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Interferon-gamma Release Assays in children's

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https://www.readbyqxmd.com/read/28284256/novel-interferon-gamma-assays-for-diagnosing-tuberculosis-in-young-children-in-india
#1
N Shaikh, A Gupte, S Dharmshale, S Pokkali, M Thakar, V J Upadhye, A A Ordonez, A Kinikar, N Gupte, V Mave, A Kagal, A Gupta, A Lalvani, R Paranjpe, R Bharadwaj, S K Jain
SETTING: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. DESIGN: Children (age 5 years) with suspected TB were prospectively screened at a tertiary hospital in Pune, India; the children underwent TST, and standard (early secretory antigenic target 6 and culture filtrate protein 10) and enhanced (five additional novel antigens) enzyme-linked immunospot (ELISpot) assays...
April 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28274215/comparing-interferon-gamma-release-assays-with-tuberculin-skin-test-for-identifying-latent-tuberculosis-infection-that-progresses-to-active-tuberculosis-systematic-review-and-meta-analysis
#2
Peter Auguste, Alexander Tsertsvadze, Joshua Pink, Rachel Court, Noel McCarthy, Paul Sutcliffe, Aileen Clarke
BACKGROUND: Timely and accurate identification of people with latent tuberculosis infection (LTBI) is important for controlling Mycobacterium tuberculosis (TB). There is no gold standard for diagnosis of LTBI. Screening tests such as interferon gamma release assays (IGRAs) and tuberculin skin test (TST) provide indirect and imperfect information. This systematic review compared two types of IGRAs QuantiFERON®-TB Gold In-Tube test (QFT-GIT) and T-SPOT.TB with TST for identification of LTBI by predicting progression to a diagnosis of active TB in three subgroups: children, immunocompromised people, and those recently arrived from countries with high TB burden...
March 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28225337/multiple-cytokines-for-the-detection-of-mycobacterium-tuberculosis-infection-in-children-with-tuberculosis
#3
N Nausch, C Lundtoft, G Schulz, H Henckel, E Mayatepek, B Fleischer, F M Marx, M Jacobsen
SETTING: Interferon-gamma (IFN-γ) release assays (IGRAs) play an important role in the diagnosis of Mycobacterium tuberculosis infection. However, in children with tuberculosis (TB), some studies have shown increased frequencies of false-negative or indeterminate IGRA results. OBJECTIVE: To analyse the spectrum of different cytokines to improve the diagnostic accuracy of IGRAs in latent tuberculous infection (LTBI) and active TB. DESIGN: We performed multiplex cytokine expression analysis of QuantiFERON® Gold In-Tube supernatants in children with active TB (n = 21) and disease-free contacts with (n = 15) and without LTBI (n = 12), to determine the sensitivity and specificity of the modified tests...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28074660/optimizing-the-management-of-children-with-latent-tuberculosis-infection
#4
E Venturini, C Tersigni, E Chiappini, M de Martino, L Galli
The management of latent tuberculosis (LTBI) in children represents an important issue for paediatricians because of the disease burden, the lack of a gold standard for the diagnosis and the high annual risk of progression to active disease. Areas covered: A review of English language articles on LTBI in children, published between the 1st of January 2010 and the 1st of July 2016, was conducted using multiple keywords and standardized terminology in PubMed database. This review provides an updated overview of the available tests for LTBI diagnosis in children, management strategies and treatment options...
April 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28000584/utility-of-the-quantiferon%C3%A2-tb-gold-in-tube-assay-for-the-diagnosis-of-tuberculosis-in-moroccan-children
#5
S El Azbaoui, A Sabri, S Ouraini, A Hassani, A Asermouh, A Agadr, R Abilkassem, N Dini, M Kmari, A Akhaddar, Z Laktati, S Aieche, N El Hafidi, F Ben Brahim, A A Bousfiha, F Ailal, C Deswarte, E Schurr, L Amar, J Bustamante, S Boisson-Dupuis, J L Casanova, L Abel, J El Baghdadi
SETTING: The utility of interferon-gamma release assays (IGRAs), such as the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test, in diagnosing active tuberculosis (TB) in children is unclear and depends on the epidemiological setting. OBJECTIVE: To evaluate the performance of QFT-GIT for TB diagnosis in children living in Morocco, an intermediate TB incidence country with high bacille Calmette-Guérin vaccination coverage. DESIGN: We prospectively recruited 109 Moroccan children hospitalised for clinically suspected TB, all of whom were tested using QFT-GIT...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931340/utility-of-the-quantiferon-tb-gold-in-tube-assay-for-the-diagnosis-of-tuberculosis-in-moroccan-children
#6
S El Azbaoui, A Sabri, S Ouraini, A Hassani, A Asermouh, A Agadr, R Abilkassem, N Dini, M Kmari, A Akhaddar, Z Laktati, S Aieche, N El Hafidi, F Ben Brahim, A A Bousfiha, F Ailal, C Deswarte, E Schurr, L Amar, J Bustamante, S Boisson-Dupuis, J L Casanova, L Abel, J El Baghdadi
SETTING: The utility of interferon-gamma release assays (IGRAs), such as the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in diagnosing active tuberculosis (TB) in children is unclear and depends on the epidemiological setting. OBJECTIVE: To evaluate the performance of QFT-GIT for TB diagnosis in children living in Morocco, an intermediate TB incidence country with high bacille Calmette-Gurin vaccination coverage. DESIGN: We prospectively recruited 109 Moroccan children hospitalised for clinically suspected TB, all of whom were tested using QFT-GIT...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27776586/controversies-in-tuberculous-infection-among-pediatric-infectious-disease-specialists-in-north-america
#7
A T Cruz, A L Hersh, J R Starke, S E Beekmann, P M Polgreen, R Banerjee
OBJECTIVE: To evaluate the extent to which advancements in the diagnosis and treatment of latent tuberculous infection (LTBI) have been integrated into practice by pediatric infectious disease (PID) specialists. DESIGN: We conducted an online survey of the Infectious Diseases Society of America's Emerging Infections Network (EIN) membership. RESULTS: Of the 323 members, 197 (61%) responded: 7% cared for ⩾5 children with TB disease and 34% for ⩾5 children with LTBI annually...
November 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27753763/pediatric-extrapulmonary-tuberculosis-clinical-spectrum-risk-factors-and-diagnostic-challenges-in-a-low-prevalence-region
#8
Begoña Santiago-García, Daniel Blázquez-Gamero, Fernando Baquero-Artigao, Jesús Ruíz-Contreras, Jose M Bellón, Maria A Muñoz-Fernández, María J Mellado-Peña
BACKGROUND: Children are at higher risk of tuberculosis (TB) dissemination and extrapulmonary disease, contributing greatly to TB-associated morbidity and long-term sequelae. However, there are very few studies that assess the impact and clinical spectrum of pediatric extrapulmonary TB (EPTB) in low-prevalence regions. METHODS: Children <18 years of age diagnosed with TB in Madrid region (2005-2013) were reviewed. We compared the epidemiology, clinical characteristics and the performance of diagnostic tests in childhood extrapulmonary and pulmonary disease...
November 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27725037/european-shortage-of-purified-protein-derivative-and-its-impact-on-tuberculosis-screening-practices
#9
M Tebruegge, D Buonsenso, F Brinkmann, A Noguera-Julian, I Pavić, A Sorete Arbore, Z Vančíková, S Velizarova, S B Welch, N Ritz
SETTING: In June 2014, we became aware that shortages of purified protein derivative (PPD), the test substance used for the tuberculin skin test (TST), had occurred in several European health care institutions providing care for children with tuberculosis (TB). OBJECTIVE: To establish the extent of the shortage, a survey was performed. DESIGN: Survey conducted over a 1-month period (June-July 2014) among members of the Paediatric Tuberculosis Network European Trials Group (ptbnet)...
October 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27716176/relation-between-bcg-vaccine-scar-and-an-interferon-gamma-release-assay-in-immigrant-children-with-positive-tuberculin-skin-test-%C3%A2-10%C3%A2-mm
#10
Margret Johansson Gudjónsdóttir, Karsten Kötz, Ruth Stangebye Nielsen, Philip Wilmar, Sofia Olausson, Daniel Wallmyr, Birger Trollfors
BACKGROUND: Immigrants from countries with high incidence of tuberculosis (TB) are usually offered screening when they arrive to low incidence countries. The tuberculin skin test (TST) is often used. The interferon gamma release assays (IGRAs) are more specific and not affected by BCG vaccination. The aims of this study were 1. To see if there if there is a correlation between a positive IGRA (QFT) and presence of a BCG scar in children with TST ≥10 mm, 2. To compare the TST diameter with QFT result, 3...
October 6, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27416010/interferon-gamma-release-assays-should-not-replace-tuberculin-skin-tests-in-screening-programs-for-children
#11
Marc Tebruegge, Vanessa Clifford, Nigel Curtis
No abstract text is available yet for this article.
August 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27220068/accurate-diagnosis-of-latent-tuberculosis-in-children-people-who-are-immunocompromised-or-at-risk-from-immunosuppression-and-recent-arrivals-from-countries-with-a-high-incidence-of-tuberculosis-systematic-review-and-economic-evaluation
#12
Peter Auguste, Alexander Tsertsvadze, Joshua Pink, Rachel Court, Farah Seedat, Tara Gurung, Karoline Freeman, Sian Taylor-Phillips, Clare Walker, Jason Madan, Ngianga-Bakwin Kandala, Aileen Clarke, Paul Sutcliffe
BACKGROUND: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) [(Zopf 1883) Lehmann and Neumann 1896], is a major cause of morbidity and mortality. Nearly one-third of the world's population is infected with MTB; TB has an annual incidence of 9 million new cases and each year causes 2 million deaths worldwide. OBJECTIVES: To investigate the clinical effectiveness and cost-effectiveness of screening tests [interferon-gamma release assays (IGRAs) and tuberculin skin tests (TSTs)] in latent tuberculosis infection (LTBI) diagnosis to support National Institute for Health and Care Excellence (NICE) guideline development for three population groups: children, immunocompromised people and those who have recently arrived in the UK from high-incidence countries...
May 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27199468/interferon-gamma-release-assays-and-pediatric-public-health-tuberculosis-screening-the-san-francisco-program-experience-2005-to-2008
#13
Jennifer A Grinsdale, Shamim Islam, Olivia Chang Tran, Christine S Ho, L Masae Kawamura, Julie M Higashi
BACKGROUND: Interferon-gamma release assay utilization in pediatric tuberculosis (TB) screening is limited by a paucity of longitudinal experience, particularly in low-TB burden populations. METHODS: We conducted a retrospective review of QuantiFERON (QFT)-TB Gold results in San Francisco children from 2005 to 2008. Concordance with the tuberculin skin test (TST) was analyzed for a subset of children. Progression to active disease was determined through San Francisco and California TB registry matches...
June 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27124042/evaluation-of-the-immune-response-to-interferon-gamma-release-assay-and-tuberculin-skin-test-among-bcg-vaccinated-children-in-east-of-egypt-a-cross-sectional-study
#14
Mohamed Refaat Beshir, Alaa Ebrahim Zidan, Hosam Fathi El-Saadny, Raghdaa Abdelaziz Ramadan, Nehad Ahmed Karam, Ezzat Kamel Amin, Marwa Zakaria Mohamed, Nahla Mohamed Abdelsamad
Bacille Calmette-Guérin vaccine (BCG) vaccination is used routinely in most of countries, especially developing one. The efficacy of the BCG vaccination generally decreases with time. The tuberculin skin test (TST) is a most popular diagnostic test for suspicion of tuberculosis (TB) in children till now, but it has many false positives. The interferon-gamma release assay (IGRA) is more specific than TST for detection of childhood TB, as it is more specific to Mycobacterium tuberculosis.Evaluate the interferon gamma response and TST reaction in BCG vaccinated children in east of Egypt...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27078123/school-based-study-to-identify-and-treat-adolescent-students-at-risk-for-tuberculosis-infection
#15
MULTICENTER STUDY
Lindsay A Hatzenbuehler, Jeffrey R Starke, Edward A Graviss, E O'Brian Smith, Andrea T Cruz
BACKGROUND: Screening for and treating tuberculosis (TB) infection in children and adolescents is an effective way of decreasing future TB cases. However, current approaches leave many children at risk for TB unidentified. METHODS: We recruited adolescent students from 2 public high schools (a magnet and a low-income) in the Houston Independent School District. Compared with the magnet school, the student population at the low-income school was larger, primarily Hispanic and economically disadvantaged...
July 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26944076/the-need-to-implement-effective-new-entrant-tuberculosis-screening-in-children-evidence-from-school-outbreak
#16
Bhanu Williams, Lucy Pickard, Louis Grandjean, Sue Pope, Sarah R Anderson, Gail Morgan, Amanda Williams
BACKGROUND: In January 2013 a secondary school pupil in London was diagnosed with sputum-smear positive pulmonary tuberculosis (TB) and was started on treatment. In April 2013 another pupil in the same year group at the same school was diagnosed with sputum-smear positive pulmonary TB. Pupils in the same year were then screened for tuberculosis. METHODS: Interferon gamma release assay (IGRA) testing was used to identify those infected with tuberculosis. Further tests were conducted to identify contacts with active tuberculosis disease and specimens were sent for genotypic testing...
March 3, 2016: Journal of Public Health
https://www.readbyqxmd.com/read/26936211/interferon-gamma-release-assays-can-effectively-screen-migrants-for-the-tuberculosis-infection-but-urgent-active-cases-need-clinical-recognition
#17
Sahar Nejat, Rutger Bennet
AIM: Increasing numbers of migrants to Sweden are screened for tuberculosis (TB), and a rational approach to screening is required. We evaluated positive tuberculin skin tests (TSTs) and interferon-gamma release assays (IGRAs) on paediatric migrants in relation to the TB incidence in the corresponding foreign-born populations in Stockholm. METHODS: This study examined the characteristics of migrants under the age of 18 who were referred to a paediatric TB clinic at Karolinska University Hospital from 2008 to 2014 by primary care centres in Stockholm County...
June 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/26917222/guidelines-for-the-use-of-interferon-%C3%AE-release-assays-in-the-diagnosis-of-tuberculosis-infection
#18
Miguel Santin, José-María García-García, José Domínguez
INTRODUCTION: Interferon-gamma release assays are widely used for the diagnosis of tuberculosis infection in low-prevalence countries. However, there is no consensus on their application. The objective of this study was to develop guidelines for the use of interferon-gamma release assays in specific clinical scenarios in Spain. METHODS: A panel of experts comprising specialists in infectious diseases, respiratory diseases, microbiology, pediatrics and preventive medicine, together with a methodologist, formulated the clinical questions and outcomes of interest...
May 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/26646547/high-discordance-between-pre-us-and-post-us-entry-tuberculosis-test-results-among-immigrant-children-is-it-time-to-adopt-interferon-gamma-release-assay-for-preentry-tuberculosis-screening
#19
Phil Lowenthal, Pennan M Barry, Jennifer Flood
BACKGROUND: Since 2007, immigration applicants 2-14 years old with a tuberculin skin test (TST) ≥10 mm and an otherwise negative evaluation for tuberculosis (TB) are assigned a classification for TB infection and instructed to seek domestic evaluation upon arrival in the US in accordance with Centers for Disease Control and Prevention instructions. We examined the characteristics and outcome of domestic evaluation of immigrant children who arrived in California with a positive TST on preimmigration examination to inform the preimmigration TB screening process...
March 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26640948/performance-of-the-interferon-gamma-release-assays-in-tuberculosis-disease-in-children-five-years-old-or-less
#20
Lin Sun, Jian-ling Tian, Qing-qin Yin, Jing Xiao, Jie-qiong Li, Ya-jie Guo, Guo-shuang Feng, Xiao-xia Peng, Hui Qi, Fang Xu, Wei-wei Jiao, Chen Shen, A-dong Shen
Interferon Gamma Release Assays (IGRAs) were developed for the indirect or immunologic diagnosis of tuberculosis infection; however, they have also been used to assist in difficult to diagnose cases of tuberculosis disease in adults, and to a lesser extent, in children, especially in those under 5 years old. We evaluated the utility of using an IGRA in pediatric tuberculosis in younger children in a hospital setting. The diagnostic accuracy of T-SPOT.TB and TST was assessed in 117 children with active tuberculosis and 413 children with respiratory tract infection...
2015: PloS One
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