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https://www.readbyqxmd.com/read/27900375/aie-phenomena-of-a-cyanostilbene-derivative-as-a-probe-of-molecular-assembly-processes
#1
Fuyuki Ito, Jun-Ichi Fujimori, Narumi Oka, Michel Sliwa, Cyril Ruckebusch, Syoji Ito, Hiroshi Miyasaka
The initial processes of the crystallization of a solute molecule, 1-cyano-trans-1,2-bis-(4'-methylbiphenyl)-ethylene (CN-MBE) in binary solution (water and acetone), were investigated by means of fluorescence spectroscopy as well as scanning electron microscopy (SEM). With an increase in the volume fraction (Vw) of the poor solvent (water) in the solution, a drastic change in the fluorescence spectra and intensity of CN-MBE was observed. This change was attributed to aggregation induced emission (AIE). By analyzing the evolution of AIE by multivariate curve resolution-alternating least squares (MCR-ALS), it was revealed that four main species appeared in the solution depending on the Vw values...
November 30, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27895009/an-incp-plasmid-carrying-the-colistin-resistance-gene-mcr-1-in-klebsiella-pneumoniae-from-hospital-sewage
#2
Feifei Zhao, Yu Feng, Xiaoju Lü, Alan McNally, Zhiyong Zong
A Klebsiella pneumoniae strain of ST313 recovered from hospital sewage was found to carry the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to be spread beyond the Enterobacteriaceae.
November 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27894831/improvement-in-routine-detection-of-colistin-resistance-in-e-coli-isolated-in-veterinary-diagnostic-laboratories
#3
Eric Jouy, Marisa Haenni, Laëtitia Le Devendec, Aurélie Le Roux, Pierre Châtre, Jean-Yves Madec, Isabelle Kempf
We have developed a phenotypic method suited to the systematic screening of resistance to colistin in E. coli, including those with the mcr-1 gene, by the absence of an inhibition zone after an application of a single drop of 8mg/L colistin solution on a previously inoculated Mueller-Hinton agar.
November 25, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27894674/emergence-of-plasmid-mediated-colistin-resistance-and-new-delhi-metallo-%C3%AE-lactamase-genes-in-extensively-drug-resistant-escherichia-coli-isolated-from-a-patient-in-thailand
#4
Wantana Paveenkittiporn, Anusak Kerdsin, Sukanya Chokngam, Charatdao Bunthi, Somchai Sangkitporn, Christopher J Gregory
We reported a case of Escherichia coli with colistin resistance and an extensively drug-resistant phenotype. Molecular analysis revealed that the isolate carried mcr-1 and multiple β-lactamase genes includingblaNDM1, blaCTX-M-15, blaTEM1, and blaCMY-2. This is the first report of a clinical mcr-1 isolate in Thailand highlighting the urgent need for a comprehensive antimicrobial resistance containment strategy to prevent further spread.
November 14, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27893854/dissemination-and-mechanism-for-the-mcr-1-colistin-resistance
#5
Rongsui Gao, Yongfei Hu, Zhencui Li, Jian Sun, Qingjing Wang, Jingxia Lin, Huiyan Ye, Fei Liu, Swaminath Srinivas, Defeng Li, Baoli Zhu, Ya-Hong Liu, Guo-Bao Tian, Youjun Feng
Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance gene (mcr-1). However, the mechanistic aspects of the MCR-1 colistin resistance are still poorly understood. Here we report the comparative genomics of two new mcr-1-harbouring plasmids isolated from the human gut microbiota, highlighting the diversity in plasmid transfer of the mcr-1 gene...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27891118/colistin-in-pig-production-chemistry-mechanism-of-antibacterial-action-microbial-resistance-emergence-and-one-health-perspectives
#6
REVIEW
Mohamed Rhouma, Francis Beaudry, William Thériault, Ann Letellier
Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in both human and veterinary medicine. For several years now, colistin has been considered the last line of defense against infections caused by multidrug-resistant Gram-negative such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Colistin has been extensively used orally since the 1960s in food animals and particularly in swine for the control of Enterobacteriaceae infections. However, with the recent discovery of plasmid-mediated colistin resistance encoded by the mcr-1 gene and the higher prevalence of samples harboring this gene in animal isolates compared to other origins, livestock has been singled out as the principal reservoir for colistin resistance amplification and spread...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27875738/heart-rate-response-to-exercise-in-heart-failure-patients-the-prognostic-role-of-metabolic-chronotropic-relation-and-heart-rate-recovery
#7
Pavel Hajdusek, Martin Kotrc, Josef Kautzner, Vojtech Melenovsky, Eva Benesova, Petr Jarolim, Jan Benes
BACKGROUND: The dynamics of the sinus node response to exercise is linked to functional capacity and outcome in heart failure (HF). The goal of the work was to analyze determinants and impacts of cardio-acceleration, described by the concept of metabolic-chronotropic relation (MCR) and of cardio-deceleration, described by heart rate recovery (HRR). METHODS: A cohort of 25 healthy controls and 78 patients with advanced systolic HF and optimized medical and/or device therapy (97% receiving beta-blockers, 54% ICD) underwent maximal cardiopulmonary exercise test and were prospectively followed...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27872110/correction-for-leangapichart-et-al-acquisition-of-mcr-1-plasmid-mediated-colistin-resistance-in-escherichia-coli-and-klebsiella-pneumoniae-during-hajj-2013-and-2014
#8
Thongpan Leangapichart, Philippe Gautret, Philippe Brouqui, Ziad A Memish, Didier Raoult, Jean-Marc Rolain
No abstract text is available yet for this article.
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27865627/epidemiology-of-infections-caused-by-polymyxin-resistant-pathogens
#9
Helen Giamarellou
Confronting the storm of carbapenemase-producing Gram-negative pathogens and thus facing the threat of untreatable infections, the medical community revived colistin. Not long since its re-introduction and despite the fact that resistance to colistin at least in Escherichia coli is rare, chromosomally-mediated colistin resistance in metallo-β-lactamase-producing Klebsiella pneumoniae strains was reported in 2004 from Greece. Subsequent studies revealed the highest predominance in Italy (38%) and Greece (26%), with colistin-resistant (Col-R) strains frequently carrying a carbapenemase...
November 10, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27858846/the-efficacy-of-fractional-carbon-dioxide-co2-laser-combined-with-luliconazole-1-cream-for-the-treatment-of-onychomycosis-a-randomized-controlled-trial
#10
Bing Rong Zhou, Yan Lu, Felicia Permatasari, He Huang, Jin Li, Juan Liu, Jia An Zhang, Dan Luo, Yang Xu
BACKGROUND: To evaluate the efficacy of fractional carbon dioxide (CO2) laser combined with luliconazole 1% cream for the treatment of onychomycosis and to compare it with that of fractional CO2 laser alone. METHODS: This was a randomized, parallel group, 2-arm, positive-controlled, single-center, superiority trial with a 1:2 allocation ratio. Sixty patients with clinical and mycological diagnosis of onychomycosis were enrolled from the Dermatology Department of the First Affiliated Hospital of Nanjing Medical University in Nanjing, China from March 2015 to May 2015...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27855074/emergence-of-colistin-resistance-gene-mcr-1-in-cronobacter-sakazakii-producing-ndm-9-and-escherichia-coli-from-the-same-animal
#11
Bao-Tao Liu, Feng-Jing Song, Ming Zou, Zhi-Hui Hao, Hu Shan
We report the presence of mcr-1 in E. coli and carbapenem-resistant Cronobacter sakazakii, from the same diseased chicken. The mcr-1gene linked with ISApl1 was located on two different IncI2 plasmids including one multidrug plasmid in E. coli, whereas blaNDM-9-fosA3 was on a IncB/O plasmid in C. sakazakii The development of fosA3-blaNDM-9 resistance region was mediated by IS26 The co-location of mcr-1 or blaNDM-9with other resistance genes will accelerate the dissemination of the two genes.
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27855068/prevalence-of-colistin-resistance-gene-mcr-1-and-absence-of-mcr-2-in-escherichia-coli-isolated-from-healthy-food-producing-animals-in-japan
#12
Michiko Kawanishi, Hitoshi Abo, Manao Ozawa, Mariko Uchiyama, Takahiro Shirakawa, Satowa Suzuki, Ayaka Shima, Akifumi Yamashita, Tsuyoshi Sekizuka, Kengo Kato, Makoto Kuroda, Ryoji Koike, Mayumi Kijima
We screened mcr-1 and mcr-2 genes in 9,306 Escherichia coli strains isolated from healthy animals in the Japanese Veterinary Antimicrobial Resistance Monitoring system (JVARM). mcr-1 was detected in 39 strains (5, 20, and 14 isolated from cattle, swine and broiler, respectively), whereas mcr-2 was not detected. mcr-2 was also not detected with the investigation sequence homology search against our curated GenEpid-J database.
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27855065/prevalence-of-mcr-1-in-us-food-animal-cecal-contents
#13
Richard J Meinersmann, Scott R Ladely, Jodie R Plumblee, Kimberly L Cook, Eileen Thacker
A survey of 2003 cecal content samples from chickens, turkeys, cattle and swine at slaughter facilities in the United States was conducted to estimate the prevalence of mcr-1 gene conferring resistance to colistin in Enterobacteriaceae Two cecal samples from swine had Escherichia coli with IncI2 plasmids bearing the mcr-1 gene.
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27836380/colistin-use-and-colistin-resistance-in-bacteria-from-animals
#14
Isabelle Kempf, Eric Jouy, Claire Chauvin
Colistin has been used in veterinary medicine for decades, mainly for the prevention and treatment of Enterobacteriaceae infections. However, data regarding colistin resistance in bacteria from animals and food of animal origin are relatively scarce, partly because there are methodological difficulties hampering the analysis of susceptibility to colistin. Most data regarding clinical isolates are related to enteropathogenic Escherichia coli and Salmonella. The resistance percentages are sometimes high for pathogenic strains, and the mcr-1 gene has been detected in pathogenic E...
October 27, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27834721/complete-genome-sequence-of-a-colistin-resistance-gene-mcr-1-bearing-isolate-of-escherichia-coli-from-the-united-states
#15
Richard J Meinersmann, Scott R Ladely, James L Bono, Jodie R Plumblee, M Carolina Hall, Linda L Genzlinger, Kimberly L Cook
Transmissible colistin resistance conferred by the mcr-1 gene-bearing IncI2 plasmid has been recently reported in Escherichia coli in the United States. We report here the completed genome sequence of a second E. coli strain isolated from swine in the United States that carried the mcr-1 gene on an IncI2-type plasmid.
November 10, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27821458/co-production-of-mcr-1-and-ndm-1-by-colistin-resistant-escherichia-coli-isolated-from-a-healthy-individual
#16
Lan-Lan Zhong, Yan-Fen Zhang, Yohei Doi, Xi Huang, Xue-Fei Zhang, Kun-Jiao Zeng, Cong Shen, Sandip Patil, Yong Xing, Yutian Zou, Guo-Bao Tian
mcr-1, the first transferable plasmid-mediated colistin resistance gene, was reported in Escherichia coli isolates from food animals, food and patients in China and now has been reported worldwide (1).….
November 7, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27816253/a-single-mcr-als-model-for-drug-analysis-in-different-formulations-application-on-diazepam-commercial-preparations
#17
Michele De Luca, Giuseppina Ioele, Claudia Spatari, Gaetano Ragno
A multivariate curve resolution - alternating least squares (MCR-ALS) analysis was used to quantify diazepam (DZP) in thirty commercial liquid formulations. MCR calibration was run on the UV spectrophotometric data of the commercial DZP samples over the range 200-400nm, allowing the resolution of the drug signal and then the excipients contained in all the formulations. A single model MCR for the determination of the drug in all samples was then built through the adoption of the correlation constraint. This model was optimized by an appropriate selection of the most useful wavelength ranges and then validated on external samples...
October 27, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27795381/description-of-the-first-escherichia-coli-clinical-isolate-harboring-colistin-resistance-mcr-1-gene-from-the-indian-subcontinent
#18
Mashkoor Mohsin, Shahbaz Raza, Nicole Roschanski, Sebastian Guenther, Aamir Ali, Peter Schierack
The first report of plasmid-mediated colistin resistance among Enterobacteriaceae in China sounded alarms in the medical community worldwide (1).….
October 24, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27777824/the-course-of-the-terminal-posterior-interosseous-nerve-and-its-relationship-with-wrist-arthroscopy-portals
#19
Yongwei Pan, Leung-Kim Hung
Purpose The terminal branches of the posterior interosseous nerve (PIN) are the main articular branch on the dorsal aspect of the wrist. Its relationship to dorsal wrist arthroscopic portals has not yet been elucidated. The purpose of this study was to quantitatively describe the anatomical relationships between the dorsal wrist arthroscopic portals and the PIN. Methods Dorsal wrist arthroscopic portals were established in 28 cadaver extremities, after which the limbs were dissected. Measurements were taken from the portals to the PIN...
November 2016: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/27769683/-low-prevalence-of-mcr-1-positive-enterobacteriaceae-isolates-in-a-health-area
#20
Víctor José Heras-Cañas, Lorena López-Cerero, Paula Díaz de-Alba, Álvaro Pascual
No abstract text is available yet for this article.
October 18, 2016: Enfermedades Infecciosas y Microbiología Clínica
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