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https://www.readbyqxmd.com/read/28643265/factors-associated-with-high-24-month-persistence-with-denosumab-results-of-a-real-world-non-interventional-study-of-women-with-postmenopausal-osteoporosis-in-germany-austria-greece-and-belgium
#1
A Fahrleitner-Pammer, N Papaioannou, E Gielen, M Feudjo Tepie, C Toffis, I Frieling, P Geusens, P Makras, E Boschitsch, J Callens, A D Anastasilakis, C Niedhart, H Resch, L Kalouche-Khalil, P Hadji
Persistence with osteoporosis therapy is vital for fracture prevention. This non-interventional study of postmenopausal women receiving denosumab in Germany, Austria, Greece, and Belgium found that persistence with denosumab remains consistently high after 24 months in patients at high risk of fracture. PURPOSE: Continued persistence with osteoporosis therapy is vital for fracture prevention. This non-interventional study of clinical practice evaluated medication-taking behavior of postmenopausal women receiving denosumab in Germany, Austria, Greece, and Belgium and factors influencing persistence...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28642846/decreased-fitness-and-virulence-in-st10-escherichia-coli-harboring-blandm-5-and-mcr-1-against-a-st4981-strain-with-blandm-5
#2
Yawei Zhang, Kang Liao, Hua Gao, Qi Wang, Xiaojuan Wang, Henan Li, Ruobing Wang, Hui Wang
Although coexistence of blaNDM-5 and mcr-1 in Escherichia coli has been reported, little is known about the fitness and virulence of such strains. Three carbapenem-resistant Escherichia coli (GZ1, GZ2, and GZ3) successively isolated from one patient in 2015 were investigated for microbiological fitness and virulence. GZ1 and GZ2 were also resistant to colistin. To verify the association between plasmids and fitness, growth kinetics of the transconjugants were performed. We also analyzed genomic sequences of GZ2 and GZ3 using PacBio sequencing...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28640456/first-environmental-sample-containing-plasmid-mediated-colistin-resistant-esbl-producing-escherichia-coli-detected-in-norway
#3
Silje Bakken Jørgensen, Arne Søraas, Lotte Stenfors Arnesen, Truls Leegaard, Arnfinn Sundsfjord, Pål A Jenum
We hereby report a detection of the plasmid borne mcr-1 gene conferring colistin resistance in an extended-spectrum β-lactamase (ESBL) producing Escherichia coli ST10 strain retrieved from seawater at a public beach in Norway. The sample was collected in September 2010 and was investigated by whole-genome sequencing in 2016. This report illustrates that E. coli strains carrying plasmid-mediated colistin resistance genes have also reached areas where this drug is hardly used at all. Surveillance of colistin resistance in environmental, veterinary, and human strains is warranted also in countries where colistin resistance is rare in clinical settings...
June 22, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28628439/locally-acquired-mcr-1-in-escherichia-coli-australia-2011-and-2013
#4
Justin A Ellem, Andrew N Ginn, Sharon C-A Chen, John Ferguson, Sally R Partridge, Jonathan R Iredell
We identified discrete importation events of the mcr-1 gene on incompatibility group IncI2 plasmids in Escherichia coli isolated from patients in New South Wales, Australia, in 2011 and 2013. mcr-1 is present in a small minority of colistin-resistant Enterobacteriaceae and appears not to be established locally.
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28621495/the-spectrum-of-pre-dementia-stages-cognitive-profile-of-motoric-cognitive-risk-syndrome-and-relationship-with-mild-cognitive-impairment
#5
H Sekhon, G Allali, C P Launay, J Chabot, O Beauchet
BACKGROUND AND PURPOSE: Motoric cognitive risk (MCR) syndrome is a pre-dementia syndrome. There is little information on the cognitive profile of individuals with MCR syndrome and its overlap with mild cognitive impairment (MCI) syndrome. This study aimed to examine and compare the cognitive performance of non-demented older community dwellers with and without MCR and MCI syndromes. METHODS: A total of 291 non-demented individuals were selected from the Gait and Alzheimer Interactions Tracking study, which is a cross-sectional study...
June 16, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28616213/postoperative-goal-directed-therapy-and-development-of-acute-kidney-injury-following-major-elective-noncardiac-surgery-post-hoc-analysis-of-pom-o-randomized-controlled-trial
#6
Amour Patel, John R Prowle, Gareth L Ackland
Background: The role of goal-directed therapy (GDT) in preventing creatinine rise following noncardiac surgery is unclear. We performed a post-hoc analysis of a randomized controlled trial to assess the relationship between postoperative optimization of oxygen delivery and development of acute kidney injury (AKI)/creatinine rise following noncardiac surgery. Methods: Patients were randomly assigned immediately postoperatively to receive either fluid and/or dobutamine therapy to maintain/restore their preoperative oxygen delivery, or protocolized standard care (oxygen delivery only recorded)...
June 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28606644/comparison-of-methods-for-detection-of-plasmid-mediated-and-chromosomally-encoded-colistin-resistance-in-enterobacteriaceae
#7
Aurélie Jayol, Patrice Nordmann, Philippe Lehours, Laurent Poirel, Véronique Dubois
OBJECTIVES: Because of the emergence of plasmid-mediated (mcr-1 and mcr-2 genes) and chromosomally-encoded colistin resistance, reliable methods for detecting colistin resistance/susceptibility in routine laboratories are required. We evaluated the respective performances of the BD Phoenix automated system, the newly-developed Rapid Polymyxin NP test and the broth microdilution (BMD) reference method to detect colistin resistance in Enterobacteriaceae, and particularly those producing MCR-1 and MCR-2...
June 9, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28604251/the-effect-of-a-vegetarian-vs-conventional-hypocaloric-diabetic-diet-on-thigh-adipose-tissue-distribution-in-subjects-with-type-2-diabetes-a-randomized-study
#8
Hana Kahleova, Marta Klementova, Vit Herynek, Antonin Skoch, Stepan Herynek, Martin Hill, Andrea Mari, Terezie Pelikanova
OBJECTIVE: The aim of our study was to compare the effects of a vegetarian and a conventional diet on thigh adipose tissue distribution in subjects with type 2 diabetes (T2D). METHODS: Seventy-four subjects with T2D were randomly assigned to either follow a vegetarian diet (V, n = 37) or a control group who followed an isocaloric conventional anti-diabetic diet (C, n = 37). Both diets were calorie restricted (-500 kcal/day). To measure insulin sensitivity, the hyperinsulinemic (1 mU...
June 10, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28598315/prevalence-of-faecal-carriage-of-colistin-resistant-gram-negative-rods-in-a-university-hospital-in-western-france-2016
#9
Marion Saly, Aurelie Jayol, Laurent Poirel, Francis Megraud, Patrice Nordmann, Veronique Dubois
Plasmid-mediated and chromosomally-encoded colistin resistance is increasingly being reported worldwide. We aimed to determine the prevalence of faecal carriage of colistin-resistant Gram-negative rod isolates in a university hospital in western France. From February to May 2016, rectal swabs from 653 patients hospitalized in various clinical settings were recovered and subsequently screened for colistin resistance using the SuperPolymyxin medium. Antimicrobial susceptibilities were determined according to EUCAST guidelines...
June 9, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28592552/colistin-and-polymyxin-b-susceptibility-testing-for-carbapenem-resistant-and-mcr-positive-enterobacteriaceae-comparison-of-sensititre-microscan-vitek-2-and-etest-with-broth-microdilution
#10
Ka Lip Chew, My-Van La, Raymond T P Lin, Jeanette W P Teo
Colistin and polymyxin B remain part of the last line of antibiotics for multi-drug-resistant Gram negative bacteria such as carbapenem-resistant-Enterobacteriaceae Current EUCAST-CLSI joint recommendations are for broth microdilution to be performed for MIC testing of colistin. Commercial susceptibility testing methods were evaluated and compared against reference broth microdilution (BMD), using a susceptible breakpoint of ≤2mg/L for both colistin and polymyxin B. Seventy-six Enterobacteriaceae were included, of which twenty-one were mcr-1 positive...
June 7, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28582865/motoric-cognitive-risk-syndrome-association-with-incident-dementia-and-disability
#11
Takehiko Doi, Hiroyuki Shimada, Hyuma Makizako, Kota Tsutsumimoto, Joe Verghese, Takao Suzuki
BACKGROUND: It is important to examine the etiology of motoric cognitive risk syndrome (MCR) and its association with dementia and disability to obtain biological insights and to develop preventive strategies. OBJECTIVE: This study aimed to examine the association of MCR with incidence of dementia and disability in a Japanese community-dwelling sample of older adults. METHODS: Participants were 4,235 older adults (50% women, mean age: 72 years)...
May 30, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28575076/prevalence-of-colistin-resistance-gene-mcr-1-containing-enterobacteriaceae-in-feces-of-patients-attending-a-tertiary-care-hospital-and-detection-of-a-mcr-1-containing-colistin-susceptible-e-coli
#12
Elisabeth M Terveer, Roel H T Nijhuis, Monique J T Crobach, Cornelis W Knetsch, Karin E Veldkamp, Jairo Gooskens, Ed J Kuijper, Eric C J Claas
The emergence of the plasmid-mediated mcr colistin resistance gene in the community poses a potential threat for treatment of patients, especially when hospitalized. The aim of this study was to determine the prevalence of all currently known mcr mediated colistin resistance gene in fecal samples of patients attending a tertiary care hospital. From November 2014 until July 2015, fecal samples of patients attending the Leiden University Medical Center were collected and screened for presence of mcr using real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/28571851/drinking-water-treatment-using-a-submerged-internal-circulation-membrane-coagulation-reactor-coupled-with-permanganate-oxidation
#13
Zhongguo Zhang, Dan Liu, Yu Qian, Yue Wu, Peiran He, Shuang Liang, Xiaozheng Fu, Jiding Li, Changqing Ye
A submerged internal circulating membrane coagulation reactor (MCR) was used to treat surface water to produce drinking water. Polyaluminum chloride (PACl) was used as coagulant, and a hydrophilic polyvinylidene fluoride (PVDF) submerged hollow fiber microfiltration membrane was employed. The influences of trans-membrane pressure (TMP), zeta potential (ZP) of the suspended particles in raw water, and KMnO4 dosing on water flux and the removal of turbidity and organic matter were systematically investigated...
June 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28559298/phylogenetic-and-structural-comparisons-of-the-three-types-of-methyl-coenzyme-m-reductase-from-methanococcales-and-methanobacteriales
#14
Tristan Wagner, Carl-Eric Wegner, Jörg Kahnt, Ulrich Ermler, Seigo Shima
The phylogenetically diverse family of methanogenic archaea universally use methyl-coenzyme M reductase (MCR) for catalyzing the final methane-forming reaction step of the methanogenic energy metabolism. Some methanogens of the orders Methanobacteriales and Methanococcales contain two isoenzymes. Comprehensive phylogenetic analyses on the basis of all three subunits grouped MCRs from Methanobacteriales, Methanococcales and Methanopyrales into three distinct types: (1) MCRs from Methanobacteriales, (2) MCRs from Methanobacteriales and Methanococcales and (3) MCRs from Methanococcales...
May 30, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28559252/occurrence-of-plasmid-and-chromosome-encoded-mcr-1-in-water-borne-enterobacteriaceae-in-china
#15
Hong-Wei Zhou, Ting Zhang, Ji-Hua Ma, Ying Fang, Han-Yu Wang, Zi-Xian Huang, Yang Wang, Congming Wu, Gong-Xiang Chen
The aim of this study was to investigate the prevalence of the polymyxin resistance gene mcr-1 in Enterobacteriaceae from environmental water sources in Hangzhou, China. Colistin-resistant bacteria were isolated from environmental water samples using an enrichment broth culture method and screened for mcr-1, and then analyzed for the location and transferability of mcr-1 Isolates positive for mcr-1 were further examined to determine their susceptibility profiles, and screened for the presence of additional resistance genes...
May 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28557542/the-efficacy-of-fractional-carbon-dioxide-co2-laser-combined-with-terbinafine-hydrochloride-1-cream-for-the-treatment-of-onychomycosis
#16
Jian Shi, Jin Li, He Huang, Felicia Permatasari, Juan Liu, Yang Xu, Di Wu, Bing-Rong Zhou, Dan Luo
BACKGROUND: Although systemic and topical antifungal agents are widely used to treat onychomycosis, oral medications can cause adverse effects and the efficacy of topical agents is not satisfying. Currently, laser treatment has been studied for its efficacy in the treatment of onychomycosis. Our study was aimed to evaluate the efficacy of fractional carbon dioxide (CO2) laser treatment combined with terbinafine cream for 6 months in the treatment of onychomycosis and to analyze the influencing factors...
May 30, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28555063/the-occurrence-of-the-colistin-resistance-gene-mcr-1-in-the-haihe-river-china
#17
Dong Yang, Zhigang Qiu, Zhiqiang Shen, Hong Zhao, Min Jin, Huaying Li, Weili Liu, Jun-Wen Li
Antibiotic failure is occurring worldwide. In a routine surveillance study on antibioticresistance genes (ARGs) in natural water bodies, we noted the detection of colistin-resistance gene mcr-1, previously identified in Escherichia coli and Klebsiella pneumoniae isolates from human beings and animals in several countries. The mcr-1 gene might be present in water environments, because aquatic ecosystems are recognized as reservoirs for antibiotic resistant bacteria (ARB) and ARGs. In this study, a qPCR assay was developed to monitor and quantify the mcr-1 gene in the Haihe River, China...
May 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28550595/clinical-pharmacokinetics-and-pharmacodynamics-of-colistin
#18
REVIEW
Nicolas Grégoire, Vincent Aranzana-Climent, Sophie Magréault, Sandrine Marchand, William Couet
In this review, we provide an updated summary on colistin pharmacokinetics and pharmacodynamics. Colistin is an old molecule that is frequently used as last-line treatment for infections caused by multidrug-resistant Gram-negative bacteria. Colistin is a decapeptide administered either as a prodrug, colistin methanesulfonate (CMS), when used intravenously, or as colistin sulfate when used orally. Because colistin binds to laboratory materials, many experimental issues are raised and studies on colistin can be tricky...
May 26, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28545990/retrospective-survey-of-mcr-1-and-mcr-2-in-german-pig-fattening-farms-2011-2012
#19
Nicole Roschanski, Linda Falgenhauer, Mirjam Grobbel, Sebastian Guenther, Lothar Kreienbrock, Can Imirzalioglu, Uwe Roesler
In November 2015, the first plasmid-encoded colistin resistance gene, mcr-1, was described in animals and in humans in China. Subsequently, a multitude of further studies was performed and quite recently the global spread of mcr-1 as well as the occurrence of a new gene variant, mcr-2, was reported. To obtain an overview of the occurrence of the colistin resistance genes mcr-1 and mcr-2 in German pig farms, a retrospective study, including 436 boot swab and pooled faeces samples collected from 58 pig-fattening farms throughout Germany, was performed...
May 22, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28541467/global-epidemiology-of-ctx-m-%C3%AE-lactamases-temporal-and-geographical-shifts-in-genotype
#20
Edward R Bevan, Annie M Jones, Peter M Hawkey
Globally, rates of ESBL-producing Enterobacteriaceae are rising. We undertook a literature review, and present the temporal trends in blaCTX-M epidemiology, showing that blaCTX-M-15 and blaCTX-M-14 have displaced other genotypes in many parts of the world. Explanations for these changes can be attributed to: (i) horizontal gene transfer (HGT) of plasmids; (ii) successful Escherichia coli clones; (iii) ESBLs in food animals; (iv) the natural environment; and (v) human migration and access to basic sanitation...
May 25, 2017: Journal of Antimicrobial Chemotherapy
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