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Regenerative injection therapy

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https://www.readbyqxmd.com/read/29467352/thioacetamide-induced-hepatic-fibrosis-in-the-common-marmoset
#1
Takashi Inoue, Yukihito Ishizaka, Emi Sasaki, Jun Lu, Takayuki Mineshige, Mikio Yanase, Erika Sasaki, Masayuki Shimoda
The common marmoset (Callithrix jacchus) is a nonhuman primate that is used for preclinical research on stem cell transplantation therapies due to its similarity to human beings as well as its small size, enabling researchers to perform experiments without preparing a large number of cells. In this study, we developed a marmoset hepatic fibrosis model for regenerative medicine research. Six female marmosets aged 4-6 years were administered thioacetamide (TAA) at a dose of 2.5-40 mg/kg two or three times a week...
February 21, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29443073/percutaneous-contrast-echocardiography-guided-intramyocardial-injection-and-cell-delivery-in-a-large-preclinical-model
#2
Alejandro Giraldo, Jesús Talavera López, Maria Josefa Fernandez-Del-Palacio, Obdulio García-Nicolás, Juan Seva, Gavin Brooks, José María Moraleda
Cell and gene therapy are exciting and promising strategies for the purpose of cardiac regeneration in the setting of heart failure with reduced ejection fraction (HFrEF). Before they can be considered for use, and implemented in humans, extensive preclinical studies are required in large animal models to evaluate the safety, efficacy, and fate of the injectate (e.g., stem cells) once delivered into the myocardium. Small rodent models offer advantages (e.g., cost effectiveness, amenability for genetic manipulation); however, given inherent limitations of these models, the findings in these rarely translate into the clinic...
January 21, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29417934/functionalized-thermosensitive-hydrogel-combined-with-tendon-stem-progenitor-cells-as-injectable-cell-delivery-carrier-for-tendon-tissue-engineering
#3
Heyong Yin, Zexing Yan, Richard Bauer, Jiang Peng, Matthias Schieker, Michael Nerlich, Denitsa Docheva
Thermosensitive hydrogels have been studied for potential application as promising alternative cell carriers in cell-based regenerative therapies. In this study, a thermosensitive butane diisocyanate (BDI)-collagen hydrogel (BC hydrogel) was designed as injectable cell delivery carrier of tendon stem/progenitor cells (TSPCs) for tendon tissue engineering. We functionalized the BDI hydrogel with the addition of 20% (v/v) collagen I gel to obtain the thermosensitive BC hydrogel, which was then seeded with TSPCs derived from human Achilles tendons...
February 8, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29399304/the-effect-of-photobiomodulation-on-the-depth-of-anesthesia-during-endodontic-treatment-of-teeth-with-symptomatic-irreversible-pulpitis-double-blind-randomized-clinical-trial
#4
Sholeh Ghabraei, Nasim Chiniforush, Behnam Bolhari, Mohsen Aminsobhani, Abbas Khosarvi
Introduction: Achieving appropriate anesthesia in patients with symptomatic irreversible pulpitis in mandibular molars during endodontic treatment is always one of the most challenging aspects. Photobiomodulation (PBM) has been used in dentistry due to its anti-inflammatory properties and regenerative effects. This study evaluates the effects of PBM in the depth of anesthesia in inferior alveolar nerve block. Methods: In this randomized clinical trial, 44 patients requiring endodontic treatment in lower molar, left or right were selected, half of them were randomly treated with PBM therapy...
2018: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29397689/dual-roles-of-graphene-oxide-to-attenuate-inflammation-and-elicit-timely-polarization-of-macrophage-phenotypes-for-cardiac-repair
#5
Jin Han, Yong Sook Kim, Min-Young Lim, Han Young Kim, Saerom Kong, Mikyung Kang, Yeon Woong Choo, Ju Hee Jun, Seungmi Ryu, Hye-Yun Jeong, Jooyeon Park, Gun-Jae Jeong, Jong-Chan Lee, Gwang Hyeon Eom, Youngkeun Ahn, Byung-Soo Kim
Development of localized inflammatory environments by M1 macrophages in the cardiac infarction region exacerbates heart failure after myocardial infarction (MI). Therefore, the regulation of inflammation by M1 macrophages and their timely polarization toward regenerative M2 macrophages suggest an immunotherapy. Particularly, controlling cellular generation of reactive oxygen species (ROS), which cause M1 differentiation, and developing M2 macrophage phenotypes in macrophages propose a therapeutic approach. Previously, stem or dendritic cells were used in MI for their anti-inflammatory and cardioprotective potentials and showed inflammation modulation and M2 macrophage progression for cardiac repair...
February 7, 2018: ACS Nano
https://www.readbyqxmd.com/read/29394953/bcn057-induces-intestinal-stem-cell-repair-and-mitigates-radiation-induced-intestinal-injury
#6
Payel Bhanja, Andrew Norris, Pooja Gupta-Saraf, Andrew Hoover, Subhrajit Saha
BACKGROUND: Radiation-induced gastrointestinal syndrome (RIGS) results from the acute loss of intestinal stem cells (ISC), impaired epithelial regeneration, and subsequent loss of the mucosal barrier, resulting in electrolyte imbalance, diarrhea, weight loss, sepsis, and mortality. The high radiosensitivity of the intestinal epithelium limits effective radiotherapy against abdominal malignancies and limits the survival of victims of nuclear accidents or terrorism. Currently, there is no approved therapy to mitigate radiation toxicity in the intestine...
February 2, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29393405/aurora-a-overexpression-is-linked-to-development-of-aggressive-teratomas-derived-from-humans-ips-cells
#7
Seiga Ohmine, Jeffrey L Salisbury, James Ingle, Giuseppe Pettinato, Candace L Haddox, Tufia Haddad, Evanthia Galanis, Yasuhiro Ikeda, Antonino B D'assoro
The discovery of human induced pluripotent stem cells (hiPSCs) is a promising advancement in the field of regenerative and personalized medicine. Expression of SOX2, KLF4, OCT4 and MYC transcription factors induces the nuclear reprogramming of somatic cells into hiPSCs that share striking similarities with human embryonic stem cells (hESCs). However, several studies have demonstrated that hESCs and hiPSCs could lead to teratoma formation in vivo, thus limiting their current clinical applications. Aberrant cell cycle regulation of hESCs is linked to centrosome amplification, which may account, for their enhanced chromosomal instability (CIN), and thus increase their tumorigenicity...
January 31, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29392844/preconditioning-influences-mesenchymal-stem-cell-properties-in%C3%A2-vitro-and-in%C3%A2-vivo
#8
REVIEW
Chenxia Hu, Lanjuan Li
Various diseases and toxic factors easily impair cellular and organic functions in mammals. Organ transplantation is used to rescue organ function, but is limited by scarce resources. Mesenchymal stem cell (MSC)-based therapy carries promising potential in regenerative medicine because of the self-renewal and multilineage potency of MSCs; however, MSCs may lose biological functions after isolation and cultivation for a long time in vitro. Moreover, after they are injected in vivo and migrate into the damaged tissues or organs, they encounter a harsh environment coupled with death signals due to the inadequate tensegrity structure between the cells and matrix...
February 1, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29392536/retrograde-coronary-venous-infusion-as-a-delivery-strategy-in-regenerative-cardiac-therapy-an-overview-of-preclinical-and-clinical-data
#9
REVIEW
Wouter A Gathier, Dirk Jan van Ginkel, Mira van der Naald, Frebus J van Slochteren, Pieter A Doevendans, Steven A J Chamuleau
An important aspect of cell therapy in the field of cardiac disease is safe and effective delivery of cells. Commonly used delivery strategies such as intramyocardial injection and intracoronary infusion both present with advantages and disadvantages. Therefore, alternative delivery routes are explored, such as retrograde coronary venous infusion (RCVI). Our aim is to evaluate safety and efficiency of RCVI by providing a complete overview of preclinical and clinical studies applying RCVI in a broad range of disease types and experimental models...
February 1, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29380749/injectable-hydrogels-of-optimized-acellular-nerve-for-injection-in-the-injured-spinal-cord
#10
Robert Chase Cornelison, Elisa Gonzalez-Rothi, Stacy L Porvasnik, Steven M Wellman, James H Park, David D Fuller, Christine E Schmidt
Spinal cord injury (SCI) affects a quarter million individuals in the United States, and there is currently no clinical treatment. Both fresh and acellular peripheral nerve grafts can induce spinal axon regeneration and support functional recovery in experimental injury models. Nonetheless, a scaffold that can be injected into a spinal contusion would be far less invasive to apply. We aimed to develop the first injectable acellular nerve graft for promoting repair after contusion SCI. Approach: We report a method to enzymatically solubilize optimized acellular (OA) nerve - a decellularized peripheral nerve graft developed in our laboratory and currently used clinically - to obtain an injectable solution that undergoes thermal gelation under physiological conditions...
January 30, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29379278/the-effects-of-injecting-intra-articular-platelet-rich-plasma-or-prolotherapy-on-pain-score-and-function-in-knee-osteoarthritis
#11
Poupak Rahimzadeh, Farnad Imani, Seyed Hamid Reza Faiz, Saeed Reza Entezary, Mahnaz Narimani Zamanabadi, Mahmoud Reza Alebouyeh
Introduction: Osteoarthritis (OA) is a chronic joint disease that usually occurs in older people and leads to pain and disabilities. OA treatment ranges from drug therapy to surgery. Drug and rehabilitation therapy are preferred over surgery, and, especially, there is a tendency toward compounds causing regenerative changes in the knee joint. In the present study, the effects of platelet-rich plasma (PRP) injection and prolotherapy (PRL) were examined on the level of pain and function of the knee joint in patients with OA...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29373816/extracellular-vesicle-therapeutics-for-liver-disease
#12
REVIEW
David Borrelli, Kiera Yankson, Neha Shukla, George Vilanilam, Taylor Ticer, Joy Wolfram
Extracellular vesicles (EVs) are endogenous nanoparticles that play important roles in intercellular communication. Unmodified and engineered EVs can be utilized for therapeutic purposes. For instance, mesenchymal stem cell (MSC)-derived EVs have shown promise for tissue repair, while drug-loaded EVs have the potential to be used for cancer treatment. The liver is an ideal target for EV therapy due to the intrinsic regenerative capacity of hepatic tissue and the tropism of systemically injected nanovesicles for this organ...
January 23, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29369541/hierarchical-design-of-tissue-regenerative-constructs
#13
REVIEW
Jonas C Rose, Laura De Laporte
The worldwide shortage of organs fosters significant advancements in regenerative therapies. Tissue engineering and regeneration aim to supply or repair organs or tissues by combining material scaffolds, biochemical signals, and cells. The greatest challenge entails the creation of a suitable implantable or injectable 3D macroenvironment and microenvironment to allow for ex vivo or in vivo cell-induced tissue formation. This review gives an overview of the essential components of tissue regenerating scaffolds, ranging from the molecular to the macroscopic scale in a hierarchical manner...
January 25, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29339111/stem-cells-for-urinary-incontinence-functional-differentiation-or-cytokine-effects
#14
REVIEW
Bradley C Gill, Daniel Z Sun, Margot S Damaser
Minimally-invasive stem cell therapy for stress urinary incontinence may provide an effective nonsurgical treatment for this common condition. Clinical trials of periurethral stem cell injection have been underway and basic science research has demonstrated the efficacy of both local and systemic stem cell therapies. Results differ as to whether stem cells have a therapeutic effect by differentiating into permanent, functional tissues, or whether they exert benefits through a transient presence and the secretion of regenerative factors...
January 12, 2018: Urology
https://www.readbyqxmd.com/read/29337123/mesenchymal-stem-cell-based-therapy-improves-lower-limb-movement-after-spinal-cord-ischemia-in-rats
#15
Shinya Takahashi, Kei Nakagawa, Mayumi Tomiyasu, Ayumu Nakashima, Keijiro Katayama, Takeshi Imura, Bagus Herlambang, Fumie Okubo, Koji Arihiro, Yumi Kawahara, Louis Yuge, Taijiro Sueda
BACKGROUND: Spinal cord ischemia is a devastating complication following thoracic and thoracoabdominal aortic surgery. In this study, we aimed to investigate the effects of mesenchymal stem cells (MSCs), which have regenerative capability and exert paracrine actions on damaged tissues, injected into rat models of spinal cord ischemia-reperfusion injury. METHODS: Forty-five Sprague-Dawley rats were divided into sham, phosphate-buffered saline (PBS), and MSC groups...
January 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29324934/stem-cells-therapy-the-future-in-the-management-of-systemic-sclerosis-a-case-report
#16
Jung In Song, Silvanie Volz, Maria Eirini Liodaki, Peter Mailänder, Konstantinos Kalousis
OBJECTIVE: Systemic sclerosis (SSc) is a connective tissue disorder of unknown etiology, with heterogeneous clinical manifestations and chronic and often progressive course. The diffuse cutaneous form of SSc (dcSSc) is characterized by thickening of the skin (scleroderma) and distinctive involvement of multiple internal organs. Patients with limited cutaneous SSc (lcSSc) generally have long-standing Raynaud's phenomenon before other manifestations of SSc appear. Over the last decade the Interest of adipose-derived cell therapy in regenerative medicine has increased continuously...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29321063/first-clinical-case-report-of-local-microinjection-of-autologous-fat-and-adipose-derived-stromal-vascular-fraction-for-perianal-fistula-in-crohn-s-disease
#17
Cécile Philandrianos, Mélanie Serrero, Fanny Grimaud, Jérémy Magalon, Carine Visée, Mélanie Velier, Pauline Francois, Pierre Orsoni, Guy Magalon, Jean-Charles Grimaud, Ariadne Desjeux, Julie Véran, Florence Sabatier
Mesenchymal stem cell therapy is a promising treatment for perianal Crohn's fistulas refractory to conventional therapy, which are an extremely morbid complication and a true therapeutic challenge. Autologous adipose-derived stromal vascular fraction (ADSVF) is an easily accessible source of cells with angiogenic, anti-inflammatory, immunomodulatory, and regenerative properties. Here, we describe a case involving a patient with severe perianal Crohn's fistulas refractory to the best medical and surgical practices who received local treatment with ADSVF and microfat...
January 10, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29298988/oxidative-stress-preconditioning-of-mouse-perivascular-myogenic-progenitors-selects-a-subpopulation-of-cells-with-a-distinct-survival-advantage-in-vitro-and-in-vivo
#18
Cesare Gargioli, Giuseppina Turturici, Maria M Barreca, Walter Spinello, Claudia Fuoco, Stefano Testa, Salvatore Feo, Stefano M Cannata, Giulio Cossu, Gabriella Sconzo, Fabiana Geraci
Cell engraftment, survival and integration during transplantation procedures represent the crux of cell-based therapies. Thus, there have been many studies focused on improving cell viability upon implantation. We used severe oxidative stress to select for a mouse mesoangioblast subpopulation in vitro and found that this subpopulation retained self-renewal and myogenic differentiation capacities while notably enhancing cell survival, proliferation and migration relative to unselected cells. Additionally, this subpopulation of cells presented different resistance and recovery properties upon oxidative stress treatment, demonstrating select advantages over parental mesoangioblasts in our experimental analysis...
January 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29246648/human-mesenchymal-stromal-cell-therapy-for-damaged-cochlea-repair-in-nod-scid-mice-deafened-with-kanamycin
#19
Simone Bettini, Valeria Franceschini, Laura Astolfi, Edi Simoni, Benedetta Mazzanti, Alessandro Martini, Roberto P Revoltella
BACKGROUND: Kanamycin, mainly used in the treatment of drug-resistant-tuberculosis, is known to cause irreversible hearing loss. Using the xeno-transplant model, we compared both in vitro and in vivo characteristics of human mesenchymal stromal cells (MSCs) derived from adult tissues, bone marrow (BM-MSCs) and adipose tissue (ADSCs). These tissues were selected for their availability, in vitro multipotency and regenerative potential in vivo in kanamycin-deafened nod-scid mice. METHODS: MSCs were isolated from informed donors and expanded ex vivo...
December 12, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29229249/enzyme-mediated-tissue-adhesive-hydrogels-for-meniscus-repair
#20
Su-Hwan Kim, Young-Hyeon An, Hwan D Kim, Kyungmin Kim, Sang-Hyuk Lee, Hyun-Gu Yim, Byung-Gee Kim, Nathaniel S Hwang
Meniscus tissues have limited regenerative capacity once damaged. The treatment options for the meniscus tissue regeneration have been limited to arthroscopic meniscectomy or surgical interventions. The injectable hydrogels based system would provide an alternative to the conventional meniscus therapy by providing a minimally invasive treatment alternative. Here we utilized enzyme-based approaches to fabricate tissue adhesive hydrogels for meniscus repair. Tyramine (TA) conjugated hyaluronic acid (TA-HA) and gelatin are susceptible to tyrosinase (TYR)-mediated crosslinking in vitro and in vivo...
December 8, 2017: International Journal of Biological Macromolecules
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