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https://www.readbyqxmd.com/read/28323123/circumventing-intratumoral-heterogeneity-to-identify-potential-therapeutic-targets-in-hepatocellular-carcinoma
#1
Ao Huang, Xin Zhao, Xin-Rong Yang, Fu-Qiang Li, Xin-Lan Zhou, Kui Wu, Xin Zhang, Qi-Man Sun, Ya Cao, Hong-Mei Zhu, Xiang-Dong Wang, Huan-Ming Yang, Jian Wang, Zhao-You Tang, Yong Hou, Jia Fan, Jian Zhou
BACKGROUND AND AIMS: Intratumoral heterogeneity (ITH) challenges identifying mutations with target therapy potential whereas circulating cell-free DNAs (cfDNAs) in blood could possibly reflect the entire mutation spectrum in certain tumors. We investigated how to minimize the limit of ITH for profiling hepatocellular carcinoma (HCC). METHODS: Thirty-two multi-regional tumor samples from five patients were subjected to whole exome sequencing (WES) and targeted deep sequencing (TDS); matched preoperative cfDNAs were sequenced accordingly...
March 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28321680/environmental-effects-of-crude-oil-spill-on-the-physicochemical-and-hydrobiological-characteristics-of-the-nun-river-niger-delta
#2
Augustine O Ifelebuegu, Justina E Ukpebor, Anita U Ahukannah, Ernest O Nnadi, Stephen C Theophilus
Oil spill pollution has remained a source of several international litigations in the Niger Delta region of Nigeria. In this paper, we examined the impacts of small recurrent crude oil spills on the physicochemical, microbial and hydrobiological properties of the Nun River, a primary source of drinking water, food and recreational activities for communities in the region. Samples were collected from six sampling points along the stretch of the lower Nun River over a 3-week period. Temperature, pH salinity, turbidity, total suspended solids, total dissolved solids, dissolved oxygen, phosphate, nitrate, heavy metals, BTEX, PAHs and microbial and plankton contents were assessed to ascertain the quality and level of deterioration of the river...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28318076/uk-policy-statements-on-testosterone-deficiency
#3
Geoffrey Hackett, Michael Kirby, David Edwards, T Hugh Jones, Jonathan Rees, Asif Muneer
To address widespread media and scientific concerns over the appropriate treatment of TDS with Testosterone Therapy (T Therapy), the Executive Committee of the British Society for Sexual Medicine developed eight consensus statements, based on current scientific evidence to address these controversial issues. These statements were in no-way designed to replace the published evidence-based guidelines on the subject developed by various professional organisations, but to provide specific answers to several current controversial issues...
March 20, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28292717/test-retest-reproducibility-of-quantitative-binding-measures-of-11-c-ro15-4513-a-pet-ligand-for-gabaa-receptors-containing-alpha5-subunits
#4
Colm J McGinnity, Daniela A Riaño Barros, Lula Rosso, Mattia Veronese, Gaia Rizzo, Alessandra Bertoldo, Rainer Hinz, Federico E Turkheimer, Matthias J Koepp, Alexander Hammers
INTRODUCTION: Alteration of γ-aminobutyric acid "A" (GABAA) receptor-mediated neurotransmission has been associated with various neurological and psychiatric disorders. [(11)C]Ro15-4513 is a PET ligand with high affinity for α5-subunit-containing GABAA receptors, which are highly expressed in limbic regions of the human brain (Sur et al., 1998). We quantified the test-retest reproducibility of measures of [(11)C]Ro15-4513 binding derived from six different quantification methods (12 variants)...
March 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28290300/identification-of-drivers-of-dis-liking-based-on-dynamic-sensory-profiles-comparison-of-temporal-dominance-of-sensations-and-temporal-check-all-that-apply
#5
Gastón Ares, Florencia Alcaire, Lucía Antúnez, Leticia Vidal, Ana Giménez, John C Castura
Temporal Dominance of Sensations (TDS) and Temporal Check-all-that-apply (TCATA) are two multi-attribute methods for dynamic sensory characterization. Previous research has shown that both methodologies provide complementary information. However, it remains an open question which of the two approaches better explains consumers' hedonic perception of products. In this context, the aim of the present work was to compare TDS and TCATA in terms of their ability to identify the influence of the dynamic sensory profile of food products on consumer overall liking scores...
February 2017: Food Research International
https://www.readbyqxmd.com/read/28285400/how-does-environmental-variation-affect-the-distribution-of-dragonfly-larvae-odonata-in-the-amazon-cerrado-transition-zone-in-central-brazil
#6
T P Mendes, A Luiza-Andrade, H S R Cabette, L Juen
This study investigated the effects of environmental variation on assemblages of dragonfly larvae (Odonata). We hypothesize that there is a significant correlation between species richness, species composition, and abundance of Odonata individuals, and habitat integrity and abiotic variables. To test this hypothesis, we sampled odonate larvae at 12 streams in the Suiá-Miçú River basin in Mato Grosso, Brazil, during three different periods of the year. Local physical and chemical variables (temperature, pH, turbidity, electrical conductivity (EC), dissolved oxygen (DO), total dissolved solids (TDS), and oxidation reduction potential (ORP)) were measured at each site using a multi-parameter probe, and integrity was assessed using the Habitat Integrity Index (HII)...
March 11, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28284001/assessing-impact-of-effluent-discharge-on-irrigation-water-quality-in-southern-region-of-khyber-pakhtunkhwa-pakistan
#7
Shabnam Zafar, Azim Khan, Hidayat Ullah, Muhammad Sohail Khan, Ilham Khan, Asma Hameed, Shafeeq Ur Rehman, Ghazala Yasmeen
Chemical quality and extent of pollution in effluent-contaminated irrigation water collected from two sectors (X and Y) of peri-urban southern regions of Khyber Pakhtunkhwa, Pakistan, were investigated. Various physico-chemical parameters like pH, EC, TS, TSS, TDS, TH, cations (Na(1+), K(1+), Li(1+), Ca(2+), Mg(2+)), anions (Cl(1-), F(1-), HCO3(1-), NO3(1-), SO4(2-)), and heavy metals (Cr, Fe, Cu, Zn, Pb, Cd) were determined. The data indicated wide ranges of variation in all the parameters. Concentration of physico-chemical properties such as EC, TS, TSS, TH, Li(1+), Ca(2+), Mg(2+), and HCO3(1-) and heavy metals (Cr, Fe, Cu, and Cd) exceeded WHO permissible limits...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28278781/phytoremediation-potential-of-water-caltrop-trapa-natans-l-using-municipal-wastewater-of-the-activated-sludge-process-based-municipal-wastewater-treatment-plant
#8
Vinod Kumar, A K Chopra
Phytoremediation experiments were carried out to assess the phytoremediation potential of water caltrop (Trapa natans L.) using municipal wastewater collected from the activated sludge process- (ASP) based municipal wastewater treatment plant. The results revealed that T. natans significantly (P ≤ .05/P ≤ .01/P ≤ .001) reduced the contents of total dissolved solids (TDS), electrical conductivity (EC), biochemical oxygen demand (BOD5), chemical oxygen demand, total Kjeldahl nitrogen, phosphate ([Formula: see text]), sodium (Na(+)), potassium (K(+)), calcium (Ca(2+)), magnesium (Mg(2+)), cadmium (Cd), chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), lead (Pb), zinc (Zn), standard plate count, and most probable number of the municipal wastewater after phytoremediation experiments...
February 22, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28273628/terahertz-spectra-of-dna-nucleobase-crystals-a-joint-experimental-and-computational-study
#9
Fang Wang, Dongbo Zhao, Hao Dong, Ling Jiang, Yunfei Liu, Shuhua Li
Terahertz (THz) spectra of DNA nucleobase crystals were experimentally studied by terahertz time domain spectroscopy (THz-TDS), Fourier transform infrared spectroscopy (FTIR), and computationally studied by the generalized energy-based fragmentation approach under periodic boundary conditions (denoted as PBC-GEBF). We analyzed the vibrational spectra of solid-state DNA nucleobases and assigned the corresponding vibrational modes to the main peaks in the experimental spectra with the PBC-GEBF results. The computational results were verified to be in good accordance with the experimental data...
February 21, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28273593/introducing-a-water-quality-index-for-assessing-water-for-irrigation-purposes-a-case-study-of-the-ghezel-ozan-river
#10
Farhad Misaghi, Fatemeh Delgosha, Mostafa Razzaghmanesh, Baden Myers
Rivers are one of the main water resources for agricultural, drinking, environmental and industrial use. Water quality indices can and have been used to identify threats to water quality along a stream and contribute to better water resources management. There are many water quality indices for the assessment and use of surface water for drinking purposes. However, there is no well-established index for the assessment and direct use of river water for irrigation purposes. The aim of this study was to adopt the framework of the National Sanitation Foundation Water Quality Index (NSFWQI) and, with adjustments, apply it in a way which will conform to irrigation water quality requirements...
March 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28267446/characterisation-of-the-pore-structure-of-functionalised-calcium-carbonate-tablets-by-terahertz-time-domain-spectroscopy-and-x-ray-computed-microtomography
#11
Daniel Markl, Parry Wang, Cathy Ridgway, Anssi-Pekka Karttunen, Mousumi Chakraborty, Prince Bawuah, Pertti Pääkkönen, Patrick Gane, Jarkko Ketolainen, Kai Peiponen, J Axel Zeitler
Novel excipients are entering the market to enhance the bioavailability of drug particles by having a high porosity and thus providing a rapid liquid uptake and disintegration to accelerate subsequent drug dissolution. One example of such a novel excipient is functionalised calcium carbonate (FCC), which enables the manufacture of compacts with a bimodal pore size distribution consisting of larger inter-particle and fine intra-particle pores. Five sets of FCC tablets with a target porosity of 45% to 65% were prepared in 5% steps and characterised using terahertz time-domain spectroscopy (THz-TDS) and X- ray computed microtomography (XμCT)...
March 3, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28260277/comparison-of-efficacy-and-tolerability-of-pharmacological-treatment-for-the-overactive-bladder-in-women-a-network-meta-analysis
#12
Sivalingam Nalliah, Pou Wg, Premjit K Masten Singh, Piravin Naidu, Vivian Lim, Arshad Asa Ahamed
BACKGROUND: Overactive bladder syndrome (OAB) is a common medical condition that causes significant distress and impact on the quality of life in women. Muscarinic receptor antagonists remain the mainstay of therapy, but they are limited by their efficacy and adverse effects. The objective of the article was to compare the clinical efficacy and tolerability of medications used to treat OAB in women through network meta-analysis. METHODS: Data from eligible studies of commonly prescribed pharmacological agents in the treatment of OAB in women were entered into Net-MetaXL after a literature search using two online databases (PubMed and Cochrane)...
March 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28244697/total-diet-score-as-a-valid-method-of-measuring-diet-quality-among-older-adults
#13
Joanna C Russell, Victoria M Flood, Ali Sadeghpour, Bamini Gopinath, Paul Mitchell
BACKGROUND AND OBJECTIVES: This study aimed to determine the accuracy of a diet quality measurement tool, the Total Diet Score (TDS) using two validation methods; firstly the TDS calculated from a food frequency questionnaire (FFQ) was compared to the TDS calculated from weighed food records (WFRs); secondly the TDS was compared to a number of dietary biomarkers. METHODS AND STUDY DESIGN: Data were collected from a population based cohort study located in the Blue Mountains region of Sydney, Australia...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28243622/data-on-secondary-structures-and-ligand-interactions-of-g-rich-oligonucleotides-that-defy-the-classical-formula-for-g4-motifs
#14
Maria Vlasenok, Anna Varizhuk, Dmitry Kaluzhny, Igor Smirnov, Galina Pozmogova
The data provided in this article are related to the research article "The expanding repertoire of G4 DNA structures" [1]. Secondary structures of G-rich oligonucleotides (ONs) that represent "imperfect" G-quadruplex (G4) motifs, i.e., contain truncated or interrupted G-runs, were analyzed by optical methods. Presented data on ON structures include circular dichroism (CD) spectra, thermal difference spectra (TDS) and UV -melting curves of the ONs; and rotational relaxation times (RRT) of ethidium bromide (EtBr) complexes with the ONs...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28241652/flexibility-and-non-destructive-conductivity-measurements-of-ag-nanowire-based-transparent-conductive-films-via-terahertz-time-domain-spectroscopy
#15
Gyujeong Hwang, Soner Balci, M Zeki Güngördü, Alex Maleski, Joseph Waters, Sunjong Lee, Sangjun Choi, Kyoungkook Kim, Soohaeng Cho, Seongsin M Kim
Highly stable and flexible transparent electrodes are fabricated based on silver nanowires (AgNWs) on both polyethylene-terephthalate (PET) and polyimide (PI) substrates. Terahertz time domain spectroscopy (THz-TDS) was utilized to probe AgNW films while bended with a radius 5 mm to discover conductivity of bended films which was further analyzed through Drude-Smith model. AgNW films experience little degradation in conductivity (<3%) before, after, and during 1000 bending cycles. Highly stable AgNW flexible electrodes have broad applications in flexible optoelectronic and electronic devices...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28231602/observational-case-series-evaluation-of-the-granisetron-transdermal-patch-system-sancuso-for-the-management-of-nausea-vomiting-of-pregnancy
#16
Tran N Le, Michael T Adler, Holly Ouillette, Pamela Berens, Judith A Smith
Objective The objective of this study was to observe the efficacy of antiemetic therapy (no emesis/retching episodes and no rescue medication use) when granisetron is administered via a transdermal patch system (TDS) in women who are 6 to 14 weeks pregnant when compared with oral ondansetron by evaluating the frequency of the use of rescue medications for control of nausea/vomiting of pregnancy (NVP). Methods This was an observational case series study to observe the potential benefits of granisetron TDS compared with oral ondansetron for management of NVP in pregnant patients during the first trimester...
February 23, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28229807/using-psychoeducation-and-role-induction-to-improve-completion-rates-in-cognitive-behavioural-therapy
#17
Jaime Delgadillo, Martin Groom
BACKGROUND: Pre-treatment role induction interventions have been suggested to potentially enhance attendance and clinical outcomes in psychotherapy. AIMS: This study aimed to evaluate the effects of a programme of three transdiagnostic seminars (TDS) for patients with common mental disorders accessing cognitive behavioural therapy (CBT) in primary care. TDS included CBT psychoeducation and role induction. METHOD: A random sample of patients (n = 49) participated in TDS followed by CBT (TDS+CBT) and they were compared with matched controls (n = 49) accessing usual CBT...
March 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28222406/leydig-cell-clustering-and-reinke-crystal-distribution-in-relation-to-hormonal-function-in-adult-patients-with-testicular-dysgenesis-syndrome-tds-including-cryptorchidism
#18
Rikke R Soerensen, Trine H Johannsen, Niels E Skakkebaek, Ewa Rajpert-De Meyts
OBJECTIVE: Testicular dysgenesis syndrome (TDS) comprises testicular germ cell cancer, cryptorchidism and some cases of male infertility and hypospadias, which can be linked to impairment of intrauterine gonadal development. Among histological signs of TDS, large Leydig cell (LC) clusters (micronodules) are frequently present. This study aimed to investigate possible associations of LC micronodules with the presence of Reinke crystals and hormonal function of LCs, the latter primarily reflected by serum concentrations of luteinising hormone (LH) and testosterone, in patients with TDS...
October 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28220444/spatial-assessment-of-water-quality-parameters-in-jhelum-city-pakistan
#19
Sadaf Javed, Asad Ali, Saleem Ullah
In this study, we assess the drinking water quality of Jhelum city. Two hundred and ninety-two drinking water samples were randomly collected in the study area. These samples were chemically analyzed for three key toxic (in excess) elements such as pH, total dissolved solids (TDS), and calcium. Geostatistical techniques such as variogram and kriging were used to investigate the spatial variations of these minerals across the city. The spatial structure for each element was found to be anisotropic, and thus, anisotropic variograms were used...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28214708/evaluating-the-role-of-smokeless-tobacco-use-indices-as-brief-measures-of-dependence
#20
Nasir Mushtaq, Laura A Beebe
INTRODUCTION: There is considerable interest in using brief measures of dependence for evaluation and treatment of tobacco dependence. The Heaviness of Smoking Index (HSI) is a validated measure of dependence among cigarette smokers. However, a similar index has not been studied among ST users. The aim of this study is to develop similar ST use indices and evaluate their utility as concise dependence measures. Time to first chew/dip of the day (TTFD), number of cans of ST used per week (CPW), and number of dips/chews per day (DPD) were used to create three ST use indices; heaviness of ST use index (HSTI), ST dependence index (STDI), and ST quantity frequency index (ST-QFI)...
February 10, 2017: Addictive Behaviors
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