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https://www.readbyqxmd.com/read/28557191/effect-of-increasing-monensin-sodium-levels-in-diets-with-virginiamycin-on-the-finishing-of-nellore-cattle
#1
João Marcos B Benatti, João Alexandrino Alves Neto, Ivanna M de Oliveira, Flávio D de Resende, Gustavo R Siqueira
This study evaluated the effect of increasing levels of monensin sodium (MON) in diets with virginiamycin (VM) on the finishing of feedlot cattle. Two hundred and eighty intact male Nellore cattle (348 ± 32 kg body weight, 22 months) received one of the following five diets: control diet (without additives); diet containing VM (25 mg per kg dry matter) combined with 0 (MON0), 10 (MON10), 20 (MON20) or 30 (MON30) mg MON per kg dry matter. During adaptation (28 days), the MON0 diet increased dietary net energy for maintenance and gain compared to the control diet (P = 0...
May 30, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28549691/27-hydroxycholesterol-upregulates-the-production-of-heat-shock-protein-60-of-monocytic-cells
#2
Bo-Young Kim, Yonghae Son, Jeongyoon Choi, Seong-Kug Eo, Young Chul Park, Koanhoi Kim
Investigating differentially expressed proteins in a milieu rich in cholesterol oxidation products, we found via mass spectrometry-based proteomics that surface levels of heat shock protein 60 (HSP60) were upregulated on monocytic cells in the presence of 27-hydroxycholesterol (27OHChol). The elevated levels of cytoplasmic membrane HSP60 were verified via Western blot analysis and visualized by confocal microscopy. Treatment with 27OHChol also resulted in increased levels of cellular HSP60 without altering its transcription...
May 23, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28516409/survival-after-severe-rhabdomyolysis-following-monensin-ingestion
#3
Michela Blain, Alexander Garrard, Robert Poppenga, Betty Chen, Matthew Valento, Melissa Halliday Gittinger
INTRODUCTION: Monensin is a veterinary antibiotic with a narrow therapeutic window that has led to lethal intoxication in many animal species. Only two prior cases of human toxicity have been reported, both fatal. We present the first case of survival from severe toxicity following monensin ingestion. CASE: A 58-year-old man presented with 8 days of vomiting and abdominal pain. Due to delusions of central nervous system toxoplasmosis, he ingested 300 mg of monensin...
May 17, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28492364/na-influx-via-orai1-inhibits-intracellular-atp-induced-mtorc2-signaling-to-disrupt-cd4-t-cell-gene-expression-and-differentiation
#4
Yong Miao, Jaya Bhushan, Adish Dani, Monika Vig
T cell effector functions require sustained calcium influx. However, the signaling and phenotypic consequences of non-specific sodium permeation via calcium channels remain unknown. α-SNAP is a crucial component of Orai1 channels, and its depletion disrupts the functional assembly of Orai1 multimers. Here we show that α-SNAP hypomorph, hydrocephalus with hopping gait, Napa(hyh/hyh) mice harbor significant defects in CD4 T cell gene expression and Foxp3 regulatory T cell (Treg) differentiation. Mechanistically, TCR stimulation induced rapid sodium influx in Napa(hyh/hyh) CD4 T cells, which reduced intracellular ATP, [ATP]i...
May 11, 2017: ELife
https://www.readbyqxmd.com/read/28476891/drosophila-tg-a-transglutaminase-is-secreted-via-an-unconventional-golgi-independent-mechanism-involving-exosomes-and-two-types-of-fatty-acylations
#5
Toshio Shibata, Jinki Hadano, Daichi Kawasaki, Xiaoqing Dong, Shun-Ichiro Kawabata
Transglutaminases (TGs) play essential intracellular and extracellular roles by covalently cross-linking many proteins. Drosophila TG is encoded by one gene and has two alternative splicing-derived isoforms, TG-A and TG-B, which contain distinct N-terminal 46- and 38-amino acid sequences, respectively. The TGs identified to date do not have a typical endoplasmic reticulum (ER)-signal peptide, and the molecular mechanisms of their secretion under physiologic conditions are unclear. Immunocytochemistry revealed that TG-A localizes to multivesicular-like structures, whereas TG-B localizes to the cytosol...
May 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28434981/protein-transport-inhibitors-downregulate-the-expression-of-lag-3-on-regulatory-t-cells
#6
Sara Anvari, Andrea Grimbergen, Carla M Davis, George Makedonas
Modern immunologic studies demand increasing complexity because of a need to improve our understanding of the relationship between a cell's phenotype and its function. Regulatory T cells (Tregs) have been defined by a narrow set of phenotypic markers, however their actual functional capacity has not been determined at the single-cell level. Although the lymphocyte activation gene 3 (LAG-3; CD223) is a key marker for the identification of exhausted T cells, it may be useful also in resolving Treg subpopulations by indicating distinct functional breadths...
April 21, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28402029/magnetic-solid-phase-extraction-based-on-carbon-nanotubes-for-the-determination-of-polyether-antibiotic-and-s-triazine-drug-residues-in-animal-food-with-lc-ms-ms
#7
Xiaoxing Liu, Shuyu Xie, Tengteng Ni, Dongmei Chen, Xu Wang, Yuanhu Pan, Yulian Wang, Lingli Huang, Guyue Cheng, Wei Qu, Zhenli Liu, Yanfei Tao, Zonghui Yuan
Carbon nanotubes-magnetic nanoparticles, comprising ferroferric oxide nanoparticles and carbon nanotubes, were prepared through a simple one-step synthesis method and subsequently applied to magnetic solid-phase extraction for the determination of polyether antibiotic and s-triazine drug residues in animal food coupled with liquid chromatography with tandem mass spectrometry. The nanocomposites were characterized by transmission electron microscopy, X-ray diffraction, and vibrating sample magnetometry. The components within the nanocomposites endowed the material with high extraction performance and manipulative convenience...
April 12, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28391864/a-simple-and-high-throughput-method-for-determination-and-confirmation-of-14-coccidiostats-in-poultry-muscle-and-eggs-using-liquid-chromatography-quadrupole-linear-ion-trap-tandem-mass-spectrometry-hplc-qqlit-ms-ms-validation-according-to-european-union-2002
#8
Fabiano Barreto, Cristina Ribeiro, Rodrigo Barcellos Hoff, Teresa Dalla Costa
A simple and fast quantitative and confirmatory multi-residue method was developed and validated for the determination of 14 coccidiostats residues in poultry muscle and eggs using liquid chromatography-tandem mass spectrometry (LC/MS-MS). The compounds were analyzed in a single run including lasalocid A, maduramicin, monensin, narasin, salinomycin, semduramicin, robenidine, diclazuril, toltrazuril, trimethoprim, clopidol, amprolium, diaveridine and nicarbazin (as the marker residue dinitrocarbanilide). A low-cost extraction and clean up procedure was optimized without the need of solid-phase extraction...
June 1, 2017: Talanta
https://www.readbyqxmd.com/read/28386903/long-term-broiler-litter-amendments-can-alter-the-soil-s-capacity-to-sorb-monensin
#9
Sarah A Doydora, Peizhe Sun, Miguel Cabrera, Nehru Mantripragada, John Rema, Spyros G Pavlostathis, Ching-Hua Huang, Aaron Thompson
Monensin is a common antiparasitic drug given to poultry that contaminates poultry manure and bedding material (broiler litter). As broiler litter is commonly applied to agricultural fields as fertilizer, monensin could be released beyond the farm if it is not retained or degraded in the soil. This study aimed to assess the impact of long-term surface application of broiler litter (i.e., 17 years) on the capacity of pasture soil to sorb monensin. The soils were exposed to a range of monensin concentrations (0...
May 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28386840/effects-of-supplements-containing-different-additives-on-nutritional-and-productive-performance-of-beef-cattle-grazing-tropical-grass
#10
V V Carvalho, M F Paulino, E Detmann, M L Chizzotti, L S Martins, A G Silva, S A Lopes, F H Moura
A grazing trial was carried out to evaluate the inclusion of three feed additives in supplements (crude protein, CP 230 g/kg dry matter, DM) on the performance, voluntary intake, and digestibility of beef heifers grazing Brachiaria decumbens (CP 81 and neutral detergent fiber, NDF 615 g/kg DM). Thirty-five Nellore heifers (21 months of age and 383 ± 6.29 kg of body weight, BW) were used in a completely randomized design. The treatments were as follows: no supplement (control); supplement fed at 1 kg/animal/day without additives (S); supplement with monensin (S + M); supplement with yeast culture (S + YC); and supplement with enzyme complex (S + EC)...
April 7, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28382302/economic-synergy-between-dry-cow-diet-improvement-and-monensin-bolus-use-to-prevent-subclinical-ketosis-an-experimental-demonstration-based-on-available-literature
#11
Didier Raboisson, Maxime Barbier
The prevention of subclinical ketosis (SCK) is based on maintaining adequate nutrition in dairy cows during the dry period and close to calving. Recently, an oral-route monensin bolus to prevent SCK was approved in Europe. The present study aims to define the allocation of resources for SCK management at the herd level and evaluate the profitability of administering monensin boluses in cows at risk for SCK. A stochastic model was used to calculate the total cost of SCK for a population with a given prevalence of cows at risk for SCK...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28366760/pilot-study-of-immunological-factors-in-non-inflammatory-bowel-disease-enterocutaneous-fistulas
#12
Goher Rahbour, Janindra Warusavitarne, Ailsa L Hart, Philip J Tozer, Mohammad R Ullah, Gregory P Thomas, Simon M Gabe, Stella C Knight, Hafid O Al-Hassi, Carolynne J Vaizey
BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a cytokine elevated in inflammatory bowel disease enterocutaneous fistula (IBD ECF). Dendritic cells are antigen presenting cells that orchestrate the immune responses and regulate the production of cytokines by immune cells including T cells. No study to date has assessed the level of TNF-α or the presence of dendritic cells in non-IBD ECF. The aim of this study was to assess the inflammatory activity, with a particular emphasis on TNF-α in non-IBD ECF when compared with control small bowel tissue...
March 30, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28366563/solid-phase-microextraction-set-up-for-the-analysis-of-liver-volatolome-to-detect-livestock-exposure-to-micropollutants
#13
Jihéne Bouhlel, Jérémy Ratel, Said Abouelkaram, Frédéric Mercier, Angelique Travel, Elisabeth Baéza, Catherine Jondreville, Gaud Dervilly-Pinel, Philippe Marchand, Bruno Le Bizec, Estelle Dubreil, Sophie Mompelat, Eric Verdon, Chanthadary Inthavong, Thierry Guérin, Douglas N Rutledge, Erwan Engel
Starting from a critical analysis of a first "proof of concept" study on the utility of the liver volatolome for detecting livestock exposure to environmental micropollutants (Berge et al., 2011), the primary aim of this paper is to improve extraction conditions so as to obtain more representative extracts by using an extraction temperature closer to livestock physiological conditions while minimizing analytical variability and maximizing Volatile Organic Compound (VOC) abundancies. Levers related to extraction conditions and sample preparation were assessed in the light of both abundance and coefficient of variation of 22 candidate VOC markers identified in earlier volatolomic studies...
May 12, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28352944/quantitative-proteomic-studies-in-resistance-mechanisms-of-eimeria-tenella-against-polyether-ionophores
#14
Ahmed Thabet, Walther Honscha, Arwid Daugschies, Berit Bangoura
Polyether ionophores are widely used to treat and control coccidiosis in chickens. Widespread use of anticoccidials resulted in worldwide resistance. Mechanisms of resistance development and expansion are complex and poorly understood. Relative proteomic quantification using LC-MS/MS was used to compare sensitive reference strains (Ref-1, Ref-2) with putatively resistant and moderately sensitive field strains (FS-R, FS-mS) of Eimeria tenella after isotopic labelling with tandem mass tags (TMT). Ninety-seven proteins were identified, and 25 of them were regulated...
March 28, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28215897/effects-of-body-condition-monensin-and-essential-oils-on-ruminal-lipopolysaccharide-concentration-inflammatory-markers-and-endoplasmatic-reticulum-stress-of-transition-dairy-cows
#15
C Drong, S Bühler, J Frahm, L Hüther, U Meyer, D von Soosten, D K Gessner, K Eder, H Sauerwein, S Dänicke
Evidence exists that dairy cows experience inflammatory-like phenomena in the transition period. Rumen health and alterations in metabolic processes and gene networks in the liver as the central metabolic organ might be key factors for cows' health and productivity in early lactation. This study made use of an animal model to generate experimental groups with different manifestations of postpartal fat mobilization and ketogenesis. In total, 60 German Holstein cows were allocated 6 wk antepartum to 3 high-body condition score (BCS) groups (BCS 3...
April 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28161182/differential-effects-of-monensin-and-a-blend-of-essential-oils-on-rumen-microbiota-composition-of-transition-dairy-cows
#16
M Schären, C Drong, K Kiri, S Riede, M Gardener, U Meyer, J Hummel, T Urich, G Breves, S Dänicke
In response to oral application, monensin alters the rumen microbiota, increasing ruminal propionate production and energy availability in the animal. Data from different studies indicate that the susceptibility of rumen bacteria to monensin is mainly cell-wall dependent but tracing its activity to specific microbial groups has been challenging. Several studies have shown a similar effect for essential oils but results are inconsistent. To investigate the influence of monensin and a blend of essential oils (BEO, containing thymol, guaiacol, eugenol, vanillin, salicylaldehyde, and limonene) on the rumen microbiome, rumen liquid samples were collected orally on d 56 postpartum from cows that had either received a monensin controlled-release capsule 3 wk antepartum, a diet containing a BEO from 3 wk antepartum onward, or a control diet (n = 12)...
April 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28123025/sodium-pumps-mediate-activity-dependent-changes-in-mammalian-motor-networks
#17
Laurence D Picton, Filipe Nascimento, Matthew J Broadhead, Keith T Sillar, Gareth B Miles
Ubiquitously expressed sodium pumps are best known for maintaining the ionic gradients and resting membrane potential required for generating action potentials. However, activity- and state-dependent changes in pump activity can also influence neuronal firing and regulate rhythmic network output. Here we demonstrate that changes in sodium pump activity regulate locomotor networks in the spinal cord of neonatal mice. The sodium pump inhibitor, ouabain, increased the frequency and decreased the amplitude of drug-induced locomotor bursting, effects that were dependent on the presence of the neuromodulator dopamine...
January 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28046158/ionophore-strategy-affects-growth-performance-and-carcass-characteristics-in-feedlot-steers
#18
RANDOMIZED CONTROLLED TRIAL
A J Thompson, Z K F Smith, M J Corbin, L B Harper, B J Johnson
One hundred ninety-two steers (BW = 354 ± 23.5 kg) were used in a randomized block design to evaluate the effects of ionophore and ractopamine hydrochloride (RH) supplementation strategies on performance and carcass characteristics. Twelve pens of 4 steers were assigned to each of the following treatments: unsupplemented control (CON), laidlomycin propionate (12.1 mg/kg DM) with or without RH (LPRH and LP, respectively), and monensin sodium (36.4 mg/kg DM) with RH (MSRH). Steers were fed for 151 d, of which respective treatments received RH (Actogain; Zoetis, Florham Park, NJ) at a rate of 300 mg/(animal · d) for the final 32 d...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28043393/anticoccidial-efficacy-testing-in-vitro-eimeria-tenella-assays-as-replacement-for-animal-experiments
#19
Ahmed Thabet, Runhui Zhang, Alaa-Aldin Alnassan, Arwid Daugschies, Berit Bangoura
SCOPE: Availability of an accurate in vitro assay is a crucial demand to determine sensitivity of Eimeria spp. field strains toward anticoccidials routinely. In this study we tested in vitro models of Eimeria tenella using various polyether ionophores (monensin, salinomycin, maduramicin, and lasalocid) and toltrazuril. Minimum inhibitory concentrations (MIC95, MIC50/95) for the tested anticoccidials were defined based on a susceptible reference (Houghton strain), Ref-1. In vitro sporozoite invasion inhibition assay (SIA) and reproduction inhibition assay (RIA) were applied on sensitive laboratory (Ref-1 and Ref-2) and field (FS-1, FS-2, and FS-3) strains to calculate percent of inhibition under exposure of these strains to the various anticoccidials (%ISIA and%IRIA, respectively)...
January 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28041730/effects-of-cinnamaldehyde-or-monensin-on-performance-of-weaned-holstein-dairy-heifers
#20
RANDOMIZED CONTROLLED TRIAL
C E Chapman, H Chester-Jones, D Ziegler, J A Clapper, P S Erickson
The objective of this 70-d study was to determine the effects of the essential oil cinnamaldehyde compared with the ionophore monensin on performance of weaned Holstein dairy heifers. Eighty-four Holstein dairy heifers (91 ± 3.33 d of age; 109 ± 7.55 kg) were housed in a naturally ventilated curtain sidewall, straw-bedded barn in 12 pens with 7 heifers/pen (3.98 m(2)/head). Heifers were randomly assigned to 1 of 4 treatments in a completely randomized design: (1) control (CON; carrier, 908 g of ground corn), (2) monensin sodium [MON; 1 mg/kg of body weight (BW) + carrier], (3) cinnamaldehyde (CIN1; 1 mg/kg of BW + carrier), or (4) cinnamaldehyde (CIN2; 2 mg/kg of BW + carrier)...
March 2017: Journal of Dairy Science
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