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hypertension and pregnancy

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https://www.readbyqxmd.com/read/29226641/modified-complete-blood-count-indices-as-predicting-markers-of-preeclampsia-from-gestational-hypertension-neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-and
#1
You La Jeon, Woo-In Lee, So Young Kang, Myeong Hee Kim
BACKGROUND: To evaluate modified complete blood count (CBC) indices as a predicting marker of preeclampsia (PE) from gestational hypertension (GH), we analyzed the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and platelet to neutrophil ratio (PNR). PNR was a newly designed index in this study based on results of PE patients having a tendency toward higher neutrophil count and lower platelet count compared to normal pregnant women in previous studies. METHODS: We recruited 86 normal pregnant women, 33 patients with GH and 68 patients with PE...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29224682/calcineurin-inhibitors-in-systemic-lupus-erythematosus
#2
REVIEW
Chi Chiu Mok
The calcineurin inhibitors (CNIs) belong to a group of immunosuppressive agents that block T-cell activation through the suppression of the calcium/calcimodulin-dependent phosphatase calcineurin. Agents such as cyclosporine A (CSA) and tacrolimus (TAC) have long been used in patients with systemic lupus erythematosus (SLE). TAC is preferred to CSA in SLE because of the lower frequency of cosmetic, hypertensive and dyslipidemic adverse effects. Recent randomised controlled trials have demonstrated noninferiority of TAC to mycophenolate mofetil (MMF) or cyclophosphamide (CYC) for induction therapy of lupus nephritis...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29222972/factors-associated-with-adverse-pregnancy-outcomes-in-women-with-systematic-lupus-erythematosus
#3
Masashi Deguchi, Yoko Maesawa, Shino Kubota, Mayumi Morizane, Kenji Tanimura, Yasuhiko Ebina, Hideto Yamada
The aim of this prospective study was to determine clinical factors associated with adverse pregnancy outcomes in women with systematic lupus erythematosus (SLE). Fifty-six pregnancies from 46 women with SLE were enrolled. Risk factors for pregnancy loss, premature delivery, hypertensive disorders of pregnancy (HDP), and light-for-date neonate (LFD), were evaluated. Univariate and multivariate logistic regression analyses revealed a history of two or more pregnancy losses before 10 gestational weeks (GW) (OR 11...
November 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29222389/natural-killer-cells-and-t-lymphocytes-in-pregnancy-and-pre-eclampsia
#4
EDITORIAL
Erin B Taylor, Jennifer M Sasser
Although pre-eclampsia (PE), a hypertensive disorder of pregnancy, has significant maternal and fetal morbidity and mortality worldwide, the mechanisms contributing to this disease have not been fully elucidated. Studies in patients and experimental models have shown that changes in the number or function of immune cells of both the adaptive and innate immune systems contribute to the development and pathogenesis of PE. This commentary summarizes our current understanding of the role of the immune system in the pathogenesis of PE, specifically focussing on dysfunction of natural killer (NK) cells and T lymphocyte populations...
December 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29217291/pregnancy-outcomes-in-adult-patients-with-dermatomyositis-and-polymyositis
#5
Kathleen D Kolstad, David Fiorentino, Shufeng Li, Eliza F Chakravarty, Lorinda Chung
OBJECTIVE: The idiopathic inflammatory myopathies dermatomyositis (DM) and polymyositis (PM) are autoimmune diseases that can affect females of childbearing potential. We assessed pregnancy outcomes in DM and PM patients compared with the general obstetric population. METHODS: The Nationwide Inpatient Sample (NIS) (1993-2007) was used to identify delivery-associated hospitalizations in women with DM or PM (DM/PM, n = 853). Controls were from the general obstetric population delivery-associated hospitalizations matched to each case by year of delivery...
November 20, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29216636/reduction-of-uterine-perfusion-pressure-induced-redistribution-of-endothelin-receptor-type-b-between-the-intima-and-media-contributes-to-the-pathogenesis-of-pregnancy-induced-hypertension
#6
Yuan Sun, Xicheng Zhang, Zhaolei Chen, Miao Xu, Minghui Ou
BACKGROUND/AIMS: Studies have shown that a change in endothelin receptor expression in the artery is related to pregnancy-induced hypertension (PIH). However, the mechanism underlying this change remains unclear. METHODS: To test whether the distribution of endothelin receptor type-A (ETAR) and type-B (ETBR) plays an important role in PIH, a reduction of uterine perfusion pressure (RUPP) rat model was used to mimic some of the features of PIH; the resulting variable endothelin receptor expression was investigated in the media and intima of the aorta...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29216009/the-first-trimester-aneuploidy-biochemical-markers-in-ivf-icsi-patients-have-no-additional-benefit-compared-to-spontaneous-conceptions-in-the-prediction-of-pregnancy-complications
#7
Iwona Szymusik, Przemyslaw Kosinski, Katarzyna Kosinska-Kaczynska, Damian Warzecha, Anetta Karwacka, Bartosz Kaczynski, Miroslaw Wielgos
OBJECTIVES: The aim of this study was to determine if the levels of biochemical aneuploidy markers in in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) pregnancies differ from those in spontaneous pregnancies and to verify if biochemical markers could predict pregnancy outcome in IVF/ICSI gestations. METHODS: This was a prospective observational study performed in a group of 551 patients who underwent a combined first trimester prenatal screening (ultrasound scan and serum markers)...
December 7, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29215527/long-term-trends-in-singleton-preterm-birth-in-south-australia-from-1986-to-2014
#8
Petra E Verburg, Gus A Dekker, Kamalesh Venugopal, Wendy Scheil, Jan Jaap H M Erwich, Ben W Mol, Claire T Roberts
OBJECTIVE: To describe long-term trends in the prevalence of preterm birth and rates of preterm birth in singleton pregnancies complicated by hypertensive disorders of pregnancy, small for gestational age (SGA), and preterm prelabor rupture of membranes (PROM) in South Australia. METHODS: We conducted a retrospective population study including all singleton live births in the state of South Australia from 1986 to 2014. Long-term trends for preterm birth, hypertensive disorders of pregnancy, SGA, preterm PROM as well as stillbirth were assessed using joinpoint regression analyses...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29215520/preeclampsia-and-long-term-renal-function-in-women-who-underwent-kidney-transplantation
#9
Valerie Vannevel, Kathleen Claes, David Baud, Yvan Vial, Delaviz Golshayan, Eugene W Yoon, Ryan Hodges, Anne Le Nepveu, Peter G Kerr, Claire Kennedy, Mary Higgins, Elisabeth Resch, Philipp Klaritsch, Tim Van Mieghem
OBJECTIVE: Preeclampsia often complicates pregnancies after maternal kidney transplantation. We aimed to assess whether preeclampsia is associated with kidney function decline either during the pregnancy or in the long term. METHODS: We performed an international multicenter retrospective cohort study. Renal function at conception, pregnancy outcomes, and short- and long-term graft outcomes were collected for women who were pregnant after renal transplantation and had transplant and obstetric care at the participating centers...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29215510/timing-and-risk-factors-of-postpartum-stroke
#10
Gloria Too, Timothy Wen, Amelia K Boehme, Eliza C Miller, Lisa R Leffert, Frank J Attenello, William J Mack, Mary E DʼAlton, Alexander M Friedman
OBJECTIVE: To characterize risk and timing of postpartum stroke readmission after delivery hospitalization discharge. METHODS: The Healthcare Cost and Utilization Project's Nationwide Readmissions Database for calendar years 2013 and 2014 was used to perform a retrospective cohort study evaluating risk of readmission for stroke within 60 days of discharge from a delivery hospitalization. Risk was characterized as odds ratios (ORs) with 95% CIs based on whether patients had hypertensive diseases of pregnancy (gestational hypertension or preeclampsia), or chronic hypertension, or neither disorder during the index hospitalization...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29212810/heme-oxygenase-1-is-a-potent-inhibitor-of-placental-ischemia-mediated-endothelin-1-production-in-cultured-human-glomerular-endothelial-cells
#11
Bhavisha A Bakrania, Frank T Spradley, Simon C Satchell, David E Stec, John M Rimoldi, Rama S V Gadepalli, Joey P Granger
Preeclampsia is a pregnancy-specific disorder of maternal hypertension and reduced renal hemodynamics linked to reduced endothelial function. Placental ischemia is thought to be the culprit of this disease, as it causes the release of factors like tumor necrosis factor (TNF)-α that induce vascular endothelin-1 (ET-1) production. Interestingly, placental ischemia-induced hypertension in rats (reduced uterine perfusion pressure, RUPP model) is abolished by ETA receptor blockade, suggesting a critical role for ET-1...
December 6, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29212620/one-year-outcome-for-congenital-diaphragmatic-hernia-results-from-the-french-national-register
#12
François Barrière, Fabrice Michel, Anderson D Loundou, Virginie Fouquet, Elsa Kermorvant, Sébastien Blanc, Elisabeth Carricaburu, Amélie Desrumaux, Odile Pidoux, Alexis Arnaud, Nicolas Berte, Thierry Blanc, Frederic Lavrand, Guillaume Levard, Isabelle Rayet, Sylvain Samperiz, Anne Schneider, Marie-Odile Marcoux, Norbert Winer, Yann Chaussy, Valérie Datin-Dorriere, Quentin Ballouhey, Aurélien Binet, Charles Muszynski, Jean Breaud, Armelle Garenne, Laurent Storme, Julia Boubnova
OBJECTIVE: To evaluate the status of congenital diaphragmatic hernia (CDH) management in France and to assess predictors of adverse outcomes. STUDY DESIGN: We reviewed the first-year outcome of all cases of CDH reported to the French National Register in 2011. RESULTS: A total of 158 cases were included. Of these, 83% (131) were prenatally diagnosed, with a mortality rate of 39% (44 of 112) for live born infants with a known outcome at hospital discharge...
December 4, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29212591/-pregnancy-after-bariatric-surgery
#13
Mette Mandrup Kjær, Lise Lotte Torvin-Andersen, Peter Dam, Dorte Møller Jensen, Jeanette Lauenborg, Louise Laage Stentebjerg, René Klinkeby Støving, Kristina Martha Renault
This is a review of the recommendations regarding pregnancy after bariatric surgery from the Danish Society of Obstetrics and Gynaecology. The risk of vitamin/mineral deficiencies should be emphasized and checked with blood samples. Measurements of fetal growth should be offered at gestational age 28 and 34 as a supplement to the standard prenatal procedures because of the increased risk of intrauterine growth retardation. Because of persistent obesity there is still an increased risk of hypertension and diabetes mellitus...
December 4, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29212472/autism-risk-classification-using-placental-chorionic-surface-vascular-network-features
#14
Jen-Mei Chang, Hui Zeng, Ruxu Han, Ya-Mei Chang, Ruchit Shah, Carolyn M Salafia, Craig Newschaffer, Richard K Miller, Philip Katzman, Jack Moye, Margaret Fallin, Cheryl K Walker, Lisa Croen
BACKGROUND: Autism Spectrum Disorder (ASD) is one of the fastest-growing developmental disorders in the United States. It was hypothesized that variations in the placental chorionic surface vascular network (PCSVN) structure may reflect both the overall effects of genetic and environmentally regulated variations in branching morphogenesis within the conceptus and the fetus' vital organs. This paper provides sound evidences to support the study of ASD risks with PCSVN through a combination of feature-selection and classification algorithms...
December 6, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29212463/could-a-remarkable-decrease-in-leptin-and-insulin-levels-from-colostrum-to-mature-milk-contribute-to-early-growth-catch-up-of-sga-infants
#15
Marina Nunes, Clécio Homrich da Silva, Vera Lucia Bosa, Juliana Rombaldi Bernardi, Isabel Cristina Ribas Werlang, Marcelo Zubaran Goldani
BACKGROUND: Breast milk is known to contain many bioactive hormones and peptides, which can influence infant growth and development. In this context, the purpose of this study was to evaluate the influence of different clinical pregnancy conditions on hormone concentrations in colostrum and mature breast milk. METHODS: An observational study was performed with mother-newborn pairs divided into five groups according to maternal clinical background: diabetes (12), hypertension (5), smoking (19), intrauterine growth restriction of unknown causes with small-for-gestational-age newborns at delivery (12), and controls (21)...
December 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29212079/plasma-et-1-concentrations-are-elevated-in-pregnant-women-with-hypertension-meta-analysis-of-clinical-studies
#16
Yong-Ping Lu, Ahmed Abdallah Hasan, Shufei Zeng, Berthold Hocher
BACKGROUND/AIMS: The ET system might be involved in the pathogenesis of hypertensive disorders during pregnancy. The objective is to analyse the impact of ET-1 in hypertensive pregnant women by a strict meta-analysis of published human clinical studies. METHODS: Based on the principle of Cochrane systematic reviews, Cohort studies in PubMed (Medline), Google Scholar and China Biological Medicine Database (CBM-disc) designed to identify the role of endothelin-1 (ET-1) in the pathophysiology of gestational hypertension and preeclampsia were screened...
November 28, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29211781/blood-pressure-patterns-and-body-mass-index-status-in-pregnancy-an-assessment-among-women-reporting-for-antenatal-care-at-the-korle-bu-teaching-hospital-ghana
#17
Mary Amoakoh-Coleman, Deda Ogum-Alangea, Emefa Modey-Amoah, Michael Yao Ntumy, Richard M Adanu, Samuel A Oppong
BACKGROUND: Maternal obesity in pregnancy has been linked with increased risk of pregnancy induced hypertension (PIH). In some tertiary referral hospitals in Ghana, PIH is the leading cause of institutional maternal mortality. OBJECTIVE: To evaluate blood pressure changes during pregnancy amongst different body mass index (BMI) groups and how this relates to the risk of developing PIH. METHODS: Women who had a dating ultrasound before 20 weeks gestation and registering for antenatal care at the Korle-Bu Teaching Hospital in Accra, between February and December 2013 and met the inclusion criteria were recruited into a cohort study...
2017: PloS One
https://www.readbyqxmd.com/read/29209815/portrait-of-women-with-type-1-or-type-2-diabetes-of-childbearing-age-attending-diabetes-clinics-in-italy-the-amd-annals-initiative
#18
Marina Scavini, Maria Chiara Rossi, Marco Scardapane, Antonio Nicolucci, Valeria Manicardi, Giuseppina Russo, Paolo Di Bartolo, Carlo B Giorda, Nicoletta Musacchio, Antonio Ceriello, Stefano Genovese, Chiara Molinari, Nicoletta Dozio
AIM: To describe characteristics relevant in case of an unplanned pregnancy for T1D or T2D women of childbearing age. METHODS: We analyzed the 2011 AMD-Annals dataset, compiling information from 300 clinics (28,840 T1D patients and 532,651 T2D patients). A risk score of unfavorable conditions for pregnancy included HbA1c > 8.0%; BMI ≥ 35; systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg; microalbuminuria/proteinuria; use of statins, ACE inhibitors, ARB; use of diabetes drugs other than metformin/insulin...
December 5, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29207813/anaesthetic-considerations-for-balloon-mitral-valvuloplasty-in-pregnant-patient-with-severe-mitral-stenosis-a-case-report-and-review-of-literature
#19
Hemlata, Puneet Goyal, Satyendra Tewari, Arindam Chatterjee
Even though, the incidence of Mitral Stenosis (MS) has reduced grossly, it still remains a health problem in developing countries and is the most common rheumatic valvular lesion encountered in pregnant patients. The already compromised cardiac status of a pregnant female deteriorates further by the presence of MS. So, pregnancy is a common situation during which untreated and frequently poorly tolerated MS are first diagnosed. Percutaneous Balloon Mitral Valvuloplasty (BMV) may be life saving in such a setting and a multidisciplinary approach in the management reduces the mortality and morbidity during the procedure...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207789/minerals-in-pregnancy-and-lactation-a-review-article
#20
REVIEW
Samira Khayat, Hamed Fanaei, Abdolhakim Ghanbarzehi
Micronutrients (include vitamins and minerals) are essential for normal function, growth and development. Minerals have important effects on the health of the mother and foetus. But biological mechanisms of minerals are not completely understood. Micronutrient deficiency during pregnancy can lead to anaemia, hypertension, obstetric complications and even maternal death and in foetus lead to a fail in growth and development. Mineral deficiency during pregnancy, particularly exist in developing countries. During pregnancy due to the increased demands caused by physiological changes, deficiency is exaggerated and as a result its complications occur...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
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