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https://www.readbyqxmd.com/read/29145710/testosterone-replacement-in-transgenic-sickle-cell-mice-controls-priapic-activity-and-upregulates-pde5-expression-and-enos-activity-in-the-penis
#1
B Musicki, S Karakus, W Akakpo, F H Silva, J Liu, H Chen, B R Zirkin, A L Burnett
Sickle cell disease (SCD)-associated priapism is characterized by decreased nitric oxide (NO) signaling and downregulated phosphodiesterase (PDE)5 protein expression and activity in the penis. Priapism is also associated with testosterone deficiency, but molecular mechanisms underlying testosterone effects in the penis in SCD are not known. Given the critical role of androgens in erection physiology and NO synthase (NOS)/PDE5 expression, we hypothesized that testosterone replacement to eugonadal testosterone levels reduces priapism by reversing impaired endothelial (e)NOS activity and molecular abnormalities involving PDE5...
November 16, 2017: Andrology
https://www.readbyqxmd.com/read/29134231/patterns-of-relapse-as-determined-by-68-ga-psma-ligand-pet-ct-after-radical-prostatectomy-importance-for-tailoring-and-individualizing-treatment
#2
Christoph Henkenberens, Thorsten Derlin, Frank M Bengel, Tobias L Ross, Hans-Jürgen Wester, Katja Hueper, Markus A Kuczyk, Hans Christiansen, Christoph A von Klot
PURPOSE: To evaluate the patterns of relapse and impact on the intended treatment when using (68)Ga-prostate-specific membrane antigen (PSMA) ligand positron emission tomography/computed tomography (PET/CT) imaging for restaging of disease in patients with biochemical relapse after radical prostatectomy (RP) before salvage radiotherapy (sRT). METHODS: In all, 39 patients with biochemical recurrence after RP who had no primary indication for adjuvant RT due to the absence of biologically unfavorable disease (e...
November 13, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29128245/the-reproductive-responses-of-earthworms-eisenia-fetida-exposed-to-nanoscale-zero-valent-iron-nzvi-in-the-presence-of-decabromodiphenyl-ether-bde209
#3
Jun Liang, Xiaoqian Xia, Ling Yuan, Wei Zhang, Kuangfei Lin, Bingsheng Zhou, Shuangqing Hu
Reproductive toxicity of nanoscale zero-valent iron (nZVI) along with coexisting decabromodiphenyl ether (BDE209) to earthworm Eisenia fetida (E. fetida) remains unknown. In the present study, the reproductive responses of E. fetida exposed to 100, 500 and 1000 mg kg(-1) of nZVI showed a significant (P < 0.05) decline up to 35.6%, 60.0% and 93.3%, respectively, compared to the controls. Expression levels of annetocin (ANN) gene indicated a remarkable (P < 0.05) down-regulation (59.2%, 58.2% and 95...
November 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29122742/myotube-migration-to-cover-and-shape-the-testis-of-drosophila-depends-on-heartless-cadherin-catenin-and-myosin-ii
#4
Silke Rothenbusch-Fender, Katharina Fritzen, Maik C Bischoff, Detlev Buttgereit, Susanne F Oenel, Renate Renkawitz-Pohl
During Drosophila metamorphosis, nascent testis myotubes migrate from the prospective seminal vesicle of the genital disc onto pupal testes and then further to cover the testes with multinucleated smooth-like muscles. Here we show that DWnt2 is likely required for determination of testis-relevant myoblasts on the genital disc. Knock down of FGFR Heartless by RNAi and a dominant-negative version revealed multiple functions of Heartless, namely regulation of the amount of myoblasts on the genital disc, connection of seminal vesicles and testes, and migration of muscles along the testes...
November 9, 2017: Biology Open
https://www.readbyqxmd.com/read/29119604/anatomy-and-histology-of-the-prostate-and-glands-of-cowper-in-three-species-of-neotropical-bats
#5
María Daniela Miotti, Marcos I Mollerach, Ruben M Barquez
The reproductive accessory glands (RAG) are essential components in reproduction because their secretion products ensure survival, viability, and sperm motility. The objective of this study was to characterize and compare the morphological and histological structure of the RAG in three species of bats of the genus Sturnira (S. erythromos, S. lilium, and S. oporaphilum). The RAG complex comprise a compact gland (prostate), which surrounds the urethra, and a pair of Glands of Cowper at the base of penis. Anatomical and histologically, the prostate are differentiated in two regions, ventral and dorsal...
November 9, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/29110079/old-and-emerging-concepts-on-adrenal-chromaffin-cell-stimulus-secretion-coupling
#6
EDITORIAL
Ricardo Borges, Luis Gandía, Emilio Carbone
The chromaffin cells (CCs) of the adrenal medulla play a key role in the control of circulating catecholamines to adapt our body function to stressful conditions. A huge research effort over the last 35 years has converted these cells into the Escherichia coli of neurobiology. CCs have been the testing bench for the development of patch-clamp and amperometric recording techniques and helped clarify most of the known molecular mechanisms that regulate cell excitability, Ca(2+) signals associated with secretion, and the molecular apparatus that regulates vesicle fusion...
November 6, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29104494/pathogenic-role-of-exosomes-in-epstein-barr-virus-ebv-associated-cancers
#7
REVIEW
Sin-Yeang Teow, Kitson Liew, Alan Soo-Beng Khoo, Suat-Cheng Peh
Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs). These nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. Exosomes serve as key mediators in intercellular communication by facilitating the transfer and exchange of cellular components from cells to cells. They contain various pathogenic factors whereby their adverse effects have been implicated in multiple viral infections and cancers...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29103269/echinostoma-macrorchis-digenea-echinostomatidae-metacercariae-in-cipangopaludina-chinensis-malleata-snails-and-adults-from-experimental-rats-in-korea
#8
Woon-Mok Sohn, Byoung-Kuk Na
A survey was performed to know the infection status of echinostome metacercariae in Cipangopaludina chinensis malleata snails from Korea. Total 75 snails collected in 5 localities, i.e., Imsil-gun, Jeollabuk-do, Hwasun-gun and Shinan-gun (Aphae and Jido), Jeollanam-do, and Jinju-si, Gyeongsangnam-do, were examined for metacercariae by the artificial digestion method. Infection rates of metacercariae were 80.0%, 66.7%, 100%, 60.0%, and 73.3%, and their densities were 39, 32, 183, 19, and 30 per snail infected, respectively...
October 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29103260/-seminal-vesicle-abscess-associated-with-zinner-syndrome
#9
Sohei Kuribayashi, Go Tanigawa, Yohei Okuda, Masataka Kawamura, Nozomu Kishimoto, Kentaro Takezawa, Koichi Tsutahara, Tetsuya Takao, Seiji Yamaguchi
We report a case of seminal vesicle abscess associated with Zinner syndrome. A 26-year-old male was admitted to our hospital because of fever and right scrotal swelling. Ultrasound showed an enlarged epididymis and color Doppler ultrasound showed increased vascularity in the epididymis. We diagnosed the case as acute epididymitis and started intravenous antibiotic therapy. Four days after admission, remittent fever persisted and blood culture was positive for Staphylococcus aureus. We performed computed tomography, which showed a right seminal vesicle cyst abscess and right renal agenesis...
October 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29099382/-neurofibromas-in-the-urogenital-system-report-of-two-cases-and-literature-review
#10
María Asunción Costa-Martínez, Matías Prieto Vita, Liliana Elisabeth Garcés Proaño, Carlos Carro Rubias, Manuel Ángel Ortiz Gorraiz, Ernesto De Nova Sánchez
OBJECTIVE: We introduce two cases of a 46 and 66-year-old patient, both diagnosed with pelvic neurofibroma (One located in a seminal vesicle, the other in the bladder). The first patient had been diagnosed with Neurofibromatosis type 1 while the other was diagnosed with a sporadic neurofibroma. METHODS: During a study for lower urinary tract symptoms referred, these patients were diagnosed seminal vesicle and bladder neurofibroma, respectively, using image and histological tests...
November 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29091009/evidence-based-reporting-a-method-to-optimize-prostate-mri-communications-with-referring-physicians
#11
Michael J Magnetta, Ashley L Donovan, Bruce L Jacobs, Benjamin J Davies, Alessandro Furlan
OBJECTIVE: The purpose of this study was to develop an evidence-based method to optimize prostate MRI reports that would improve communication between urologists and radiologists. MATERIALS AND METHODS: This quality improvement initiative was approved by the institutional Quality Improvement Review Committee. A structured report was developed containing essential components defined by local practice norms and Prostate Imaging Reporting and Data System (PI-RADS) lexicon version 2...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29081928/primary-adenocarcinoma-of-the-seminal-vesicle
#12
Safae Terrisse, Maria Eugenia Comblor, Jérôme Vérine, Hélène Gauthier, Pierre Mongiat-Artus, Stéphane Culine
Primary adenocarcinoma of the seminal vesicle is a rare condition with only about 60 cases described in the literature. The unusual characteristics of this disease makes diagnosis difficult and treatment strategies differ as there are no specific guidelines available. This report presents a case of adenocarcinoma of the seminal vesicle with lung metastases in which surgical and chemotherapeutic treatments have been carried out. The MVAC dose dense regimen following local resection seems effective in this scenario and may be used in the treatment of this disease...
October 3, 2017: Rare Tumors
https://www.readbyqxmd.com/read/29066868/protective-effect-of-da-9401-in-finasteride-induced-apoptosis-in-rat-testis-inositol-requiring-kinase-1-and-c-jun-n-terminal-kinase-pathway
#13
Kiran Kumar Soni, Yu Seob Shin, Bo Ram Choi, Keshab Kumar Karna, Hye Kyung Kim, Sung Won Lee, Chul Young Kim, Jong Kwan Park
Finasteride is used to treat male pattern baldness and benign prostatic hyperplasia. This study investigated the toxicity of finasteride and recovery by DA-9401 using Sprague Dawley (SD) rats. Forty adult male SD rats were assigned to four groups: control (CTR), finasteride 1 mg/kg/day (F), finasteride 1 mg/kg + DA-9401 100 mg/kg/day (F + DA 100) and finasteride 1 mg/kg + DA-9401 200 mg/kg/day (F + DA 200). Treatments were by oral delivery once daily for 90 consecutive days. The gross anatomical parameters assessed included: genital organ weight; vas deferens sperm count and sperm motility; testosterone, dihydrotestosterone (DHT) and malondialdehyde levels; and histological and terminal deoxynucleotidyl transferase enzyme mediated dUTP nick-end labeling (TUNEL) staining of testis for spermatogenic cell density, Johnsen's score and apoptosis...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29064654/an-unusual-presentation-of-urethral-duplication-presenting-with-chronic-bladder-retention-left-scrotal-transposition-and-left-renal-agenesis
#14
Antonio Macedo, Marcela Leal da Cruz, João Luiz Gomes Parizi, Gustavo Marconi Caetano Martins, Riberto Liguori, Sérgio Leite Ottoni, Bruno Leslie, Gilmar Garrone
INTRODUCTION AND OBJECTIVE: Urethral duplication is a rare congenital anomaly, with roughly 200 cases reported in the literature (1). It is more frequent in males, with few cases reported in females. The clinical presentation differs according to the anatomical variant present. The duplication most commonly occurs in the sagittal plane with one urethra located ventrally and the other dorsally (2). Usually the ventral urethra is the more functional of both. Duplications occurring in the coronal plane are quite rare and they are usually associated with bladder duplication (3)...
October 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29063715/comparative-aspects-of-pre-and-postnatal-development-of-the-male-reproductive-system
#15
REVIEW
Catherine A Picut, Mary K Ziejewski, D Stanislaus
This review describes pre- and postnatal development of the male reproductive system in humans and laboratory animals, and highlights species differences in the timing and control of hormonal and morphologic events. Major differences are that the fetal testis is dependent on gonadotropins in humans, but is independent of such in rats; humans have an extended postnatal quiescent period, whereas rats exhibit no quiescence; and events such as secretion by the prostate and seminal vesicles, testicular descent, and the appearance of spermatogonia are all prenatal events in humans, but are postnatal events in rats...
October 24, 2017: Birth defects research
https://www.readbyqxmd.com/read/29055140/morphological-analysis-of-the-male-reproductive-accessory-glands-of-the-bat-artibeus-lituratus-phyllostomidae-chiroptera
#16
Renata T S Santos, Laís R M Pires, Edna S S Albernaz, Cleber S Andrade, Cornélio S Santiago, Eliana Morielle-Versute, Sebastião R Taboga, Mateus R Beguelini
Bats are distributed worldwide from tropical to temperate regions. Despite their wide geographical radiation and advances in studies using evolutionary approaches, aspects related to the reproduction of these animals remain poorly explored, especially those related to the male reproductive accessory glands (RAGs). Thus, the aim of this study was to analyze the morphophysiology of the male RAGs in the bat Artibeus lituratus. The RAGs in A. lituratus are composed of a compact intra-abdominal glandular complex, consisting of the prostate with two prostatic regions (ventral and dorsal), plus Littre glands and a pair of extra-abdominal bulbourethral glands...
October 21, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/29051038/image-guided-radiation-therapy-strategies-for-pelvic-lymph-node-irradiation-in-high-risk-prostate-cancer-motion-and-margins
#17
Lucy Kershaw, Laila van Zadelhoff, Wilma Heemsbergen, Floris Pos, Marcel van Herk
PURPOSE: To quantify the relative motion of the pelvic lymph nodes (LNs), seminal vesicles (SV) and prostate and define indicative margins for image-guided radiotherapy based on bony anatomy or prostate correction strategies for a 3 or 6 degrees-of-freedom couch. METHODS AND MATERIALS: Nineteen patients had a planning computed tomography (CT) scan followed by a mean of 11 repeated CT scans during radiation therapy. The prostate, SV, and external and internal iliac LN regions on the left and right were outlined on each CT scan...
September 8, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29048208/an-innovative-technique-of-transurethral-seminal-vesiculoscopy-with-ultrasonic-lithotripter-for-severe-persistent-hematospermia
#18
Wei Zhang, Guang'an Xiao, Shenfei Qin, Amanda B Reed-Maldonado, Jian Xu, Guanghua Chen, Lei Wang, Tie Zhou
BACKGROUND AND PURPOSE: Transurethral seminal vesiculoscopy (TSV) provides an efficient approach to diagnose and treat the hematospermia but still need further improvement in manipulation and corresponding instruments. In this study, we develop an innovative technique with ultrasonic lithotripter (EMS) to treat severe, persistent hematospermia. PATIENTS AND METHODS: Data of patients who underwent TSV with or without ultrasonic lithotripter between May 2012 and December 2015 was reviewed...
October 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29039893/open-radical-prostatectomy-reproducing-robot-assisted-radical-prostatectomy-involving-antegrade-nerve-sparing-and-continuous-anastomosis
#19
Se Yun Kwon, Jun Nyung Lee, Yun-Sok Ha, Seock Hwan Choi, Tae-Hwan Kim, Tae Gyun Kwon
PURPOSE: To present modified RRP using the same method as RALP and compare its surgical outcomes with RALP. MATERIALS AND METHODS: Demographics, perioperative and functional outcomes of the 322 patients that underwent RRP (N=99) or RALP (N=223) at our institution from January 2011 through June 2013 were evaluated retrospectively. Postoperative incontinence and erectile dysfunction are involved functional outcomes. During the modified procedure, the bladder neck was dissected first as for RALP...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29037803/prognostic-significance-and-biopsy-characteristics-of-prostate-cancer-with-seminal-vesicle-invasion-on-radical-prostatectomy-a-nationwide-population-based-study
#20
Anna Kristiansen, Linda Drevin, Brett Delahunt, Hemamali Samaratunga, David Robinson, Ingela Franck Lissbrant, Pär Stattin, Lars Egevad
The objective of this study was to evaluate the prognostic significance of seminal vesicle invasion (SVI, pT3b) compared with extraprostatic extension (EPE) alone (pT3a) after radical prostatectomy, and to correlate pre-operative biopsy pathology with SVI and EPE. The National Prostate Cancer Register includes all prostate cancers diagnosed in Sweden. We analysed 4063 cases with stage category pT3a and 1371 cases with pT3b at radical prostatectomy between 2000 and 2012. Associations between pT3a and pT3b and progression were evaluated and adjusted for year, age, biopsy grade and s-PSA...
October 13, 2017: Pathology
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