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https://www.readbyqxmd.com/read/28818436/use-of-the-hemangioma-severity-scale-to-facilitate-treatment-decisions-for-infantile-hemangiomas
#1
Andre Vadimovich Moyakine, Bjorn Herwegen, Catharina Joanna Maria van der Vleuten
BACKGROUND: The Hemangioma Severity Scale (HSS) assesses the severity of an infantile hemangioma (IH). OBJECTIVE: First, to compare HSS scores between patients with IH for whom propranolol treatment was indicated at their first visit and those who were not treated. Second, to assess suitable cutoff values for the need for propranolol treatment. METHOD: All patients with IH who attended our tertiary referral center since 2008 and were 0 to 6 months of age at their first visit were included...
August 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28813599/tetraterpene-synthase-substrate-and-product-specificity-in-the-green-microalga-botryococcus-braunii-race-l
#2
Hem Raj Thapa, Su Tang, James C Sacchettini, Timothy P Devarenne
Recently, the biosynthetic pathway for lycopadiene, a C40 tetraterpenoid hydrocarbon, was deciphered from the L race of Botryococcus braunii, an alga that produces hydrocarbon oils capable of being converted into combustible fuels. The lycopadiene pathway is initiated by the squalene synthase (SS)-like enzyme lycopaoctaene synthase (LOS), which catalyzes the head-to-head condensation of two C20 geranylgeranyl diphosphate (GGPP) molecules to produce C40 lycopaoctaene. LOS shows unusual substrate promiscuity for SS or SS-like enzymes by utilizing C15 farnesyl diphosphate (FPP) and C20 phytyl diphosphate in addition to GGPP as substrates...
August 16, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28791806/ultra-high-performance-liquid-chromatography-coupled-with-electrospray-ionization-quadrupole-time-of-flight-mass-spectrometry-for-the-rapid-analysis-of-constituents-in-the-traditional-chinese-medicine-formula-wu-ji-bai-feng-pill
#3
Shengnan Duan, Wen Qi, Siwen Zhang, Kunkun Huang, Dan Yuan
An ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry method in both positive and negative ion modes was established in order to comprehensively investigate the major constituents in Wu-Ji-Bai-Feng-Pill. Briefly, a Waters ACQUITY UPLC HSS C18 column was used to separate the aqueous extract of Wu-Ji-Bai-Feng-Pill. 0.1% formic acid in acetonitrile and 0.1% aqueous formic acid v/v were used as the mobile phase. All analytes were determined using quadrupole time-of-flight mass spectrometry with electrospray ionization source in positive and negative ion modes...
August 9, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28763505/impact-of-a-district-wide-health-center-strengthening-intervention-on-healthcare-utilization-in-rural-rwanda-use-of-interrupted-time-series-analysis
#4
Hari S Iyer, Lisa R Hirschhorn, Marie Paul Nisingizwe, Emmanuel Kamanzi, Peter C Drobac, Felix C Rwabukwisi, Michael R Law, Andrew Muhire, Vincent Rusanganwa, Paulin Basinga
BACKGROUND: Evaluations of health systems strengthening (HSS) interventions using observational data are rarely used for causal inference due to limited data availability. Routinely collected national data allow use of quasi-experimental designs such as interrupted time series (ITS). Rwanda has invested in a robust electronic health management information system (HMIS) that captures monthly healthcare utilization data. We used ITS to evaluate impact of an HSS intervention to improve primary health care facility readiness on health service utilization in two rural districts of Rwanda...
2017: PloS One
https://www.readbyqxmd.com/read/28757196/air-pollution-and-its-relationship-to-lung-function-among-adolescents-from-taubate-s%C3%A3-o-paulo-brazil
#5
M Froio Toledo, B Mangueira Saraiva-Romanholo, R Carvalho Oliveira, L Ferraz da Silva, D Solé
BACKGROUND: This paper sought to evaluate individual exposure to air pollution by quantifying the carbon in alveolar macrophages (AMs) and its relationship to lung function. We also examined the proximity of participants' residences to the Presidente Dutra highway (PDH) in adolescents with asthma from Taubaté, São Paulo, Brazil. METHODS: This descriptive study examined fifty 13- to 14-year-old adolescents with asthma identified by the International Study of Asthma and Allergies in Childhood (ISAAC) in Taubaté...
July 27, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28738709/nebulized-hypertonic-saline-to-prevent-ventilator-associated-pneumonia-in-premature-infants-a-randomized-trial
#6
Zahra Ezzeldin, Yasmeen Mansi, Mervat Gaber, Rania Zakaria, Rehab Fawzy, Mohamed A Mohamed
BACKGROUND/OBJECTIVES: Ventilator associated pneumonia (VAP) is a leading cause of death. Nebulized hypertonic saline solution (HSS) has been used to improve pulmonary clearance and reduce infection in intubated patients. This study examines whether nebulized HSS may reduce VAP in intubated premature infants. METHODS: We analyzed results of 100 intubated premature infants who completed the study. Infants were divided into the "Control" group where VAP prevention protocol was implemented and the "Intervention" group where nebulized HSS twice daily was added to the package of care...
July 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28737123/development-and-validation-of-eco-friendly-liquid-chromatographic-and-spectrophotometric-methods-for-simultaneous-determination-of-coformulated-drugs-phenylephrine-hydrochloride-and-prednisolone-acetate
#7
Nadia M Mostafa, Ghada M Elsayed, Nagiba Y Hassan, Dina A El Mously
Five simple, sensitive, and eco-friendly LC and UV spectrophotometric methods have been developed for the simultaneous determination of phenylephrine hydrochloride (PHE) and prednisolone acetate (PRD) in their combined dosage form. The first method was reversed-phase (RP) LC using methanol-water-heptane-1-sulfonic acid sodium salt (75 + 25 + 0.1, v/v/w) as a mobile phase. Separation was achieved using an XSelect HSS reversed-phase C18 analytical column (250 × 4.6 mm, 5µm). The flow rate was 1.0 mL/min and UV detection was done at 230 nm...
July 24, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28735245/association-of-16-priority-polycyclic-aromatic-hydrocarbons-with-humic-acid-and-humin-fractions-in-a-peat-soil-and-implications-for-their-long-term-retention
#8
Weixiao Chen, Hui Wang, Qian Gao, Yin Chen, Senlin Li, Yu Yang, David Werner, Shu Tao, Xilong Wang
To elucidate the environmental fate of polycyclic aromatic hydrocarbons (PAHs) once released into soil, sixteen humic acids (HAs) and one humin (HM) fractions were sequentially extracted from a peat soil, and sixteen priority PAHs in these humic substances (HSs) were analyzed. It was found that the total concentration of 16 PAHs (∑16PAHs) increased evidently from HA1 to HA16, and then dramatically reached the highest value in HM. The trend of ∑16PAHs in HAs relates to surface carbon and C-H/C-C contents, the bulk aliphatic carbon content and aliphaticity, as well as the condensation enhancement of carbon domains, which were derived from elemental composition, XPS, (13)C NMR, as well as thermal analyses...
July 20, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28729782/holding-strength-of-suture-an-experimental-study-using-porcine-kidney
#9
Ünsal Özkuvanci, Haluk Akpinar, Mert Ali Karadag, Muhammet İrfan Dönmez, Fatih Altunrende
BACKGROUND AND OBJECTIVES: The search for the perfect suture is going on and has resulted in the introduction of many different suture types into the market. The purpose of this study is to investigate the holding strength (HS) of different sutures in the renal parenchyma in an experimental study on pig kidneys. METHODS: The HS that caused sliding of the suture was investigated in 5 adult porcine kidneys with 7 suture variants. HS-caused tearing of the kidney was investigated with 3 suture types on 5 kidneys...
July 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28723749/effects-of-sealing-the-intramedullary-femoral-canal-in-total-knee-arthroplasty-a-randomized-study
#10
RANDOMIZED CONTROLLED TRIAL
Xu Li, Xiang-Bei Qi, Xue Han, Wei Wang, Jian-Ning Liu, Ji-Chao Guo, Zhi-Yong Li
BACKGROUND: This study investigates the clinical effects of sealing the femoral canal by intramedullary alignment instrumentation in total knee arthroplasty (TKA). METHODS: One hundred twenty consecutive patients with knee osteoarthritis, who underwent unilateral TKA, were enrolled in the study and equally randomized into 2 groups: the sealing group and the control group. In the sealing group, the femoral canal was sealed with autogenous bone and cement using intramedullary alignment instrumentation, while the femoral hole was left open for patients in the control group...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28701670/impact-of-compound-hypertonic-saline-solution-on-decompensated-heart-failure
#11
RANDOMIZED CONTROLLED TRIAL
Yanfang Wan, Lei Li, Heping Niu, Xiaoli Ma, Jing Yang, Chen Yuan, Guichen Mu, Jun Zhang
The aim of the present study was to evaluate the effects of hypertonic saline solution (C-HSS) with high dose furosemide on hospitalization time, readmission, and mortality in patients with New York Heart Association (NYHA) class III heart failure.Decompensated heart failure patients (NYHA III) with chronic ischemic or nonischemic cardiomyopathy and ejection fraction < 40% were divided into 2 groups in an open-label random manner: the first group received a 1-hour intravenous infusion of furosemide (100 mg) plus compound C-HSS (100 mL) twice daily and underwent serious water restriction (500 mL/day); the second group received furosemide intravenous bolus (100 mg) twice a day and water restriction (500 mL/day), without C-HSS...
August 3, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28693888/do-patient-expectations-influence-patient-reported-outcomes-and-satisfaction-in-total-hip-arthroplasty-a-prospective-multicenter-study
#12
Deeptee Jain, Ilya Bendich, Long-Co L Nguyen, Long L Nguyen, Courtland G Lewis, James I Huddleston, Paul J Duwelius, Brian T Feeley, Kevin J Bozic
BACKGROUND: The relationship between patient expectations and patient-reported outcomes (PROs) in total hip arthroplasty (THA) patients is controversial. The purpose of this study was to examine the impact of preoperative patient expectations on postoperative PROs and patient satisfaction. METHODS: This was a prospective multicenter observational cohort study of primary THA patients. Preoperatively, patients completed Hospital for Special Surgery (HSS) Hip Replacement Expectations Survey (expectations), 12 item Short Form Survey (SF-12), University of California, Los Angeles (UCLA) activity score, and Hip Disability and Osteoarthritis Score (HOOS)...
June 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28690461/hospital-for-special-surgery-acl-registry-2-year-outcomes-suggest-low-revision-and-return-to-or-rates
#13
Moira McCarthy, Katherine Mallett, Matthew Abola, Sherrie Vassallo, Joseph Nguyen
BACKGROUND: Anterior cruciate ligament (ACL) injuries are among the most common knee injuries. Patient outcomes, rate of subsequent operations, and rate of subsequent ACL reconstruction following primary ACL reconstruction need to be evaluated. QUESTIONS/PURPOSES: This study was designed to answer the following questions: (1) What is the return to surgery (OR) rate following primary ACL reconstruction and (2) what is the revision ACL reconstruction rate? METHODS: Data was drawn from the Hospital for Special Surgery (HSS) ACL Registry...
July 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28689325/factors-affecting-separation-and-detection-of-bile-acids-by-liquid-chromatography-coupled-with-mass-spectrometry-in-negative-mode
#14
Shanshan Yin, Mingming Su, Guoxiang Xie, Xuejing Li, Runmin Wei, Changxiao Liu, Ke Lan, Wei Jia
Bile acids (BAs) are cholesterol metabolites with important biological functions. They undergo extensive host-gut microbial co-metabolisms during the enterohepatic circulation, creating a vast structural diversity and resulting in great challenges to separate and detect them. Based on the bioanalytical reports in the past decade, this work developed three chromatographic gradient methods to separate a total of 48 BA standards on an ethylene-bridged hybrid (BEH) C18 column and high-strength silica (HSS) T3 column and accordingly unraveled the factors affecting the separation and detection of them by liquid chromatography coupled with mass spectrometry (LC-MS)...
July 8, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28689038/a-phylogenetic-view-of-the-out-of-asia-eurasia-and-out-of-africa-hypotheses-in-the-light-of-recent-molecular-and-palaeontological-finds
#15
REVIEW
Úlfur Árnason
The substantiality of the Out of Africa hypothesis was addressed in the light of recent genomic analysis of extant humans (Homo sapiens sapiens, Hss) and progress in Neanderthal palaeontology. The examination lent no support to the commonly assumed Out of Africa scenario but favoured instead a Eurasian divergence between Neanderthals and Hss (the Askur/Embla hypothesis) and an Out of Asia/Eurasia hypothesis according to which all other parts of the world were colonized by Hss migrations from Asia. The examination suggested furthermore that the ancestors of extant KhoeSan and Mbuti composed the first Hss dispersal(s) into Africa and that the ancestors of Yoruba made up a later wave into the same continent...
July 5, 2017: Gene
https://www.readbyqxmd.com/read/28679895/residence-as-a-diagnostic-and-therapeutic-area-a-smart-home-approach
#16
Corinna Mielke, Thorsten Voss, Reinhold Haux
The "research apartment Halberstadtstraße" (HSS) in Braunschweig, Germany, is the attempt to realize a personal living environment as a room for diagnostics and therapy with the support of health-enabling and ambient assistive technologies (HEAAT). As a research tool, the HSS will enable the efficient implementation of new HEAAT and help in evaluating these under controlled real-life conditions. This new research tool will therefore be the missing link between artificial laboratory and complete real-life conditions...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28676850/current-therapeutic-approach-to-hypertrophic-scars
#17
REVIEW
Zrinka Bukvić Mokos, Anamaria Jović, Lovorka Grgurević, Ivo Dumić-Čule, Krešimir Kostović, Romana Čeović, Branka Marinović
Abnormal scarring and its accompanying esthetic, functional, and psychological sequelae still pose significant challe nges. To date, there is no satisfactory prevention or treatment option for hypertrophic scars (HSs), which is mostly due to not completely comprehending the mechanisms underlying their formation. That is why the apprehension of regular and controlled physiological processes of scar formation is of utmost importance when facing hypertrophic scarring, its pathophysiology, prevention, and therapeutic approach...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28659156/the-arm-movement-detection-amd-test-a-fast-robotic-test-of-proprioceptive-acuity-in-the-arm
#18
Leigh Ann Mrotek, Maria Bengtson, Tina Stoeckmann, Lior Botzer, Claude P Ghez, John McGuire, Robert A Scheidt
BACKGROUND: We examined the validity and reliability of a short robotic test of upper limb proprioception, the Arm Movement Detection (AMD) test, which yields a ratio-scaled, objective outcome measure to be used for evaluating the impact of sensory deficits on impairments of motor control, motor adaptation and functional recovery in stroke survivors. METHODS: Subjects grasped the handle of a horizontal planar robot, with their arm and the robot hidden from view...
June 28, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28646508/hepatic-stimulator-substance-resists-hepatic-ischemia-reperfusion-injury-by-regulating-drp1-translocation-and-activation
#19
Chao Zhang, Jing Huang, Wei An
Ischemia-reperfusion injury (IRI), induced by abnormal mitochondrial fission related apoptosis, is a major concern in liver transplantation settings. Our previous studies have demonstrated that hepatic stimulator substance (HSS) is an anti-apoptotic effector and could protect liver from IRI. However, the underlying mechanism remains unclear. In the present study, we report that in vitro and in vivo HSS could regulate mitochondrial fission and hepatocyte apoptosis during liver IRI by orchestrating the translocation and activation of dynamin-related protein 1 (Drp1)...
June 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28627051/investigating-the-job-satisfaction-of-healthcare-providers-at%C3%A2-primary-healthcare-centres-in-lebanon-a-national-cross-sectional-study
#20
Mohamad Alameddine, Maysa Baroud, Samer Kharroubi, Randa Hamadeh, Walid Ammar, Hikma Shoaib, Hiba Khodr
Low job satisfaction is linked to higher staff turnover and intensified shortages in healthcare providers (HCP). This study investigates the level of, and factors associated with, HCP job satisfaction in the national primary healthcare (PHC) network in Lebanon. The study adopts a cross-sectional design to survey HCP at 99 PHC centres distributed across the country between October 2013 and May 2014. The study questionnaire consisted of four sections: socio-demographics/professional background, employment characteristics, level of job satisfaction (Measure of Job Satisfaction scale) and level of professional burnout (Maslach Burnout Inventory-HSS scale)...
June 18, 2017: Health & Social Care in the Community
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