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https://www.readbyqxmd.com/read/27865382/bcg-infection-in-mice-is-promoted-by-na%C3%A3-ve-mesenchymal-stromal-cells-msc-and-suppressed-by-poly-a-u-conditioned-msc
#1
Yakov Sh Schwartz, Sergey N Belogorodtsev, Pavel N Filimonov, Andrey G Cherednichenko, Sergey V Pustylnikov, Vladimir A Krasnov
Mesenchymal stromal cells (MSC) transplantation is an actively studied therapeutic approach used in regenerative medicine and in the field of control of immunoinflammatory response. Conditioning of MSC in culture can form their predominantly pro- or anti-inflammatory phenotypes. We demonstrated that poly(A:U)-conditioning of bone marrow-derived mouse MSC induced predominantly pro-inflammatory phenotype. The effects of administration of naïve MSC (nMSC) or conditioned MSC (cMSC) on the course of mycobacterial infection were studied...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27861845/quantum-dots-labelling-allows-detection-of-the-homing-of-mesenchymal-stem-cells-administered-as-immunomodulatory-therapy-in-an-experimental-model-of-pancreatic-islets-transplantation
#2
Silvia Mannucci, Laura Calderan, Paola Quaranta, Sara Antonini, Franco Mosca, Biancamaria Longoni, Pasquina Marzola, Federico Boschi
Cell transplantation is considered a promising therapeutic approach in several pathologies but still needs innovative and non-invasive imaging technologies to be validated. The use of mesenchymal stem cells (MSCs) attracts major interest in clinical transplantation thanks to their regenerative properties, low immunogenicity and ability to regulate immune responses. In several animal models, MSCs are used in co-transplantation with pancreatic islets (PIs) for the treatment of type I diabetes, supporting graft survival and prolonging normal glycaemia levels...
November 15, 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/27817105/neuro-regeneration-therapy-using-human-muse-cells-is-highly-effective-in-a-mouse-intracerebral-hemorrhage-model
#3
Norihito Shimamura, Kiyohide Kakuta, Liang Wang, Masato Naraoka, Hiroki Uchida, Shohei Wakao, Mari Dezawa, Hiroki Ohkuma
A novel type of non-tumorigenic pluripotent stem cell, the Muse cell (multi-lineage, differentiating stress enduring cell), resides in the connective tissue and in cultured mesenchymal stem cells (MSCs) and is reported to differentiate into multiple cell types according to the microenvironment to repair tissue damage. We examined the efficiency of Muse cells in a mouse intracerebral hemorrhage (ICH) model. Seventy μl of cardiac blood was stereotactically injected into the left putamen of immunodeficient mice...
November 5, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27804974/mesenchymal-stem-cells-combined-with-hepatocyte-growth-factor-therapy-for-attenuating-ischaemic-myocardial-fibrosis-assessment-using-multimodal-molecular-imaging
#4
Huizhu Chen, Rui Xia, Zhenlin Li, Lizhi Zhang, Chunchao Xia, Hua Ai, Zhigang Yang, Yingkun Guo
Clinically, myocardial fibrosis is increasingly being recognized as a new therapeutic target for ischaemic heart diseases. The aim of this study was to investigate whether noninvasive multimodal molecular imaging could be used to dynamically assess whether the combination of bone marrow mesenchymal stem cells (BMSCs) and hepatocyte growth factor (HGF) therapy can synergistically attenuate myocardial fibrosis after myocardial infarction (MI). MI was induced in 28 rats by coronary ligation with subsequent injection of BMSCs/HGF, BMSCs, HGF, or saline into the border zone under echocardiography guidance...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27798372/safety-studies-for-use-of-adipose-tissue-derived-mesenchymal-stromal-stem-cells-in-a-rabbit-model-for-osteoarthritis-to-support-a-phase-i-clinical-trial
#5
Scott M Riester, Janet M Denbeigh, Yang Lin, Dakota L Jones, Tristan de Mooij, Eric A Lewallen, Hai Nie, Christopher R Paradise, Darcie J Radel, Amel Dudakovic, Emily T Camilleri, Dirk R Larson, Wenchun Qu, Aaron J Krych, Matthew A Frick, Hee-Jeong Im, Allan B Dietz, Jay Smith, Andre J van Wijnen
: : Adipose-derived mesenchymal stem cells (AMSCs) offer potential as a therapeutic option for clinical applications in musculoskeletal regenerative medicine because of their immunomodulatory functions and capacity for trilineage differentiation. In preparation for a phase I clinical trial using AMSCs to treat patients with osteoarthritis, we carried out preclinical studies to assess the safety of human AMSCs within the intra-articular joint space. Culture-expanded human AMSCs grown in human platelet-lysate were delivered via intra-articular injections into normal healthy rabbit knees and knees at risk for the development of osteoarthritis after bilateral medial anterior hemimeniscectomy...
October 26, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27779646/heparin-binding-epidermal-growth-factor-like-growth-factor-and-hepatocyte-growth-factor-inhibit-cholestatic-liver-injury-in-mice-through-different-mechanisms
#6
Kouichi Sakamoto, Ngin Cin Khai, Yuqing Wang, Rie Irie, Hideo Takamatsu, Hiroshi Matsufuji, Ken-Ichiro Kosai
In contrast to hepatocyte growth factor (HGF), the therapeutic potential and pathophysiologic roles of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in liver diseases remain relatively unknown. To address the lack of effective pharmacologic treatments for cholestatic liver injuries, as well as to clarify the biologic features of these growth factors, we explored the effects of HB-EGF and HGF in mice with cholestatic liver injury induced by bile duct ligation (BDL). The mice were assessed 3, 5 and/or 14 days after BDL (acute, subacute and/or chronic phases, respectively) and intravenous injection of adenoviral vector expressing LacZ (control), HB-EGF, HGF, or HB-EGF and HGF...
October 20, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27727015/clinical-safety-of-intrathecal-administration-of-mesenchymal-stromal-cell-derived-neural-progenitors-in-multiple-sclerosis
#7
Violaine K Harris, Tamara Vyshkina, Saud A Sadiq
BACKGROUND AIMS: There is a critical unmet need to develop regenerative therapies for the demyelinating disease multiple sclerosis (MS). We previously characterized the immunoregulatory and trophic properties of neural progenitors derived from bone marrow mesenchymal stromal cells (MSC-NPs) and established that cells derived from MS and non-MS patients alike were therapeutically viable. In an experimental model of MS, intrathecal MSC-NP injection resulted in disease amelioration with decreased T-cell infiltration, and less severe lesion pathology associated with recruitment of resident progenitors to inflammatory sites...
October 7, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27721705/cardiovascular-regenerative-technologies-update-and-future-outlook
#8
Anna Mallone, Benedikt Weber, Simon P Hoerstrup
In the effort of improving treatment for cardiovascular disease (CVD), scientists struggle with the lack of the regenerative capacities of finally differentiated cardiovascular tissues. In this context, the advancements in regenerative medicine contributed to the development of cell-based therapies as well as macro- and micro-scale tissue-engineering technologies. The current experimental approaches focus on different regenerative strategies including a broad spectrum of techniques such as paracrine-based stimulation of autologous cardiac stem cells, mesenchymal cell injections, 3D microtissue culture techniques and vascular tissue-engineering methods...
July 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27721238/dendritic-cells-maintain-dermal-adipose-derived-stromal-cells-in-skin-fibrosis
#9
Jennifer J Chia, Tong Zhu, Susan Chyou, Dragos C Dasoveanu, Camila Carballo, Sha Tian, Cynthia M Magro, Scott Rodeo, Robert F Spiera, Nancy H Ruddle, Timothy E McGraw, Jeffrey L Browning, Robert Lafyatis, Jessica K Gordon, Theresa T Lu
Scleroderma is a group of skin-fibrosing diseases for which there are no effective treatments. A feature of the skin fibrosis typical of scleroderma is atrophy of the dermal white adipose tissue (DWAT). Adipose tissue contains adipose-derived mesenchymal stromal cells (ADSCs) that have regenerative and reparative functions; however, whether DWAT atrophy in fibrosis is accompanied by ADSC loss is poorly understood, as are the mechanisms that might maintain ADSC survival in fibrotic skin. Here, we have shown that DWAT ADSC numbers were reduced, likely because of cell death, in 2 murine models of scleroderma skin fibrosis...
November 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27701826/in-vitro-topographical-model-of-fuchs-dystrophy-for-evaluation-of-corneal-endothelial-cell-monolayer-formation
#10
Muhammad Rizwan, Gary S Peh, Khadijah Adnan, Sacha L Naso, Alon R Mendez, Jodhbir S Mehta, Evelyn K F Yim
A common indication for corneal transplantation, which is the most transplanted tissue, is a dysfunctional corneal endothelium due to Fuchs' endothelial dystrophy (FED). FED is diagnosed by the presence of in vivo pathological microtopography on the Descemet membrane, which is called corneal guttata. Minimally invasive corneal endothelial cell regenerative procedures such as endothelial cell injection therapy and Rho kinase inhibitor pharmacotherapy have been proposed as alternatives to conventional corneal transplantation for FED patients...
October 4, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27690716/development-of-a-combined-radiation-and-full-thickness-burn-injury-minipig-model-to-study-the-effects-of-uncultured-adipose-derived-regenerative-cell-therapy-in-wound-healing
#11
Philippe Foubert, Melanie Doyle-Eisele, Andreina Gonzalez, Felipe Berard, Waylon Weber, Diana Zafra, Zeni Alfonso, Sherry Zhao, Mayer Tenenhaus, John K Fraser
PURPOSE: The objective of this study was to develop an approach that models the cutaneous healing that occurs in a patient with full thickness thermal burn injury complicated by total body radiation exposure sufficient to induce sub-lethal prodromal symptoms. An assessment of the effects of an autologous cell therapy on wound healing on thermal burn injury with concomitant radiation exposure was used to validate the utility of the model. METHODS: Göttingen minipigs were subjected to a 1...
October 3, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27689996/an-inflammatory-nucleus-pulposus-tissue-culture-model-to-test-molecular-regenerative-therapies-validation-with-epigallocatechin-3-gallate
#12
Olga Krupkova, Marian Hlavna, Julie Amir Tahmasseb, Joel Zvick, Dominik Kunz, Keita Ito, Stephen J Ferguson, Karin Wuertz-Kozak
Organ cultures are practical tools to investigate regenerative strategies for the intervertebral disc. However, most existing organ culture systems induce severe tissue degradation with only limited representation of the in vivo processes. The objective of this study was to develop a space- and cost-efficient tissue culture model, which represents degenerative processes of the nucleus pulposus (NP). Intact bovine NPs were cultured in a previously developed system using Dyneema jackets. Degenerative changes in the NP tissue were induced either by the direct injection of chondroitinase ABC (1-20 U/mL) or by the diffusion of interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) (both 100 ng/mL) from the culture media...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27677916/biological-therapies-in-regenerative-sports-medicine
#13
Isabel Andia, Nicola Maffulli
Regenerative medicine seeks to harness the potential of cell biology for tissue replacement therapies, which will restore lost tissue functionality. Controlling and enhancing tissue healing is not just a matter of cells, but also of molecules and mechanical forces. We first describe the main biological technologies to boost musculoskeletal healing, including bone marrow and subcutaneous fat-derived regenerative products, as well as platelet-rich plasma and conditioned media. We provide some information describing possible mechanisms of action...
September 28, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27676677/timing-of-platelet-rich-plasma-injections-during-antithrombotic-therapy
#14
Ryan Ravi Ramsook, Houman Danesh
The use of platelet rich plasma (PRP) spans across many fields owing to its role in healing and as a natural alternative to surgery. PRP continues to grow however much of the literature is anecdotal or case report based and there is a lack of controlled trials to evaluate standards for PRP. The International Cellular Medical Society (ICMS) has developed guidelines to help with the safe advancement of PRP; however there remains a gap in literature concerning the timing of PRP injections in patients who are on antithrombotic therapy...
September 2016: Pain Physician
https://www.readbyqxmd.com/read/27659216/impact-of-the-secretome-of-human-mesenchymal-stem-cells-on-brain-structure-and-animal-behavior-in-a-rat-model-of-parkinson-s-disease
#15
Fábio G Teixeira, Miguel M Carvalho, Krishna M Panchalingam, Ana J Rodrigues, Bárbara Mendes-Pinheiro, Sandra Anjo, Bruno Manadas, Leo A Behie, Nuno Sousa, António J Salgado
: : Research in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated therapeutic benefits are mainly due to their secretome, which has been proposed as a possible therapeutic tool for the treatment of Parkinson's disease (PD). Indeed, it has been shown that the MSC secretome increases neurogenesis and cell survival, and has numerous neuroprotective actions under different conditions. Additionally, using dynamic culturing conditions (through computer-controlled bioreactors) can further modulate the MSC secretome, thereby generating a more potent neurotrophic factor cocktail (i...
September 22, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27651860/neural-growth-factor-stimulates-proliferation-of-spinal-cord-derived-neural-precursor-stem-cells
#16
Youngmin Han, Kyoung-Tae Kim
OBJECTIVE: Recently, regenerative therapies have been used in clinical trials (heart, cartilage, skeletal). We don't make use of these treatments to spinal cord injury (SCI) patients yet, but regenerative therapies are rising interest in recent study about SCI. Neural precursor/stem cell (NPSC) proliferation is a significant event in functional recovery of the central nervous system (CNS). However, brain NPSCs and spinal cord NPSCs (SC-NPSCs) have many differences including gene expression and proliferation...
September 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27619838/regenerative-effects-of-peptide-nanofibers-in-an-experimental-model-of-parkinson-s-disease
#17
Melike Sever, Mesut Turkyilmaz, Cansu Sevinc, Aysen Cakir, Busra Ocalan, Mehmet Cansev, Mustafa O Guler, Ayse B Tekinay
Parkinson's Disease (PD) is characterized by progressive degeneration of dopaminergic nigrostriatal neurons and reduction in striatal dopamine levels. Although there are few treatment options for PD such as Levodopa, they are used just to relieve and modify the symptoms. There are no therapies available for PD to slow down the degeneration process in the brain and recover the lost function. In this study, we used extracellular matrix (ECM) mimetic peptide amphiphile (PA) nanofibers as a potential therapeutic approach in a PD rat model...
September 9, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27609786/epo-pretreatment-of-ecfcs-enhances-functional-recovery-after-transplantation-in-a-rat-model-of-cerebral-ischemia-through-an-increase-of-their-homing-abilities-a-spect-ct-study
#18
Philippe Garrigue, Guillaume Hache, Youssef Bennis, Pauline Brige, Jimmy Stalin, Lionel Pellegrini, Lionel Velly, Francesca Orlandi, Elena Castaldi, Françoise Dignat-George, Florence Sabatier, Benjamin Guillet
BACKGROUND: endothelial colony-forming cells (ECFCs) are promising candidates for cell therapy of ischemic diseases, as less than 10% of patients suffering from an ischemic stroke are eligible for thrombolysis. We previously reported that erythropoietin priming of ECFCs increased their in vitro and in vivo angiogenic properties in mice with hind limb ischemia. OBJECTIVE: the present study aimed to evaluate whether priming of ECFCs with erythropoietin could enhance their homing into the ischemic site after transient middle cerebral artery occlusion (MCAO) followed by reperfusion in rats and potentiate their protective or regenerative effects on brain-blood barrier disruption (BBBd), cerebral apoptosis and cerebral blood flow (CBF) by Single Photon Emission/Computed Tomography (SPECT/CT) imaging...
September 8, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27604559/autologous-fat-injection-therapy-including-a-high-concentration-of-adipose-derived-regenerative-cells-in-a-vocal-fold-paralysis-model-animal-pilot-study
#19
N Nishio, Y Fujimoto, K Suga, Y Iwata, K Toriyama, K Takanari, Y Kamei, T Yamamoto, M Gotoh
OBJECTIVES: To verify the effectiveness and safety of the addition of adipose-derived regenerative cells to autologous fat injection therapy. METHODS: Unilateral vocal fold paralysis models were made by cutting the right recurrent laryngeal nerve in two pigs. At day 30, 0.5 ml adipose-derived regenerative cells mixed with 1 ml autologous fat was injected into the right vocal fold of one pig, with the other receiving 0.5 ml Ringer's solution mixed with 1 ml autologous fat...
October 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27592819/safety-and-tolerability-of-silk-fibroin-hydrogels-implanted-into-the-mouse-brain
#20
Laura Fernández-García, Núria Marí-Buyé, Juan A Barios, Rodrigo Madurga, Manuel Elices, José Pérez-Rigueiro, Milagros Ramos, Gustavo V Guinea, Daniel González-Nieto
: At present, effective therapies to repair the central nervous system do not exist. Biomaterials might represent a new frontier for the development of neurorestorative therapies after brain injury and degeneration. In this study, an in situ gelling silk fibroin hydrogel was developed via the sonication-induced gelation of regenerated silk fibroin solutions. An adequate timeframe for the integration of the biomaterial into the brain tissue was obtained by controlling the intensity and time of sonication...
November 2016: Acta Biomaterialia
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