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Barrett's esophagus pathology

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https://www.readbyqxmd.com/read/28798532/adenocarcinoma-of-barrett-s-esophagus-in-a-dog
#1
James K Chambers, Tsubasa Saito, Kenjiro Fukushima, Shigeru Kakuta, Jun Nakayama, Koichi Ohno, Hajime Tsujimoto, Hiroyuki Nakayama, Kazuyuki Uchida
An endoscopic examination revealed a mass in the distal esophagus of a 9-year-old intact male bulldog. Histopathologically, the mass was composed of cuboidal to columnar neoplastic epithelial cells and extended from the squamous epithelium of the esophageal mucosa, indicating that the tumor was derived from Barrett's esophagus. Moreover, highly atypical foci that exhibited a cribriform pattern and high mitotic indices were also observed. The epithelial cells on the surface of the lesion often produced mucus that was positive for Alcian blue and immunohistochemically positive for MUC5AC...
July 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28720474/nitrous-oxide-cryotherapy-for-treatment-of-esophageal-squamous-cell-neoplasia-initial-multicenter-international-experience-with-a-novel-portable-cryoballoon-ablation-system-with-video
#2
Marcia Irene Canto, Julian A Abrams, Hannah T Künzli, Bas Weusten, Yoshihiro Komatsu, Blair A Jobe, Charles J Lightdale
BACKGROUND AND AIMS: Early esophageal squamous cell neoplasia (ESCN) can be successfully treated by EMR, endoscopic submucosal dissection (ESD), or radiofrequency ablation. A new portable, battery-powered cryotherapy system using nitrous oxide (cryoballoon focal ablation system [CbFAS]) has been used for Barrett's esophagus. It consists of a small hand-held device containing liquid nitrous oxide, which converts to gas within a low-pressure-compliant through-the-scope balloon and freezes targeted mucosa in contact with the balloon...
July 16, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28687434/prevalence-of-barrett-s-esophagus-an-observational-study-from-a-gastroenterology-clinic
#3
J L Herrera Elizondo, R Monreal Robles, D García Compean, E I González Moreno, O D Borjas Almaguer, H J Maldonado Garza, J A González González
INTRODUCTION AND AIMS: Barrett's esophagus is a condition that predisposes to esophageal adenocarcinoma. Our aim was to establish the prevalence of Barrett's esophagus at our center, as well as determine its associated factors. MATERIALS AND METHODS: We retrospectively assessed the endoscopic reports of 500 outpatients seen at our Gastroenterology Service from November 2014 to April 2016. We determined the prevalence of Barrett's esophagus and analyzed the demographic, clinical, and endoscopic findings associated with that pathology...
July 4, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28551084/barrett-s-esophagus-ten-years-of-experience-at-a-tertiary-care-hospital-center-in-mexico
#4
F Valdovinos-Andraca, A R Bernal-Méndez, R Barreto-Zúñiga, D Briseño-García, J A Martínez-Lozano, A F Romano-Munive, J Elizondo-Rivera, F I Téllez-Ávila
INTRODUCTION: The prevalence of Barrett's esophagus has been calculated at between 1.3 and 1.6%. There is little information with respect to this in Mexico. AIM: To determine the frequency and characteristics of Barrett's esophagus in patients that underwent endoscopy at a national referral center, within a 10-year time frame. MATERIAL AND METHODS: The databases of the pathology and gastrointestinal endoscopy departments of the Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" were analyzed, covering the period of January 2002 to December 2012...
May 24, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28548120/early-barrett-esophagus-related-neoplasia-in-segments-1%C3%A2-cm-or-longer-is-always-associated-with-intestinal-metaplasia
#5
Benjamin Michael Allanson, Jessica Bonavita, Bob Mirzai, Tze Sheng Khor, Spiro C Raftopoulos, Willem Bastiaan de Boer, Ian S Brown, Marian Priyanthi Kumarasinghe
The assumption that intestinal metaplasia is a prerequisite for intraepithelial neoplasia/dysplasia and adenocarcinoma in the distal esophagus has been challenged by observations of adenocarcinoma without associated intestinal metaplasia. This study describes our experience of intestinal metaplasia in association with early Barrett neoplasia in distal esophagus and gastroesophageal junction. We reviewed the first endoscopic mucosal resection of 139 patients with biopsy-proven neoplasia. In index endoscopic mucosal resection, 110/139 (79%) cases showed intestinal metaplasia...
August 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28446998/pathology-of-esophageal-cancer-and-barrett-s-esophagus
#6
REVIEW
Shilpa Jain, Sadhna Dhingra
Esophageal cancer is a serious malignancy with high mortality. The two common distinctive pathologic subtypes of esophageal cancer are squamous cell carcinoma and adenocarcinoma. These differ with regards to etiology, ethnic distribution, pathogenesis, and location in the esophagus. The precursor lesions are also unique to each subtype. Squamous cell carcinoma is more common in East Asia, is linked to smoking and tobacco use, more commonly involves the middle esophagus, and the precursor lesion is squamous dysplasia...
March 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28425652/endoscopic-findings-of-esophagogastric-junction-in-children
#7
Yoshiko Nakayama, Shinobu Ida
Esophagogastric landmarks are recognizable in the same way both in children and in adults, and palisade-shaped vessels can be observed at the distal position of esophageal mucosa, even in infants. Few studies have been done in respect to Barrett's esophagus (BE) in children. Incidence of endoscopically suspected BE among all children undergoing esophagogastroduodenoscopy (EGD) is approximately 0.25-1.4%, but can be up to 9.7% in patients with gastroesophageal reflux disease (GERD). Some data suggest that BE is an acquired disorder and point to the possibility of a congenital component in combination with severe mucosal injury...
April 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28342132/endoscopic-mucosal-resection-versus-esophagectomy-for-intramucosal-adenocarcinoma-in-the-setting-of-barrett-s-esophagus
#8
Chao Li, Denise Tami Yamashita, Jeffrey David Hawel, Drew Bethune, Harry Henteleff, James Ellsmere
BACKGROUND: Esophagectomy has been the standard of care for patients with intramucosal adenocarcinoma (IMC) in the setting of Barrett's esophagus. It is, however, associated with significant post-operative morbidity and mortality. Endoscopic mucosal resection (EMR) offers a minimally invasive approach with lesser morbidity. This study investigates the transition from esophagectomy to EMR for IMC with respect to eradication rates, post-operative morbidity, and long-term survival. METHODS: Patients diagnosed with IMC from 2005 to 2013 were identified retrospectively...
March 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28338484/the-importance-of-biopsy-sampling-practices-in-the-pathologic-evaluation-of-gastrointestinal-disorders
#9
Nicole C Panarelli, Rhonda K Yantiss
PURPOSE OF REVIEW: To summarize the literature regarding appropriate endoscopic sampling and surveillance protocols for common inflammatory diseases of the digestive tract. Gastroenterologists increasingly use endoscopy with mucosal biopsy to detect inflammatory diseases, assess response to therapy, and monitor for progression to dysplasia. RECENT FINDINGS: Many diseases show a patchy distribution in the digestive tract and there may be poor correlation between the endoscopic appearance and presence of histologic abnormalities...
September 2016: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28293080/tgr5-expression-in-benign-preneoplastic-and-neoplastic-lesions-of-barrett-s-esophagus-case-series-and-findings
#10
Shivali Marketkar, Dan Li, Dongfang Yang, Weibiao Cao
AIM: To examined the bile acid receptor TGR5 expression in squamous mucosa, Barrett's mucosa, dysplasia and esophageal adenocarcinoma (EA). METHODS: Slides were stained with TGR5 antibody. The staining intensity was scored as 1+, 2+ and 3+. The extent of staining (percentage of cells staining) was scored as follows: 1+, 1%-10%, 2+, 11%-50%, 3+, 51%-100%. A combined score of intensity and extent was calculated and categorized as negative, weak, moderate and strong staining...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28265829/a-multicenter-study-of-a-fluorescence-in-situ-hybridization-probe-set-for-diagnosing-high-grade-dysplasia-and-adenocarcinoma-in-barrett-s-esophagus
#11
MULTICENTER STUDY
John M Poneros, Adam S Faye, Emily G Barr Fritcher, Ananda Sen, Sharmila Anandasabapathy, Robert S Bresalier, Norman Marcon, D Kim Turgeon, Henry Appelman, Daniel Normolle, Larry E Morrison, Dean E Brenner, Kevin C Halling
BACKGROUND AND AIMS: Preliminary single-institution data suggest that fluorescence in situ hybridization (FISH) may be useful for detecting high-grade dysplasia (HGD) and esophageal adenocarcinoma (EA) in patients with Barrett's esophagus (BE). This multicenter study aims to validate the measurement of polysomy (gain of at least two loci) by FISH as a way to discriminate degrees of dysplasia in BE specimens. METHODS: Tissue specimens were collected from four different hospitals and read by both the local pathology department ("Site diagnosis") and a single central pathologist ("Review diagnosis") at a separate institution...
May 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28263955/pathway-cross-talk-analysis-in-detecting-significant-pathways-in-barrett-s-esophagus-patients
#12
Zhengyuan Xu, Yan Yan, Jian He, Xinfang Shan, Weiguo Wu
BACKGROUND The pathological mechanism of Barrett's esophagus (BE) is still unclear. In the present study, pathway cross-talks were analyzed to identify hub pathways for BE, with the purpose of finding an efficient and cost-effective detection method to discover BE at its early stage and take steps to prevent its progression. MATERIAL AND METHODS We collected and preprocessed gene expression profile data, original pathway data, and protein-protein interaction (PPI) data. Then, we constructed a background pathway cross-talk network (BPCN) based on the original pathway data and PPI data, and a disease pathway cross-talk network (DPCN) based on the differential pathways between the PPI data and the BE and normal control...
March 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28258451/surgical-treatment-of-high-grade-dysplasia-and-early-esophageal-cancer
#13
Patrick J McLaren, James P Dolan
BACKGROUND: The treatment of early-stage esophageal cancer and high-grade dysplasia of the esophagus has changed significantly in recent years. Many early tumors that were traditionally treated with esophagectomy can now be resected with endoscopic therapy alone. These new endoscopic modalities can offer similar survival outcomes without the associated morbidity of a major operation. However, a number of these cases may still require surgical intervention as the best treatment option...
July 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28250898/gastric-intestinal-metaplasia-is-associated-with-gastric-dysplasia-but-is-inversely-correlated-with-esophageal-dysplasia
#14
Justin M Gomez, James T Patrie, Wissam Bleibel, Jeanetta W Frye, Bryan G Sauer, Vanessa M Shami, Edward B Stelow, Christopher A Moskaluk, Andrew Y Wang
AIM: To determine which clinical factors might be associated with gastric intestinal metaplasia (IM) in a North American population. METHODS: Pathology and endoscopy databases at an academic medical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed. RESULTS: Four hundred and sixty-eight patients with gastric IM (mean age: 61...
February 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28248814/the-use-of-ancillary-stains-in-the-diagnosis-of-barrett-esophagus-and-barrett-esophagus-associated-dysplasia-recommendations-from-the-rodger-c-haggitt-gastrointestinal-pathology-society
#15
REVIEW
Amitabh Srivastava, Henry Appelman, Jeffrey D Goldsmith, Jon M Davison, John Hart, Alyssa M Krasinskas
Barrett esophagus (BE) is a known risk factor for the development of esophageal adenocarcinoma. Pathologists play a critical role in confirming the diagnosis of BE and BE-associated dysplasia. As these diagnoses are not always straightforward on routine hematoxylin and eosin-stained slides, numerous ancillary stains have been used in an attempt to help pathologists confirm the diagnosis. On the basis of an in-depth review of the literature, the Rodger C. Haggitt Gastrointestinal Pathology Society provides recommendations regarding the use of ancillary stains in the diagnosis of BE and BE-associated dysplasia...
May 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28248794/intestinal-metaplasia-of-the-esophagus-in-children-with-esophageal-atresia
#16
Helen Hsieh, Adam Frenette, Laurent Michaud, Usha Krishnan, Dorothée B Dal-Soglio, Frederic Gottrand, Christophe Faure
OBJECTIVES: Patients with esophageal atresia/tracheoesophageal fistula (EA-TEF) can develop Barrett esophagus as a long-term consequence of their condition. Intestinal metaplasia (IM), a risk factor for developing adenocarcinoma of the esophagus, has not been well characterized in the pediatric population. METHODS: Retrospective review of patients with EA-TEF followed at 3 academic pediatric centers between the years 1997 and 2014. RESULTS: Among 542 children and adolescents, 1...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28173664/-pathology-consensus-of-gastroesophageal-reflux-disease-barrett-s-esophagus-and-adenocarcinoma-of-esophagogastric-junction
#17
(no author information available yet)
No abstract text is available yet for this article.
February 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28116788/columnar-islands-in-barrett-s-esophagus-do-they-impact-prague-c-m-criteria-and-dysplasia-grade
#18
Jeremy A Epstein, Hilary Cosby, Gary W Falk, Mouen A Khashab, Ralf Kiesslich, Elizabeth A Montgomery, Jean S Wang, Marcia Irene Canto
BACKGROUND AND AIM: The standard for classifying Barrett's metaplasia on endoscopy, the Prague C&M criteria, ignore all islands of metaplastic-appearing tissue. The aim of the present study was to measure the prevalence of columnar islands, quantify their impact on metaplasia extent, and determine if they harbor advanced dysplasia. METHODS: Data from two prospective patient cohorts were retrospectively analyzed. They included adults who underwent upper endoscopy to evaluate for gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), dysplasia, or adenocarcinoma between 2003-2012 at tertiary care centers in the United States and Germany...
January 23, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28026198/the-importance-of-a-second-opinion-in-the-diagnosis-of-barrett-s-esophagus-a-real-life-study
#19
Vincenzo Villanacci, Marianna Salemme, Italo Stroppa, Valerio Balassone, Gabrio Bassotti
BACKGROUND: Barrett's esophagus is a precancerous lesion, and its identification with the early detection of dysplasia is of paramount importance to prevent adenocarcinoma onset. However, there is still debate on the correct pathological identification of Barrett's esophagus (and of associated dysplasia), and most studies have been conducted in an experimental setting. AIMS: To assess previous uncertain diagnoses of Barrett's (with and without dysplasia) via a second opinion of an expert pathologist in a real life setting...
March 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27997963/efficacy-of-the-cryoballoon-focal-ablation-system-for-the-eradication-of-dysplastic-barrett-s-esophagus-islands
#20
Hannah T Künzli, Dirk W Schölvinck, Sybren L Meijer, Kees A Seldenrijk, Jacques G H M Bergman, Bas L A M Weusten
Background and study aim Cryoablation can be used for the treatment of Barrett's esophagus (BE). A recent dosimetry study, using the CryoBalloon Focal Ablation System (CryoBalloon), demonstrated that 10-second ablations result in complete eradication of BE. However, the efficacy of 10-second ablation in a larger cohort of patients has not been investigated, nor has the potential of precise targeting of specific areas. The aim of the study was to assess the efficacy and performance (i. e. targeting of BE islands) of a 10-second cryoablation using the CryoBalloon...
February 2017: Endoscopy
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