at diagnosis, pathology Gleason score, surgical margin, seminal vesicle invasion, extracapsular extension, and lymph node involvement...
2016: Advances in Medicine
https://www.readbyqxmd.com/read/27813338/dutasteride-mediated-morphological-changes-in-the-genitourinary-tract-associated-with-altered-expression-patterns-of-the-androgen-and-estrogen-receptors-in-male-rats
#17
N Enatsu, K Chiba, K Sumii, T Fukuda, K Okada, K Matsushita, M Fujisawa
We evaluated the effects of dutasteride on the genitourinary tract using fifteen 8-week-old male Sprague-Dawley rats. Animals were divided into three groups comprising five animals each and treated as follows. Group A was a control group, members of Group B received oral administration of dutasteride 0.1 mg/kg/day from the age of 8 to 16 weeks, and members of Group C were castrated at the age of 8 weeks. All rats were killed at the age of 16 weeks for the sample collection of blood, bladder, prostate, seminal vesicles, and penis...
November 3, 2016: Andrology
https://www.readbyqxmd.com/read/27804894/nuclear-and-mitochondrial-dna-analysis-reveals-that-hybridization-between-fasciola-hepatica-and-fasciola-gigantica-occurred-in-china
#18
Madoka Ichikawa-Seki, Mao Peng, Kei Hayashi, Takuya Shoriki, Uday Kumar Mohanta, Toshiyuki Shibahara, Tadashi Itagaki
The well-known pathogens of fasciolosis, Fasciola hepatica (Fh) and Fasciola Gigantica (Fg), possess abundant mature sperms in their seminal vesicles, and thus, they reproduce bisexually. On the other hand, aspermic Fasciola flukes reported from Asian countries, which have no sperm in their seminal vesicles, probably reproduce parthenogenetically. The aim of this study was to reveal the origin of aspermic Fasciola flukes. The nuclear single copy markers, phosphoenolpyruvate carboxykinase and DNA polymerase delta, were employed for analysis of Fasciola species from China...
November 2, 2016: Parasitology
https://www.readbyqxmd.com/read/27802428/effect-of-melatonin-on-telocytes-in-the-seminal-vesicle-of-the-soay-ram-an-immunohistochemical-ultrastructural-and-morphometrical-study
#19
Hanan H Abd-Elhafeez, Doaa M Mokhtar, Ahmed H S Hassan
Telocytes (TCs) are a special type of interstitial cell with characteristic cellular processes that are described in many organs. The current study aimed to investigate TCs in seminal vesicles of the Soay ram responding to melatonin treatment during the nonbreeding season by conventional immunohistochemical stains, and to detect the ultrastructural and morphometrical changes of TCs. TCs in the control group showed a broad range of staining affinity and also reacted positively to CD117/c-kit, CD34, desmin, S-100 protein, and progesterone and estrogen receptors alpha, while after melatonin treatment a strong reaction against these 6 antibodies was recorded...
November 2, 2016: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/27802002/robot-assisted-laparoscopic-radical-prostatectomy-with-early-retrograde-release-of-the-neurovascular-bundle-and-endopelvic-fascia-sparing
#20
George Augusto Monteiro Lins de Albuquerque, Giuliano Betoni Guglielmetti, Maurício Dener Cordeiro, William Carlos Nahas, Rafael Ferreira Coelho
INTRODUCTION: Robotic-assisted radical prostatectomy (RAP) is the dominant minimally invasive surgical treatment for patients with localized prostate cancer. The introduction of robotic assistance has the potential to improve surgical outcomes and reduce the steep learning curve associated with conventional laparoscopic radical prostatectomy. The purpose of this video is to demonstrate the early retrograde release of the neurovascular bundle without open the endopelvic fascia during RAP...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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