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https://www.readbyqxmd.com/read/28223389/analysis-of-serial-isolates-of-mcr-1-positive-escherichia-coli-reveals-a-highly-active-isapl1-transposon
#1
Erik Snesrud, Ana C Ong, Brendan Corey, Yoon I Kwak, Robert Clifford, Todd Gleeson, Shannon Wood, Timothy J Whitman, Emil P Lesho, Mary Hinkle, Patrick Mc Gann
The emergence of the transferable colistin resistance gene mcr-1 is of global concern. The insertion sequence (IS) Apl1 is a key component in the mobilization of this gene, but its role remains poorly understood.Six Escherichia coli were cultured from the same patient over one month in Germany and the USA after a brief hospitalization in Bahrain for an unconnected illness. Four carried mcr-1 by real-time PCR, but two were negative. Two additional mcr-1-negative E. coli were collected during follow-up surveillance nine months later...
February 21, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28221105/zoonotic-transmission-of-mcr-1-colistin-resistance-gene-from-small-scale-poultry-farms-vietnam
#2
Nguyen Vinh Trung, Sébastien Matamoros, Juan J Carrique-Mas, Nguyen Huu Nghia, Nguyen Thi Nhung, Tran Thi Bich Chieu, Ho Huynh Mai, Willemien van Rooijen, James Campbell, Jaap A Wagenaar, Anita Hardon, Nguyen Thi Nhu Mai, Thai Quoc Hieu, Guy Thwaites, Menno D de Jong, Constance Schultsz, Ngo Thi Hoa
We investigated the consequences of colistin use in backyard chicken farms in Vietnam by examining the prevalence of mcr-1 in fecal samples from chickens and humans. Detection of mcr-1-carrying bacteria in chicken samples was associated with colistin use and detection in human samples with exposure to mcr-1-positive chickens.
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28217874/fabricating-triple-sensitive-polymer-nano-aggregates-via-an-aqueous-iminoboronate-multicomponent-reaction
#3
Yanning Liu, Guo Li, Jiangang Chen, Zhaotie Liu, Zhongwen Liu, Jinqiang Jiang
A triple-sensitive polymer of poly(ethylene glycol)-iminoboronate nitrobenzyl ethanediol chelate (PEG-INEC) is efficiently fabricated via the convenient aqueous iminoboronate multi-component reaction (MCR) of methoxypolyethylene glycol amine (mPEG-NH2 ), 2-formylphenylboronic acid (FPBA), and bis(2-nitrophenyl) ethanediol (BNPE, a photo-cleavable nitrobenzyl alcohol derivate). The aqueous MCR synthetic procedure is followed using (1) H NMR and turbidity analysis. It is shown that polymer nano-aggregates of PEG-INEC in aqueous solution can be dissociated through the stimuli responsive reactions of the hydrophobic iminoboronate nitrobenzyl ethanediol chelates (INECs) when exposed to UV light, acid, and H2 O2 , respectively...
February 20, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28208218/antibiotic-resistance-in-escherichia-coli-in-husbandry-animals-the-african-perspective
#4
REVIEW
Carla Andrea Alonso, Myriam Zarazaga, Rym Ben Sallem, Ahlem Jouini, Karim Ben Slama, Carmen Torres
In the last years different surveillances have been published in Africa, especially in Northern countries, regarding antimicrobial resistance among husbandry animals. Information is still scarce, but the available data shows a worrying picture. Although the highest resistance rates have been described against tetracycline, penicillins and sulphonamides, prevalence of plasmid mediated quinolone resistance genes and extended-spectrum β-lactamase (ESBL) are being increasingly reported. Among ESBLs, the CTX-M-1 group was dominant in most African surveys, being CTX-M-15 the main variant both in animals and humans, except in Tunisia where CTX-M-1 was more frequently detected among E...
February 16, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28193665/chicken-meat-as-reservoir-of-colistin-resistant-escherichia-coli-carrying-mcr-1-genes-in-south-america
#5
Daniel F M do Monte, Andressa Mem, Miriam R Fernandes, Louise Cerdeira, Fernanda Esposito, Julia A Galvão, Bernadette D G M Franco, Nilton Lincopan, Mariza Landgraf
The detection and rapid spread of colistin-resistant Enterobacteriaceae carrying the mcr-1 gene has created an urgent need to strengthen surveillance. In this study, eight clonally unrelated colistin-resistant Escherichia coli isolates carrying mcr-1, and blaCTX-M or blaCMY-2 genes, were isolated from commercial chicken meat in Brazil. Most E. coli carried IncX4 plasmids, previously identified in human and animal isolates. These results highlight a new reservoir of mcr-1-harboring E. coli in South America.
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28193662/prevalence-and-molecular-characterization-of-mcr-1-positive-salmonella-strains-recovered-from-clinical-specimens-in-china
#6
Mingquan Cui, Jinfei Zhang, Zhen Gu, Ruichao Li, Edward Wai-Chi Chan, Meiyin Yan, Xuebin Xu, Sheng Chen, Congming Wu
The recently discovered colistin resistance-encoding element, mcr-1, adds to the list of antimicrobial resistance genes that rapidly erodes the antimicrobial efficacy of not only the commonly used antibiotics, but also the last line agents of carbapenems and colistin. This study investigated the prevalence of the mobile colistin resistance determinant mcr-1 in Salmonella strains recovered from clinical settings in China, and the transmission potential of mcr-1-bearing mobile elements harbored by such isolates...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28192965/advantages-of-data-fusion-first-multivariate-curve-resolution-analysis-of-fused-liquid-chromatographic-second-order-data-with-dual-diode-array-fluorescent-detection
#7
Rocío B Pellegrino Vidal, Gabriela A Ibañez, Graciela M Escandar
For the first time, liquid chromatography-diode array detection (LC-DAD) and liquid-chromatography fluorescence detection (LC-FLD) second-order data, collected in a single chromatographic run, were fused and chemometrically processed for the quantitation of coeluting analytes. Two different experimental mixtures composed of fluorescent and nonfluorescent endocrine disruptors were analyzed. Adequate pretreatment of the matrices before their fusion was crucial to attain reliable results. Multivariate curve resolution-alternating least-squares (MCR-ALS) was applied to LC-DAD, LC-FLD, and fused LC-DAD-FLD data...
February 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28188703/the-effect-of-radiation-therapy-in-the-treatment-of-adult-soft-tissue-sarcomas-of-the-extremities-a-long-term-community-based-cancer-center-experience
#8
Jeffrey S Kneisl, Chad Ferguson, Myra Robinson, Anthony Crimaldi, Will Ahrens, James Symanowski, Michael Bates, Jennifer L Ersek, Michael Livingston, Joshua Patt, Edward S Kim
The aim of the study was to determine the effect of external beam radiotherapy (RT) in the treatment of extremity soft tissue sarcoma (STS) before or after limb-sparing surgery (LSS) in a community-based setting. Patients presenting to our institution from 1992 to 2010 and meeting eligibility criteria were stratified into low (G1) or high (G2, G3) pathologic grade and evaluated. Major complication events, including amputation, radiation-induced sarcoma, and pathologic fracture, were assessed. Kaplan-Meier techniques and Cox proportional hazards regression models were used...
February 11, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28165472/comprehensive-resistome-analysis-reveals-the-prevalence-of-ndm-and-mcr-1-in-chinese-poultry-production
#9
Yang Wang, Rongmin Zhang, Jiyun Li, Zuowei Wu, Wenjuan Yin, Stefan Schwarz, Jonathan M Tyrrell, Yongjun Zheng, Shaolin Wang, Zhangqi Shen, Zhihai Liu, Jianye Liu, Lei Lei, Mei Li, Qidi Zhang, Congming Wu, Qijing Zhang, Yongning Wu, Timothy R Walsh, Jianzhong Shen
By 2030, the global population will be 8.5 billion, placing pressure on international poultry production, of which China is a key producer(1). From April 2017, China will implement the withdrawal of colistin as a growth promoter, removing over 8,000 tonnes per year from the Chinese farming sector(2). To understand the impact of banning colistin and the epidemiology of multi-drug-resistant (MDR) Escherichia coli (using blaNDM and mcr-1 as marker genes), we sampled poultry, dogs, sewage, wild birds and flies...
February 6, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28161487/extended-spectrum-%C3%AE-lactamases-carbapenemases-and-the-mcr-1-gene-is-there-a-historical-link
#10
EDITORIAL
Mohamed Rhouma, Ann Letellier
The plasmid mediated mcr-1 gene encoding for Enterobacteriaceae colistin resistance has been recently identified across five continents. The objective of the present study was to trace historical events concerning the discovery and emergence of the mcr-1 gene along with ESBL and carbapenemase genes since several studies have reported identifying mcr-1 genes among Extended-Spectrum β-Lactamases (ESBL) and/or carbapenemase producing Escherichia coli. A retrospective study reported the identification of the mcr-1 gene in E...
February 1, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28139431/prevalence-risk-factors-outcomes-and-molecular-epidemiology-of-mcr-1-positive-enterobacteriaceae-in-patients-and-healthy-adults-from-china-an-epidemiological-and-clinical-study
#11
Yang Wang, Guo-Bao Tian, Rong Zhang, Yingbo Shen, Jonathan M Tyrrell, Xi Huang, Hongwei Zhou, Lei Lei, Hong-Yu Li, Yohei Doi, Ying Fang, Hongwei Ren, Lan-Lan Zhong, Zhangqi Shen, Kun-Jiao Zeng, Shaolin Wang, Jian-Hua Liu, Congming Wu, Timothy R Walsh, Jianzhong Shen
BACKGROUND: The mcr-1 gene confers transferable colistin resistance. mcr-1-positive Enterobacteriaceae (MCRPE) have attracted substantial medical, media, and political attention; however, so far studies have not addressed their clinical impact. Herein, we report the prevalence of MCRPE in human infections and carriage, clinical associations of mcr-1-positive Escherichia coli (MCRPEC) infection, and risk factors for MCRPEC carriage. METHODS: We undertook this study at two hospitals in Zhejiang and Guangdong, China...
January 27, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28139430/prevalence-of-mcr-1-in-escherichia-coli-and-klebsiella-pneumoniae-recovered-from-bloodstream-infections-in-china-a-multicentre-longitudinal-study
#12
Jingjing Quan, Xi Li, Yan Chen, Yan Jiang, Zhihui Zhou, Huichuan Zhang, Lu Sun, Zhi Ruan, Ye Feng, Murat Akova, Yunsong Yu
BACKGROUND: Polymyxin antibiotics are used as last-resort therapies to treat infections caused by multidrug-resistant Gram-negative bacteria. The plasmid-mediated colistin resistance determinant MCR-1 has been identified in Enterobacteriaceae in China. We did this study to investigate the prevalence of the mcr-1 gene in clinical isolates from patients with bloodstream infections in China. METHODS: Clinical isolates of Escherichia coli and Klebsiella pneumoniae were collected from patients with bloodstream infections at 28 hospitals in China, then screened for colistin resistance by broth microdilution and for the presence of the mcr-1 gene by PCR amplification...
January 27, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28137802/detection-of-the-mcr-1-gene-in-a-multidrug-resistant-escherichia-coli-isolate-from-an-austrian-patient
#13
Rainer Hartl, Heidrun Kerschner, Sarah Lepuschitz, Werner Ruppitsch, Franz Allerberger, Petra Apfalter
Since the first description of colistin resistance based on the plasmid encoded mcr-1 gene, the occurrence of this resistance gene in Enterobacteriaceae has been described in Europe and many other areas worldwide (1-3).….
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28137796/evaluation-of-a-lamp-based-assay-for-the-rapid-detection-of-plasmid-encoded-colistin-resistance-gene-mcr-1-in-enterobacteriaceae-isolates
#14
Can Imirzalioglu, Linda Falgenhauer, Judith Schmiedel, Said-Elias Waezsada, Konrad Gwozdzinski, Nicole Roschanski, Uwe Roesler, Lothar Kreienbrock, Arthur P Schiffmann, Alexandra Irrgang, Annemarie Käsbohrer, Rolf Bauerfeind, Eugen Domann, Trinad Chakraborty
Colistin, which belongs to the class of polypeptide antibiotics known as polymyxins, is a 'last-resort' antibiotic often used for treatment of patients infected with extensively multidrug-resistant (MDR) bacteria such as carbapenem-resistant Enterobacteriaceae….
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28134443/challenges-and-opportunities-for-whole-genome-sequencing-based-surveillance-of-antibiotic-resistance
#15
Anita C Schürch, Willem van Schaik
Infections caused by drug-resistant bacteria are increasingly reported across the planet, and drug-resistant bacteria are recognized to be a major threat to public health and modern medicine. In this review, we discuss how whole-genome sequencing (WGS)-based approaches can contribute to the surveillance of the emergence and spread of antibiotic resistance. We outline the characteristics of sequencing technologies that are currently most used for WGS (Illumina short-read technologies and the long-read sequencing platforms developed by Pacific Biosciences and Oxford Nanopore)...
January 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28122910/environmental-emission-of-multiresistant-escherichia-coli-carrying-the-colistin-resistance-gene-mcr-1-from-german-swine-farms
#16
Sebastian Guenther, Linda Falgenhauer, Torsten Semmler, Can Imirzalioglu, Trinad Chakraborty, Uwe Roesler, Nicole Roschanski
OBJECTIVES: Pigs have been the focus of the worldwide spread of colistin resistance. However, there is little information on the transmission of mcr-1-containing bacteria into the environment of pig farms. We therefore rescreened environmental Escherichia coli isolates from the surrounding farm areas of three previously mcr-1-positive swine herds in Germany. METHODS: Thirty-five mixed bacterial cultures obtained from boot swabs, flies, dog faeces and manure from three pig farms in Germany in 2011-12 were non-selectively recultivated and the presence of the mcr-1 gene was checked by real-time PCR...
January 25, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28122677/colistin-and-carbapenem-resistant-klebsiella-oxytoca-harboring-blavim-2-and-an-insertion-in-the-mgrb-gene-isolated-from-blood-culture
#17
Michaela Simon, Holger Melzl, Andreas Hiergeist, Katharina Richert, Linda Falgenhauer, Yvonne Pfeifer, Roman G Gerlach, Kornelius Fuchs, Udo Reischl, André Gessner, Jonathan Jantsch
A carbapenemase-producing colistin-resistant Klebsiella oxytoca isolate was recovered from a blood culture of a female patient without previous report of risk factors to obtain multidrug-resistant Gram-negative bacilli. A combination of biochemical and molecular methods was used to identify the resistance mechanism of this isolate. Carbapenemase production was mediated by Verona integron-encoded metallo-β-lactamase (VIM)-2. Colistin resistance was not due to plasmid- borne mcr-1 gene, but we found an integration of IS5-like sequence in the mgrB gene of K...
January 18, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28119531/changes-in-glycemia-insulin-and-gut-hormone-responses-to-a-slowly-ingested-solid-low-carbohydrate-mixed-meal-after-laparoscopic-gastric-bypass-or-band-surgery
#18
J C Bunt, R Blackstone, M S Thearle, K L Vinales, S Votruba, J Krakoff
OBJECTIVE: To evaluate early changes in glycemia, insulin physiology and gut hormone responses to an easily tolerated and slowly ingested solid, low-carbohydrate mixed meal (MMT) following adjustable gastric banding (LAGB) or Roux-en-Y gastric bypass (RYGB) surgery. SUBJECTS/METHODS: This was a prospective non-randomized study. Plasma glucose, insulin and c-peptide (to estimate hepatic insulin extraction; %HIE), incretins (GIP, aGLP-1) and pancreatic polypeptide (PP) responses to the MMT were measured at 4-8 weeks before and after surgery in obese, metabolically healthy patients (RYGB=10F or LAGB=7F/1M)...
January 25, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28115344/occurrence-of-blakpc-2-blactx-m-and-mcr-1-in-enterobacteriaceae-from-well-water-in-rural-china
#19
Pan Sun, Zhenwang Bi, Maud Nilsson, Beiwen Zheng, Björn Berglund, Cecilia Stålsby Lundborg, Stefan Börjesson, Xuewen Li, Baoli Chen, Hong Yin, Lennart E Nilsson
We report on co-existence of mcr-1 and blaCTX-M in multidrug-resistant ESBL-producing E. coli belonging to the ST10 complex, isolated from well water in rural China. Raoultella ornithinolytica with blaKPC-2 was also detected in the well water from the same area. This study shows that genes coding for resistance to last resort antibiotics are present in wells in rural China, indicating a potential source for antibiotic resistance.
January 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28098547/mcr-1-harboring-salmonella-enterica-serovar-typhimurium-sequence-type-34-in-pigs-china
#20
Linxian Yi, Jing Wang, Yanling Gao, Yiyun Liu, Yohei Doi, Renjie Wu, Zhenling Zeng, Zisen Liang, Jian-Hua Liu
We detected the mcr-1 gene in 21 (14.8%) Salmonella isolates from pigs at slaughter; 19 were serovar Typhimurium sequence type 34. The gene was located on IncHI2-like plasmids that also harbored IncF replicons and lacked a conjugative transfer region. These findings highlight the need to prevent further spread of colistin resistance in animals and humans.
February 2017: Emerging Infectious Diseases
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