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https://www.readbyqxmd.com/read/28808664/expression-of-telomere-repeat-binding-factor-1-and-trf2-in-prostate-cancer-and-correlation-with-clinical-parameters
#1
Wei Chen, Yong Wang, Fei Li, Wei Lin, Yong Liang, Zhiwei Ma
OBJECTIVE: The objective of this study was to investigate the expression of telomere repeat binding factor 1 (TRF1) and TRF2 in prostate cancer and their relationships with clinicopathological features. METHODS: In total 50 prostate cancer tissues and paired benign prostate hyperplasia tissues were analyzed. The telomere-binding proteins TRF1 and TRF2 were measured using immunohistochemical method. Correlation analyses were used to evaluate the association between immunohistochemical score and clinical parameters...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28807747/pretreatment-3t-multiparametric-mri-staging-predicts-for-biochemical-failure-in-high-risk-prostate-cancer-treated-with-combination-high-dose-rate-brachytherapy-and-external-beam-radiotherapy
#2
John V Hegde, D Jeffrey Demanes, Darlene Veruttipong, Jagdeep Raince, Sang-June Park, Steven S Raman, Nicholas G Nickols, Christopher R King, Amar U Kishan, Michael L Steinberg, Mitchell Kamrava
PURPOSE: To determine whether pretreatment 3T multiparametric MRI (mpMRI) staging impacts biochemical recurrence-free survival (BRFS) or distant metastasis-free survival (DMFS) for men with high-risk prostate cancer treated with combination high-dose-rate (HDR) brachytherapy and external beam radiation therapy (EBRT). MATERIALS AND METHODS: This institutional review board-approved retrospective study included a cohort of 37 men with high-risk prostate cancer treated with HDR brachytherapy and EBRT after 3T mpMRI...
August 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28799121/3-t-multiparametric-mri-characteristics-of-prostate-cancer-patients-suspicious-for-biochemical-recurrence-after-primary-focal-cryosurgery-hemiablation
#3
Michael Kongnyuy, Daniel M Halpern, Corinne C Liu, Kaitlin E Kosinski, David J Habibian, Anthony T Corcoran, Aaron E Katz
INTRODUCTION: We aimed to report on multiparametric MRI (mpMRI) characteristics of post-primary focal cryosurgery (PFC) patients suspected of biochemical recurrence (BCR) by the Phoenix criteria. METHODS: We retrospectively reviewed all patients at our institution who had undergone PFC. Prostate-specific antigen nadir was determined using 2 or more post-PFC values. Suspicion of BCR was determined using the Phoenix criteria (nadir + 2 ng/ml). At the discretion of the physician, pre-and post-PFC 3-T mpMRIs were obtained and in a few cases biopsies were performed...
August 10, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28798494/identification-and-functional-characterization-of-the-sex-determining-gene-doublesex-in-the-sawfly-athalia-rosae%C3%A2-hymenoptera-tenthredinidae
#4
Shotaro Mine, Megumi Sumitani, Fugaku Aoki, Masatsugu Hatakeyama, Masataka G Suzuki
Sexual fate of the sawfly, Athalia rosae (Hymenoptera: Tenthredinidae) is determined by the complementary sex determination (CSD) mechanism as is the case in honeybees. However, to date, genes involved in sex determination have not been identified in this species. In this study, we attempted to identify orthologs of complementary sex-determiner (csd), feminizer (fem), and doublesex (dsx) from the A. rosae genome, all of which are crucial components of the sex determination cascade in the honeybee. As a result, we identified a sawfly ortholog of dsx (designated as Ardsx)...
2017: Applied Entomology and Zoology
https://www.readbyqxmd.com/read/28798242/a-rare-urological-presentation-of-appendicitis
#5
Nick Simson, Thomas Stonier, Alberto Coscione, Ahmed Qteishat
A 17-year-old boy with no medical comorbidities, but a significant family history of malignancy, presented to Accident and Emergency following 3 days of increasing rectal pain, symptoms of bladder outflow obstruction (poor flow, intermittent stream and hesitancy) and dysuria. Notably he had no abdominal pain. Digital rectal examination revealed a tender, enlarged prostate. Inflammatory markers were significantly raised (white cell count 17.7, C reactive protein 191). He was diagnosed clinically as prostatitis and commenced on intravenous antibiotics...
August 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28795212/a-review-of-adverse-events-related-to-prostatic-artery-embolization-for-treatment-of-bladder-outlet-obstruction-due-to-bph
#6
Airton Mota Moreira, André Moreira de Assis, Francisco Cesar Carnevale, Alberto Azoubel Antunes, Miguel Srougi, Giovanni Guido Cerri
INTRODUCTION: Minimally invasive procedures have gained great importance among the treatments for benign prostate hyperplasia (BPH) due to their low morbidity. Prostate artery embolization has emerged as a safe and effective alternative for patients with large volume BPH, not suited for surgery. MATERIALS AND METHODS: Low adverse events rates have been reported following prostate artery embolization and may include dysuria, urinary infection, hematuria, hematospermia, acute urinary retention and rectal bleeding...
August 9, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28794880/relationship-between-semenogelins-bound-to-human-sperm-and-other-semen-parameters-and-pregnancy-outcomes
#7
Kazumitsu Yamasaki, Kaoru Yoshida, Miki Yoshiike, Kazuhiko Shimada, Hiroyuki Nishiyama, Satoru Takamizawa, Kaoru Yanagida, Teruaki Iwamoto
BACKGROUND: Semenogelins (SEMGs) are major components of human seminal vesicle secretions. Due to SEMG's sperm-motility inhibitor, a significant negative correlation between sperm motility and the proportion of SEMG-bound spermatozoa (SEMG+) was found in asthenozoospermic patients. SEMGs also show intrinsic inhibitory capability for sperm capacitation; however, studies on actual clinical specimens have not been conducted. METHODS: To reveal the relationship between SEMGs and the fertilizing capacity of sperm from male infertile patients who are not restricted to asthenozoospermia, we measured the proportion of SEMG+ in the spermatozoa of 142 male infertile patients...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28779974/impact-of-early-salvage-radiation-therapy-in-patients-with-persistently-elevated-or-rising-prostate-specific-antigen-after-radical-prostatectomy
#8
Nicola Fossati, R Jeffrey Karnes, Michele Colicchia, Stephen A Boorjian, Alberto Bossi, Thomas Seisen, Nadia Di Muzio, Cesare Cozzarini, Barbara Noris Chiorda, Claudio Fiorino, Giorgio Gandaglia, Paolo Dell'Oglio, Shahrokh F Shariat, Gregor Goldner, Steven Joniau, Antonino Battaglia, Karin Haustermans, Gert De Meerleer, Valérie Fonteyne, Piet Ost, Hendrik Van Poppel, Thomas Wiegel, Francesco Montorsi, Alberto Briganti
BACKGROUND: Salvage radiation therapy (SRT) is a recommended treatment option for biochemical recurrence after radical prostatectomy (RP). However, its effectiveness may be limited to specific categories of patients. OBJECTIVE: We aimed to identify the optimal candidates for early SRT after RP. DESIGN, SETTING, AND PARTICIPANTS: The study included 925 node-negative patients treated with SRT after RP at seven institutions. Patients received SRT for either prostate-specific antigen (PSA) rising, or PSA persistence after RP that was defined as PSA level ≥0...
August 2, 2017: European Urology
https://www.readbyqxmd.com/read/28765067/development-and-validation-of-objective-performance-metrics-for-robot-assisted-radical-prostatectomy-a-pilot-study
#9
Andrew J Hung, Jian Chen, Anthony Jarc, David Hatcher, Hooman Djaladat, Inderbir S Gill
PURPOSE: We explore and validate objective surgeon performance metrics using a novel recorder ("dVLogger") to directly capture surgeon manipulations on the da Vinci robot. We present the initial construct and concurrent validation study of objective metrics during pre-selected steps of robot-assisted radical prostatectomy (RARP). METHODS: Kinematic and events data were recorded for expert (≥100 cases) and novice (<100 cases) surgeons performing bladder mobilization (BM), seminal-vesicle dissection (SVD), anterior vesicourethral anastomosis (AA) and right pelvic lymphadenectomy (RLD)...
July 29, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28761595/case-spontaneous-regression-of-post-radical-prostatectomy-prostate-specific-antigen-elevation-without-adjuvant-therapy-in-a-patient-with-lymph-node-metastasis
#10
Taehyoung Lee, Yanbo Guo, Saahil Vij, Rahul Bansal, Nathan C Wong, Bobby Shayegan
Prostate cancer remains the most frequently diagnosed cancer among men. The combination of clinical stage, serum prostate-specific antigen (PSA), and Gleason score (biopsy) assists in predictive assessment of pathological stage and prognosis. Furthermore, pathological criteria, including Gleason score, surgical margin status, extracapsular extension, seminal vesicle invasion, and lymph node involvement, provide prognostication in patients undergoing radical prostatectomy (RP). In this paper, we present a case of a patient with high-risk prostate cancer with persistent PSA elevation post-RP who experiences a complete regression of PSA without any adjuvant therapy...
July 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28757111/organ-specific-gene-expression-in-the-regenerating-tail-of-macrostomum-lignano
#11
Birgit Lengerer, Julia Wunderer, Robert Pjeta, Giada Carta, Damian Kao, Aziz Aboobaker, Christian Beisel, Eugene Berezikov, Willi Salvenmoser, Peter Ladurner
Temporal and spatial characterization of gene expression is a prerequisite for the understanding of cell-, tissue-, and organ-differentiation. In a multifaceted approach to investigate gene expression in the tail plate of the free-living marine flatworm Macrostomum lignano, we performed a posterior-region-specific in situ hybridization screen, RNA sequencing (RNA-seq) of regenerating animals, and functional analyses of selected tail-specific genes. The in situ screen revealed transcripts expressed in the antrum, cement glands, adhesive organs, prostate glands, rhabdite glands, and other tissues...
July 28, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28747519/the-impact-of-adding-sentinel-node-biopsy-to-extended-pelvic-lymph-node-dissection-on-the-biochemical-recurrence-of-prostate-cancer-patients-treated-with-robot-assisted-radical-prostatectomy
#12
Nikolaos Grivas, Esther Wit, Teele Kuusk, Gijs KleinJan, Maarten Donswijk, Fijs van Leeuwen, Henk van der Poel
The benefit of adding sentinel node biopsy (SNB) to extended pelvic lymph node dissection (ePLND), remains controversial. Aim of our study was to evaluate biochemical recurrence (BCR) after robot-assisted radical prostatectomy (RARP) and ePLND in prostate cancer (PCa) patients, stratified by the application of SNB. The results were compared with the predictions of the updated Memorial Sloan Kettering Cancer Center (MSKCC) nomogram. Methods: Between January 2006 and November 2016, 920 patients underwent RARP with ePLND combined with or without SNB (184 and 736 patients, respectively)...
July 26, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28746190/vasa-mrna-ddx4-detection-is-more-specific-than-immunohistochemistry-using-poly-or-monoclonal-antibodies-for-germ-cells-in-the-male-urogenital-tract
#13
Willem P A Boellaard, Hans Stoop, Ad J M Gillis, J Wolter Oosterhuis, Leendert H J Looijenga
VASA, also known as DDX4, is reported to be specifically expressed in cells belonging to the germ cell lineage, both in males and females. Therefore, it could be an informative protein biomarker to be applied on semen to differentiate between obstructive and nonobstructive azoospermia (OA and NOA, respectively). In addition, it could be of value to predict sperm retrieval based on testicular sperm extraction. Immunocytochemistry of proven OA semen using both polyclonal and monoclonal antibodies against VASA showed positive staining of both cells and cell sized particles...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28745327/seminal-vesicle-fluid-increases-the-efficacy-of-intravaginal-hsv-2-vaccination
#14
A Varese, F Remes Lenicov, M Gonzalez Prinz, A Paletta, G Ernst, C Maeto, A Merlotti, J Sabatte, S Símula, M P Holgado, E Dantas, J Geffner, A Ceballos
Once considered merely as a vehicle for spermatozoa, it is now clear that seminal plasma (SP) induces a variety of biological actions on the female reproductive tissues able to modulate the immune response against paternal antigens. To our knowledge, the influence of SP on the immune response against sexually transmitted pathogens has not been yet evaluated. We here analyzed whether the seminal vesicle fluid (SVF), which contributes almost 60% of the SP volume in mice, could modulate the immune response against herpes simplex virus type 2 (HSV-2)...
July 26, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28744861/gonadal-morphogenesis-and-sex-differentiation-in-cultured-ussuri-catfish-tachysurus-ussuriensis
#15
Z J Pan, C K Zhu, H Wang, F J Zhou, X G Qiang
The objective of this study was to investigate the optimal developmental time to perform sex reversal in Ussuri catfish Tachysurus ussuriensis, to develop monosex breeding in aquaculture. Systematic observations of gonadal sex differentiation of P. ussiriensis were conducted. The genital ridge formed at 9 days post fertilization (dpf) and germ cells begin to proliferate at 17 dpf. The ovarian cavity began forming on 21 dpf and completed by 25 dpf while presumptive testis remained quiescent. The primary oocytes were at the chromatin nucleolus stage by 30 dpf, the peri-nucleolus stage by 44 dpf and the cortical alveoli stage by 64 dpf...
July 26, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28740903/hypofractionated-image-guided-radiation-therapy-followed-by-prostate-seed-implant-boost-for-men-with-newly-diagnosed-intermediate-and-high-risk-adenocarcinoma-of-the-prostate-preliminary-results-of-a-phase-2-prospective-study
#16
Steven Gresswell, Rodney E Wegner, Day Werts, Ralph Miller, Russell Fuhrer
PURPOSE: A phase 2 protocol was designed and implemented to assess the toxicity and efficacy of hypofractionated image guided intensity modulated radiation therapy (IG-IMRT) combined with low-dose rate (103)Pd prostate seed implant for treatment of localized intermediate- and high-risk adenocarcinoma of the prostate. METHODS AND MATERIALS: This is a report of an interim analysis on 24 patients enrolled on an institutional review board-approved phase 2 single-institution study of patients with intermediate- and high-risk adenocarcinoma of the prostate...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740902/urinary-quality-of-life-outcomes-in-men-who-were-treated-with-image-guided-intensity-modulated-radiation-therapy-for-prostate-cancer
#17
Simpa S Salami, Edward Obedian, Shawn Zimberg, Carl A Olsson
PURPOSE: Quality of life (QoL) outcomes play a major role in the treatment selection for prostate cancer (CaP). We evaluated the urinary QoL outcomes in men who were treated with image-guided intensity-modulated radiation therapy (IG-IMRT) for CaP. METHODS AND MATERIALS: We enrolled men who were diagnosed with CaP and underwent IG-IMRT in a large urological group practice into a prospectively maintained database. The typical radiation treatment dosage to prostates and seminal vesicles was 8100 cGy in 45 fractions...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28734642/extreme-hypofractionation-for-high-risk-prostate-cancer-dosimetric-correlations-with-rectal-bleeding
#18
Glenn Bauman, Jeff Chen, George Rodrigues, Melanie Davidson, Andrew Warner, Andrew Loblaw
PURPOSE: We explored the association of dosimetric parameters with late rectal bleeding among high-risk prostate cancer patients treated with hypofractionated simultaneous in-field boost (H-SIB) to prostate with nodal treatment. METHODS AND MATERIALS: Rectal toxicity results and dose-volume histogram (DVH) information from patients treated on FASTR and SATURN were combined. Patients in both trials received long-term androgen deprivation and H-SIB with prescription dose 40 Gy to the prostate and proximal seminal vesicles and 25 Gy to the lymph nodes delivered over 5 weekly fractions using image guidance with cone beam computed tomography...
June 9, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28723911/male-reproductive-system-and-spermatogenesis-of-limodromus-assimilis-paykull-1790
#19
Lea F Schubert, Stephanie Krüger, Gerald B Moritz, Veit Schubert
Based on advanced light and electron microscopy, we describe the male reproductive system and sperm development of Limodromus assimilis. The genital tract consists of pairs of uni-follicular testes, spermatic ducts with diverticula regions, seminal vesicles, accessory glands, an unpaired ejaculatory duct and an aedeagus containing an internal sac equipped with sclerotic scales. Based on their morphology, we draw conclusions about their functions. After spermatogenesis within the follicle, the spermatozoa become released from the sperm cysts...
2017: PloS One
https://www.readbyqxmd.com/read/28714645/-extra-renal-manifestations-of-the-autosomal-dominant-polycystic-kidney-disease
#20
Aurélie Butscher, Olivier Phan, Olivier Bonny
Extra-renal complications of autosomal dominant polycystic kidney disease (ADPKD) are often unrecognized. Liver cysts are usually benign, but may cause chronic pain, may interfere with nutrition and may necessitate partial liver resection or even liver transplant. Somatostatin analogs may be an alternative therapy. Cerebral aneurisms are rare, but devastating. They must be investigated in case of positive familial history. Cardiac valvulopathies will be searched for by echocardiography. Abdominal wall herniae are often identified during the physical exam in ADPKD patients...
February 22, 2017: Revue Médicale Suisse
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