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https://www.readbyqxmd.com/read/28916273/identification-of-recurrence-sites-following-post-prostatectomy-treatment-for-prostate-cancer-using-11-c-choline-positron-emission-tomography-and-multiparametric-pelvic-mri
#1
Avinash Nehra, William P Parker, Rimki Haloi, Sean S Park, Lance A Mynderse, Val J Lowe, Brian J Davis, J Fernando Quevedo, Geoffrey B Johnson, Eugene D Kwon, R Jeffrey Karnes
PURPOSE: To describe anatomic sites of recurrence among prostate cancer patients with biochemical recurrence following radical prostatectomy (RP) and postoperative radiotherapy (RT) and/or androgen deprivation therapy (ADT) using (11)C-Choline PET/CT and multiparametric-MRI. MATERIALS AND METHODS: RP patients evaluated with (11)C-Choline PET/CT and multiparametric-MRI following RT and/or ADT were evaluated for patterns of recurrence and clinicopathologic features...
September 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28915245/effects-of-gnrh-vaccination-in-wild-and-captive-african-elephant-bulls-loxodonta-africana-on-reproductive-organs-and-semen-quality
#2
Imke Lueders, Debbie Young, Liana Maree, Gerhard van der Horst, Ilse Luther, Stephan Botha, Brendan Tindall, Geoffrey Fosgate, André Ganswindt, Henk J Bertschinger
OBJECTIVES: Although the African elephant (Loxodonta africana) is classified as endangered by the International Union for Conservation of Nature (IUCN), in some isolated habitats in southern Africa, contraception is of major interest due to local overpopulation. GnRH vaccination has been promoted as a non-invasive contraceptive measure for population management of overabundant wildlife. We tested the efficacy of this treatment for fertility control in elephant bulls. METHODS: In total, 17 male African elephants that were treated with a GnRH vaccine were examined in two groups...
2017: PloS One
https://www.readbyqxmd.com/read/28905446/impact-of-five-tiered-gleason-grade-groups-on-prognostic-prediction-in-clinical-stage-t3-prostate-cancer-undergoing-high-dose-rate-brachytherapy
#3
Hideyasu Tsumura, Hiromichi Ishiyama, Ken-Ichi Tabata, Hiroki Katsumata, Momoko Kobayashi, Masaomi Ikeda, Shinji Kurosaka, Tetsuo Fujita, Masashi Kitano, Takefumi Satoh, Nobuyuki Yanagisawa, Kazushige Hayakawa, Masatsugu Iwamura
BACKGROUND: We evaluated a five-tiered Gleason grade groups arising from the 2014 International Society of Urological Pathology consensus conference on prognostic prediction in clinical stage T3a (extracapsular invasion) and T3b (seminal vesicle involvement) prostate cancer undergoing high-dose-rate brachytherapy (HDR-BT). METHODS: From November 2003 to December 2012, 283 patients with stage T3 prostate cancer received HDR-BT and external beam radiation therapy (EBRT) with long-term androgen deprivation therapy (ADT)...
September 14, 2017: Prostate
https://www.readbyqxmd.com/read/28879804/evaluation-of-the-endocrine-disrupting-effects-of-homosalate-hms-and-2-ethylhexyl-4-dimethylaminobenzoate-od-paba-in-rat-pups-during-the-prenatal-lactation-and-early-postnatal-periods
#4
Meltem Erol, Ismet Çok, Özlem Bostan Gayret, Pembegül Günes, Özgül Yigit, Elif Sayman, Aysegül Günes, Duygu Sultan Çelik, Sahin Hamilçikan, Serdar Altinay, Oya Ercan
Homosalate (HMS) and 2-ethylhexyl 4-dimethylaminobenzoate (OD-PABA) are ultraviolet filters. We aimed to investigate the effects of dermal exposure to HMS and OD-PABA during the prenatal, lactation, and early infancy periods on pubertal development and thyroid function in male and female rats. The thyroid glands, uteri, testes, prostate glands, and seminal vesicles were excised and weighed, the reproductive organs were analyzed histologically, and the serum hormone levels were measured. In the prenatal period, the thyroxine (T4) levels increased in the female rats in the exposed groups ( p < 0...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28879095/unilateral-complete-agenesis-of-mesonephric-duct-derivatives-in-an-82-year-old-male-cadaver-embryology-anatomy-and-clinical-considerations
#5
David G Darcy, Morgen Yao-Cohen, Todd R Olson, Sherry A Downie
Development of urogenital anatomy in the human fetus is the result of a complex interplay between multiple different tissues. The time course of development is well documented and the morphologic outcomes of insults at various time points during development are predictable. We present a cadaveric case of unilateral agenesis of the left kidney, ureter, bladder hemitrigone, ureteric opening, seminal vesicle, vas deferens, and epididymis. Failure of development of the mesonephric duct early during embryogenesis, likely between the third and fifth week, caused ipsilateral urogenital organ agenesis...
November 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28875088/unique-association-of-multiple-seminal-vesicle-cysts-with-contralateral-renal-agenesis-a-rare-variant-of-zinner-syndrome
#6
Sachin Khanduri, Gaurav Katyal, Hritik Sharma, Aakshit Goyal, Nikita Singh, Harsh Yadav
Zinner syndrome is a rare developmental anomaly of the Wolffian (mesonephric) duct which is characterised by a triad of obstruction of the ejaculatory duct, the ipsilateral seminal vesicle cyst, and the ipsilateral renal agenesis. The aim of this case report is to emphasize the importance of radiological imaging in diagnosing the condition and to report its rare unusual variant.
July 1, 2017: Curēus
https://www.readbyqxmd.com/read/28869168/influence-du-score-de-gleason-des-marges-chirurgicales-de-prostatectomie-totale-sur-la-r%C3%A3-cidive-biologique
#7
J Susperregui, C Pierry, B Bonhomme, G Pasticier, J-C Bernhard, G Capon, H Bensadoun, P Ballanger, J-M Ferrière, G Robert
OBJECTIVES: The aim of this study was to assess the impact of the aggressiveness of cancer cells at the level of positive surgical margins (PSM) on the biochemical recurrence rate (BRR) by studying the Gleason score (GS) at this level. METHODS: We included all radical prostatectomy (RP) procedures performed from January 2007 to November 2011. All of the RP specimens with PSM were reviewed to determine the GS at the level of PSM. We compared the GS at PSM with BRR...
August 28, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28869022/-accidental-find-of-scrotal-tuberculosis-on-a-computed-tomography
#8
Thomas Christensen, Sami Beji, Nis Nørgaard
The prevalence of tuberculosis in Denmark is low compared to many developing countries. It is most commonly found in socially marginalized communities. We present an unusual case of a man, who was referred to urological treatment as a computed tomography had showed a tumour with a suspicious process in the left scrotum and in relation to the left seminal vesicle. Histopathology of the testis showed granuloma formation. A Ziehl-Neelsen staining showed no acid-fast bacilli, but polymerase chain reaction revealed Mycobacterium tuberculosis...
August 21, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28864047/-combination-external-beam-radiation-and-brachytherapy-boost-for-prostate-cancer
#9
O Chapet, A Bossi, S Horn, G Créhange
Brachytherapy as sole treatment is standard of care for D'Amico classification low-risk prostate cancer. For intermediate and high-risk patients, brachytherapy can be associated to external beam radiation therapy to better take into account the risk of extracapsular effraction and/or seminal vesicle involvement. Three randomized studies have shown that this association increases freedom from relapse survival compared to exclusive external beam radiation therapy. This benefit is not shown for overall survival...
August 29, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28860050/a-prospective-study-to-evaluate-sexual-dysfunction-and-enlargement-of-seminal-vesicles-in-sexually-active-men-treated-for-benign-prostatic-hyperplasia-by-alpha-blockers
#10
Ashok Kumar Sokhal, Satyanarayan Sankhwar, Apul Goel, Kawaljit Singh, Manoj Kumar, Bimalesh Purkait, Durgesh Kumar Saini
OBJECTIVE-: To evaluate sexual dysfunction and enlargement of seminal vesicles in sexually active male who were treated by α1-blockers for benign prostatic hyperplasia and its possible clinical application. METHODS-: A prospective cohort study from January 2015 to December 2016. We enrolled sexually active men above the age of 40 years having moderate to severe lower urinary tract symptoms. We excluded patients with a history of prostate surgery, suspicious DRE findings, serum PSA >4 ng/dl, history of medication with anticholinergic/cholinergic /diuretic agents...
August 28, 2017: Urology
https://www.readbyqxmd.com/read/28858728/a-carbapenem-antibiotic-imipenem-cilastatin-induces-an-oxidative-stress-status-and-gonadotoxic-effects-in-%C3%A2-wistar-%C3%A2-rats
#11
Amal Tahri, Kamilia Ksouda, Rim Kallel, Salima Daoud, Tahia Boudawara, Khaled Mounir Zeghal, Zouheir Sahnoun
Imipenem is a carbapenem antibiotic largely used to treat infection diseases. The present study was designed to investigate the effects of imipenem/cilastatin (IMP) on oxidative stress, antioxidant levels, testicular structure and sperm parameters in rats. Adult Wistar rats (84days old; N=8/group) were treated intraperitoneally with physiological serum containing 0mg/kg, 30mg/kg, 50mg/kg and 80mg/kg of IMP for one week. The results revealed that exposure to IMP especially at high doses, significantly decreased sexual organs weights (testis, epididymis, seminal vesicle and prostate), sperm characteristics (motility, viability and count) and plasma testosterone level while increased sperm abnormality...
August 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28853814/magnetic-resonance-imaging-and-clinical-findings-in-seminal-vesicle-pathologies
#12
Zafer Ozmen, Fatma Aktas, Nihat Uluocak, Eda Albayrak, Ayşegül Altunkaş, Fatih Çelikyay
PURPOSE: Congenital and acquired pathologies of the seminal vesicles (SV) are rare diseases. The diagnosis of SV anomalies is frequently delayed or wrong due to the rarity of these diseases and the lack of adequate evaluation of SV pathology. For this reason, we aimed to comprehensively evaluate SV pathologies and accompanying genitourinary system abnormalities. MATERIALS AND METHODS: Between March 2012 and December 2015, 1455 male patients with different provisional diagnosis underwent MRI...
August 30, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28851581/topography-of-prostate-cancer-recurrence-after-radiation-therapy-a-detailed-mapping-study-of-salvage-radical-prostatectomy-specimens
#13
Toshikazu Takeda, Amy L Tin, Renato B Corradi, Maha Mamoor, Nicole E Benfante, Daniel D Sjoberg, Peter T Scardino, James A Eastham, Samson W Fine, Karim A Touijer
In men who do not respond to initial radiation therapy, accurate knowledge of the site of cancer recurrence or persistence is necessary to understand treatment failure. We evaluated the pathologic characteristics of recurrent/persistent prostate cancer with tumor maps from the whole-mount slides of salvage radical prostatectomies performed between 2000 and 2014. Of 216 consecutive patients, detailed tumor maps were available for 77. Sixty-nine patients (90%) were found to have tumor in the apex, of which 46% occurred in the most apical 3mm...
August 26, 2017: European Urology
https://www.readbyqxmd.com/read/28845570/peripheral-blood-monocyte-count-reflecting-tumor-infiltrating-macrophages-is-a-predictive-factor-of-adverse-pathology-in-radical-prostatectomy-specimens
#14
Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Norihiko Kawamura, Kentaro Jingushi, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Ryoichi Imamura, Eiichi Morii, Norio Nonomura
BACKGROUND: Tumor-infiltrating macrophages, which are thought to be derived from blood monocytes, interact with tumor cells to promote cancer progression. The aim of this study was to assess the association of peripheral blood monocyte count with pathological findings and local tumor-infiltrating macrophages in prostatectomy specimens. METHODS: Preoperative peripheral blood monocyte counts were retrospectively assessed for their associations with pathological findings (pathological T stage, Gleason Score, extraprostatic extension, seminal vesicle invasion, and surgical margin) and biochemical recurrence of 248 patients who underwent radical prostatectomy...
August 28, 2017: Prostate
https://www.readbyqxmd.com/read/28843377/favorable-gleason-3%C3%A2-4-prostate-cancer-shows-comparable-outcomes-with-gleason-3%C3%A2-3-prostate-cancer-implications-for-the-expansion-of-selection-criteria-for-active-surveillance
#15
Hakmin Lee, In Jae Lee, Seok-Soo Byun, Sang Eun Lee, Sung Kyu Hong
BACKGROUND: To investigate the feasibility of active surveillance (AS) in biopsy Gleason score (GS) 3 + 4 prostate cancer (PCa), we compared the outcomes of biopsy GS 3 + 3 and 3 + 4 PCa after radical prostatectomy. PATIENTS AND METHODS: We analyzed the data of 1491 patients undergoing radical prostatectomy for biopsy GS 3 + 3 or 3 + 4 PCa who fulfilled the low-risk criteria of the National Comprehensive Cancer Network guidelines regardless of GS. The favorable GS 3 + 4 group was defined as having core involvement ≤ 50%, prostate-specific antigen density ≤ 0...
August 3, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28821268/hypo-fractionated-sbrt-for-localized-prostate-cancer-a-german-bi-center-single-treatment-group-feasibility-trial
#16
Ping Jiang, Katja Krockenberger, Reinhard Vonthein, Jane Tereszczuk, Arne Schreiber, Sebastian Liebau, Stefan Huttenlocher, Detlef Imhoff, Panagiotis Balermpas, Christian Keller, Kathrin Dellas, Rene Baumann, Claus Rödel, Guido Hildebrandt, Klaus-Peter Jünemann, Alex S Merseburger, Alan Katz, Andreas Ziegler, Oliver Blanck, Jürgen Dunst
BACKGROUND: For prostate cancer treatment, treatment options with minimal side effects are desired. External beam radiation therapy (EBRT) is non-invasive, standard of care and delivered in either conventional fractionation over 8 weeks or with moderate hypo-fractionation over about 5 weeks. Recent advances in radiotherapy technology have made extreme hypo-fractionated stereotactic body radiation therapy (SBRT) of prostate cancer feasible, which has not yet been introduced as a standard treatment method in Germany...
August 18, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28808664/expression-of-telomere-repeat-binding-factor-1-and-trf2-in-prostate-cancer-and-correlation-with-clinical-parameters
#17
Wei Chen, Yong Wang, Fei Li, Wei Lin, Yong Liang, Zhiwei Ma
OBJECTIVE: The objective of this study was to investigate the expression of telomere repeat binding factor 1 (TRF1) and TRF2 in prostate cancer and their relationships with clinicopathological features. METHODS: In total 50 prostate cancer tissues and paired benign prostate hyperplasia tissues were analyzed. The telomere-binding proteins TRF1 and TRF2 were measured using immunohistochemical method. Correlation analyses were used to evaluate the association between immunohistochemical score and clinical parameters...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28807747/pretreatment-3t-multiparametric-mri-staging-predicts-for-biochemical-failure-in-high-risk-prostate-cancer-treated-with-combination-high-dose-rate-brachytherapy-and-external-beam-radiotherapy
#18
John V Hegde, D Jeffrey Demanes, Darlene Veruttipong, Jagdeep Raince, Sang-June Park, Steven S Raman, Nicholas G Nickols, Christopher R King, Amar U Kishan, Michael L Steinberg, Mitchell Kamrava
PURPOSE: To determine whether pretreatment 3T multiparametric MRI (mpMRI) staging impacts biochemical recurrence-free survival (BRFS) or distant metastasis-free survival (DMFS) for men with high-risk prostate cancer treated with combination high-dose-rate (HDR) brachytherapy and external beam radiation therapy (EBRT). MATERIALS AND METHODS: This institutional review board-approved retrospective study included a cohort of 37 men with high-risk prostate cancer treated with HDR brachytherapy and EBRT after 3T mpMRI...
August 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28799121/3-t-multiparametric-mri-characteristics-of-prostate-cancer-patients-suspicious-for-biochemical-recurrence-after-primary-focal-cryosurgery-hemiablation
#19
Michael Kongnyuy, Daniel M Halpern, Corinne C Liu, Kaitlin E Kosinski, David J Habibian, Anthony T Corcoran, Aaron E Katz
INTRODUCTION: We aimed to report on multiparametric MRI (mpMRI) characteristics of post-primary focal cryosurgery (PFC) patients suspected of biochemical recurrence (BCR) by the Phoenix criteria. METHODS: We retrospectively reviewed all patients at our institution who had undergone PFC. Prostate-specific antigen nadir was determined using 2 or more post-PFC values. Suspicion of BCR was determined using the Phoenix criteria (nadir + 2 ng/ml). At the discretion of the physician, pre-and post-PFC 3-T mpMRIs were obtained and in a few cases biopsies were performed...
August 10, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28798494/identification-and-functional-characterization-of-the-sex-determining-gene-doublesex-in-the-sawfly-athalia-rosae%C3%A2-hymenoptera-tenthredinidae
#20
Shotaro Mine, Megumi Sumitani, Fugaku Aoki, Masatsugu Hatakeyama, Masataka G Suzuki
Sexual fate of the sawfly, Athalia rosae (Hymenoptera: Tenthredinidae) is determined by the complementary sex determination (CSD) mechanism as is the case in honeybees. However, to date, genes involved in sex determination have not been identified in this species. In this study, we attempted to identify orthologs of complementary sex-determiner (csd), feminizer (fem), and doublesex (dsx) from the A. rosae genome, all of which are crucial components of the sex determination cascade in the honeybee. As a result, we identified a sawfly ortholog of dsx (designated as Ardsx)...
2017: Applied Entomology and Zoology
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