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Interferon-gamma Release Assays in children's

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https://www.readbyqxmd.com/read/29140946/comparison-of-the-quantiferon-tb-gold-in-tube-assay-with-tuberculin-skin-test-for-the-diagnosis-of-latent-tuberculosis-infection-among-hiv-infected-and-uninfected-children
#1
Walter Dehority, Rolando M Viani, Maria Rosario G Araneta, Graciano Lopez, Stephen A Spector
BACKGROUND: Diagnosis of latent tuberculosis infection (LTBI) is facilitated by tuberculin skin testing (TST) or interferon-gamma release assays such as the QuantiFERON TB Gold In-Tube (QTF-GIT) assays. Limited data exist on the utility of interferon-gamma release assays in HIV-infected children, which may be falsely negative due to immunosuppression. METHODS: A cross-sectional study comparing TST to QTF-GIT for the diagnosis of suspected LTBI was performed in children in Tijuana, Mexico, and in San Diego, California...
December 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29122311/-uveitis-diagnostic-work-up-recommendations-from-an-expert-committee
#2
P Sève, B Bodaghi, S Trad, J Sellam, D Bellocq, P Bielefeld, D Sène, G Kaplanski, D Monnet, A Brézin, M Weber, D Saadoun, P Cacoub, C Chiquet, L Kodjikian
INTRODUCTION: Diagnostic work-up of uveitis involves many uncertainties. Search for an etiology should take into account the epidemiology of uveitis and focus on the most severe diseases or those, which can be treated. This work was undertaken to establish recommendations for the diagnosis work-up of uveitis. METHODS: Recommendations were developed by a multidisciplinary panel of 15 experts, including internists, ophthalmologists and a rheumatologist and are based on a review of the literature with regard to effectiveness of investigations and the results of the ULISSE study, which is the first prospective study assessing the efficiency of a standardized strategy for the etiological diagnosis of uveitis...
November 6, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29037906/uveitis-diagnostic-work-up-a-literature-review-and-recommendations-from-an-expert-committee
#3
REVIEW
Pascal Sève, Patrice Cacoub, Bahram Bodaghi, Salim Trad, Jérémie Sellam, David Bellocq, Philip Bielefeld, Damien Sène, Gilles Kaplanski, Dominique Monnet, Antoine Brézin, Michel Weber, David Saadoun, Christophe Chiquet, Laurent Kodjikian
PURPOSE: Diagnosis of uveitis is difficult. Etiologic investigations should take into account the epidemiology of uveitis and should focus on the most severe forms of the disease and those which can be treated. This study was undertaken to establish recommendations for the diagnosis of uveitis. METHODS: Recommendations were developed by a multidisciplinary panel of 14 experts, including internists, ophthalmologists, and rheumatologists, and are based on a review of the literature and the results of the ULISSE study, which was the first prospective study to assess the efficacy of a standardized strategy for the etiologic diagnosis of uveitis...
October 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28840843/interferon-gamma-release-assay-in-response-to-pe35-ppe68-proteins-a-promising-diagnostic-method-for-diagnosis-of-latent-tuberculosis
#4
Shima Mahmoudi, Babak Pourakbari, Setareh Mamishi
Tuberculosis control relies on the identification and preventive treatment of people who are latently infected with Mycobacterium tuberculosis (Mtb). PE/PPE proteins have been reported to elicit CD4 and/or CD8 responses either in the form of whole recombinant proteins or as individual peptides. Very few of the PE and PPE proteins have been previously tested for responses in patients with TB and healthy donors. This is the first study to evaluate the Interferon Gamma Release Assay (IGRA) after stimulation with PE35 and PPE68...
March 1, 2017: European Cytokine Network
https://www.readbyqxmd.com/read/28754530/tuberculosis-in-children-from-diagnosis-to-decision-to-treat
#5
S Ramos, R Gaio, F Ferreira, J Paulo Leal, S Martins, J Vasco Santos, I Carvalho, R Duarte
SETTING: Confirmation of tuberculosis (TB) in children is difficult, so clinicians use different procedures when deciding to treat. OBJECTIVE: Identify criteria to initiate and maintain TB treatment in children younger than 5 years-old, without diagnosis confirmation. DESIGN: A web-based survey was distributed by email to the corresponding authors of journal articles on childhood TB. The observations were clustered into disjoint groups, and analyzed by Ward's method...
July 25, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28722570/mycobacterium-tuberculosis-infection-in-close-childhood-contacts-of-adults-with-pulmonary-tuberculosis-is-increased-by-secondhand-exposure-to-tobacco
#6
COMPARATIVE STUDY
Ifedayo M O Adetifa, Lindsay Kendall, Simon Donkor, Moses D Lugos, Abdulrahman S Hammond, Patrick K Owiafe, Martin O C Ota, Roger H Brookes, Philip C Hill
Tobacco use is a major risk factor for tuberculosis (TB). Secondhand smoke (SHS) is also a risk factor for TB and to a lesser extent, Mycobacterium tuberculosis infection without disease. We investigated the added risk of M. tuberculosis infection due to SHS exposure in childhood contacts of TB cases in The Gambia. Participants were childhood household contacts aged ≤ 14 years of newly diagnosed pulmonary TB (PTB) cases. The intensity of exposure to the case was categorized according to whether contacts slept in the same room, same house, or a different house as the case...
August 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28284256/novel-interferon-gamma-assays-for-diagnosing-tuberculosis-in-young-children-in-india
#7
N Shaikh, A Gupte, S Dharmshale, S Pokkali, M Thakar, V J Upadhye, A A Ordonez, A Kinikar, N Gupte, V Mave, A Kagal, A Gupta, A Lalvani, R Paranjpe, R Bharadwaj, S K Jain
SETTING: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. DESIGN: Children (age 5 years) with suspected TB were prospectively screened at a tertiary hospital in Pune, India; the children underwent TST, and standard (early secretory antigenic target 6 and culture filtrate protein 10) and enhanced (five additional novel antigens) enzyme-linked immunospot (ELISpot) assays...
April 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28274215/comparing-interferon-gamma-release-assays-with-tuberculin-skin-test-for-identifying-latent-tuberculosis-infection-that-progresses-to-active-tuberculosis-systematic-review-and-meta-analysis
#8
REVIEW
Peter Auguste, Alexander Tsertsvadze, Joshua Pink, Rachel Court, Noel McCarthy, Paul Sutcliffe, Aileen Clarke
BACKGROUND: Timely and accurate identification of people with latent tuberculosis infection (LTBI) is important for controlling Mycobacterium tuberculosis (TB). There is no gold standard for diagnosis of LTBI. Screening tests such as interferon gamma release assays (IGRAs) and tuberculin skin test (TST) provide indirect and imperfect information. This systematic review compared two types of IGRAs QuantiFERON®-TB Gold In-Tube test (QFT-GIT) and T-SPOT.TB with TST for identification of LTBI by predicting progression to a diagnosis of active TB in three subgroups: children, immunocompromised people, and those recently arrived from countries with high TB burden...
March 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28225337/multiple-cytokines-for-the-detection-of-mycobacterium-tuberculosis-infection-in-children-with-tuberculosis
#9
N Nausch, C Lundtoft, G Schulz, H Henckel, E Mayatepek, B Fleischer, F M Marx, M Jacobsen
SETTING: Interferon-gamma (IFN-γ) release assays (IGRAs) play an important role in the diagnosis of Mycobacterium tuberculosis infection. However, in children with tuberculosis (TB), some studies have shown increased frequencies of false-negative or indeterminate IGRA results. OBJECTIVE: To analyse the spectrum of different cytokines to improve the diagnostic accuracy of IGRAs in latent tuberculous infection (LTBI) and active TB. DESIGN: We performed multiplex cytokine expression analysis of QuantiFERON® Gold In-Tube supernatants in children with active TB (n = 21) and disease-free contacts with (n = 15) and without LTBI (n = 12), to determine the sensitivity and specificity of the modified tests...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28074660/optimizing-the-management-of-children-with-latent-tuberculosis-infection
#10
REVIEW
E Venturini, C Tersigni, E Chiappini, M de Martino, L Galli
The management of latent tuberculosis (LTBI) in children represents an important issue for paediatricians because of the disease burden, the lack of a gold standard for the diagnosis and the high annual risk of progression to active disease. Areas covered: A review of English language articles on LTBI in children, published between the 1st of January 2010 and the 1st of July 2016, was conducted using multiple keywords and standardized terminology in PubMed database. This review provides an updated overview of the available tests for LTBI diagnosis in children, management strategies and treatment options...
April 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28000584/utility-of-the-quantiferon%C3%A2-tb-gold-in-tube-assay-for-the-diagnosis-of-tuberculosis-in-moroccan-children
#11
S El Azbaoui, A Sabri, S Ouraini, A Hassani, A Asermouh, A Agadr, R Abilkassem, N Dini, M Kmari, A Akhaddar, Z Laktati, S Aieche, N El Hafidi, F Ben Brahim, A A Bousfiha, F Ailal, C Deswarte, E Schurr, L Amar, J Bustamante, S Boisson-Dupuis, J L Casanova, L Abel, J El Baghdadi
SETTING: The utility of interferon-gamma release assays (IGRAs), such as the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test, in diagnosing active tuberculosis (TB) in children is unclear and depends on the epidemiological setting. OBJECTIVE: To evaluate the performance of QFT-GIT for TB diagnosis in children living in Morocco, an intermediate TB incidence country with high bacille Calmette-Guérin vaccination coverage. DESIGN: We prospectively recruited 109 Moroccan children hospitalised for clinically suspected TB, all of whom were tested using QFT-GIT...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931340/utility-of-the-quantiferon-tb-gold-in-tube-assay-for-the-diagnosis-of-tuberculosis-in-moroccan-children
#12
S El Azbaoui, A Sabri, S Ouraini, A Hassani, A Asermouh, A Agadr, R Abilkassem, N Dini, M Kmari, A Akhaddar, Z Laktati, S Aieche, N El Hafidi, F Ben Brahim, A A Bousfiha, F Ailal, C Deswarte, E Schurr, L Amar, J Bustamante, S Boisson-Dupuis, J L Casanova, L Abel, J El Baghdadi
SETTING: The utility of interferon-gamma release assays (IGRAs), such as the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in diagnosing active tuberculosis (TB) in children is unclear and depends on the epidemiological setting. OBJECTIVE: To evaluate the performance of QFT-GIT for TB diagnosis in children living in Morocco, an intermediate TB incidence country with high bacille Calmette-Gurin vaccination coverage. DESIGN: We prospectively recruited 109 Moroccan children hospitalised for clinically suspected TB, all of whom were tested using QFT-GIT...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27776586/controversies-in-tuberculous-infection-among-pediatric-infectious-disease-specialists-in-north-america
#13
A T Cruz, A L Hersh, J R Starke, S E Beekmann, P M Polgreen, R Banerjee
OBJECTIVE: To evaluate the extent to which advancements in the diagnosis and treatment of latent tuberculous infection (LTBI) have been integrated into practice by pediatric infectious disease (PID) specialists. DESIGN: We conducted an online survey of the Infectious Diseases Society of America's Emerging Infections Network (EIN) membership. RESULTS: Of the 323 members, 197 (61%) responded: 7% cared for ⩾5 children with TB disease and 34% for ⩾5 children with LTBI annually...
November 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27753763/pediatric-extrapulmonary-tuberculosis-clinical-spectrum-risk-factors-and-diagnostic-challenges-in-a-low-prevalence-region
#14
Begoña Santiago-García, Daniel Blázquez-Gamero, Fernando Baquero-Artigao, Jesús Ruíz-Contreras, Jose M Bellón, Maria A Muñoz-Fernández, María J Mellado-Peña
BACKGROUND: Children are at higher risk of tuberculosis (TB) dissemination and extrapulmonary disease, contributing greatly to TB-associated morbidity and long-term sequelae. However, there are very few studies that assess the impact and clinical spectrum of pediatric extrapulmonary TB (EPTB) in low-prevalence regions. METHODS: Children <18 years of age diagnosed with TB in Madrid region (2005-2013) were reviewed. We compared the epidemiology, clinical characteristics and the performance of diagnostic tests in childhood extrapulmonary and pulmonary disease...
November 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27725037/european-shortage-of-purified-protein-derivative-and-its-impact-on-tuberculosis-screening-practices
#15
M Tebruegge, D Buonsenso, F Brinkmann, A Noguera-Julian, I Pavić, A Sorete Arbore, Z Vančíková, S Velizarova, S B Welch, N Ritz
SETTING: In June 2014, we became aware that shortages of purified protein derivative (PPD), the test substance used for the tuberculin skin test (TST), had occurred in several European health care institutions providing care for children with tuberculosis (TB). OBJECTIVE: To establish the extent of the shortage, a survey was performed. DESIGN: Survey conducted over a 1-month period (June-July 2014) among members of the Paediatric Tuberculosis Network European Trials Group (ptbnet)...
October 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27716176/relation-between-bcg-vaccine-scar-and-an-interferon-gamma-release-assay-in-immigrant-children-with-positive-tuberculin-skin-test-%C3%A2-10%C3%A2-mm
#16
Margret Johansson Gudjónsdóttir, Karsten Kötz, Ruth Stangebye Nielsen, Philip Wilmar, Sofia Olausson, Daniel Wallmyr, Birger Trollfors
BACKGROUND: Immigrants from countries with high incidence of tuberculosis (TB) are usually offered screening when they arrive to low incidence countries. The tuberculin skin test (TST) is often used. The interferon gamma release assays (IGRAs) are more specific and not affected by BCG vaccination. The aims of this study were 1. To see if there if there is a correlation between a positive IGRA (QFT) and presence of a BCG scar in children with TST ≥10 mm, 2. To compare the TST diameter with QFT result, 3...
October 6, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27416010/interferon-gamma-release-assays-should-not-replace-tuberculin-skin-tests-in-screening-programs-for-children
#17
Marc Tebruegge, Vanessa Clifford, Nigel Curtis
No abstract text is available yet for this article.
August 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27220068/accurate-diagnosis-of-latent-tuberculosis-in-children-people-who-are-immunocompromised-or-at-risk-from-immunosuppression-and-recent-arrivals-from-countries-with-a-high-incidence-of-tuberculosis-systematic-review-and-economic-evaluation
#18
Peter Auguste, Alexander Tsertsvadze, Joshua Pink, Rachel Court, Farah Seedat, Tara Gurung, Karoline Freeman, Sian Taylor-Phillips, Clare Walker, Jason Madan, Ngianga-Bakwin Kandala, Aileen Clarke, Paul Sutcliffe
BACKGROUND: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) [(Zopf 1883) Lehmann and Neumann 1896], is a major cause of morbidity and mortality. Nearly one-third of the world's population is infected with MTB; TB has an annual incidence of 9 million new cases and each year causes 2 million deaths worldwide. OBJECTIVES: To investigate the clinical effectiveness and cost-effectiveness of screening tests [interferon-gamma release assays (IGRAs) and tuberculin skin tests (TSTs)] in latent tuberculosis infection (LTBI) diagnosis to support National Institute for Health and Care Excellence (NICE) guideline development for three population groups: children, immunocompromised people and those who have recently arrived in the UK from high-incidence countries...
May 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27199468/interferon-gamma-release-assays-and-pediatric-public-health-tuberculosis-screening-the-san-francisco-program-experience-2005-to-2008
#19
Jennifer A Grinsdale, Shamim Islam, Olivia Chang Tran, Christine S Ho, L Masae Kawamura, Julie M Higashi
BACKGROUND: Interferon-gamma release assay utilization in pediatric tuberculosis (TB) screening is limited by a paucity of longitudinal experience, particularly in low-TB burden populations. METHODS: We conducted a retrospective review of QuantiFERON (QFT)-TB Gold results in San Francisco children from 2005 to 2008. Concordance with the tuberculin skin test (TST) was analyzed for a subset of children. Progression to active disease was determined through San Francisco and California TB registry matches...
June 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27124042/evaluation-of-the-immune-response-to-interferon-gamma-release-assay-and-tuberculin-skin-test-among-bcg-vaccinated-children-in-east-of-egypt-a-cross-sectional-study
#20
Mohamed Refaat Beshir, Alaa Ebrahim Zidan, Hosam Fathi El-Saadny, Raghdaa Abdelaziz Ramadan, Nehad Ahmed Karam, Ezzat Kamel Amin, Marwa Zakaria Mohamed, Nahla Mohamed Abdelsamad
Bacille Calmette-Guérin vaccine (BCG) vaccination is used routinely in most of countries, especially developing one. The efficacy of the BCG vaccination generally decreases with time. The tuberculin skin test (TST) is a most popular diagnostic test for suspicion of tuberculosis (TB) in children till now, but it has many false positives. The interferon-gamma release assay (IGRA) is more specific than TST for detection of childhood TB, as it is more specific to Mycobacterium tuberculosis.Evaluate the interferon gamma response and TST reaction in BCG vaccinated children in east of Egypt...
April 2016: Medicine (Baltimore)
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