keyword
https://read.qxmd.com/read/38475906/menstrual-blood-derived-mesenchymal-stem-cells-combined-with-collagen-i-gel-as-a-regenerative-therapeutic-strategy-for-degenerated-disc-after-discectomy-in-rats
#1
JOURNAL ARTICLE
Li Yu, Honghao Wu, Shumei Zeng, Xiaojian Hu, Yuxu Wu, Jinhong Zhou, Li Yuan, Qingqing Zhang, Charlie Xiang, Zhiyun Feng
BACKGROUND: Annulus fibrosis (AF) defects have been identified as the primary cause of disc herniation relapse and subsequent disc degeneration following discectomy. Stem cell-based tissue engineering offers a promising approach for structural repair. Menstrual blood-derived mesenchymal stem cells (MenSCs), a type of adult stem cell, have gained attention as an appealing source for clinical applications due to their potential for structure regeneration, with ease of acquisition and regardless of ethical issues...
March 13, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38470874/parotid-glands-have-a-dysregulated-immune-response-following-radiation-therapy
#2
JOURNAL ARTICLE
Jordan A Gunning, Kristy E Gilman, Tiffany M Zúñiga, Richard J Simpson, Kirsten H Limesand
Head and neck cancer treatment often consists of surgical resection of the tumor followed by ionizing radiation (IR), which can damage surrounding tissues and cause adverse side effects. The underlying mechanisms of radiation-induced salivary gland dysfunction are not fully understood, and treatment options are scarce and ineffective. The wound healing process is a necessary response to tissue injury, and broadly consists of inflammatory, proliferative, and redifferentiation phases with immune cells playing key roles in all three phases...
2024: PloS One
https://read.qxmd.com/read/38468689/amnion-derived-hydrogels-as-a-versatile-platform-for-regenerative-therapy-from-lab-to-market
#3
REVIEW
Golara Kafili, Hassan Niknejad, Elnaz Tamjid, Abdolreza Simchi
In recent years, the amnion (AM) has emerged as a versatile tool for stimulating tissue regeneration and has been of immense interest for clinical applications. AM is an abundant and cost-effective tissue source that does not face strict ethical issues for biomedical applications. The outstanding biological attributes of AM, including side-dependent angiogenesis, low immunogenicity, anti-inflammatory, anti-fibrotic, and antibacterial properties facilitate its usage for tissue engineering and regenerative medicine...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38461100/platelet-rich-plasma-prp-treatment-in-recalcitrant-bilateral-phono-traumatic-lesions
#4
JOURNAL ARTICLE
Peak Woo, Thomas Murry
OBJECTIVE: Mature vocal fold nodules and fibrous phono-traumatic lesions that have failed standard voice therapy can be challenging. Autologous platelet-rich plasma (PRP) is rich in growth factors and easily obtained from a simple blood draw. Growth factor injection into the vocal folds may reverse the scar and inflammation in recalcitrant, bilateral phono-traumatic lesions such as mature vocal fold nodules. This study reports the short-term (3months) voice results after PRP injection in 11 subjects with recalcitrant, bilateral phono-traumatic lesions that have failed voice therapy...
March 8, 2024: Journal of Voice
https://read.qxmd.com/read/38457904/in-vitro-development-and-optimization-of-cell-laden-injectable-bioprinted-gelatin-methacryloyl-gelma-microgels-mineralized-on-the-nanoscale
#5
JOURNAL ARTICLE
Mauricio Gonçalves da Costa Sousa, Gabriela de Souza Balbinot, Ramesh Subbiah, Rahul Madathiparambil Visalakshan, Anthony Tahayeri, Maria Elisa Lima Verde, Avathamsa Athirasala, Genevieve Romanowicz, Robert E Guldberg, Luiz E Bertassoni
Bone defects may occur in different sizes and shapes due to trauma, infections, and cancer resection. Autografts are still considered the primary treatment choice for bone regeneration. However, they are hard to source and often create donor-site morbidity. Injectable microgels have attracted much attention in tissue engineering and regenerative medicine due to their ability to replace inert implants with a minimally invasive delivery. Here, we developed novel cell-laden bioprinted gelatin methacrylate (GelMA) injectable microgels, with controllable shapes and sizes that can be controllably mineralized on the nanoscale, while stimulating the response of cells embedded within the matrix...
March 2, 2024: Biomater Adv
https://read.qxmd.com/read/38455624/effect-of-umbilical-cord-mesenchymal-stem-cells-on-hypoxia-inducible-factor-1-alpha-hif-1%C3%AE-production-in-arteriovenous-fistula-avf-animal-model-a-preliminary-study
#6
JOURNAL ARTICLE
Yopie A Habibie, Dessy R Emril, Azharuddin Azharuddin, Dedy Syahrizal
Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor that plays a crucial role in cellular responses to hypoxia, such as in the development of intimal hyperplasia, a common complication in arteriovenous fistula (AVF) creation. While the application of umbilical cord mesenchymal stem cells (UC-MSCs) has shown promise in various regenerative medicine applications, including tissue repair and angiogenesis, the effect of UC-MSCs on HIF-1α level in the AVF has not been tested. Therefore, the aim of this study was to evaluate the effect of UC-MSCs administration on HIF-1α levels in the AVF animal model...
December 2023: Narra J
https://read.qxmd.com/read/38443118/examining-the-uncertainties-surrounding-exosome-therapy-in-androgenetic-alopecia-a-call-for-evidence-based-practice
#7
JOURNAL ARTICLE
Michael G Buontempo, Lina Alhanshali, Mirena Ide, Jerry Shapiro, Kristen Lo Sicco
Hair loss, a pervasive and often distressing condition, affects a substantial number of individuals globally. Although conventional treatments such as hair transplantation, topicals, oral medications, and injectables exist, they have limitations, including the necessity for repeated treatments, potential adverse effects, and cost barriers. Exosome therapy, an innovative and burgeoning option within regenerative medicine, offers a novel approach to hair loss treatment. Exosomes are small vesicles that are produced from the membranes of late-endosomes and secreted by cells, playing a crucial role in intercellular communication...
March 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38439108/culture-of-hoffa-fat-pad-mesenchymal-stem-stromal-cells-on-microcarrier-suspension-in-vertical-wheel-bioreactor-for-extracellular-vesicle-production
#8
JOURNAL ARTICLE
Alexander Otahal, Karina Kramer, Markus Neubauer, Slavomira Gulová, Zsombor Lacza, Stefan Nehrer, Andrea De Luna
BACKGROUND: Mesenchymal stromal cells (MSCs) are increasingly employed in regenerative medicine approaches for their immunomodulatory and anti-inflammatory properties, which are encoded in their secretome including extracellular vesicles (EVs). The Hoffa fat pad (HFP) located infrapatellarly harbours MSCs that could assist in tissue homeostasis in osteoarthritic joints. Intraarticular injection therapies based on blood products could modulate the populations of released HFP-MSC-EVs in a quantitative manner...
March 5, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38412778/skin-derived-precursor-conditioned-medium-alleviated-photoaging-via-early-activation-of-tgf-%C3%AE-smad-signaling-pathway-by-thrombospondin1-in-vitro-and-in-vivo-studies
#9
JOURNAL ARTICLE
Yiming Li, Lingyun Zhao, Shiyi Li, Danhua Ruan, Lidan Xiong, Jie Tang, Meng Hu, Yixin Wang, Wen Huang, Li Li, Zhiwei Zhao
Photoaging is one major exogenous factor of skin aging. Efficacy and safety of current anti-photoaging therapies remained to be improved. Our previous studies indicated that skin-derived precursors (SKPs) alleviated photodamage by early activation of TGF-β/Smad signaling pathway via thrombospondin1 (TSP1). However, the research concerning SKP conditioned medium (SKP-CM) has never been reported. In the current study, we aimed to explore the anti-photoaging effects of SKP-CM both in vitro and in vivo, and to elucidate the possible mechanisms...
February 22, 2024: Journal of Photochemistry and Photobiology. B, Biology
https://read.qxmd.com/read/38411508/comparative-analysis-of-fluorescent-labeling-techniques-for-tracking-canine-amniotic-stem-cells
#10
JOURNAL ARTICLE
Andressa Valim Parca, Naira C G Pieri, Paulo Fantinato Neto, Fabiana F Bressan, Carlos Eduardo Ambrosio, Daniele Dos Santos Martins
The utmost aim of regenerative medicine is to promote the regeneration of injured tissues using stem cells. Amniotic mesenchymal stem cells (AmMSCs) have been used in several studies mainly because of their easy isolation from amniotic tissue post-partum and immunomodulatory and angiogenic properties, and the low level of rejection. These cells share characteristics of both embryonic/fetal and adult stem cells and are particularly advantageous because they do not trigger tumorigenic activity when injected into immunocompromised animals...
February 27, 2024: Tissue Engineering. Part C, Methods
https://read.qxmd.com/read/38409835/thermoresponsive-and-injectable-pluronic-f127-hydrogel-for-loading-adipose-derived-mesenchymal-stem-cells
#11
JOURNAL ARTICLE
Khan Sharun, Shajahan Amitha Banu, Merlin Mamachan, Rony S Emmanuel, Rohit Kumar, Obli Rajendran Vinodhkumar, Kuldeep Dhama, Abhijit Motiram Pawde, Swapan Kumar Maiti, Amar Pal
BACKGROUND: Stem cell-based therapies display immense potential in regenerative medicine, highlighting the crucial significance of devising efficient delivery methods. This study centers on a pioneering approach that utilizes Pluronic F127 (PF127) as a thermoresponsive and injectable hydrogel designed for the encapsulation of adipose-derived mesenchymal stem cells (AdMSCs). METHODS: The degradation profile, gelation time, and microstructure of the PF127 hydrogel were thoroughly examined...
February 2024: Discovery Medicine
https://read.qxmd.com/read/38405378/current-advancements-in-therapeutic-approaches-in-orthopedic-surgery-a-review-of-recent-trends
#12
REVIEW
Wenqing Liang, Chao Zhou, Juqin Bai, Hongwei Zhang, Bo Jiang, Jiangwei Wang, Lifeng Fu, Hengguo Long, Xiaogang Huang, Jiayi Zhao, Haibing Zhu
Recent advancements in orthopedic surgery have greatly improved the management of musculoskeletal disorders and injuries. This review discusses the latest therapeutic approaches that have emerged in orthopedics. We examine the use of regenerative medicine, including stem cell therapy and platelet-rich plasma (PRP) injections, to accelerate healing and promote tissue regeneration. Additionally, we explore the application of robotic-assisted surgery, which provides greater precision and accuracy during surgical procedures...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38378655/multi-modal-assessment-of-a-cardiac-stem-cell-therapy-reveals-distinct-modulation-of-regional-scar-properties
#13
JOURNAL ARTICLE
Moritz Schweins, Ralf Gäbel, Matti Raitza, Praveen Vasudevan, Heiko Lemcke, Markus Joksch, Anna Schildt, Jens Kurth, Tobias Lindner, Felix G Meinel, Alper Öner, Hüseyin Ince, Brigitte Vollmar, Bernd Joachim Krause, Robert David, Cajetan Immanuel Lang
BACKGROUND: The initial idea of functional tissue replacement has shifted to the concept that injected cells positively modulate myocardial healing by a non-specific immune response of the transplanted cells within the target tissue. This alleged local modification of the scar requires assessment of regional properties of the left ventricular wall in addition to commonly applied measures of global morphological and functional parameters. Hence, we aimed at investigating the effect of cardiac cell therapy with cardiovascular progenitor cells, so-called cardiac induced cells, on both global and regional properties of the left ventricle by a multimodal imaging approach in a mouse model...
February 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38371711/intra-articular-injection-of-platelet-lysate-derived-extracellular-vesicles-recovers-from-knee-osteoarthritis-in-an-in-vivo-rat-model
#14
JOURNAL ARTICLE
Maria Antònia Forteza-Genestra, Miquel Antich-Rosselló, Carmen Ráez-Meseguer, Anna Tomàs Sangenís, Javier Calvo, Antoni Gayà, Marta Monjo, Joana Maria Ramis
OBJECTIVE: MSCs and Platelet-Rich Plasma are the main focus in the study of new regenerative treatments aimed to reverse Osteoarthritis (OA). However, extracellular vesicles (EVs) present several advantages to cell-based treatments. Thus, the aim of this study was to compare and evaluate the regenerative potential of MSC-derived EVs (cEVs) and platelet-derived EVs (pEVs) in an OA cartilage rat model. DESIGN: OA in vivo model was established through injection of 6 mg MIA in the rat knee joints...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38357772/dilutional-rheology-of-radiesse-implications-for-regeneration-and-vascular-safety
#15
JOURNAL ARTICLE
Alec D McCarthy, Danny J Soares, Akash Chandawarkar, Radia El-Banna, Nadine Hagedorn
BACKGROUND: Calcium hydroxylapatite-carboxymethylcellulose (CaHA-CMC) injectables have emerged as dual-purpose fillers with bioregenerative and direct filling capabilities. AIMS: This study investigates the rheological properties of CaHA-CMC and its CMC carrier gel at various dilutions. METHODS: The storage modulus (G'), loss modulus (G″), complex viscosity (η*), loss factor (tan δ), cohesivity, and extrusion force were evaluated for a range of CaHA-CMC aqueous dilutions with an oscillatory rheometer, drop weight testing, and force analysis, respectively...
February 15, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38352913/rejuvenation-of-bone-volume-with-cgf-and-i-prf-in-intra-osseous-defects
#16
JOURNAL ARTICLE
Koppu Sitamahalakshmi, Sai Krishna Bingi, Govardhani Krishna Kumar, Yanamala Bhuvanesh, Surapaneni Keerthi Sai, Subramanyam Parkavi
The risk of further periodontal breakdown increases with a deep intrabony defect. Non-surgical periodontal therapy could pose a challenge and surgical intervention is mainly required to manage the defect. Autologous platelet concentrates such as Injectable platelet rich fibrin (i-PRF) and concentrated growth factor (CGF) may improve surgical outcome due to its enrichment with growth factors. Total of 04 patients involved in this study. After conventional flap debridement of intrabony defects, CGF is placed in 2 patients and the other 2 patients received i-PRF in their respective intrabony defects...
2024: Bioinformation
https://read.qxmd.com/read/38337604/trans-arterial-stem-cell-injection-tasi-the-role-of-interventional-radiology-in-regenerative-medicine
#17
REVIEW
Makoto Taninokuchi Tomassoni, Yinghui Zhou, Lorenzo Braccischi, Francesco Modestino, Junji Fukuda, Cristina Mosconi
Regenerative medicine is taking a step forward in treating multiple diseases. The possibility of renewing damaged tissues with stem cells has become a topic of interest in recent decades. Still a relatively new research topic, many issues in this discipline are being addressed, from cell culturing to the study of different graft materials, and, moreover, cell delivery. For instance, direct intravenous injection has a big downfall regarding its lack of precision and poorly targeted treatment. Trans-arterial and direct percutaneous infusion to the aimed tissue/organ are both considered ideal for reaching the desired region but require image guidance to be performed safely and precisely...
February 5, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38333727/harnessing-cytokine-induced-killer-cells-to-accelerate-diabetic-wound-healing-an-approach-to-regulating-post-traumatic-inflammation
#18
JOURNAL ARTICLE
Yixi Yang, Cheng Zhang, Yuan Jiang, Yijun He, Jiawei Cai, Lin Liang, Zhaohuan Chen, Sicheng Pan, Chu Hua, Keke Wu, Le Wang, Zhiyong Zhang
Impaired immunohomeostasis in diabetic wounds prolongs inflammation and cytokine dysfunction, thus, delaying or preventing wound-surface healing. Extensive clinical studies have been conducted on cytokine-induced killer (CIK) cells recently, as they can be easily proliferated using a straightforward, inexpensive protocol. Therefore, the function of CIK cells in regulating inflammatory environments has been drawing attention for clinical management. Throughout the current investigation, we discovered the regenerative capacity of these cells in the challenging environment of wounds that heal poorly due to diabetes...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38331557/pluripotent-stem-cell-based-cardiac-regenerative-therapy-for-heart-failure
#19
REVIEW
Yusuke Soma, Hidenori Tani, Yuika Morita-Umei, Yoshikazu Kishino, Keiichi Fukuda, Shugo Tohyama
Cardiac regenerative therapy using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is expected to become an alternative to heart transplantation for severe heart failure. It is now possible to produce large numbers of human pluripotent stem cells (hPSCs) and eliminate non-cardiomyocytes, including residual undifferentiated hPSCs, which can cause teratoma formation after transplantation. There are two main strategies for transplanting hPSC-CMs: injection of hPSC-CMs into the myocardium from the epicardial side, and implantation of hPSC-CM patches or engineered heart tissues onto the epicardium...
February 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38327717/minimally-invasive-scar-release-by-autologous-adipose-tissue-transfer-for-post-traumatic-neuropathic-pain
#20
Giorgio Pietramaggiori, Federico Ricci, Stefano L'Erario, Franco Bassetto, Saja Scherer
INTRODUCTION: Addressing post traumatic lower limb neuropathic pain is challenging across medical specialties. To address this potentially devastating condition, several invasive and non-invasive approaches have been proposed with inconsistent results. Adipose fat transfer (AFT), also known as fat grafting, is a regenerative medicine technique in which a patient's own fat is harvested from one area of the body (usually through liposuction) and then injected into another area for various purposes, such as aesthetic contour enhancement or reconstruction and regeneration of scarred tissues...
March 2024: Regenerative Therapy
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