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JOURNAL ARTICLE
Nicolai Jessen, Jens Aamann Andersen, Bhupendar Tayal, Lauge Østergaard, Mikkel Porsborg Andersen, Morten Schmidt, Emil Loldrup Fosbøl, Morten Schou, Peter Søgaard, Gunnar Gislason, Christian Torp-Pedersen, Lars Køber, Kristian Kragholm
AIMS: Previous small-scale studies have indicated a short-term stroke incidence of 1.0-1.3% following Takotsubo (syndrome). In this nationwide register-based study, we investigated the 90-day risk of ischemic stroke (IS) or transient ischemia attack (TIA) and mortality of patients with Takotsubo. METHODS AND RESULTS: Patients with incident Takotsubo between January 1st 2009 to September 30th 2018 were identified from Danish nationwide registries. Takotsubo patients were age- and sex-matched with background-, atrial fibrillation/flutter- (AF) and myocardial infarction (MI) cohorts...
August 22, 2023: International Journal of Cardiology
#22
JOURNAL ARTICLE
Clara Fernández-Cordón, Iván Javier Núñez-Gil, Irene Martín de Miguel, Alberto Pérez-Castellanos, Oscar Vedia, Manuel Almendro-Delia, Javier López-País, Aitor Uribarri, Albert Duran-Cambra, Agustín Martín-García, Sergio Raposeiras-Roubin, Emilia Blanco-Ponce, Miguel Corbí-Pascual, Marta Guillén Marzo, Mireia Andrés, Gisela Feltes, Manuel Martínez-Selles
The risk of recurrence in takotsubo syndrome (TTS) appears to be low, although previous studies have shown conflicting results and factors associated with recurrences are unclear. The aim of this study is to evaluate the incidence and predictors of TTS recurrences. Adult patients included in the Spanish Multicenter REgistry of TAKOtsubo syndrome (RETAKO) between January 2003 and September 2019 were identified. Patients were categorized based on recurrences during follow-up and a multivariate logistic regression model was used to identify factors associated with recurrences...
August 14, 2023: American Journal of Cardiology
#23
REVIEW
Federica Dell'Aversana, Carlo Tedeschi, Rosita Comune, Luigi Gallo, Giovanni Ferrandino, Emilia Basco, Stefania Tamburrini, Giacomo Sica, Salvatore Masala, Mariano Scaglione, Carlo Liguori
Awareness of gender differences in cardiovascular disease (CVD) has increased: both the different impact of traditional cardiovascular risk factors on women and the existence of sex-specific risk factors have been demonstrated. Therefore, it is essential to recognize typical aspects of ischemic heart disease (IHD) in women, who usually show a lower prevalence of obstructive coronary artery disease (CAD) as a cause of acute coronary syndrome (ACS). It is also important to know how to recognize pathologies that can cause acute chest pain with a higher incidence in women, such as spontaneous coronary artery dissection (SCAD) and myocardial infarction with non-obstructive coronary arteries (MINOCA)...
August 7, 2023: Diagnostics
#24
JOURNAL ARTICLE
Ovidio De Filippo, Victoria L Cammann, Corrado Pancotti, Davide Di Vece, Angelo Silverio, Victor Schweiger, David Niederseer, Konrad A Szawan, Michael Würdinger, Iva Koleva, Veronica Dusi, Michele Bellino, Carmine Vecchione, Guido Parodi, Eduardo Bossone, Sebastiano Gili, Michael Neuhaus, Jennifer Franke, Benjamin Meder, Miłosz Jaguszewski, Michel Noutsias, Maike Knorr, Thomas Jansen, Wolfgang Dichtl, Dirk von Lewinski, Christof Burgdorf, Behrouz Kherad, Carsten Tschöpe, Annahita Sarcon, Jerold Shinbane, Lawrence Rajan, Guido Michels, Roman Pfister, Alessandro Cuneo, Claudius Jacobshagen, Mahir Karakas, Wolfgang Koenig, Alexander Pott, Philippe Meyer, Marco Roffi, Adrian Banning, Mathias Wolfrum, Florim Cuculi, Richard Kobza, Thomas A Fischer, Tuija Vasankari, K E Juhani Airaksinen, L Christian Napp, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Christina Chan, Paul Bridgman, Daniel Beug, Clément Delmas, Olivier Lairez, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, Ibrahim El-Battrawy, Ibrahim Akin, Karolina Poledniková, Petr Toušek, David E Winchester, Michael Massoomi, Jan Galuszka, Christian Ukena, Gregor Poglajen, Pedro Carrilho-Ferreira, Christian Hauck, Carla Paolini, Claudio Bilato, Yoshio Kobayashi, Ken Kato, Iwao Ishibashi, Toshiharu Himi, Jehangir Din, Ali Al-Shammari, Abhiram Prasad, Charanjit S Rihal, Kan Liu, P Christian Schulze, Matteo Bianco, Lucas Jörg, Hans Rickli, Gonçalo Pestana, Thanh H Nguyen, Michael Böhm, Lars S Maier, Fausto J Pinto, Petr Widimský, Stephan B Felix, Ruediger C Braun-Dullaeus, Wolfgang Rottbauer, Gerd Hasenfuß, Burkert M Pieske, Heribert Schunkert, Monika Budnik, Grzegorz Opolski, Holger Thiele, Johann Bauersachs, John D Horowitz, Carlo Di Mario, Francesco Bruno, William Kong, Mayank Dalakoti, Yoichi Imori, Thomas Münzel, Filippo Crea, Thomas F Lüscher, Jeroen J Bax, Frank Ruschitzka, Gaetano Maria de Ferrari, Piero Fariselli, Jelena R Ghadri, Rodolfo Citro, Fabrizio D'Ascenzo, Christian Templin
AIMS: Takotsubo syndrome (TTS) is associated with a substantial rate of adverse events. We sought to design a machine-learning (ML) based model to predict the risk of in-hospital death and to perform a clustering of TTS patients to identify different risk profiles. METHODS AND RESULTS: A Ridge Logistic Regression-based ML model for predicting in-hospital death was developed on 3482 TTS patients from the International Takotsubo Registry, randomly split in a train and an internal validation cohort (75% and 25% of the sample size, respectively) and evaluated in an external validation cohort (1037 patients)...
July 31, 2023: European Journal of Heart Failure
#25
Abdul Haseeb Riaz, Alison Gordon, Manoj Bhandari
Acute myocardial infarction (AMI) in women of reproductive age is uncommon; however, the risk of AMI increases four to five-fold during pregnancy as compared to non-pregnant women of similar age. In the period following childbirth, the incidence of AMI is often attributed to a range of factors. These factors encompass coronary vessel dissection related to atherosclerosis, thrombosis, coronary spasm, and, in rare cases, takotsubo cardiomyopathy. The physiological alterations that accompany pregnancy induce a state of heightened coagulation, thereby elevating the risk of ischemic heart disease (IHD) in women...
June 2023: Curēus
#26
JOURNAL ARTICLE
Maria Garcia de Oteyza, Paola Dolader, Ferran Gran
Takotsubo cardiomyopathy has an incidence of 1% of acute coronary syndrome in the adult population, and the risk of recurrence is approximately 1.5% per year. However, only a few cases have been reported in children. Having a neurologic disorder and being exposed to the same trigger repeatedly have been associated with an increased risk.
July 11, 2023: Cardiology in the Young
#27
Sarah Rikabi, Sachin Kumar, Gautam Shah
Stress-induced cardiomyopathy presents like acute coronary syndrome and is triggered by emotional stress or critical illness. Increased incidence has been reported during the COVID-19 pandemic and natural disasters. We describe a case of stress-induced cardiomyopathy as an indirect consequence of the Russia-Ukraine war. ( Level of Difficulty: Beginner. ).
June 21, 2023: JACC. Case reports
#28
JOURNAL ARTICLE
Giacomo Coppalini, Michele Salvagno, Lorenzo Peluso, Elisa Gouvêa Bogossian, Armin Quispe Cornejo, Vincent Labbé, Filippo Annoni, Fabio Silvio Taccone
Traumatic brain injury (TBI) is a significant public health issue because of its increasing incidence and the substantial short-term and long-term burden it imposes. This burden includes high mortality rates, morbidity, and a significant impact on productivity and quality of life for survivors. During the management of TBI, extracranial complications commonly arise during the patient's stay in the intensive care unit. These complications can have an impact on both mortality and the neurological outcome of patients with TBI...
April 2024: Neurocritical Care
#29
Sawyer Cimaroli, Yesha Maniar, James Ciancarelli, Adam Stright, D'Andrea Joseph
BACKGROUND: Takotsubo Cardiomyopathy (TTC) is characterized by reversible left ventricular apical ballooning in the absence of angiographically significant coronary artery disease. While TTC is usually preceded by an emotionally stressful event, physical trauma has been documented as a precipitating incident as well. CASE SUMMARY: An 82-year-old female with no past medical history, presented to the emergency department following a motor vehicle collision. Trauma workup was significant for an ulnar fracture, elevated cardiac enzymes, and ST-segment changes...
August 2023: Trauma Case Reports
#30
JOURNAL ARTICLE
Yuta Suzuki, Hidehiro Kaneko, Yuichi Tamura, Akira Okada, Katsuhito Fujiu, Nobuaki Michihata, Norifumi Takeda, Taisuke Jo, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Issei Komuro
We sought to clarify the incidence of major adverse cardiac events (MACE) after the initiation of immune checkpoint inhibitors (ICIs). We analyzed the JMDC Claims Database between 2005 and 2021. The study included 2972 patients with no history of cardiovascular disease and a prescription for an ICI. The primary outcome was the incidence of MACE, including myocarditis, pericarditis, Takotsubo cardiomyopathy, atrio-ventricular block, heart failure, myocardial infarction, and stroke. The median age of study participants was 59 (Q1-Q3 53-65) years, and 2163 participants (72...
May 2023: Heliyon
#31
JOURNAL ARTICLE
Kamila M Ludwikowska, Nafeesa Moksud, Paweł Tracewski, Mateusz Sokolski, Leszek Szenborn
Multisystem inflammatory syndrome in children (MIS-C) is an immune-mediated complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Cardiovascular system is commonly involved. Acute heart failure (AHF) is the most severe complication of MIS-C, leading to cardiogenic shock. The aim of the study was to characterise the course of MIS-C with a focus on cardiovascular involvement, based on echocardiographic (echo) evaluation, in 498 children (median age 8.3 years, 63% boys) hospitalised in 50 cities in Poland...
April 23, 2023: Biomedicines
#32
JOURNAL ARTICLE
Christina Ekenbäck, Jannike Nickander, Fadi Jokhaji, Per Tornvall, Henrik Engblom, Jonas Spaak, Jonas Persson
AIMS: Coronary microvascular dysfunction (CMD) has been proposed as an important pathophysiological mechanism in Takotsubo syndrome (TTS). Our aims were (i) to evaluate and compare levels of CMD in patients with TTS and patients with ischaemia and no obstructive coronary arteries (INOCA) and (ii) to investigate associations between CMD and clinical parameters, left ventricular function, and coronary atherosclerosis in TTS. METHODS AND RESULTS: We conducted a prospective study of 27 female TTS patients and an equally sized, age- and gender-matched, cohort of INOCA patients...
May 22, 2023: ESC Heart Failure
#33
REVIEW
Tessa J Helman, John P Headrick, Nicolas J C Stapelberg, Nady Braidy
Stress is an important risk factor for modern chronic diseases, with distinct influences in males and females. The sex specificity of the mammalian stress response contributes to the sex-dependent development and impacts of coronary artery disease (CAD). Compared to men, women appear to have greater susceptibility to chronic forms of psychosocial stress, extending beyond an increased incidence of mood disorders to include a 2- to 4-fold higher risk of stress-dependent myocardial infarction in women, and up to 10-fold higher risk of Takotsubo syndrome-a stress-dependent coronary-myocardial disorder most prevalent in post-menopausal women...
2023: Frontiers in Cardiovascular Medicine
#34
Aniekeme S Etuk, Celestine I Odigwe, Christabel Nyange, Stanley Thornton, Michael Pursley
Stress-induced cardiomyopathy, otherwise known as takotsubo cardiomyopathy, typically presents with chest pain and acute left ventricular failure with unobstructed coronary arteries. There is an increase in disease incidence as clinicians are becoming more aware of this clinical entity. An atypical variant exists where there is left ventricular dysfunction with apical sparing. Various precipitants have been described in the literature, however, there has not been any documented case following massive gastrointestinal bleeding...
February 2023: Curēus
#35
REVIEW
Anthony Georges Matta, Didier Carrié
Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy, is a reversible syndrome commonly found among patients presenting for acute coronary syndromes, especially women. With the COVID-19 pandemic, the incidence of takotsubo cardiomyopathy was dramatically increased. However, this clinical cardiac entity remains underdiagnosed, largely due to the interplay with acute coronary syndrome. The pathophysiology of takotsubo cardiomyopathy is miscellaneous, including coronary vasospasm, microcirculatory dysfunction, catecholamine surge, and sympathetic overdrive...
March 6, 2023: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
#36
JOURNAL ARTICLE
Chin-Chin Ho, Shang-Liang Wu, Han-Yi Tsai, Yu-Wen Hu, Yuh-Lih Chang
BACKGROUND: This present study investigated the incidence rates of cardiotoxicity among cancer patients treated with immune checkpoint inhibitors (ICIs) plus other anticancer drugs. CONCLUSION: The incidence rate of ICI-related cardiotoxicity is low. Combination of ICI with either chemotherapy or targeted therapy might not significantly increase the risk of cardiotoxicities among cancer patients. Nevertheless, it is recommend being careful in patients treated high-risk cardiotoxicity medications to avoid drug-related cardiotoxicity with a combination of ICI therapy...
March 6, 2023: Journal of the Chinese Medical Association: JCMA
#37
REVIEW
Sittinun Thangjui, Harshith Thyagaturu, Angkawipa Trongtorsak, Ratdanai Yodsuwan, Muhammad Fayaz, Jakrin Kewcharoen, Leenhapong Navaravong
The incidence of cardioversion-associated takotsubo cardiomyopathy in patients with atrial fibrillation undergoing electrical cardioversion is unknown. We aimed to determine the incidence of cardioversion-associated takotsubo cardiomyopathy using a National Readmission Database 2018 and a systematic review. We identified all patients with the index diagnosis of atrial fibrillation who underwent electrical cardioversion and were readmitted within 30 days with a primary diagnosis of takotsubo cardiomyopathy by International Classification of Diseases, Tenth Revision, Clinical Modification codes to find the incidence and risk factors of the disease...
February 2023: Anatolian Journal of Cardiology
#38
JOURNAL ARTICLE
Paulina Wieczorkiewicz, Konrad Szymczyk, Marzenna Zielinska
The 12-lead electrocardiogram (ECG) remains a key tool to diagnose ST elevation myocardial infarction (STEMI). However, a variety of other conditions aside from obstructive coronary disease, including hyperkalemia, myocarditis, pericarditis, and Takotsubo and Brugada syndrome, may also cause ST segment elevation, with an incidence rate of 3%-15% and mean age of 45 ± 14 years. A combination of a detailed past medical history, thorough physical examination, and additional imaging tests may allow physicians to make the correct diagnosis...
January 23, 2023: International Heart Journal
#39
JOURNAL ARTICLE
Kenshiro Arao, Tsutomu Yoshikawa, Toshiaki Isogai, Yoichi Imori, Hiroki Mochizuki, Konomi Sakata, Yoshimitsu Takaoka, Tetsuo Yamaguchi, Ken Nagao, Takeshi Yamamoto, Morimasa Takayama
BACKGROUND: Takotsubo syndrome (TTS) is an acute cardiovascular disease with clinical manifestations similar to those of acute myocardial infarction (AMI), and TTS sometimes occurs just after catastrophes. Large-scale studies of TTS in Japan are scarce, so we examined data over 9 years from Tokyo metropolitan acute cardiovascular care hospital network registry. METHODS: A total of 1626 patients were diagnosed with TTS between 2010 and 2018 at Tokyo Cardiovascular Care Unit Network facilities, and data from all these patients were analyzed...
January 11, 2023: Journal of Cardiology
#40
JOURNAL ARTICLE
Lauren A Farina, Anjan Tibrewala, Zhiying Meng, Abigail S Baldridge, Jay M Voit, Sasan R Raissi, Michelle Lu, Sadiya S Khan, Benjamin H Freed, Nausheen Akhter
INTRODUCTION: Takotsubo syndrome (TTS) is characterized by transient left ventricular dysfunction and associated with considerable morbidity and mortality. We sought to evaluate the association between change in cardiac mechanics after diagnosis of TTS with 1-year incidence of major adverse cardiovascular events (MACE). METHODS: We retrospectively identified 85 patients with apical TTS based on ICD 9/10 codes and chart adjudication, who had a follow-up echocardiogram within 6 months of diagnosis...
January 11, 2023: Echocardiography
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