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JOURNAL ARTICLE
Ahmet Gorkem Er, Daisy Yi Ding, Berrin Er, Mertcan Uzun, Mehmet Cakmak, Christoph Sadee, Gamze Durhan, Mustafa Nasuh Ozmen, Mine Durusu Tanriover, Arzu Topeli, Yesim Aydin Son, Robert Tibshirani, Serhat Unal, Olivier Gevaert
Through technological innovations, patient cohorts can be examined from multiple views with high-dimensional, multiscale biomedical data to classify clinical phenotypes and predict outcomes. Here, we aim to present our approach for analyzing multimodal data using unsupervised and supervised sparse linear methods in a COVID-19 patient cohort. This prospective cohort study of 149 adult patients was conducted in a tertiary care academic center. First, we used sparse canonical correlation analysis (CCA) to identify and quantify relationships across different data modalities, including viral genome sequencing, imaging, clinical data, and laboratory results...
May 7, 2024: NPJ Digital Medicine
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JOURNAL ARTICLE
Maurice Pasternak, Saira S Mirza, Nicholas Luciw, Henri J M M Mutsaerts, Jan Petr, David Thomas, David Cash, Martina Bocchetta, Maria Carmela Tartaglia, Sara B Mitchell, Sandra E Black, Morris Freedman, David Tang-Wai, Ekaterina Rogaeva, Lucy L Russell, Arabella Bouzigues, John C van Swieten, Lize C Jiskoot, Harro Seelaar, Robert Laforce, Pietro Tiraboschi, Barbara Borroni, Daniela Galimberti, James B Rowe, Caroline Graff, Elizabeth Finger, Sandro Sorbi, Alexandre de Mendonça, Chris Butler, Alex Gerhard, Raquel Sanchez-Valle, Fermin Moreno, Matthis Synofzik, Rik Vandenberghe, Simon Ducharme, Johannes Levin, Markus Otto, Isabel Santana, Antonio P Strafella, Bradley J MacIntosh, Jonathan D Rohrer, Mario Masellis
INTRODUCTION: Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD). We investigate the utility of cerebral perfusion as one such biomarker in presymptomatic FTD mutation carriers. METHODS: We investigated longitudinal profiles of cerebral perfusion using arterial spin labeling magnetic resonance imaging in 42 C9orf72, 70 GRN, and 31 MAPT presymptomatic carriers and 158 non-carrier controls...
April 16, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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JOURNAL ARTICLE
Marcos Fernando Xisto Braga Cavalcanti, Roseli Alves Cabette, Angelina Cirelli Moraes, Francesca Diomede, Oriana Trubiani, Durvanei Augusto Maria
Objective: The objective of this study is to evaluate the potential effects of photobiomodulation (PBM) on cell proliferation and extracellular matrix production of human fibroblasts (FN1) cultured in 2D. Background: Patients with healing difficulties suffer injuries that take time to recover. In addition, aging can be seen in our faces daily when we look in the mirror; in both situations, collagen production is reduced. Fibroblasts act in the beginning and at the end of the inflammation phase, signaling to immune agents, and platelets, and producing collagen, coordinating repair...
February 2024: Photobiomodulation, photomedicine, and laser surgery
#4
JOURNAL ARTICLE
Liuhong Zhu, Funan Wang, Heqing Wang, Jinhui Zhang, Anjie Xie, Jinkui Pei, Jianjun Zhou, Hao Liu
BACKGROUND: In recent years, spectral CT-derived liver fat quantification method named multi-material decomposition (MMD) is playing an increasingly important role as an imaging biomarker of hepatic steatosis. However, there are various measurement ways with various results among different researches, and the impact of measurement methods on the research results is unknown. The aim of this study is to evaluate the reproducibility of liver fat volume fraction (FVF) using MMD algorithm in nonalcoholic fatty liver disease (NAFLD) patients when taking blood vessel, location, and iodine contrast into account during measurement...
February 7, 2024: BMC Medical Imaging
#5
JOURNAL ARTICLE
Matthias P Fabritius, Benjamin Garlipp, Osman Öcal, Daniel Puhr-Westerheide, Holger Amthauer, Thomas Geyer, Adrien Holzgreve, Jens Ricke, Dennis Kupitz, Oliver S Grosser, Jazan Omari, Maciej Pech, Max Seidensticker, Freba Grawe, Ricarda Seidensticker
BACKGROUND: To compare Gd-ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) and 99m Tc-labelled mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests after unilateral radioembolisation (RE) in patients with primary or secondary liver malignancies. METHODS: Twenty-three patients with primary or secondary liver malignancies who underwent Gd-EOB-DTPA-enhanced MRI within a prospective study (REVoluTion) were evaluated...
January 29, 2024: European Radiology Experimental
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JOURNAL ARTICLE
Qidi Shi, Anmin Gong, Peng Ding, Fan Wang, Yunfa Fu
Light and noise are important factors affecting shooting performance, and shooters can exhibit physiological processes that differ from normal shooting when they are subjected to disturbed visual and auditory conditions. The purpose of this study was to explore the neural mechanism of shooting preparation in skilled shooters with visual and auditory limitations. We designed an experiment and recorded the electroencephalograph (EEG) and shooting performance indexes of 40 individuals skilled in marksmanship during the shooting preparation stage under three conditions: low light, noise interference, and a normal environment...
December 10, 2023: Brain Sciences
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Ahmet Gorkem Er, Daisy Yi Ding, Berrin Er, Mertcan Uzun, Mehmet Cakmak, Christoph Sadée, Gamze Durhan, Mustafa Nasuh Ozmen, Mine Durusu Tanriover, Arzu Topeli, Yesim Aydin Son, Robert Tibshirani, Serhat Unal, Olivier Gevaert
Through technological innovations, patient cohorts can be examined from multiple views with high-dimensional, multiscale biomedical data to classify clinical phenotypes and predict outcomes. Here, we aim to present our approach for analyzing multimodal data using unsupervised and supervised sparse linear methods in a COVID-19 patient cohort. This prospective cohort study of 149 adult patients was conducted in a tertiary care academic center. First, we used sparse canonical correlation analysis (CCA) to identify and quantify relationships across different data modalities, including viral genome sequencing, imaging, clinical data, and laboratory results...
November 20, 2023: Research Square
#8
JOURNAL ARTICLE
Ziyun Wang, Yao Wang, Yuqi Ji, Ziwei Yang, Yixiu Pei, Jiankun Dai, Yong Zhang, Fuqing Zhou
PURPOSE: To explore resting-state functional connectivity (rsFC) of the amygdala in patients with low-back-related leg pain (LBLP). PATIENTS AND METHODS: For this prospective study, a total of 35 LBLP patients and 30 healthy controls (HCs) were included and underwent functional MRI and clinical assessments. Then, patients with LBLP were divided into acute LBLP (aLBLP) and chronic LBLP (cLBLP) subgroups. We further evaluated the between-group rsFC differences using left and right amygdala seeds in a whole-brain voxel analysis strategy...
2023: Journal of Pain Research
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JOURNAL ARTICLE
Keisuke Miyajima, Tsuyoshi Urushida, Yuichiro Tomida, Takumi Tamura, Sakito Masuda, Ayako Okazaki, Yoshitaka Kawaguchi, Yasushi Wakabayashi, Yuichiro Maekawa
BACKGROUND: Left bundle branch area pacing (LBBAP) has emerged as a novel physiological pacing method to reduce left ventricular (LV) dyssynchrony due to ventricular pacing. Only lumen-less pacing leads (LLLs) with fixed helixes could achieve LBBAP previously, but recently, LBBAP has been performed using stylet-driven leads (SDLs). This study aimed to evaluate the LV dyssynchrony between SDLs and LLLs techniques in LBBAP. METHODS: We retrospectively evaluated patients who underwent LBBAP with either SDLs or LLLs...
October 1, 2023: Quantitative Imaging in Medicine and Surgery
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JOURNAL ARTICLE
Minwoo Lee, Yuseong Hong, Sungsik An, Ukeob Park, Jaekang Shin, Jeongjae Lee, Mi Sun Oh, Byung-Chul Lee, Kyung-Ho Yu, Jae-Sung Lim, Seung Wan Kang
OBJECTIVES: More than half of patients with acute ischemic stroke develop post-stroke cognitive impairment (PSCI), a significant barrier to future neurological recovery. Thus, predicting cognitive trajectories post-AIS is crucial. Our primary objective is to determine whether brain network properties from electroencephalography (EEG) can predict post-stroke cognitive function using machine learning approach. METHODS: We enrolled consecutive stroke patients who underwent both EEG during the acute stroke phase and cognitive assessments 3 months post-stroke...
2023: Frontiers in Aging Neuroscience
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JOURNAL ARTICLE
Changqin Jiang, Ruisheng Jiang, Wanwei Zhang, Zhijun Ma, Haixia Dong, Zhaoqian Wang, Qiang Feng
BACKGROUND: Computed tomography (CT) in port-venous phase can display the intra-hepatic vessels, and may provide the possibility for segment function evaluation for cirrhosis. PURPOSE: To assess the value of iodine mixed imaging of dual-source dual-energy CT in port-venous phase in segmental evaluation of liver cirrhosis with different etiologies. MATERIAL AND METHODS: Patients diagnosed with liver cirrhosis were enrolled. Patients without cirrhosis were included as a control group...
October 4, 2023: Acta Radiologica
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JOURNAL ARTICLE
H Tanaka, K Ueda, M Karita, T Ono, M Kajima, Y Manabe, T Sera, K Fujimoto, Y Yuasa, T Shiinoki
PURPOSE/OBJECTIVE(S): There are several methods used against respiratory motion (RM). Expiratory breath-hold (BH) is considered more stable and reproducible than inspiratory BH; therefore, BH with spirometry is often used for expiration. The real-time tumor tracking radiotherapy (RTRT) system is a highly effective method for reducing the margin of RM. This system ambushes and irradiates tumors during the expiratory phase when tumors move slowly. Although these methods usually involve expiration, it is advantageous to expand the lungs with inspiration to reduce the risk of adverse events...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
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JOURNAL ARTICLE
Kenji Ishihara, Misa Kakurai, Keiko Endoh, Kazuhiko Kobayashi, Toshiomi Asahi
We report a patient presenting with crossed aphasia following infarction in the territory of the right anterior cerebral artery (ACA). A right-handed 68-year-old woman without a history of correction had acute disturbance of consciousness, left hemiparesis predominant in the lower extremity, speech disorder and left unilateral spatial neglect during the admission due to hypertensive emergency. No other family member was left-handed. MRI of the head revealed acute phase infarction in the territory of the right ACA: mesial frontal lobe including the supplementary motor area, anterior cingulate gyrus, and the corpus callosum...
June 30, 2023: Rinshō Shinkeigaku, Clinical Neurology
#14
Wenpeng Huang, Xiaonan Liu, Liming Li, Yongbai Zhang, Yuan Gao, Jianbo Gao, Lei Kang
BACKGROUND: Extranodal natural killer/T-cell lymphoma (ENKTCL) is a distinct pathological entity and accounts for ~10% of T-cell lymphomas. The histological features of ENKTCL include angiodestruction and coagulative necrosis and the association with EBV infection. ENKTCL is typically aggressive and mainly affects the nasal cavity and nasopharyngeal region. However, some patients can present with distant nodal or extranodal involvement such as the Waldeyer ring, gastrointestinal tract, genitourinary organs, lung, thyroid, skin, and testes...
2023: Frontiers in Medicine
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JOURNAL ARTICLE
Bo Peng, Kaiyu Wang, Ran Xu, Congying Guo, Tong Lu, Yongchao Li, Yiqiao Wang, Chenghao Wang, Xiaoyan Chang, Zhiping Shen, Jiaxin Shi, Chengyu Xu, Linyou Zhang
OBJECTIVES: The purpose of this study was to evaluate whether preoperative radiomics features could meliorate risk stratification for the overall survival (OS) of non-small cell lung cancer (NSCLC) patients. METHODS: After rigorous screening, the 208 NSCLC patients without any pre-operative adjuvant therapy were eventually enrolled. We segmented the 3D volume of interest (VOI) based on malignant lesion of computed tomography (CT) imaging and extracted 1542 radiomics features...
2023: Frontiers in Oncology
#16
JOURNAL ARTICLE
Nguyen Dang Khoa, Sixiao Li, Nguyen Lu Phuong, Kazuki Kuga, Hidetake Yabuuchi, Keiko Kan-O, Koichiro Matsumoto, Kazuhide Ito
BACKGROUND AND OBJECTIVES: Suspended respirable airborne particles are associated with human health risks and especially particles within the range of ultrafine (< 0.1 μm) or fine (< 2.5 μm) have a high possibility of penetrating the lung region, which is concerned to be closely related to the bronchial or alveoli tissue dosimetry. Nature complex structure of the respiratory system requires much effort to explore and comprehend the flow and the inhaled particle dynamics for precise health risk assessment...
May 6, 2023: Computer Methods and Programs in Biomedicine
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JOURNAL ARTICLE
Ender Anılır, Alihan Oral, Alp Atasoy, Hasret Ayyıldız Civan, Feyza Sönmez Topçu, Mert Bayramoğlu, Emrah Şahin, Abuzer Dirican, Bülent Ünal
BACKGROUND: Living donor liver transplantation (LDLT) has become an increasingly common surgical option because the number of cadaveric donors is insufficient to fulfill the organ needs of patients facing end-stage cirrhosis. Many centers are investigating different surgical techniques to achieve lower complication rates. We aimed to examine our complication rates in light of demographic data, graft data, and perioperative findings as a single-center experience. METHODS: The study included one hundred and three patients who underwent LDLT for end-stage liver cirrhosis...
April 28, 2023: Transplantation Proceedings
#18
JOURNAL ARTICLE
Mijntje Mi Schellekens, Esther M Boot, Jamie I Verhoeven, Merel S Ekker, Mayte E van Alebeek, Paul Jam Brouwers, Renate M Arntz, Gert W van Dijk, Rob Ar Gons, Inge Wm van Uden, Tom den Heijer, Paul Lm de Kort, Karlijn F de Laat, Anouk van Norden, Sarah E Vermeer, Marian Sg van Zagten, Robert J van Oostenbrugge, Marieke Jh Wermer, Paul J Nederkoorn, Frank G van Rooij, Ido R van den Wijngaard, Frank-Erik de Leeuw, Roy Pc Kessels, Anil M Tuladhar
INTRODUCTION: We aimed to investigate the prevalence of cognitive impairment in the subacute phase after transient ischemic attack (TIA) and ischemic stroke (IS), factors associated with a vascular cognitive disorder, and the prevalence of subjective cognitive complaints and their relation with objective cognitive performance. PATIENTS AND METHODS: In this multicenter prospective cohort study, we recruited patients with first-ever TIA and IS, aged 18-49 years, between 2013 and 2021 for cognitive assessment up to 6 months after index event...
March 2023: European Stroke Journal
#19
JOURNAL ARTICLE
María Victoria Sánchez Sánchez, María Alejandra Santana Suárez, Ludmila Ocón Padrón, Fidel García Anguiano, Elia Archilla Andrés, Claudia Martínez Barreto, María Elena Pérez Morales, Alicia Inmaculada Martín Martínez
BACKGROUND Endometriosis is a chronic inflammatory disease caused by endometrial tissue that grows outside the uterus. Deep endometriosis surgery is associated with considerable rates of complications, although such rates are lower in surgical procedures carried out by expert surgical teams. This report details a case of a rare but life-threatening complication in the postoperative period following 72 h of endometriosis surgery: a giant subcapsular hepatic hematoma, which was successfully managed conservatively...
February 25, 2023: American Journal of Case Reports
#20
JOURNAL ARTICLE
Barbara Tomasino, Ilaria Guarracino, Tamara Ius, Miran Skrap
BACKGROUND: Executive functions are multi-component and are based on large-scale brain networks. For patients undergoing brain surgery in the prefrontal cortex, resection in the anterior prefrontal sites is assisted by continuous monitoring of their performance on several tasks measuring components of executive functions. In this study, we did not test patients during direct cortical stimulation, but during resection itself. We chose tests routinely used to assess executive functions and included them in a protocol for left (LH) and right (RH) hemisphere prefrontal resections...
February 6, 2023: Current Oncology
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