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https://www.readbyqxmd.com/read/27935994/comparison-of-polyethylene-wear-before-and-after-hip-revision-with-liner-exchange-fixed-with-the-original-locking-mechanism
#1
Xinfeng Gu, Jie He, Yiwen Tang, Yuxin Zheng
OBJECTIVE: To compare the wear of conventional ultra-high molecular weight polyethylene (CUHMWPE) and highly cross-linked polyethylene (HCLPE) in hip revision with liner exchange fixed with original locking mechanism using analysis of history medical data. METHODS: From Jan. 1, 2000, to Dec. 31, 2007, 26 patients (with 29 involved hips) underwent liner exchange revision fixed with the original locking mechanism due to wear of CUHMWPE and/or osteolysis. The mean age was 53 ± 9 years at the time of the primary total hip arthroplasty (THA) and 64 ± 9 years at the revision...
2016: PloS One
https://www.readbyqxmd.com/read/27935213/uhplc-q-tof-ms-based-metabolomics-approach-to-compare-the-saponin-compositions-of-xueshuantong-injection-and-xuesaitong-injection
#2
Changliang Yao, Wenzhi Yang, Jingxian Zhang, Shi Qiu, Ming Chen, Xiaojian Shi, Huiqin Pan, Wanying Wu, Dean Guo
Various traditional Chinese medicine preparations developed from Notoginseng total saponins, including Xueshuantong Injection and Xuesaitong Injection, are extensively used in China to treat cardio-cerebrovascular diseases. However, the difference of their saponin compositions remains unknown. An ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry based metabolomics approach was developed to probe the saponin discrimination between Xueshuantong and Xuesaitong and the related factors by large sample analysis...
December 9, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27930972/the-anti-hyperplasia-of-mammary-gland-effect-of-protein-extract-hss-from-tegillarca-granosa
#3
Yuping Jia, Xiu Liu, Qingwen Jia, Wei Zhang, Chao Sun, Dongdong Yuan, Haoran Zhang, Ena Jiang, Dongshun Zhou
Tegillarca granosa Linnaeus, possesses various biological functions and has been used a Chinese traditional medicine more than one century, but there is no report about anti-hyperplasia of mammary gland (HMG) activity of drugs from T. granosa. In this study, we investigated the anti-HMG effect of protein extract named HSS from T. granosa. The HMG model of virgin female Sprague Dawley rats was prepared by injecting estrogen in the thigh muscle of the rats and progestogen consecutively. HMG rats were treated with either HSS or positive control drug by i...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27929700/the-mediating-effects-of-coping-strategies-on-the-relationship-between-secondary-traumatic-stress-and-burnout-in-professional-caregivers-in-the-uae
#4
Abdalla A R M Hamid, Saif A Musa
BACKGROUND: Professional caregivers dealing with traumatized victims or mental health clients are at increased risk for developing the same symptoms as persons who are exposed directly to the trauma. AIMS: This research was aimed at examining the relationship between secondary traumatic stress, burnout and coping strategies in 502 professional caregivers who work in schools, hospitals, charity institutes and welfare centers in the United Arab Emirates (UAE). A further aim was to test the mediating effect of coping on the relationship between burnout and secondary traumatic stress...
December 8, 2016: Journal of Mental Health
https://www.readbyqxmd.com/read/27919072/structure-and-regulation-of-the-chromatin-remodeller-iswi
#5
Lijuan Yan, Li Wang, Yuanyuan Tian, Xian Xia, Zhucheng Chen
ISWI is a member of the SWI2/SNF2 family of chromatin remodellers, which also includes Snf2, Chd1, and Ino80. ISWI is the catalytic subunit of several chromatin remodelling complexes, which mobilize nucleosomes along genomic DNA, promoting replication progression, transcription repression, heterochromatin formation, and many other nuclear processes. The ATPase motor of ISWI is an autonomous remodelling machine, whereas its carboxy (C)-terminal HAND-SAND-SLIDE (HSS) domain functions in binding extranucleosomal linker DNA...
December 5, 2016: Nature
https://www.readbyqxmd.com/read/27917793/high-dose-oral-furosemide-with-salt-ingestion-in-the-treatment-of-refractory-ascites-of-liver-cirrhosis
#6
Tolga Yakar, Mehmet Demir, Ozlem Dogan, Alper Parlakgumus, Birol Ozer, Ender Serin
PURPOSE: We aimed to evaluate and compare the efficacy and safety of high-dose furosemide+salt orally by comparing HSS+ furosemide (i.v.) and repeated paracentesis in patients with RA. METHODS: This was a prospective study of 78 cirrhotic patients with RA, randomized into three groups: Group A (n= 25) i.v. furosemide (200-300 mg bid) and 3% hypotonic saline solution (HSS) (once or twice a day); Group B (n= 26) oral furosemide tablets (360-520 mg bid) and salt (2...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27912782/health-systems-strengthening-in-german-development-cooperation-making-the-case-for-a-comprehensive-strategy
#7
REVIEW
Khullat Munir, Ilse Worm
In the aftermath of the Ebola crisis and with renewed attention to resilient health systems, the process of improving approaches of global health actors to health systems strengthening is of great relevance. Despite the increased amount of attention paid to health systems strengthening, there is no standard definition of this concept among global health actors. Germany is no exception. Though there have been recent commitments to increase resources allocated to health systems strengthening, German Development Cooperation has no comprehensive strategy for its pursuit...
December 3, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27903348/-clinical-observations-of-medial-compartment-knee-osteoarthritis-by-proximal-fibular-osteotomy-with-arthroscopy
#8
G Tong, Q Xie
Objective: To explore the clinical short-term result of proximal fibular osteotomy with arthroscopy in the treatment of knee osteoarthritis. Methods: From August 2015 to March 2016 thirty six patients with medial compartment knee osteoarthritis were treated by proximal fibular osteotomy with arthroscopy in Department of Orthopaedics, Beijing Tongren Hospital, Capital Medical University.The preoperative and postoperative visual analogue scale (VAS) and the hospital for special surgery (HSS) knee score were compared in follow-up...
November 22, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27893437/silicon-nanowire-heterostructures-for-advanced-energy-and-environmental-applications-a-review
#9
Ramesh Ghosh, P K Giri
Semiconductor nanowires (NWs), in particular Si NWs, have attracted much attention in the last decade for their unique electronic properties and potential applications in several emerging areas. With the introduction of heterostructures (HSs) on NWs, new functionalities are obtained and the device performance is improved significantly in many cases. Due to the easy fabrication techniques, excellent optoelectronic properties and compatibility of forming HSs with different inorganic/organic materials, Si NW HSs have been utilized in various configurations and device architectures...
January 6, 2017: Nanotechnology
https://www.readbyqxmd.com/read/27889405/primary-total-knee-arthroplasty-for-elderly-complex-tibial-plateau-fractures
#10
Jie-Feng Huang, Jian-Jian Shen, Jun-Jie Chen, Pei-Jian Tong
OBJECTIVE: The aim of this study is to evaluate the clinical and radiologic results of primary Total Knee Arthroplasty (TKA) for elderly complex tibial plateau fractures. MATERIALS AND METHODS: Between November 2010 and February 2012, six cases of elderly complex tibial plateau fractures were treated with primary TKA using the standard medial parapatellar approach. All six patients were available at follow up with mean duration of 32.3 months (range 25-41 months)...
November 23, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27886359/normal-population-reference-values-for-the-oxford-and-harris-hip-scores-electronic-data-collection-and-its-implications-for-clinical-practice
#11
James M Mclean, Jacob Cappelletto, Jock Clarnette, Catherine L Hill, Tiffany Gill, Daniel Mandziak, Jordan Leith
BACKGROUND: The aim of this study was to assess whether the Harris Hip Score (HHS) and the Oxford Hip Score (OHS) were comparable in normal, healthy, pathology-free individuals of different age, gender, ethnicity, handedness and nationality. The purpose of this study was to establish normal population values for the HHS and OHS using an electronic data collection system. METHODS: 317 Australian and 310 Canadian citizens with no active hip pain, injury or pathology in the ipsilateral hip corresponding to their dominant arm, were evaluated...
November 15, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/27882029/effects-of-comprehensive-rehabilitation-training-in-combination-with-multi-mode-analgesia-on-body-function-recovery-after-tumor-type-knee-replacement
#12
Junjuan Zhang, Yahan Wang, Guangyu Yang, Jing Liu, Junjie Wang
OBJECTIVE: To discuss the significance of comprehensive rehabilitation training combined with multimodal analgesia (MMA) for the early knee function recovery of patients with knee bone tumor who underwent prosthesis replacement operation. METHODS: Sixty patients with knee bone tumor who underwent prosthesis replacement operation were selected and randomly divided into two groups according to rehabilitation training and postoperative analgesic methods, namely, observation group and control group, 30 cases in each group...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27881618/simultaneous-screening-and-quantification-of-basic-neutral-and-acidic-drugs-in-blood-using-uplc-qtof-ms
#13
Sergei Bidny, Kim Gago, Phuong Chung, Desdemona Albertyn, Daniel Pasin
An analytical method using ultra performance liquid chromatography (UPLC) quadrupole time-of-flight mass spectrometry (QTOF-MS) was developed and validated for the targeted toxicological screening and quantification of commonly used pharmaceuticals and drugs of abuse in postmortem blood using 100 µL sample. It screens for more than 185 drugs and metabolites and quantifies more than 90 drugs. The selected compounds include classes of pharmaceuticals and drugs of abuse such as: antidepressants, antipsychotics, analgesics (including narcotic analgesics), anti-inflammatory drugs, benzodiazepines, beta-blockers, amphetamines, new psychoactive substances (NPS), cocaine and metabolites...
November 22, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27880970/total-knee-arthroplasty-what-to-expect-a-survey-of-the-members-of-the-dutch-knee-society-on-long-term-recovery-after-total-knee-arthroplasty
#14
Jaap J Tolk, Marieke C van der Steen, Rob P A Janssen, Max Reijman
The rate of satisfaction after total knee arthroplasty (TKA) is consistently reported around 80%, leaving one in five patients unsatisfied to some extent. Fulfillment of expectations is reported as the strongest predictor of treatment satisfaction. In this study, we aimed to evaluate what Dutch orthopedic surgeons assume are realistic expectations for recovery 1 year after TKA. We invited the members of the Dutch Knee Society (DKS) to fill out a web-based questionnaire. For expectation measurement, the validated Dutch version of the Hospital for Special Surgery (HSS) knee replacement expectations survey was used...
November 23, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27863836/looking-at-flubromazolam-metabolism-from-four-different-angles-metabolite-profiling-in-human-liver-microsomes-human-hepatocytes-mice-and-authentic-human-urine-samples-with-liquid-chromatography-high-resolution-mass-spectrometry
#15
Ariane Wohlfarth, Svante Vikingsson, Markus Roman, Mikael Andersson, Fredrik C Kugelberg, Henrik Green, Robert Kronstrand
Flubromazolam is a triazolam benzodiazepine that recently emerged as a new psychoactive substance. Since metabolism data are scarce and good analytical targets besides the parent are unknown, we investigated flubromazolam metabolism in vitro and in vivo. 10μmol/L flubromazolam was incubated with human liver microsomes for 1h and with cryopreserved human hepatocytes for 5h. Mice were administered 0.5 or 1.0mg flubromazolam/kg body weight intraperitoneally, urine was collected for 24h. All samples, together with six authentic forensic human case specimens, were analyzed (with or without hydrolysis, in case it was urine) by UHPLC-HRMS on an Acquity HSS T3 column with an Agilent 6550 QTOF...
November 5, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27862094/uplc-ms-ms-method-for-the-determination-of-tobacco-specific-biomarker-nnal-tamoxifen-and-its-main-metabolites-in-rat-plasma
#16
Wei Xiong, Jiajia Zhao, Lin Wang, Xuehua Jiang
Cigarette smoke is known to interact with tamoxifen metabolizing enzymes and transporters and potentially affect its treatment outcome. 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanol (NNAL) is an important metabolite of 4-(methylnitro-samino)-1-(3-pyridyl)-1-butanone (NNK) because it is frequently used as biomarker to assess human smoke exposure. In order to study the potential pharmacokinetic interaction between cigarette smoke and tamoxifen in rats. A UPLC-MS/MS method for the simultaneous determination of NNAL, tamoxifen along with its metabolites in rat plasma has been developed and validated...
November 8, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27857502/comparison-of-closing-wedge-and-opening-wedge-high-tibial-osteotomies-for-medial-compartment-osteoarthritis-of-knee-in-asian-population-mid-term-follow-up
#17
Sanjay Agarwala, Anshul Sobti, Siddhant Naik, Sameer Chaudhari
BACKGROUND: Valgus high tibial osteotomy (HTO) is a well-established treatment option for patients with early osteoarthritis of the medial compartment of the knee. It is achievable with either open-wedge or closed-wedge technique. The aim of the study was to compare the radiological and clinical outcomes following HTO done with open- and closed-wedge techniques. MATERIAL AND METHODS: Two groups of patients undergoing HTO and fixation with locking plates were compared...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27845210/changes-in-hemolymph-characteristics-of-ark-shell-scapharaca-broughtonii-dealt-with-vibrio-anguillarum-challenge-in-vivo-and-various-of-anticoagulants-in-vitro
#18
Liqing Zhou, Aiguo Yang, Zhihong Liu, Biao Wu, Xiujun Sun, Zhenming Lv, Ji-Teng Tian, Meirong Du
The ark shell Scapharca broughtonii is a commercially important shellfish in China. Alserver's solution (AS), modified Alserver's solution (MAS) and Heparin sodium solution (HSS) are common anticoagulants used for shellfish blood. To observe the immune response mediated by its hemocytes, we challenged in vivo S. broughtonii hemolymph with Vibrio anguillarum and dealt with the following three anticagulants in vitro: Alserver's solution (AS), modified Alserver's solution (MAS) and Heparin sodium solution (HSS)...
November 11, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27819528/interferon-gamma-ifn-%C3%AE-is-elevated-in-wound-exudate-from-hidradenitis-suppurativa
#19
Anirban Banerjee, Sean McNish, Victoria K Shanmugam
Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease of apocrine glands which affects 1-4% of young adults. The purpose of this study was to investigate inflammatory cytokines in effluent from HS lesions and to identify potential local drivers of inflammation in HS. Wound fluid specimens from HS patients (n = 8) and age-matched chronic wound patients (n = 8) were selected for analysis. The hidradenitis suppurativa score (HSS) was used to determine the extent of HS activity. Cytokine analysis was conducted using Meso Scale Discovery cytokine and proinflammatory panels...
November 7, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27819157/improvement-of-side-effects-and-treatment-on-the-experimental-colitis-in-mice-of-a-resin-microcapsule-loading-hydrocortisone-sodium-succinate
#20
Kai Dong, Hefeng Zhang, Yan Yan, Jinyao Sun, Yalin Dong, Ke Wang, Lu Zhang, Xianpeng Shi, Jianfeng Xing
CONTEXT: Extensive or long-time use of corticosteroids often causes many toxic side-effects. The ion exchange resins and the coating material, Eudragit, can be used in combination to form a new oral delivery system to deliver corticosteroids. OBJECTIVES: The resin microcapsule (DRM) composed by Amberlite 717 and Eudragit S100 was used to target hydrocortisone (HC) to the colon in order to improve its treatment effect on ulcerative colitis (UC) and reduce its toxic side-effects...
November 21, 2016: Drug Development and Industrial Pharmacy
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