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K Louati, I Bargaoui, F Safta
The main objective was to develop a suitable and rapid ultra-performance liquid chromatography (UPLC) method for the quantitative determination of meloxicam and its impurities. Starting from data in literature, we calculated the new parameters to translate a high performance liquid chromatography method used for the analysis of meloxicam with its major degradation products to UPLC method, and then we switched on many trials to optimize and improve its analytical performance. Chromatographic separation was achieved on ACQUITY UPLC HSS-T3 (2...
March 12, 2018: Annales Pharmaceutiques Françaises
Peter D Fabricant, Joash R Suryavanshi, Jacob G Calcei, Robert G Marx, Roger F Widmann, Daniel W Green
BACKGROUND: Recent data have shown an increase in youth sports participation at younger ages, which may be linked to greater musculoskeletal injury risk. The Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS) is a validated 8-item instrument designed to quantify the activity of children between 10 and 18 years old. Normative data on pediatric and adolescent activity level are unknown. PURPOSE: To establish normative activity-level data for American youth and to determine if there is a natural decrease in activity level during adolescence...
March 1, 2018: American Journal of Sports Medicine
Xue-Hong Chen, Yan-Tao Han, Jun-Li Ye, Zhi-Shang Chang, Chun-Bo Wang, Shou-Guo Chen
Haishengsu (HSS) is an active natural extract isolated from Tegillarca granosa, which has previously been demonstrated to inhibit the proliferation of several types of cancer cells in vitro. Our previous study indicated that HSS may induce apoptosis to suppress growth of human hepatocellular carcinoma BEL‑7402 cells by activating Fas pathway. The present study demonstrated that HSS treatment induces the in vitro apoptosis of BEL‑7402 cells via the mitochondrial‑mediated apoptotic pathway detected by DNA fragmentation assay, caspase activity assay and transmission electron microscopy assay, and inhibits tumor xenograft growth in vivo...
March 1, 2018: Molecular Medicine Reports
Emma J Stinson, Paolo Piaggi, Mostafa Ibrahim, Colleen Venti, Jonathan Krakoff, Susanne B Votruba
OBJECTIVE: To determine how macronutrients accompanying foods with high energy density (EnDen) affect energy intake and weight gain. METHODS: A total of 214 subjects (130 males, BMI: 32 ± 7 kg/m2 ) ate ad libitum for 3 days. Food intake was expressed as the mean daily intake (in kilocalories) and the percentage of weight-maintaining energy needs (%WMEN). EnDen was expressed as the ratio of intake (in kilocalories) to food weight (in grams). Food choices were expressed as absolute and percent intake (kilocalories), categorized as high in fat (HF; ≥ 45% kcal) or low in fat (LF; < 20% kcal), and further categorized as high in complex carbohydrates (≥ 30% kcal), high in simple sugars (HSS; ≥ 30% kcal), or high in protein (HP; ≥ 13% kcal)...
March 4, 2018: Obesity
Omid Rezaei, Kamelia Habibi, Davood Arab Ghahestany, Mohammad Sayadnasiri, Bahram Armoon, Vida Khan, Ladan Fattah Moghadam
Background One of the most prevalent problems in work places that is considered as an important risk factor for the health of the employee is job burnout (JB). JB could be harmful to employees, their families and society. Therefore, decreasing JB among individuals and determining factors associated with it is important to improve the working environment and prevent its negative outcomes. This study aims to elicit the conditions and factors that cause job burnout among nurses of the Razi Psychiatric Hospital, Iran...
March 3, 2018: International Journal of Adolescent Medicine and Health
Shenglan Qi, Huida Guan, Gang Deng, Tao Yang, Xuemei Cheng, Wei Liu, Ping Liu, Changhong Wang
Adenosine deaminase (ADA), which is a key enzyme in the metabolism of purine nucleosides, plays important roles in diverse disorders, such as tuberculosis, diabetes, liver disorders, and cancer. Determination of the activities of ADA and its isoenzymes in body fluids has received considerable attention in the diagnosis and treatment of relative diseases. Ultraviolet spectroscopy with adenosine (AD) as a substrate is a classical approach for screening potential ADA inhibitors by measuring the decrease in substrate (AD) at 265 nm or increase in the product (inosine) at 248 nm...
February 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
Suhua Zhang, Chunnong Jike, Shujuan Yang, Qiang Liao, Gang Yu, Ke Wang, Ju Wang, Lin Xiao, Qixing Wang, Yuhan Gong, Jianxin Zhang, Shichao Bian, Qian Liu
We evaluated HIV prevalence among unmarried youth in rural areas of Liangshan Prefecture in southwest China over the period of 2011-2015, and the interactions between behaviors associated with HIV risk. We used HIV sentinel surveillance (HSS) data for our analysis. We used questionnaires to investigate information among unmarried youth aged 15 to 25 years and performed HIV testing. Multivariate logistic regression and path analysis were applied to explore associations between behavioral factors related with HIV infection...
March 2, 2018: AIDS Care
Xiao-Wei Jia, Zi-Wei Li, Ling-Yue Dong, Guang-Yong Sun, Xin Wang, Jian Gao, Yi-Peng Li, Yuan Wu, Wei An
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies due to its high frequency of metastasis via the epithelial-mesenchymal transition (EMT) pathway. Hepatic stimulator substance (HSS) can protect hepatocytes from injury and promote liver growth. Recent studies indicated that HSS expression is increased in HCC tissues; however, whether HSS expression is potentially associated with HCC metastasis, particularly through the EMT pathway, remains largely unknown. In this study, the relationship between HSS expression and HCC metastasis was investigated in clinical samples of HCC...
March 1, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
D Zhao, X L Ma, W L Wang, L Zhang
Objective: To investigate the clinical effect of enhanced recovery after surgery (ERAS) in unilateral total knee arthroplasty (TKA). Methods: Retrospective analysis of 98 patients received unilateral TKA from September 2015 to September 2016 in the Orthopaedic Departmentof Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces.Of the patients, 52 cases were treated by traditional operation (routine group) and the other 46 cases were treated with ERAS concept (ERAS group). The following data were gathered and statistically analyzed between the groups: gender, age, body mass index, preoperative hemoglobin, preoperative visual analogue scale (VAS) score, postoperative visible blood loss, postoperative hemoglobin at 24 hour after operation, blood transfusion rate, postoperative VAS score, length of hospital stay, the satisfaction rate, preoperative and 1 and 6 months postoperative evaluation with hospital for special surgery knee score (HSS), postoperative range of motion (ROM) of knees after 2 weeks, 1 month and 6 months of surgery, incidence rate of complications after surgery...
February 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Zhijun Diao, Jing Li, Qian Liu, Yutang Wang
Chicoric acid (CA) is an active derivative of caffeic acid, which is naturally present in many medicinal plants and vegetables. In the present study, the metabolic profile of CA was determined in rat plasma, urine and feces and was subsequently used to propose the metabolic pathways of CA. CA (100 mg/kg) was orally administered to rats by gastric intubation. Then, the plasma, urine and feces samples were collected and treated with methanol and acetonitrile (1:1, V/V) to precipitate the proteins. The pretreated samples were separated by ultra performance liquid chromatography (UPLC) equipped with an HSS T3 column (2...
February 13, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Mirco Lo Presti, Giuseppe Gianluca Costa, Sergio Cialdella, Giuseppe Agrò, Alberto Grassi, Silvio Caravelli, Massimiliano Mosca, Giulio Maria Marcheggiani Muccioli, Stefano Zaffagnini
Unicompartmental knee arthroplasty (UKA) has increased in popularity in the last years, also in younger and more active patients with great expectancies. The purpose of our study was to investigate the change in sports activities before and after medial UKA. We surveyed 53 athletic patients; all underwent cemented medial UKA, to determine not only their subjective and objective evaluation of clinical status with Hospital for Special Surgery (HSS) and visual analog score (VAS) score, but also their sporting and recreational activities at a mean follow-up of 48 ± 6 months (range, 18-56 months)...
February 28, 2018: Journal of Knee Surgery
Hyun Il Lee, Dongjun Park, Jinho Cho
Purpose: To identify the structural integrity of the healing site after medial open wedge high tibial osteotomy (MOWHTO) in patients with a posterior root tear of the medial meniscus (PRTMM) and chondral lesion by second-look arthroscopy and to determine the clinical and radiological findings. Materials and Methods: From August 2010 to June 2016, 52 consecutive patients underwent MOWHTO and arthroscopic examination without a chondral resurfacing procedure and meniscal treatment for PRTMM...
March 1, 2018: Knee Surgery & related Research
Tatyana Livshultz, Elisabeth Kaltenegger, Shannon C K Straub, Kevin Weitemier, Elliot Hirsch, Khrystyna Koval, Lumi Mema, Aaron Liston
Plants produce specialized metabolites for their defence. However, specialist herbivores adapt to these compounds and use them for their own benefit. Plants attacked predominantly by specialists may be under selection to reduce or eliminate production of co-opted chemicals: the defence de-escalation hypothesis. We studied the evolution of pyrrolizidine alkaloids (PAs) in Apocynaceae, larval host plants for PA-adapted butterflies (Danainae, milkweed and clearwing butterflies), to test if the evolutionary pattern is consistent with de-escalation...
February 26, 2018: New Phytologist
Luisa N Borrell, Sharon P Joseph
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Socioeconomic position during life and periodontitis in adulthood: a systematic review. Schuch HS, Peres KG, Singh A, Peres MA, Do LG. Community Dent Oral Epidemiol 2017; 45(3):201-8. SOURCE OF FUNDING: Brazilian Government Agency-CAPES: Coordination for the Improvement of Higher Education Personnel for the PhD Scholarship (HSS-Process 13374-13-1) TYPE OF STUDY/DESIGN: Systematic review.
March 2018: Journal of Evidence-based Dental Practice
Wei-Nan Zeng, Jun-Li Liu, Fu-You Wang, Cheng Chen, Qiang Zhou, Liu Yang
BACKGROUND: The reductions of perioperative blood loss and inflammatory response are important in total knee arthroplasty. Tranexamic acid reduced blood loss and the inflammatory response in several studies. However, the effect of epinephrine administration plus tranexamic acid has not been intensively investigated, to our knowledge. In this study, we evaluated whether the combined administration of low-dose epinephrine plus tranexamic acid reduced perioperative blood loss or inflammatory response further compared with tranexamic acid alone...
February 21, 2018: Journal of Bone and Joint Surgery. American Volume
Hector Rosas-Hernandez, Elvis Cuevas, Claudia Escudero-Lourdes, Susan M Lantz, Nasya M Sturdivant, Syed Z Imam, Sumit Sarkar, William Slikker, Merle G Paule, Kartik Balachandran, Syed F Ali
Traumatic brain injury (TBI) occurs when external mechanical forces induce brain damage as result of impact, penetration or rapid acceleration/deceleration that causes deformation of brain tissue. Depending on its severity, TBI can be classified as mild, moderate or severe and can lead to blood-brain barrier (BBB) dysfunction. In the present study, we evaluated the effects of uniaxial high-speed stretch (HSS) at 0, 5, 10 and 15% on a pure culture of primary rat brain endothelial cells as an in vitro model of TBI to the BBB...
February 16, 2018: Neuroscience Letters
Hong-Lue Tan, Peng-Yi Dai, Wei-Feng Liu, Yan-Hao Yuan
OBJECTIVE: To explore the clinical efficacy of double-plate fixation for the treatment of old tibial plateau fractures with Schatzker type IV through anterior midline and posteromedial approaches. METHODS: From July 2013 to July 2015, 15 patients with old tibial plateau fractures were treated with internal fixation using locking reconstructive plate for the posteromedial fragment and anatomical locking plate for anteromedial fragment through antero midline and posteromedial approaches...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Long Xu, Bao-Hu Wang, Qing-Yu Lin, Zhan-Feng Zhang
OBJECTIVE: To analyze and compare the efficacy of surgical approaches and fixations of anterolateral approach, lateral approach and posterolateral approach in treating posterolateral tibial plateau fracture. METHODS: A retrospective study of 44 cases from May 2010 to July 2014 were enrolled, of which there were 21 males and 23 females, and the mean age was 42.5 years old (ranged, 26 to 61 years). All the cases were divided into 3 groups according to the surgical approach, group A was anterolateral approach (19 cases), group B was lateral approach (15 cases), group C was posterolateral approach (10 cases)...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Zhan-Feng Zhang, Ji-Kang Min, Dan Wang, Jian-Ming Zhong, Heng Li
OBJECTIVE: To calculate the volume of occult blood loss after unicompartment knee arthroplasty(UKA), and analyze its influential factors by comparing with total knee arthroplasty. METHODS: A retrospective study of 130 cases from July 2012 to July 2015 were enrolled, of which and 65 cases were UKA, and 65 cases were TKA. In UKA group there were 27 males and 38 females, and the mean age was (62.3±4.3) years old (ranged, 50 to 82 years old). There were 14 cases older than 70 years old, while 51 cases among 50 to 70 years old...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Hui Kang, Wei Wang, Hong-Chuan Li, Jian Li
OBJECTIVE: To study the effects of surgical reconstruction of the lateral ligament complex for posterolateral rotatory instability (PLRI) of the elbow joint. METHODS: From January 2013 to January 2015, 20 patients with posterolateral rotatory instability of elbow joint were treated in our department. There were 12 males and 8 females whose age ranged from 30 to 60 years old, with an average age of 45.5 years old. Sixteen patients had injuries on the right side and 4 patients had injuries on the left side...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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