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TC thorax lung pulmonary

V Favaudon, C Fouillade, M-C Vozenin
PURPOSE: Pencil beam scanning and filter free techniques may involve dose-rates considerably higher than those used in conventional external-beam radiotherapy. Our purpose was to investigate normal tissue and tumour responses in vivo to short pulses of radiation. MATERIAL AND METHODS: C57BL/6J mice were exposed to bilateral thorax irradiation using pulsed (at least 40 Gy/s, flash) or conventional dose-rate irradiation (0.03 Gy/s or less) in single dose. Immunohistochemical and histological methods were used to compare early radio-induced apoptosis and the development of lung fibrosis in the two situations...
October 2015: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Sina Izadyar, Sassan Saber, Ali Gholamrezanezhad
UNLABELLED: The presence of a highly nonuniform distribution of attenuating tissues in the thorax may lead to attenuation artifacts and inaccuracies in reconstructed lung ventilation/perfusion SPECT images. The Chang algorithm is an easily applicable and accessible method of attenuation correction. The advantages inherent in the technique prompted us to evaluate the effect of using Chang attenuation correction on the quality of lung SPECT images and the clinical impact on interpretation...
December 2011: Journal of Nuclear Medicine Technology
Timothy A Morris, Michael Gerometta, Richard C Smart, Paul Eisenberg, Paul J Roach, Wendy W Tsui, Nathan Better, Kim L Taubman, Steven A Unger, David Macfarlane
OBJECTIVES: Pre-clinical experiments demonstrated that intravenous (99m)Tc labelled DI-DD-3B6/22-80B3 humanised anti-fibrin-D-dimer Fab' fragments ((99m)Tc-DI-80B3) allowed scintigraphic imaging of acute pulmonary emboli (PE). The aims of this clinical study were to determine the safety of (99m)Tc-DI-80B3 in patients with PE and evaluate the resulting scintigraphic images for the localisation of acute PE. MATERIALS/PATIENTS AND METHODS: (99m)Tc-DI-80B3 (0.5mg, 710-850MBq) was administered intravenously to subjects (n=14) with segmental or larger PE on recent contrast-enhanced helical CT scans...
August 2011: Heart, Lung & Circulation
Mortada Hassan El-Shabrawi, Salwa Omran, Shereine Wageeh, Mona Isa, Sawsan Okasha, Nabil A Mohsen, Ola Zekry, Gamal E-Bartan, Hanaa M El-Karaksy
BACKGROUND AND AIMS: The hepatopulmonary syndrome (HPS) is a triad of advanced chronic liver disease (CLD), arterial hypoxemia and intrapulmonary arteriovenous shunting in the absence of a primary cardiopulmonary disease. HPS has been more frequently reported in adults than in children with no data on its prevalence in children with CLD. The aim of this study was to detect the prevalence of the HPS in a cohort of children with CLD because of chronic hepatitis B and/or C virus infection, schistosomiasis as well as inborn metabolic errors...
August 2010: European Journal of Gastroenterology & Hepatology
L M Seccombe, S C S Chung, C R Jenkins, C J Frater, D W J Mackey, M A Pearson, L Emmett, M J Peters
Glossopharyngeal insufflation is used by competitive breath-hold divers to increase lung gas content above baseline total lung capacity (TLC) in order improve performance. Whilst glossopharyngeal insufflation is known to induce hypotension and tachycardia, little is known about the effects on the pulmonary circulation and structural integrity of the thorax. Six male breath-hold divers were studied. Exhaled lung volumes were measured before and after glossopharyngeal insufflation. On two study days, subjects were studied in the supine position at baseline TLC and after maximal glossopharyngeal insufflation above TLC...
July 2010: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Shigeyuki Ogi, Eisuke Gotoh, Mayuki Uchiyama, Kunihiko Fukuda, Mitsuyoshi Urashima, Nobuyoshi Fukumitsu
PURPOSE: We investigated whether hilar radioaerosol deposition affects the clearance rate of technetium-99m-labeled diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) from peripheral alveolar regions. MATERIALS AND METHODS: A total of 38 patients underwent (99m)Tc-DTPA inhalation lung scintigraphy. Six region of interest (ROI) patterns were adopted: ROI 1 was outlined around the entire hemithorax, and ROIs 2-6 were outlined around the hemithorax but excluded square ROIs of different size in the hilar region...
January 2009: Japanese Journal of Radiology
Cipriana Stefanescu, V Rusu, Daniela Boişteanu, Doina Azoicai, Mihaela Costin, Daniela Oleniuc, Mihaela Hurjui, P Sattish
UNLABELLED: The aim of our study was to compare the role of lung perfusion scintigraphy with 1mTc MIBI and 99mTc Tetrofosmin (Mw) for the initial diagnostic evaluation of pulmonary tuberculosis-PTB). MATERIAL AND METHOD: Two groups of new PTB diagnosed patients, without treatment, were studied: group I--41 patients were imaged with 99mTc MIBI (sex ratio men:women = 17:24, mean age 25 years, 26 positive Mycobacterium Tuberculosis (MT) smears, 15 negative MT smears), group II--40 patients were imaged with 99mTc Mw (sex ratio men:women = 21:19; mean age: 32...
October 2006: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
A Hubalewska-Dydejczyk, K Fröss-Baron, F Gołkowski, A Sowa-Staszczak, R Mikołajczak, B Huszno
UNLABELLED: Pulmonary carcinoids cause serious difficulties in imaging diagnostics in all stages of the disease. SRS holds great promise for detecting occult primary tu and metastatic lesions. (99m)Tc-EDDA/HYNIC-octreotate, a new scintigraphic agent, should significantly improve sensitivity of the diagnostics of carcinoids due to better affinity to SSR2 than (111)In-Octreoscan and the higher count rate obtained from (99m)Tc over (111)In. We present a case of a 40-year-old women operated on because of lung carcinoid tumour in 2002...
January 2007: Experimental and Clinical Endocrinology & Diabetes
Eva Bondesson, Thomas Bengtsson, Lars-Erik Nilsson, Per Wollmer
PURPOSE: The effects of a natural surface-active agent, sodium taurocholate (NaTC), on the absorption of a hydrophilic solute, technetium-99m-labelled diethylene triamine pentaacetic acid (99mTc-DTPA), deposited at various sites within the airways were evaluated in this open, cross-over, and single-dose study. METHODS: Nine healthy non-smokers received 99mTc-DTPA with or without the addition of NaTC, administered as an oropharyngeal aerosol and as nebulized large and fine droplet-sized pulmonary aerosols delivered by Pari and UltraVent nebulizers inhaled at fairly rapid and slow flows, respectively...
September 2006: Pharmaceutical Research
Gulay Durmuş-Altun, Armagan Altun, Ranan Gülhan Aktas, Yavuz Sami Salihoglu, Necmi Omer Yigitbasi
The purpose of the study was; (i) to determine whether 123I-MIBG scintigraphy is sensitive for detection of amiodarone induced pulmonary toxicity (AIPT) and (ii) to compare it with 99mTc-DTPA radioaerosol. Twelve white New Zealand rabbit with initial mean body weight 4.24 +/- 0.47 g were divided into two groups. AIPT group (n = 7) was administered amiodarone (20 mg/kg BW). The control group (n = 5) received the same amount of 0.9% saline. All animals underwent 123I-MIBG and 99mTc-DTPA radioaerosol scintigraphy at the end of the treatment period...
May 2005: Annals of Nuclear Medicine
Anna Płachcińska, Renata Mikołajczak, Józef Kozak, Katarzyna Rzeszutek, Jacek Kuśmierek
BACKGROUND: The aim of the study was the assessment of the clinical usefulness of scintigraphy with (99m)Tc-EDDA/HYNIC-TOC for purposes of a differential diagnosis of SPNs by means of a visual inspection and semi-quantitative assessment of uptake intensity of the radiopharmaceutical (RPh). MATERIAL AND METHODS: In 53 patients (32 males and 21 females at the ages between 38 and 78 years, mean value 57) with SPN on chest radiographs or CT scans, of diameters from 1 to 5...
2004: Nuclear Medicine Review. Central & Eastern Europe
Haşim Boyaci, Fatma Berk, Ahmet Ilgazli, Cengiz Erçin, Füsun Yildiz, Canan Sengül
This study was conducted to assess the feasibility of using Tc-99m labelled 2-methoxy isobutyl isonitrile (MIBI) scintigraphy, to evaluate benign and malignant intratoracic lesions and to assess the value in the differential diagnosis. The eligible population of the study included randomly selected 37 patients examined in Kocaeli University Pulmonary Clinic (19 men, 18 women) who had a abnormality in the PA chest X-ray and hadn't received any therapy. After intravenous injection of 15-25 mCi Tc-99m MIBI, early (10 minutes) and delayed (2...
2003: Tüberküloz Ve Toraks
José Hinz, Peter Neumann, Taras Dudykevych, Lars Goran Andersson, Hermann Wrigge, Hilmar Burchardi, Goran Hedenstierna
STUDY OBJECTIVE: The validation of electrical impedance tomography (EIT) for measuring regional ventilation distribution by comparing it with single photon emission CT (SPECT) scanning. DESIGN: Randomized, prospective animal study. SETTINGS: Animal laboratories and nuclear medicine laboratories at a university hospital. PARTICIPANTS: Twelve anesthetized and mechanically ventilated pigs. INTERVENTIONS: Lung injury was induced by central venous injection of oleic acid...
July 2003: Chest
Peter D Correa, Vinay Sharma, Venkatesh Rangarajan, Sarojini Sunder, Ketayun A Dinshaw
PURPOSE: To investigate whether changes in diethylenetriamine pentaacetic acid (DTPA) aerosol clearance lung scans predict the development of radiation pneumonitis. METHODS AND MATERIALS: Thirty-three patients with advanced non-small-cell lung cancer were treated with palliative radiation therapy to thorax. All patients were subjected to pretreatment and post-treatment DTPA aerosol clearance lung scans. The clearance t1/2 values were compared using the paired t test...
June 1, 2003: International Journal of Radiation Oncology, Biology, Physics
H Ortapamuk, A Alp
Pulmonary involvement secondary to Waldenstrom's macroglobulinemia (WMG) is described in a 40-year-old male by incidental findings on a bone scan. He was examined for right leg pain, and bone scan revealed unexpected pulmonary uptake of Tc-99m MDP. CT scan of the thorax revealed pleural effusion and slightly disseminated micronoduler density increase in the right lung and parenchymal infiltration in the left lung. Transdermal lung biopsy demonstrated diffuse infiltration of lymphoplasmocytoids. Reporting the presence of pulmonary involvement is important because it may prevent morbidity from pulmonary dysfunction...
November 2002: Annals of Nuclear Medicine
Wei-Jen Shih, Edward Hirschowitz, Eric Bensadoun, John Woodring, Yun U Ryo, Steve Kraman
PURPOSE: To determine the biodistribution of Tc-99m labeled somatostatin receptor-binding peptide (Depreotide) on planar and SPECT studies of the thorax and upper abdomen in order to improve diagnostic accuracy. METHODS AND MATERIALS: Retrospectively 29 planar and SPECT studies from 28 patients (all males, average age of 65.79) were reviewed. All the patients had been referred for evaluation of solitary pulmonary nodules. Two to four hours after IV injection of 555- to 740-MBq (15-20 mCi) Tc-99m Depreotide, anterior and posterior total body images, and anterior, posterior, right lateral and left lateral planar images were obtained, and thoracic SPECT was acquired with a three-head gamma camera...
May 2002: Annals of Nuclear Medicine
Ole Greisen, Jim Thuesen Pedersen
INTRODUCTION: Respiratory symptoms (stridor) in thyroid diseases are rather common, but often overlooked, especially in older people in whom they may be misinterpreted as asthma or chronic bronchitis. MATERIAL AND METHODS: To assess the value of lung function tests for differential diagnosis we used these tests in 33 patients with upper airway obstruction caused by an enlargement of the thyroid gland. The clinical examination consisted of an evaluation of the respiration, examination of the movement of the vocal chords, thyroid parameters, Tc scintigraphy, ultrasound examination, and X-ray examination of the thorax and trachea up to the level of the glottis, supplemented by a CT scan if needed...
April 8, 2002: Ugeskrift for Laeger
Wei-jen Shih, Vickie Kiefer, Kelly Gross, Becky Wierzbinski, Judy Collins, Calixto Pulmano, Yun U Ryo
PURPOSE: The lower thorax and upper abdomen are visualized during cardiac acquisition of rest Tl-201 and stress Tc-99m tetrofosmin gated SPECT. Thus, abnormal Tl-201 localization in these areas and in organs such as parts of the lungs, liver, spleen, and kidneys can be observed, including rotating raw cine data. MATERIALS AND METHODS: Other than cardiac images, the authors retrospectively reviewed Tl-201 rotating (raw data) images of 235 patients. Abnormal findings in the lungs, liver, spleen, and kidneys were identified that correlated with the patients' clinical information; radiographic findings, including computed tomography and ultrasonography of the abdomen; other scintigraphic studies; and laboratory findings...
January 2002: Clinical Nuclear Medicine
J Palmer, U Bitzén, B Jonson, M Bajc
UNLABELLED: Lung scintigraphy is the primary tool for diagnostics of pulmonary embolism. A perfusion study is often complemented by a ventilation study. Intermediate probability scans are frequent. Our goal was to develop a fast method for tomographic ventilation and perfusion scintigraphy to improve the diagnostic value of lung scintigraphy. METHODS: SPECT was performed with a dual-head gamma camera. Acquisition parameters were determined using a thorax phantom...
August 2001: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
C R Berry, E C Hawkins, K J Hurley, K Monce
The purpose of this study was to determine the frequency of hypoxemia and pulmonary mineralization using 99mTc-methylene diphosphonate (99mTc-MDP) in dogs with pituitary-dependent hyperadrenocorticism (PDH). Twenty-one dogs with PDH were prospectively evaluated using thoracic radiography, arterial blood gas analysis, and bone phase and pulmonary perfusion scintigraphy (using 99mTc-macro-aggregated albumin [99mTc-MAA]). The radiographs and bone and perfusion studies were evaluated subjectively. An averaged quantitative count density ratio was calculated between the thorax and cranial thoraco-lumbar vertebrae from lateral thoracic 99mTc-MDP images...
March 2000: Journal of Veterinary Internal Medicine
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