Joanne A Hoogerland, Yu Lei, Justina C Wolters, Jan Freark de Boer, Trijnie Bos, Aycha Bleeker, Niels L Mulder, Theo H van Dijk, Jan A Kuivenhoven, Fabienne Rajas, Gilles Mithieux, Rebecca A Haeusler, Henkjan J Verkade, Vincent W Bloks, Folkert Kuipers, Maaike H Oosterveer
It is well-established that, besides facilitating lipid absorption, bile acids act as signaling molecules that modulate glucose and lipid metabolism. Bile acid metabolism, in turn, is controlled by several nutrient-sensitive transcription factors. Altered intrahepatic glucose signaling in type 2 diabetes associates with perturbed bile acid synthesis. However, an independent role of glucose in regulation of bile acid metabolism has as yet not been established. We aimed to characterize the regulatory role of the primary intracellular metabolite of glucose, glucose-6-phosphate (G6P), on bile acid metabolism...
May 18, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases