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Mariateresa Ferone, Francesca Raganati, Alessia Ercole, Giuseppe Olivieri, Piero Salatino, Antonio Marzocchella
Background: Succinic acid is one of the most interesting platform chemicals that can be produced in a biorefinery approach. In this study, continuous succinic acid production by Actinobacillus succinogenes fermentation in a packed-bed biofilm reactor (PBBR) was investigated. Results: The effects of the operating conditions tested, dilution rate (D), and medium composition (mixture of glucose, xylose, and arabinose-that simulate the composition of a lignocellulosic hydrolysate)-on the PBBR performances were investigated...
2018: Biotechnology for Biofuels
Rabia Nabi, Sahir Sultan Alvi, Rizwan Khan, Shafeeque Ahmad, Saheem Ahmad, M Salman Khan
Non-enzymatic glycation mediated advanced glycation end products (AGEs) generation results in the pathogenesis of diabetic complications and atherosclerotic cardiovascular disease (ASCVD) which is greatly influenced by 3-hydroxy-3-methyl-glutaryl Co-A reductase (HMG-R) activity. HMG-R inhibitors, statins, are well known for reducing mortality and morbidity of ASCVD in patients with diabetes due to their pleiotropic effects independent of cholesterol lowering. Due to distinct chemical structures, various statins may play important role in the inhibition of AGEs mediated pathologies...
May 18, 2018: International Journal of Biological Macromolecules
Jessica Reid, Maria Makrides, Andrew J McPhee, Michael J Stark, Jacqueline Miller, Carmel T Collins
The aim of this study was to assess the effect of feeding high protein human milk fortifier (HMF) on growth in preterm infants. In this single-centre randomised trial, 60 infants born 28⁻32 weeks' gestation were randomised to receive a higher protein HMF providing 1.8 g protein ( n = 31) or standard HMF providing 1 g protein per 100 mL expressed breast milk (EBM) ( n = 29). The primary outcome was rate of weight gain. Baseline characteristics were similar between groups. There was no difference between high and standard HMF groups for weight gain (mean difference (MD) -14 g/week; 95% CI -32, 4; p = 0...
May 17, 2018: Nutrients
Nick Sweygers, Niels Alewaters, Raf Dewil, Lise Appels
In this study, the effect of microwaves on the production of 5-hydroxymethylfurfural (HMF) in a biphasic system was evaluated via a kinetic analysis. The reaction system consisted of an acidified aqueous phase and methyl isobutyl ketone (MIBK) as an organic phase, in which HMF is extracted directly upon formation during the reaction. Two identically shaped reactors were used to assess the influence of microwaves on the production of HMF. A borosilicate glass reactor was used to heat the reaction mixture via microwaves directly, whereas the silicon carbide (SiC) wall of the second reactor absorbed all microwaves and hence the reactor content was heated via convective heat transfer...
May 16, 2018: Scientific Reports
Yimin Chen, Giamila Fantuzzi, Michael Schoeny, Paula Meier, Aloka L Patel
BACKGROUND: Premature infants are susceptible to oxidative stress, increasing the risk for serious morbidities. High-dose human milk (HM) feedings decrease morbidity risks and may reduce oxidative stress in this population. The purpose of this study was to compare oxidative stress using serial urinary F2 -isoprostane concentrations in predominantly HM and preterm formula (PF)-fed premature infants over the first 21 days of life (DOL), while controlling for perinatal oxidative stress exposures including bovine-based human milk fortifier (HMF) or PF introduction to predominantly HM-fed infants...
May 15, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Christian M Pichler, Mohammad Ghith Al-Shaal, Dong Gu, Hrishikesh Joshi, Wirawan Ciptonugroho, Ferdi Schüth
Different ZrO2 supported ruthenium catalysts were prepared and utilized in the oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) under base-free conditions. Full conversion of HMF and almost perfect selectivity towards FDCA (97%) were achieved after 16 h, using pure O2 as an oxidant and water as a solvent. The catalytic tests show that the size of the Ru particles is crucial for the catalytic performance and that the utilization of high surface area ZrO2 leads to formation of very small Ru particles...
May 15, 2018: ChemSusChem
Minjune Kim, Yaqiong Su, Atsushi Fukuoka, Emiel J M Hensen, Kiyotaka Nakajima
The utilization of 5-(hydroxymethyl)furfural (HMF) for the large-scale production of essential chemicals has been largely limited by the formation of solid humin as a by-product, which prevents continuous operation of step-wise batch-type processes and continuous flow-type processes. The reaction of HMF with 1,3-propanediol produces an HMF-acetal derivative that exhibits excellent thermal stability. Aerobic oxidation of the HMF-acetal with a CeO2-supported Au catalyst and Na2CO3 in water gives a 90-95% yield toward furan 2,5-dicarboxylic acid, an increasingly important commodity chemical for the biorenewables industry, from concentrated HMF-acetal solutions (10-20 wt%) without humin formation...
May 14, 2018: Angewandte Chemie
Mohamed Al-Farsi, Sharifa Al-Belushi, Abeer Al-Amri, Ahlam Al-Hadhrami, Mahfoodha Al-Rusheidi, Amani Al-Alawi
This study was intended to evaluate the quality parameters of 58 Apis mellifera honey samples, from different regions in the Sultanate of Oman. Physicochemical analyses were carried out and examined according to the Gulf Standardization Organization (GSO). The results revealed that 64.4% of the samples were failing to meet the GSO standards due to acidity, hydroxyl methyl furfural (HMF), diastase, sucrose, and glucose & fructose. Acidity and HMF were above the limits in 30% and 29% of the failed samples respectively, where diastase and total glucose & fructose were below the limits in 25% and 5% respectively...
October 1, 2018: Food Chemistry
Atul Kumar, Jatinder Paul Singh Gill, Jasbir Singh Bedi, Manmeet Manav, Mohd Javed Ansari, Gurjeet Singh Walia
In the present study, sensory and physicochemical properties of raw honey samples originating from different floral sources of India were investigated. Sensory analysis was carried out by quantitative descriptive analysis method. Samples having higher scores for flowery aroma, amber colour together with less crystallization were perceived to be more desirable with greater acceptability. The values obtained for electrical conductivity (0.28-1.0 mS/cm), moisture content (18.37-22%), HMF content (3.65-23.16 mg/kg), free acidity (14...
June 2018: Food Research International
Regiane Alves de Oliveira, Carlos Eduardo Vaz Rossell, Joachim Venus, Sarita Cândida Rabelo, Rubens Maciel Filho
Furfural and HMF are known for a negative impact in different bioprocesses, including lactic acid fermentation. There are already some methods described to remove these inhibitory compounds from the hydrolysates. However, these methods also reduce the yield of sugars from the hydrolysis and increase the process costs. In this work, the detoxification of sugarcane-derived hemicellulosic hydrolysate was performed by Lactobacillus plantarum during the fermentation time. At the end of the fermentation, a decrease of 98 % of furfural and 86 % of HMF and was observed, with a final lactic acid titer of 34...
May 4, 2018: Journal of Biotechnology
Haibo Yuan, Yanfeng Liu, Jianghua Li, Hyun-Dong Shin, Guocheng Du, Zhongping Shi, Jian Chen, Long Liu
The compound, 5-hydroxymethylfurfural (HMF), has attracted much attention due to its versatility as an important bio-based platform chemical. Here, we engineered Raoultella ornithinolytica BF60 as a whole-cell biocatalyst for highly efficient synthesis of 2,5-furandicarboxylic acid (FDCA) from HMF. Specifically, various expression cassettes of key genes, such as hmfH (gene encoding HMF/furfural oxidoreductase [HmfH]) and hmfo (gene encoding HMF oxidase [HMFO]) were designed and constructed for fine-tuning FDCA synthesis from HMF...
May 7, 2018: Biotechnology and Bioengineering
Zhong-Hua Xu, Ai-Di Cheng, Xu-Pu Xing, Min-Hua Zong, Yun-Peng Bai, Ning Li
Upgrading of biomass-derived 5-hydroxymethylfurfural (HMF) has attracted considerable interest recently. In this work, efficient synthesis of 2,5-bis(hydroxymethyl)furan (BHMF) from HMF was reported with the acclimatized Meyerozyma guilliermondii SC1103 cells entrapped in calcium alginate beads. Catalytic activities of the cells as well as their HMF-tolerant level increased significantly upon acclimatization and immobilization. BHMF was obtained within 7-24 h with good yields (82-85%) and excellent selectivities (99%) when the substrate concentrations were 200-300 mM...
April 22, 2018: Bioresource Technology
Nasib Qureshi, K Thomas Klasson, Badal C Saha, Siqing Liu
In these studies we pretreated sweet sorghum bagasse (SSB) using liquid hot water (LHW) or dilute H2 SO4 (2 g·L-1 ) at 190°C for zero min (as soon as temperature reached 190°C, cooling was started) to reduce generation of sugar degradation fermentation inhibiting products such as furfural and hydroxymethyl furfural (HMF). The solids loading were 250-300 gL-1 . This was followed by enzymatic hydrolysis. After hydrolysis, 89.0 gL-1 sugars, 7.60 gL-1 acetic acid, 0.33 gL-1 furfural, and 0.07 gL-1 HMF were released...
April 25, 2018: Biotechnology Progress
Duangkamon Suttipat, Wannaruedee Wannapakdee, Thittaya Yutthalekha, Somlak Ittisanronnachai, Thasanaporn Ungpittagul, Khamphee Phomphrai, Sareeya Bureekaew, Chularat Wattanakit
The composite of hierarchical faujasite nanosheets and zeolitic imidazolate framework-8 (Hie-FAU/ZIF-8) has been successfully prepared via a stepwise deposition of ZIF-8 on modified zeolite surfaces. Compared to the direct deposition of MOF on zeolite surfaces, ZIF-8 nanospheres were selectively attached to external surfaces of the MOF ligand-grafted FAU crystals because of the enhancing interaction between zeolite and MOF in the composite. In addition, the degree of surface functionalization can be greatly enhanced due to the presence of hierarchical structures...
April 20, 2018: ACS Applied Materials & Interfaces
Ruiqi Fang, Panliang Tian, Xianfeng Yang, Rafael Luque, Yingwei Li
The development of efficient encapsulation strategies has attracted intense interest for preparing highly active and stable heterogeneous metal catalysts. However, issues related to low loadings, costly precursors and complex synthesis processes restrict their potential applications. Herein, we report a novel and general strategy to encapsulate various ultrafine metal-oxides nanoparticles (NPs) into the mesoporous KIT-6. The synthesis is facile, which only involves self-assembly of a metal-organic framework (MOF) precursor in the silica mesopores and a subsequent calcination process to transform the MOF into metal-oxide NPs...
February 21, 2018: Chemical Science
Sarajit Biswas
Electronic, magnetic, and structural properties of pure and V-doped CrO2 were extensively investigated utilizing density functional theory. Usually, pure CrO2 is a half-metallic ferromagnet with conductive spin majority species and insulating spin minority species. This system remains in its half-metallic ferromagnetic phase even at 50% V-substitution for Cr within the crystal. The V-substituted compound Cr0.5 V0.5 O2 encounters metal-insulator transition upon the application of on-site Coulomb repulsion U = 7 eV preserving its ferromagnetism in the insulating phase...
April 17, 2018: Journal of Molecular Modeling
Z Lewis Liu, Xu Wang, Scott A Weber
Cell wall integrity signaling pathway in Saccharomyces cerevisiae is a conserved function for detecting and responding to cell stress conditions but less understood for industrial yeast. We examined gene expression dynamics for a tolerant industrial yeast strain NRRL Y-50049 in response to challenges of furfural and HMF through comparative quantitative gene expression analysis using pathway-based qRT-PCR array assays. All tested genes from Y-50049, except for MLP2, demonstrated more resistant and significantly increased gene expression than that from a laboratory strain BY4741...
April 14, 2018: Journal of Biotechnology
Prinjiya Dhungel, Yuliya Hrynets, Mirko Betti
Sous-vide is increasingly popular method of cooking under controlled conditions of temperature and time inside vacuumed pouches to preserve the nutritional and sensory qualities of food. Sous-vide non-enzymatic browning of glucosamine (GlcN) was investigated at 50, 60 and 70°C for 12 h. Changes investigated were pH, color, level of browning and in the concentration of the key Maillard and caramelization reaction products, including α-dicarbonyls and pyrazines. The concentrations of undesired 4-methylimidazole (4-MEI), 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI) and 5-hydroxymethylfurfural (5-HMF) were also determined...
April 16, 2018: Journal of Agricultural and Food Chemistry
Yajing Qi, Hao Zhang, Gangcheng Wu, Hui Zhang, Li Wang, Haifeng Qian, Xiguang Qi
BACKGROUND: 5-Hydroxymethylfurfural (HMF) is regarded as a thermal process contaminant in foods. Six flavan-3-ol fractions were isolated or semisynthesized from sorghum, cranberry and grape seed. Their unit compositions, interflavan linkages and degree of polymerization (DP) were characterized. The aim of this study was to investigate the effect of flavan-3-ols on the formation of HMF in chemical reaction models and fried potato chips. RESULTS: Results showed that all flavan-3-ols significantly mitigated the HMF formation at concentrations of 50, 100 and 200 μg mL-1 in chemical model system, and the inhibition was positively related to dose...
April 13, 2018: Journal of the Science of Food and Agriculture
Qing Qing, Qi Guo, Pengbo Wang, Hongjia Qian, Xiaohang Gao, Yue Zhang
Levulinic acid (LA) is an ideal platform chemical that can be produced through acid-catalyzed dehydration and hydrolysis of hexose sugars obtained from lignocellulosic materials. In this study, SnCl4 was identified as an efficient catalyst for LA production and the reaction kinetics was investigated in a single water phase under different reaction conditions. The Box-Behnken design response surface methodology (RSM) was applied to determine the optimized reaction conditions and three individual variables including reaction temperature, duration, and catalyst concentration were evaluated...
March 29, 2018: Bioresource Technology
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