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https://www.readbyqxmd.com/read/29225893/a-novel-approach-to-glycemic-control-in-type-2-diabetes-mellitus-partial-jejunal-diversion-pre-clinical-to-clinical-pathway
#1
Martin Fried, Karin Dolezalova, Adam P Chambers, Elliott J Fegelman, Robin Scamuffa, Michael L Schwiers, Jason R Waggoner, Martin Haluzik, Randy J Seeley
Objective: To explore partial jejunal diversion (PJD) via a side-to-side jejuno-jejunostomy for improved glycemic control in type 2 diabetes mellitus (T2DM). PJD is an anatomy-sparing, technically simple surgery in comparison to the predominate metabolic procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Positive results in a rodent model prompted a human proof-of-concept study. Research design and methods: Pre-clinically, 71 rats were studied in a model of metabolic dysfunction induced by a high-fat diet; 33 animals undergoing one of two lengths of PJD were compared with 18 undergoing sham, 10 RYGB and 10 jejuno-ileal bypass...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29217651/interleukin-18-serum-level-is-elevated-in-type-2-diabetes-and-latent-autoimmune-diabetes
#2
Emanuela Zaharieva, Zdravko Kamenov, Tsvetelina Velikova, Adelina Tsakova, Yosif El-Darawish, Haruki Okamura
BACKGROUND: Interleukin-18 (IL-18) is an inflammatory cytokine found to be elevated in obesity, metabolic syndrome and type 2 diabetes (T2D) as a part of the chronic low-grade inflammatory process in these states. The aim of the study was to evaluate the interleukin level in patients with latent autoimmune diabetes of the adults (LADA) in comparison to that in T2D subjects. MATERIALS AND METHODS: IL-18 was analyzed through Enzyme-Linked Immunosorbent Assay in 76 participants with T2D and 24 with LADA and 14 control subjects...
December 7, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29215189/dapagliflozin-as-add-on-therapy-in-asian-patients-with-type-2-diabetes-inadequately-controlled-on-insulin-%C3%A2-oral-antihyperglycemic-drugs-a-randomized-controlled-trial
#3
Wenying Yang, Jianhua Ma, Yiming Li, Yanbing Li, Zhiguang Zhou, Jae Hyeon Kim, June Zhao, Agata Ptaszynska
BACKGROUND: This 24-week, phase 3, double-blind, placebo-controlled study (NCT02096705) assessed the safety and efficacy of dapagliflozin as add-on to insulin ± oral antihyperglycemic drugs (OADs) in Asian patients with inadequately controlled type 2 diabetes. METHODS: Patients (adults; HbA1c ≥7.5-≤10.5%; body mass index ≤45 kg/m2 ; insulin dose ≥20 IU daily) were randomized to dapagliflozin 10 mg (N=139) or placebo (N=133) to assess the 24-week change in HbA1c (primary outcome), fasting plasma glucose (FPG), body weight, total daily dose of insulin (TDDI), and seated systolic blood pressure (SeSBP; exploratory outcome)...
December 7, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29204855/achieving-good-glycemic-control-early-after-onset-of-diabetes-a-cost-effectiveness-analysis-in-patients-with-type-1-diabetes-in-sweden
#4
Johan Jendle, Åsa Ericsson, Barnaby Hunt, William J Valentine, Richard F Pollock
INTRODUCTION: Sweden has amongst the highest incidence rates of type 1 diabetes (T1D) in Europe. The high incidence and chronic nature of T1D result in high prevalence and economic burden. Improving glycemic control reduces the incidence of microvascular complications, which in turn reduces medical costs. The present study aimed to quantify the reductions in cost and improvements in quality-adjusted life expectancy with varying reductions in HbA1c in the T1D population. METHODS: The IQVIA CORE Diabetes Model was used to simulate a typical Swedish population of patients with T1D experiencing HbA1c reductions from 0...
December 4, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29197387/liraglutide-and-metformin-alone-or-combined-therapy-for-type-2-diabetes-patients-complicated-with-coronary-artery-disease
#5
Ying Liu, Xia Jiang, Xin Chen
BACKGROUND: This study is to compare the effects of Liraglutide and Metformin alone or combined treatment on the cardiac function in T2DM patients complicated with CAD. METHODS: 120 T2DM patients were included at Endocrinology Department of Tianjin First Center Hospital (Tianjin, China) from April 2012 to September 2013. The study contained two sections. Section 1: 30 patients in group 1 was treated with Liraglutide (Novo Nordisk) (1.2 mg/d), and 30 patients in group 2 with Metformin (Shiguibao) (1500 mg/d) for 24 weeks...
December 2, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29184243/starch-digestibility-and-glycemic-index-of-paranthas-supplemented-with-citrus-maxima-burm-merr-fruit-segments
#6
S K Reshmi, M L Sudha, M N Shashirekha
The present investigation was undertaken to develop paranthas suiting diabetic population with added health benefits. Paranthas were prepared using fresh and dry segments of pomelo. The increase in the concentration of segments decreased the texture value from 1080 to 1022 g force (fresh segments) and 1005 to 870 g force (dry segments). Naringin along with other bioactive compounds were retained to a greater extent in Paranthas containing dry pomelo fruit segments. Paranthas prepared using 20% (fresh) and 5% (dry) were sensorily acceptable...
December 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29178536/effects-of-an-energy-restricted-low-carbohydrate-high-unsaturated-fat-low-saturated-fat-diet-versus-a-high-carbohydrate-low-fat-diet-in-type-2-diabetes-a-2-year-randomized-clinical-trial
#7
Jeannie Tay, Campbell H Thompson, Natalie D Luscombe-Marsh, Thomas P Wycherley, Manny Noakes, Jonathan D Buckley, Gary A Wittert, William S Yancy, Grant D Brinkworth
AIM: To examine whether a low-carbohydrate, high unsaturated/low saturated fat diet (LC) improves glycemic control and cardiovascular disease (CVD) risk factors in overweight and obese patients with type 2 diabetes (T2D). METHODS: 115 adults with T2D (mean[SD]; BMI:34.6[4.3]kg/m2 , age:58[7]yrs, HbA1c:7.3[1.1]%) were randomized to one of two planned energy-matched, hypocaloric diets combined with aerobic/resistance exercise (1hr,3d/wk) for 2 years:(1) LC:14% energy as carbohydrate, 28% protein, 58% fat [<10% saturated fat]) or (2) low fat, high-carbohydrate, low glycemic index diet (HC):53% CHO, 17% protein, 30% fat [<10% saturated fat])...
November 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29166321/adipose-lipolysis-unchanged-by-preexercise-carbohydrate-regardless-of-glycemic-index
#8
Daniel A Baur, Brandon D Willingham, Kyle A Smith, Jacob N Kisiolek, Margaret C Morrissey, Patrick G Saracino, Tristan J Ragland, Michael J Ormsbee
PURPOSE: To determine the impact of pre-exercise carbohydrate of different glycemic indices on subcutaneous abdominal adipose tissue (SCAAT) metabolism and running performance. METHODS: Ten trained male runners completed three experimental trials consisting of 30 min at 60% VO2max, 30 min at 75% VO2max, and a 5-km time trial (TT). Thirty min prior to exercise, participants consumed one of three beverages: 1) 75 g low glycemic index modified starch supplement (UCAN), 2) 75 g high glycemic index glucose-based supplement (G), or 3) a flavor-matched non-caloric placebo (PL)...
November 20, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29158252/food-addiction-high-glycemic-index-carbohydrates-and-obesity
#9
REVIEW
Belinda Lennerz, Jochen K Lennerz
BACKGROUND: Treatment success in obesity remains low, and recently food addiction has been delineated as an underlying etiologic factor with therapeutic relevance. Specifically, current treatment focuses on reduced food intake and increase of physical activity, whereas interventions for addiction encompass behavioral therapy, abstinence, and environmental interventions such as taxation, restrictions on advertising, and regulation of school menus. CONTENT: Here, we reviewed the pertinent literature on food addiction with a specific focus on the role of high-glycemic-index carbohydrates in triggering addictive symptoms...
November 20, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29133220/effects-of-exercise-and-diet-in-nonobese-asthma-patients-a-randomized-controlled-trial
#10
Louise Lindhardt Toennesen, Howraman Meteran, Morten Hostrup, Nina Rica Wium Geiker, Camilla Bjoern Jensen, Celeste Porsbjerg, Arne Astrup, Jens Bangsbo, Debbie Parker, Vibeke Backer
BACKGROUND: Behavioral interventions focusing on exercise and healthy diet improve asthma control in obese patients with asthma, but whether these interventions can lead to improvements in nonobese patients remains unclear. OBJECTIVES: In a randomized, controlled parallel-group design, we studied the effects of an 8-week intervention of either exercise (high-intensity interval training), diet (high protein/low glycemic index), or a combination of the 2, on asthma control and clinical outcomes in nonobese patients with asthma...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29130716/-effect-of-quinua-chenopodium-quinoa-consumption-as-a-coadjuvant-in-nutritional-intervention-in-prediabetic-subjects
#11
María Salud Abellán Ruiz, María Dolores Barnuevo Espinosa, Carlos García Santamaría, Carlos Javier Contreras Fernández, Miriam Aldeguer García, Fulgencio Soto Méndez, Isabel Guillén Guillén, Antonio Jesús Luque Rubia, Francisco Javier Quinde Ràzuri, Antonio Martínez Garrido, Francisco Javier López Román
INTRODUCTION: Quinoa is a pseudocereal containing low glycemic index carbohydrates, dietary fiber, high biological value protein, phytosterols, and n-3 and n-6 fatty acids, which has generated interest in prediabetes nutritional interventions. This randomized (2:1), placebo-controlled, double-blind study evaluated the effects of processed quinoa on body mass index (BMI), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG) and the satiation and fullness (complete) degree in prediabetic patients...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29125537/associations-of-fasting-blood-glucose-with-influencing-factors-in-northeast-china-a-quantile-regression-analysis
#12
Xin Guo, Li Shen, Jing Dou, Yaogai Lv, Anning Zhang, Fanchao Shi, Zhiqiang Xue, Yaqin Yu, Lina Jin, Yan Yao
Background: Diabetes mellitus (DM) has become a major public health problem in China. Although a number of researchers have investigated DM risk factors, little is known about the associations between values of fasting blood glucose (FBG) and influencing factors. This study aims to explore these associations by the quantile regression (QR) model. Methods: A cross-sectional survey based on a sample of 23,050 adults aged 18 to 79 years was conducted in Jilin in 2012, and some subjects were excluded due to missing values with respect to necessary variables or having glycemic control, in accordance with the purposes of this study...
November 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29121408/community-health-workers-supporting-clinical-pharmacists-in-diabetes-management-a-randomized-controlled-trial
#13
Lisa K Sharp, Jessica J Tilton, Daniel R Touchette, Yinglin Xia, Daniel Mihailescu, Michael L Berbaum, Ben S Gerber
OBJECTIVES: To evaluate the effectiveness of clinical pharmacists and community health workers (CHWs) in improving glycemic control within a low-income, ethnic minority population. METHODS: In a two-arm, 2-year, crossover trial, 179 African-American and 65 Hispanic adult patients with uncontrolled diabetes mellitus (hemoglobin A1c [HbA1c] ≥ 8%) were randomized to CHW support either during the first or second year of the study. All participants received clinical pharmacist support for both years of the study...
November 9, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29110406/switching-from-low-dose-thiazide-diuretics-to-sodium-glucose-cotransporter-2-inhibitor-improves-various-metabolic-parameters-without-affecting-blood-pressure-in-patients-with-type-2-diabetes-and-hypertension
#14
Tomohiko Kimura, Junpei Sanada, Masashi Shimoda, Hidenori Hirukawa, Yoshiro Fushimi, Momoyo Nishioka, Tomoe Kinoshita, Seizo Okauchi, Atsushi Obata, Kenji Kohara, Fuminori Tatsumi, Shinji Kamei, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
AIMS/INTRODUCTION: Sodium-glucose cotransporter 2 (SGLT2) inhibitors function to increase urinary glucose excretion and improve glycemic control in individuals with type 2 diabetes mellitus. SGLT2 inhibitors, as well as diuretics, increase urinary volume, which leads to the reduction of blood pressure. The aim of the present study was to compare the effects of SGLT2 inhibitor and thiazide diuretic on blood pressure, metabolic parameters and body mass composition. MATERIALS AND METHODS: A total of 31 participants were enrolled in the present study...
November 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29106816/insulin-glargine-300-u-ml-is-associated-with-less-weight-gain-while-maintaining-glycemic-control-and-low-risk-of-hypoglycemia-compared-with-insulin-glargine-100-u-ml-in-an-aging-population-with-type-2-diabetes
#15
Medha N Munshi, Jasvinder Gill, Jason Chao, Elena V Nikonova, Meenakshi Patel
OBJECTIVE: Assess efficacy, hypoglycemia and weight gain in patients with type 2 diabetes (T2D) treated with insulin glargine 300 U/mL (Gla-300) or 100 U/mL (Gla-100) across different age groups. METHODS: Pooled data were generated for patients randomized to Gla-300 or Gla-100 in the EDITION 2 (NCT01499095) and 3 (NCT01676220) studies. In four age groups (<55, ≥55 to <60, ≥60 to <65, ≥65 years), glycated hemoglobin A1C (A1C), percentage of patients reaching A1C <7...
November 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29098639/tef-the-rising-ancient-cereal-what-do-we-know-about-its-nutritional-and-health-benefits
#16
Habtu Shumoy, Katleen Raes
This review covers the nutritional significance of tef cereal as compared to other common cereals with emphasis on carbohydrate content and starch digestibility, protein content, iron and zinc bioavailability and antioxidant potentials. Tef is a gluten free cereal and contains the highest iron and calcium among other cereals. It has high micro- and macro- nutritional profile and is becoming globally popular in the healthy grain food chain. Tef starch has a high gelatinization temperature, an essential precondition in the preparation of low glycemic index foods...
November 2, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29089617/low-dose-doxycycline-decreases-systemic-inflammation-and-improves-glycemic-control-lipid-profiles-and-islet-morphology-and-function-in-db-db-mice
#17
Na Wang, Xiong Tian, Yu Chen, Hui-Qi Tan, Pei-Jian Xie, Shao-Jun Chen, Yu-Cai Fu, Yi-Xin Chen, Wen-Can Xu, Chi-Ju Wei
The aim of this study was to determine whether low dose doxycycline as an anti-inflammatory agent could improve glucose metabolism in diabetic animals. Therefore, doxycycline was supplemented in drinking water to 6-week-old male db/db mice for 10 weeks. Doxycycline reduced perirenal/epididymal fat, Lee's index, and liver cholesterol. Blood HDL-cholesterol increased, but total cholesterol and aspartate transaminase decreased. Glucose and insulin tolerances were improved, accompanying with reduced fasting blood glucose, insulin, HOMA-IR and advanced glycation end products...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29083138/an-early-customized-low-glycaemic-index-diet-prevents-adverse-pregnancy-outcomes-in-overweight-obese-women
#18
Elisabetta Petrella, Valeria Tamborrino, Lidia DI Cerbo, Isabella Neri, Fabio Facchinetti
OBJECTIVE: To determine whether the prescription and follow-up of a behavioral program (customized nutritional advices and a constant physical activity) influences the occurrence of unfavorable maternal/neonatal outcomes among overweight/obese women. METHODS: A case-control study (1:3) included single pregnant women with BMI≥25, enrolled at 1st trimester. Cases (95) were prescribed (by both the dietitian and gynecologist) a low-glycemic index diet with an average intake of 1700/1800 Kcal/day plus 30 minutes walking at least 3 times/week (with four follow-up visits until delivery)...
October 27, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29079384/effects-of-bariatric-surgery-on-glycemic-and-lipid-metabolism-surgical-complication-and-quality-of-life-in-adolescents-with-obesity-a-systematic-review-and-meta-analysis
#19
Lin Qi, Yan Guo, Chao-Qian Liu, Zhi-Ping Huang, Yuan Sheng, Da-Jin Zou
BACKGROUND: Obesity in adolescents is associated with numerous health risks and co-morbidities, including type 2 diabetes and dyslipidemia. Bariatric surgery on adolescents induces weight loss, but little is known about metabolic effects of these operations. OBJECTIVE: To explore weight loss and metabolic effects of bariatric surgery on young people. SETTING: A systematic review and meta-analysis. University Hospital, China. METHODS: PubMed and EMBASE were searched for relevant studies up to July 2017...
December 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29072163/effect-of-high-and-low-glycemic-index-breakfast-on-postprandial-metabolic-parameters-and-satiety-in-subjects-with-type-2-diabetes-mellitus-under-intensive-insulin-therapy-controlled-clinical-trial
#20
Daniela R Lobos, Isabella A Vicuña, Victoria Novik, Claudia A Vega
BACKGROUND AND AIM: The results of studies evaluating the metabolic effects of glycemic index (GI) in subjects with type 2 diabetes mellitus (DM2) have been contradictory. Consequently, the benefits of its application are controversial and polarized opinions of international organizations have been disclosed. The above situation leads this study to evaluate the acute effect of low and high GI breakfast on the glycemic response and satiety in subjects with DM2 under intensive insulin therapy (IIT)...
August 2017: Clinical Nutrition ESPEN
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