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JOURNAL ARTICLE
Kelly Jiang, Andrew M Hersh, Meghana Bhimreddy, Carly Weber-Levine, A Daniel Davidar, Arjun K Menta, Denis Routkevitch, Safwan Alomari, Brendan F Judy, Daniel Lubelski, Jon Weingart, Nicholas Theodore
BACKGROUND AND OBJECTIVES: Robot-assisted pedicle screw placement is associated with greater accuracy, reduced radiation, less blood loss, shorter hospital stays, and fewer complications than freehand screw placement. However, it can be associated with longer operative times and an extended training period. We report the initial experience of a surgeon using a robot system at an academic medical center. METHODS: We retrospectively reviewed all patients undergoing robot-assisted pedicle screw placement at a single tertiary care institution by 1 surgeon from 10/2017 to 05/2022...
August 14, 2023: Operative Neurosurgery (Hagerstown, Md.)
#22
JOURNAL ARTICLE
Douglas K Rex, Uri Ladabaum, Joseph C Anderson, Aasma Shaukat, Lynn F Butterly, Jason A Dominitz, Tonya Kaltenbach, Theodore R Levin, Cesare Hassan
No abstract text is available yet for this article.
November 2023: Clinical Gastroenterology and Hepatology
#23
REVIEW
Peter Levine
Boredom is a topic in philosophy. Philosophers have offered close descriptions of the experience of boredom that should inform measurement and analysis of empirical results. Notable historical authors include Seneca, Martin Heidegger, and Theodor Adorno; current philosophers have also contributed to the literature. Philosophical accounts differ in significant ways, because each theory of boredom is embedded in a broader understanding of institutions, ethics, and social justice. Empirical research and interventions to combat boredom should be conscious of those frameworks...
2023: Frontiers in sociology
#24
JOURNAL ARTICLE
Robert S Bresalier, Carlo Senore, Graeme P Young, James Allison, Robert Benamouzig, Sally Benton, Patrick M M Bossuyt, Luis Caro, Beatriz Carvalho, Han-Mo Chiu, Veerle M H Coupé, Willemijn de Klaver, Clasine Maria de Klerk, Evelien Dekker, Sunil Dolwani, Callum G Fraser, William Grady, Lydia Guittet, Samir Gupta, Stephen P Halloran, Ulrike Haug, Geir Hoff, Steven Itzkowitz, Tim Kortlever, Anastasios Koulaouzidis, Uri Ladabaum, Beatrice Lauby-Secretan, Mārcis Leja, Bernard Levin, Theodore Robert Levin, Finlay Macrae, Gerrit A Meijer, Joshua Melson, Colm O'Morain, Susan Parry, Linda Rabeneck, David F Ransohoff, Roque Sáenz, Hiroshi Saito, Silvia Sanduleanu-Dascalescu, Robert E Schoen, Kevin Selby, Harminder Singh, Robert J C Steele, Joseph J Y Sung, Erin Leigh Symonds, Sidney J Winawer
OBJECTIVE: New screening tests for colorectal cancer (CRC) are rapidly emerging. Conducting trials with mortality reduction as the end point supporting their adoption is challenging. We re-examined the principles underlying evaluation of new non-invasive tests in view of technological developments and identification of new biomarkers. DESIGN: A formal consensus approach involving a multidisciplinary expert panel revised eight previously established principles. RESULTS: Twelve newly stated principles emerged...
October 2023: Gut
#25
JOURNAL ARTICLE
A Daniel Davidar, Brendan F Judy, Andrew M Hersh, Carly Weber-Levine, Safwan Alomari, Arjun K Menta, Kelly Jiang, Meghana Bhimreddy, Mir Hussain, Neil R Crawford, Majid Khan, Gary Gong, Nicholas Theodore
BACKGROUND: Synthetic computed tomography (sCT) can be created from magnetic resonance imaging (MRI) utilizing newer software. sCT is yet to be explored as a possible alternative to routine CT (rCT). In this study, rCT scans and MRI-derived sCT scans were obtained on a cadaver. Morphometric analysis was performed comparing the 2 scans. The ExcelsiusGPS robot was used to place lumbosacral screws with both rCT and sCT images. OBSERVATIONS: In total, 14 screws were placed...
July 10, 2023: J Neurosurg Case Lessons
#26
JOURNAL ARTICLE
Ronit R Dalmat, Rebecca A Ziebell, Aruna Kamineni, Amanda I Phipps, Noel S Weiss, Erica S Breslau, Andrea N Burnett-Hartman, Douglas A Corley, V Paul Doria-Rose, Beverly B Green, Ethan A Halm, Theodore R Levin, Joanne E Schottinger, Jessica Chubak
BACKGROUND: Colorectal cancer (CRC) screening is universally recommended for adults ages 45-75 years. Noninvasive fecal occult blood tests are effective screening tests recommended by guidelines. However, empirical evidence to inform older adults' decisions about whether to continue screening is sparse, especially for individuals with prior screening. METHODS: This study used a retrospective cohort of older adults at three Kaiser Permanente integrated healthcare systems (Northern California, Southern California, Washington) and Parkland Health (Dallas, Texas)...
July 14, 2023: Cancer Epidemiology, Biomarkers & Prevention
#27
JOURNAL ARTICLE
Eliot R Dow, Nergis C Khan, Karen M Chen, Kapil Mishra, Chandrashan Perera, Ramsudha Narala, Marina Basina, Jimmy Dang, Michael Kim, Marcie Levine, Anuradha Phadke, Marilyn Tan, Kirsti Weng, Diana V Do, Darius M Moshfeghi, Vinit B Mahajan, Prithvi Mruthyunjaya, Theodore Leng, David Myung
OBJECTIVE: Detection of diabetic retinopathy (DR) outside of specialized eye care settings is an important means of access to vision-preserving health maintenance. Remote interpretation of fundus photographs acquired in a primary care or other nonophthalmic setting in a store-and-forward manner is a predominant paradigm of teleophthalmology screening programs. Artificial intelligence (AI)-based image interpretation offers an alternative means of DR detection. IDx-DR (Digital Diagnostics Inc) is a Food and Drug Administration-authorized autonomous testing device for DR...
December 2023: Ophthalmol Sci
#28
JOURNAL ARTICLE
Douglas A Corley, Christopher D Jensen, Jeffrey K Lee, Theodore R Levin, Wei K Zhao, Joanne E Schottinger, Nirupa R Ghai, Chyke A Doubeni, Ethan A Halm, Celette Sugg-Skinner, Natalia Udaltsova, Richard Contreras, Bruce H Fireman, Charles P Quesenberry
BACKGROUND AND AIMS: Endoscopist adenoma detection rates (ADR) vary widely and are associated with patients' risk of post-colonoscopy colorectal cancers (PCCRC). However, few scalable physician-directed interventions demonstrably both improve ADR and reduce PCCRC risk. METHODS: Among patients undergoing colonoscopy, we evaluated a scalable online training's influence on individual-level ADRs and PCCRC risk. The intervention was a 30-minute, interactive, online training, developed using behavior-change theory to address factors that potentially impede adenoma detection...
April 22, 2023: Gastrointestinal Endoscopy
#29
JOURNAL ARTICLE
Yohannes Tseha, Yinuo Zeng, Carly Weber-Levine, Tolulope Awosika, Max Kerensky, Andrew M Hersh, Ze Ou, Kelly Jiang, Meghana Bhimreddy, Stuart J Bauer, John N Theodore, Victor M Quiroz, Ian Suk, Safwan Alomari, Junfeng Sun, Shanbao Tong, Nitish Thakor, Joshua C Doloff, Nicholas Theodore, Amir Manbachi
OBJECTIVE: Here we investigate the ability of low-intensity ultrasound (LIUS) applied to the spinal cord to modulate the transmission of motor signals. METHODS: Male adult Sprague-Dawley rats (n = 10, 250-300 g, 15 weeks old) were used in this study. Anesthesia was initially induced with 2% isoflurane carried by oxygen at 4 L/min via a nose cone. Cranial, upper extremity, and lower extremity electrodes were placed. A thoracic laminectomy was performed to expose the spinal cord at the T11 and T12 vertebral levels...
January 2, 2023: IEEE Transactions on Bio-medical Engineering
#30
JOURNAL ARTICLE
Ronit Endevelt, Theodore H Tulchinsky, Ziva Stahl, Zohar Mor, Nadav Davidovitch, Hagai Levine, Aron M Troen
The World Health Organization (WHO) recognizes food fortification as one of the most cost-effective and beneficial public health measures available. Mass fortification policies and regulations can reduce health disparities, including in high-income countries, by improving micronutrient intake among food-insecure or high-risk populations without changing their diet or behavior. While international health organizations have traditionally prioritized technical assistance and grants to medium and low-income countries, it is important to recognize that micronutrient deficiencies may also pose an important yet underappreciated public health problem in many high-income countries...
2023: Frontiers in Public Health
#31
JOURNAL ARTICLE
Meghana Bhimreddy, Denis Routkevitch, Andrew M Hersh, Ali Mohammadabadi, Arjun K Menta, Kelly Jiang, Carly Weber-Levine, A Daniel Davidar, Joshua Punnoose, Kelley M Kempski Leadingham, Joshua C Doloff, Betty Tyler, Nicholas Theodore, Amir Manbachi
Low-intensity focused ultrasound (LIFU) uses ultrasonic pulsations at lower intensities than ultrasound and is being tested as a reversible and precise neuromodulatory technology. Although LIFU-mediated blood-brain barrier (BBB) opening has been explored in detail, no standardized technique for blood-spinal cord barrier (BSCB) opening has been established to date. Therefore, this protocol presents a method for successful BSCB disruption using LIFU sonication in a rat model, including descriptions of animal preparation, microbubble administration, target selection and localization, as well as BSCB disruption visualization and confirmation...
March 10, 2023: Journal of Visualized Experiments: JoVE
#32
JOURNAL ARTICLE
Theodore E Harrison, Jannice Bowler, Todd N Levins, K Dean Reeves
Platelet-rich plasma (PRP), an inexpensive yet powerful treatment modality, is widely used but poorly understood. Three areas of unmet need are the ability to compare results using differing centrifuges and methods; translating a study result into a specific practice; and estimating yield and dosage without the benefit of an in-office hematology analyzer. PRPCalc2 is a set of software tools that facilitates these goals. The app consists of software tools that (1) calculate the appropriate radius for centrifugation, (2) calculate the correct revolutions per minute (RPM) for the centrifuge, (3) calculate the mean yield for the method and its confidence interval, and (4) calculate platelet dosage...
March 2023: Curēus
#33
REVIEW
Theodore Quan, Alex Gu, Amil R Agarwal, Simone A Bernstein, Alisa Malyavko, William N Levine, Lisa K Cannada
UNLABELLED: Orthopaedic surgery has become an increasingly popular field of residency training for medical students. Many institutions offer elective time to explore areas of interest through clinical rotations and research; however, most of these opportunities are reserved for senior medical students. The purpose of this study was to evaluate the impact of a dedicated medical student orthopaedic surgery symposium to increase awareness about the field and to assess students' interest and knowledge of orthopaedic surgery before and after the symposium...
2022: JB & JS Open Access
#34
JOURNAL ARTICLE
Andrew B Hawkey, Janequia Evans, Zade R Holloway, Erica Pippen, Olivia Jarrett, Bruny Kenou, Theodore A Slotkin, Frederic J Seidler, Edward D Levin
BACKGROUND: Human exposures to organophosphate flame retardants result from their use as additives in numerous consumer products. These agents are replacements for brominated flame retardants but have not yet faced similar scrutiny for developmental neurotoxicity. We examined a representative organophosphate flame retardant, triphenyl phosphate (TPP) and its potential effects on behavioral development and dopaminergic function. METHODS: Female Sprague-Dawley rats were given low doses of TPP (16 or 32 mg kg-1 day-1 ) via subcutaneous osmotic minipumps, begun preconception and continued into the early postnatal period...
November 11, 2022: Birth Defects Research
#35
JOURNAL ARTICLE
Sara R Alcorn, Anna W LaVigne, Christen R Elledge, Jacob Fiksel, Chen Hu, Lawrence Kleinberg, Adam Levin, Thomas Smith, Zhi Cheng, Kibem Kim, Avani D Rao, Lindsey Sloan, Brandi Page, Susan F Stinson, K Ranh Voong, Todd R McNutt, Michael R Bowers, Theodore L DeWeese, Scott Zeger, Jean L Wright
PURPOSE: The Bone Metastases Ensemble Trees for Survival Decision Support Platform (BMETS-DSP) provides patient-specific survival predictions and evidence-based recommendations to guide multidisciplinary management for symptomatic bone metastases. We assessed the clinical utility of the BMETS-DSP through a pilot prepost design in a simulated clinical environment. METHODS: Ten Radiation Oncology physicians reviewed 55 patient cases at two time points: without and then with the use of BMETS-DSP...
October 2022: JCO Clinical Cancer Informatics
#36
JOURNAL ARTICLE
Sara A Nolin, Hannah Cowart, Stacy Merritt, Katalina McInerney, P K Bharadwaj, Mary Kate Franchetti, David A Raichlen, Cortney J Jessup, G Alex Hishaw, Emily J Van Etten, Theodore P Trouard, David S Geldmacher, Virginia G Wadley, Eric S Porges, Adam J Woods, Ron A Cohen, Bonnie E Levin, Tatjana Rundek, Gene E Alexander, Kristina M Visscher
OBJECTIVE: To evaluate the construct validity of the NIH Toolbox Cognitive Battery (NIH TB-CB) in the healthy oldest-old (85+ years old). METHOD: Our sample from the McKnight Brain Aging Registry consists of 179 individuals, 85 to 99 years of age, screened for memory, neurological, and psychiatric disorders. Using previous research methods on a sample of 85 + y/o adults, we conducted confirmatory factor analyses on models of NIH TB-CB and same domain standard neuropsychological measures...
October 14, 2022: Journal of the International Neuropsychological Society: JINS
#37
REVIEW
Andrew M Hersh, Meghana Bhimreddy, Carly Weber-Levine, Kelly Jiang, Safwan Alomari, Nicholas Theodore, Amir Manbachi, Betty M Tyler
Glioblastoma (GBM) is an aggressive primary astrocytoma associated with short overall survival. Treatment for GBM primarily consists of maximal safe surgical resection, radiation therapy, and chemotherapy using temozolomide. Nonetheless, recurrence and tumor progression is the norm, driven by tumor stem cell activity and a high mutational burden. Focused ultrasound (FUS) has shown promising results in preclinical and clinical trials for treatment of GBM and has received regulatory approval for the treatment of other neoplasms...
October 8, 2022: Cancers
#38
JOURNAL ARTICLE
Rosita van den Puttelaar, Iris Lansdorp-Vogelaar, Anne I Hahn, Carolyn M Rutter, Theodore R Levin, Ann G Zauber, Reinier G S Meester
BACKGROUND: Many colorectal cancer (CRC)-related procedures were suspended during the COVID-19 pandemic. In this study, we predict the impact of resulting delays in screening (colonoscopy, FIT, sigmoidoscopy) and diagnosis on CRC outcomes, and compare different recovery scenarios. METHODS: Using the MISCAN-Colon model, we simulated the US population and evaluated different impact and recovery scenarios. Scenarios were defined by the duration and severity of the disruption (% of eligible adults affected), the length of delays, and the duration of the recovery...
October 10, 2022: Cancer Epidemiology, Biomarkers & Prevention
#39
JOURNAL ARTICLE
Carly Weber-Levine, Andrew M Hersh, Kelly Jiang, Denis Routkevitch, Yohannes Tsehay, Alexander Perdomo-Pantoja, Brendan F Judy, Max Kerensky, Ann Liu, Melanie Adams, Jessica Izzi, Joshua C Doloff, Amir Manbachi, Nicholas Theodore
Spinal cord injury (SCI) is a devastating disease with limited effective treatment options. Animal paradigms are vital for understanding the pathogenesis of SCI and testing potential therapeutics. The porcine model of SCI is increasingly favored because of its greater similarity to humans. However, its adoption is limited by the complexities of care and range of testing parameters. Researchers need to consider swine selection, injury method, post-operative care, rehabilitation, behavioral outcomes, and histology metrics...
2022: Neurotrauma reports
#40
JOURNAL ARTICLE
Ronit R Dalmat, Rebecca A Ziebell, Aruna Kamineni, Amanda I Phipps, Noel S Weiss, Erica S Breslau, Douglas A Corley, Beverly B Green, Ethan A Halm, Theodore R Levin, Joanne E Schottinger, Jessica Chubak
BACKGROUND: Few empirical data are available to inform older adults' decisions about whether to screen or continue screening for colorectal cancer (CRC) based on their prior history of screening, particularly among individuals with a prior negative exam. METHODS: Using a retrospective cohort of older adults receiving healthcare at three Kaiser Permanente integrated healthcare systems in Northern California (KPNC), Southern California (KPSC), and Washington (KPWA), we estimated the cumulative risk of CRC incidence and mortality among older adults who had a negative colonoscopy ten years earlier, accounting for death from other causes...
September 13, 2022: Cancer Epidemiology, Biomarkers & Prevention
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