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https://www.readbyqxmd.com/read/29145871/challenges-to-implementing-gavi-s-health-system-strengthening-support-in-chad-and-cameroon-results-from-a-mixed-methods-evaluation
#1
Emily Dansereau, Yodé Miangotar, Ellen Squires, Honoré Mimche, Charbel El Bcheraoui
BACKGROUND: Since 2005, Gavi has provided health system strengthening (HSS) grants to address bottlenecks affecting immunization services. This study is the first to evaluate the Gavi HSS implementation process in either Cameroon or Chad, two countries with significant health system challenges and poor achievement on the child and maternal health Millennium Development Goals. METHODS: We triangulated quantitative and qualitative data including financial records, document review, field visit questionnaires, and key informant interviews (KII) with representatives from the Ministries of Health, Gavi, and other partners...
November 16, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29140241/direct-biomarkers-of-microbial-translocation-correlate-with-immune-activation-in-adult-zambians-with-environmental-enteropathy-and-hepatosplenic-schistosomiasis
#2
Patrick Kaonga, Evans Kaimoyo, Ellen Besa, Kanekwa Zyambo, Edford Sinkala, Paul Kelly
Microbial translocation is a poorly understood consequence of several disorders such as environmental enteropathy (EE) and hepatosplenic schistosomiasis (HSS). Herein, we compared biomarkers of microbial origin and immune activation in adults with these disorders and in healthy controls. A cross-sectional study was conducted in participants with EE recruited from Misisi compound, Lusaka, Zambia; HSS patients and healthy controls from the University Teaching Hospital, Lusaka. Plasma lipopolysaccharides (LPSs) was measured by limulus amoebocyte lysate assay, plasma 16S ribosomal RNA (16S rRNA) gene copy number was quantified by quantitative real-time polymerase chain reaction, Toll-like receptor ligand (TLRL) activity by QUANTI-Blue detection medium, and cytokines from cell culture supernatant by Cytometric Bead Array...
November 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29139272/-comparative-study-on-specific-chromatograms-and-main-active-components-of-wild-and-cultivated-rhizomes-of-paris-polyphylla-var-yunnanensis
#3
Ke Zan, Yu-Ming Gao, Gan Cui, Jie Liu, Li-Nong Guo, Jian Zheng, Shuang-Cheng Ma
The present study is to compare specific chromatograms and main acitive components between wild and cultivated rhizomes of Paris polyphylla var. yunnanensis by HPLC. HPLC analysis was performed on a Waters XSelect HSS T3 C₁₈ clumn (4.6 mm×250 mm, 5 μm), with a mobile phase consisting of acetonitrile (A)-water (B) at a flow rate of 1 mL•min⁻¹ (0-50 min,30%-50%A;50-80 min,50% A,80-85 min,50%-30%A;85-100 min,30% A). The detection wavelength was 203 nm and the column temperature was controlled at 30 ℃, and the injection volume was 10 μL...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29130482/longitudinal-observational-study-of-hidradenitis-suppurativa-impact-of-surgical-intervention-with-adjunctive-biologic-therapy
#4
Victoria K Shanmugam, Shaunak Mulani, Sean McNish, Sarah Harris, Teresa Buescher, Richard Amdur
BACKGROUND: Hidradenitis supppurativa (HS) is a chronic inflammatory disease of the apocrine sweat glands affecting 1-4% of the population. While surgical excision is a mainstay of therapy, lesions often recur. Biologic therapies, including tumor necrosis factor-α and IL-12/23 inhibitors, are effective for mild to moderate HS. However, longitudinal studies investigating biologic therapy in conjunction with surgery are limited. The purpose of this analysis was to investigate impact of surgery and biologic therapy on HS disease activity...
November 11, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29127904/pharmacokinetics-and-brain-uptake-study-of-novel-ampa-receptor-antagonist-perampanel-in-sd-rats-using-a-validated-uhplc-qtof-ms-method
#5
David Paul, Lingesh Allakonda, Amit Sahu, Shruti Surendran, Nanjappan Satheeshkumar
Perampanel (PER) is a novel AMPA receptor antagonist for antiepileptic therapy and is prospective for the treatment of other neurological disorders. A highly sensitive and rapid UHPLC-QTOF-MS method was developed for the quantification of PER in plasma/brain homogenate of SD rat with alogliptin as an internal standard (IS). Chromatographic separation was carried out on an Acquity UPLC HSS Cyano column (100mm×2.1mm, 1.8μm) using gradient mobile phase consisting of 0.1% formic acid and acetonitrile at a flow rate of 0...
November 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29125696/detection-of-13-mycotoxins-in-feed-using-modified-quechers-with-dispersive-magnetic-materials-and-uhplc-ms-ms
#6
Mingrong Qian, Hua Yang, Zuguang Li, Yanping Liu, Jianmei Wang, Huizhen Wu, Xiaofeng Ji, Jie Xu
An analytical method for the simultaneous determination of 13 mycotoxins in feed by magnetic dispersive solid-phase extraction combined with ultra high performance liquid chromatography and tandem mass spectrometry was developed. The samples were extracted with acetonitrile/water (80:20, v/v, containing 3% acetic acid), and separated by centrifugation after salting-out, and then treated with magnetic adsorbents to remove interferences. The separation of target mycotoxins was performed on an ACQUITY UPLC HSS T3 column using a mobile phase consisting of 1 mmol/L ammonium acetate with 0...
November 10, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29121223/health-system-strengthening-prospects-and-threats-for-its-sustainability-on-the-global-health-policy-agenda
#7
Joseph F Naimoli, Sweta Saxena, Laurel E Hatt, Kristina M Yarrow, Trenton M White, Temitayo Ifafore-Calfee
In 2013, Hafner and Shiffman applied Kingdon's public policy process model to explain the emergence of global attention to health system strengthening (HSS). They questioned, however, HSS's sustainability on the global health policy agenda, citing various concerns. Guided by the Grindle and Thomas interactive model of policy implementation, we advance and elaborate a proposition: a confluence of developments will contribute to maintaining HSS's prominent place on the agenda until at least 2030. Those developments include (1) technical, managerial, financial, and political responses to unpredictable public health crises that imperil the routine functioning of health systems, such as the 2014-2015 Ebola virus disease (Ebola) epidemic in West Africa; (2) similar responses to non-crisis situations requiring fully engaged, robust health systems, such as the pursuit of the new Sustainable Development Goal for health (SDG3); and (3) increased availability of new knowledge about system change at macro, meso, and micro levels and its effects on people's health and well-being...
November 7, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29106064/chemical-profiling-and-quantification-of-shenkang-injection-a-systematic-quality-control-strategy-using-ultra-high-performance-liquid-chromatography-with-q-exactive-hybrid-quadrupole-orbitrap-high-resolution-accurate-mass-spectrometry
#8
Tanye Xu, Lihua Zuo, Zhi Sun, Peile Wang, Lin Zhou, Xiaojing Lv, Qingquan Jia, Xin Liu, Xiaofang Jiang, Zhenfeng Zhu, Jian Kang, Xiaojian Zhang
ShenKang injection is traditional Chinese medicine used to treat chronic renal failure in China. It is a compound preparation that consists of four herbs: Rhubarb, Salvia miltiorrhiza, Safflower and Radix Astragali. We developed an ultra high pressure liquid chromatography coupled with Q Exactive hybrid quadrupole-orbitrap high resolution accurate mass spectrometry tandem mass spectrometry method to analyze its chemical compositions, and a total of 90 compounds were identified from ShenKang injection. Among them, 19 major compounds were unambiguously detected by comparing with reference standards...
November 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29102502/total-knee-replacement-cementless-tibial-fixation-with-screws-10-year-results
#9
Önder Ersan, Alper Öztürk, Mehmet Faruk Çatma, Serhan Ünlü, Mutlu Akdoğan, Yalım Ateş
BACKGROUND: The aim of this study was to evaluate the long term clinical and radiological results of cementless total knee replacement. METHODS: A total of 51 knees of 49 patients (33 female and 16 male; mean age: 61.6 years (range, 29-66 years)) who underwent TKR surgery with a posterior stabilized hydroxyapatite coated knee implant were included in this study. All of the tibial components were fixed with screws. The HSS scores were examined preoperatively and at the final follow-up...
November 1, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29096929/reinforcement-strategy-for-lateral-rafting-plate-fixation-in-posterolateral-column-fractures-of-the-tibial-plateau-the-magic-screw-technique
#10
Hui Sun, Yi Zhu, Qi-Fang He, Lin-Yuan Shu, Wei Zhang, Yi-Min Chai
BACKGROUND: A posterolateral column fracture of the tibial plateau (PLCF) is not uncommon, especially lateral and bicondylar tibial plateau fractures. Currently, there is no consensus on the methods of surgical treatment for PLCF, including the surgical approach or the fixation strategy. Though various posterior approaches have been explored and can allow posterior buttress plate fixation, the necessity of a posterior approach with fixation for PLCFs is increasingly questioned. Meanwhile, there is no literature to analyse the morphological features of PLCFs...
October 30, 2017: Injury
https://www.readbyqxmd.com/read/29095118/screening-and-quantification-of-18-glucocorticoid-adulterants-from-herbal-pharmaceuticals-and-health-foods-by-hplc-and-confirmed-by-lc-q-tof-ms-ms
#11
Pengfei Jin, Xiaoli Liang, Xuejun Wu, Xiaorong He, Yongmei Kuang, Xin Hu
A procedure for the screening and quantification of 18 glucocorticoids, i.e. hydrocortisone sodium succinate (HSS), prednisolone (PDL), prednisone (PDS), hydrocortisone (HCS), methylprednisolone (MPS), betamethasone (BTM), dexamethasone (DXM), triamcinolone acetonide (TA), prednisolone acetate (PLA), hydrocortisone acetate (HA), fludrocortisone acetate (FA), prednisone acetate (PA), cortisone acetate (CA), dexamethasone acetate (DA), hydrocortisone butyrate (HB), triamcinolone acetonide acetate (TAA), fluocinonide (FN) and halcinonide (HC) from herbal pharmaceuticals and health foods was established and fully validated...
November 14, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29090615/simultaneous-determination-of-three-pesticides-and-their-metabolites-in-unprocessed-foods-using-ultraperformance-liquid-chromatography-tandem-mass-spectrometry
#12
Lili Rong, Xiaohu Wu, Jun Xu, Fengshou Dong, Xingang Liu, Xinglu Pan, Pengqiang Du, Dongmei Wei, Yongquan Zheng
We have developed a rapid, multi-compound analytical method for measuring residues of the pesticides thiamethoxam and its metabolite, clothianidin; fipronil and its three metabolites, fipronil sulfone, fipronil sulfide, and fipronil desulfinyl; and pyraclostrobin in unprocessed foods (rice, corn, cucumbers, tomatoes, apples, and bananas) by ultra-performance liquid chromatography coupled to tandem mass spectrometry. Acetonitrile was used as the extraction solvent, and an octadecylsilane-dispersive solid-phase extraction was used to clean up the analytes, which were then separated through a UPLC HSS T3 column connected to a tandem mass spectrometer via an electrospray ionization source...
November 1, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29084165/simultaneous-determination-of-twenty-five-compounds-in-rat-plasma-using-ultra-high-performance-liquid-chromatography-polarity-switching-tandem-mass-spectrometry-and-its-application-to-a-pharmacokinetic-study
#13
Na Zhang, Yueting Li, Jing Sun, Chun Li, Yuelin Song, Jun Li, Pengfei Tu, Yunfang Zhao
An attempt was made to characterize the pharmacokinetic profiles of Qishen Keli (QSKL) that has been widely proved to be effective in clinical practice. A method using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) for the simultaneous determination of 25 analytes in rat plasma was developed and validated. Satisfactory chromatographic separation was achieved on an ACQUITY UPLC HSS T3 column with gradient elution using mobile phase consisting of 0.02% aqueous formic acid (A) and acetonitrile fortified with 0...
October 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29071237/the-effect-of-daily-versus-weekly-levothyroxine-replacement-on-thyroid-function-test-in-hypothyroid-patients-at-a-tertiary-care-centre-in-haryana
#14
Rajesh Rajput, Vaibhav Pathak
OBJECTIVE: We compare the effect of daily versus weekly levothyroxine (LT4) replacement on thyroid function test (TFT) in hypothyroid patients at a tertiary care centre in Haryana. MATERIALS AND METHODS: This was a randomised crossover study in which 100 hypothyroid patients on a stable LT4 dose were divided into 2 groups of 50 each. In group I, patients were given daily therapy for 6 weeks and then shifted to weekly therapy for the next 6 weeks. In group II, patients were given LT4 once a week for 6 weeks and then switched to daily therapy for the next 6 weeks...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29068816/concerns-and-responses-for-integrating-health-systems-science-into-medical-education
#15
Jed D Gonzalo, Kelly J Caverzagie, Richard E Hawkins, Luan Lawson, Daniel R Wolpaw, Anna Chang
With the aim of improving the health of individuals and populations, medical schools are transforming curricula to ensure physician competence encompasses health systems science (HSS), which includes population health, health policy, high-value care, interprofessional teamwork, leadership, quality improvement, and patient safety. Large-scale, meaningful integration remains limited, however, and a major challenge in HSS curricular transformation efforts relates to the receptivity and engagement of students, educators, clinicians, scientists, and health system leaders...
October 24, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29067330/differential-medial-temporal-lobe-morphometric-predictors-of-item-and-relational-encoded-memories-in-healthy-individuals-and-in-individuals-with-mild-cognitive-impairment-and-alzheimer-s-disease
#16
Jesus J Gomar, J Daniel Ragland, Aziz M Uluğ, Amber Sousa, Edward D Huey, Concepcion Conejero-Goldberg, Peter Davies, Terry E Goldberg
INTRODUCTION: Episodic memory processes are supported by different subregions of the medial temporal lobe (MTL). In contrast to a unitary model of memory recognition supported solely by the hippocampus, a current model suggests that item encoding engages perirhinal cortex, whereas relational encoding engages parahippocampal cortex and the hippocampus. However, this model has not been examined in the context of aging, neurodegeneration, and MTL morphometrics. METHODS: Forty-four healthy subjects (HSs) and 18 cognitively impaired subjects (nine mild cognitive impairment [MCI] and nine Alzheimer's disease [AD] patients) were assessed with the relational and item-specific encoding task (RISE) and underwent 3T magnetic resonance imaging...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29051759/ifn%C3%AE-enhances-cd64-potentiated-phagocytosis-of-treponema-pallidum-opsonized-with-human-syphilitic-serum-by-human-macrophages
#17
Kelly L Hawley, Adriana R Cruz, Sarah J Benjamin, Carson J La Vake, Jorge L Cervantes, Morgan LeDoyt, Lady G Ramirez, Daniza Mandich, Mary Fiel-Gan, Melissa J Caimano, Justin D Radolf, Juan C Salazar
Syphilis is a multi-stage, sexually transmitted disease caused by the spirochete Treponema pallidum (Tp). Considered broadly, syphilis can be conceptualized as a dualistic process in which spirochete-driven inflammation, the cause of clinical manifestations, coexists to varying extents with bacterial persistence. Inflammation is elicited in the tissues, along with the persistence of spirochetes to keep driving a robust immune response while evading host defenses; this duality is best exemplified during the florid, disseminated stage called secondary syphilis (SS)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29048856/-rapid-determination-of-four-phenolic-environmental-estrogen-residues-in-cooking-oil-by-ultra-performance-liquid-chromatography-high-resolution-mass-spectrometry-coupled-with-solid-phase-extraction
#18
Shengdong Pan, Qian He, Xiaohong Chen, Li Wang, Qiaoli Qiu, Micong Jin
A fast, sensitive and accurate method for the determination of trace bisphenol S (BPS), bisphenol F (BPF), bisphenol A (BPA) and 4-nonylphenol (4-NP) in cooking oil samples was developed by ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) coupled with solid-phase extraction (SPE). Cooking oil samples were extracted by acetonitrile, then the supernatant was purified by SLC SPE cartridges. The chromatographic separation was carried out on a Waters ACQUITY UPLC HSS T3 column (100 mm×2...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048812/-rapid-and-simultaneous-determination-of-seven-microcystins-in-fish-meat-by-liquid-chromatography-tandem-mass-spectrometry-coupled-with-pass-through-solid-phase-extraction
#19
Shiyan Li, Yang Wang, Dingnan Wang, Hongxi Wu, Xueyan Ding, Yiwei Cui, Qing Shen
An analytical method was developed for the simultaneous and rapid determination of seven microcystins in fish meat by liquid chromatography-tandem mass spectrometry (LC-MS/MS) coupled with pass-through solid phase extraction (SPE). The samples were extracted with methanol-water (90:10, v/v) after heat treatment by water bath at 80℃, and then cleaned up with an Oasis PRiME HLB pass-through SPE column. The samples were analyzed directly on a Waters XSelect HSS T3 column using 0.1% (v/v) aqueous formic acid and acidified acetonitrile (0...
August 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048805/-simultaneous-determination-of-nine-perfluorinated-compound-precursors-in-atmospheric-precipitation-by-solid-phase-extraction-and-ultra-performance-liquid-chromatography-with-tandem-mass-spectrometry
#20
Ming Zhang, Fangliang Tang, Jianfen Xu, Bo Yu, Wei Zhang, Jianliang Yao, Minhua Hu
A high-throughput detection method has been developed for the determination of nine perfluorinated compound precursors (PFCPs) in atmospheric precipitation by solid phase extraction-ultra performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (SPE-UPLC-ESI-MS/MS). The atmospheric precipitation samples were concentrated and purified with HLB solid phase extraction cartridges. The UPLC separation was performed on an HSS T3 column (100 mm×2.1 mm, 1.7 μm) utilizing a gradient elution program of methanol and water as the mobile phases at a flow rate of 0...
October 8, 2017: Se Pu, Chinese Journal of Chromatography
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