gemstones

Complex nuclear magnetic resonance (NMR) signals of organic compounds containing multiple analogous substructures or mixtures pose a significant challenge to structural identification, thus resulting in frequent misassignment of structures. The GEMSTONE method, a single-scan technique that selectively excites a specific proton signal among the crowded NMR signals, was recently proposed as a solution. However, its extension to the polarization transfer method for heteronuclear spin systems was unsuccessful. Here, we present an extension method that addresses the altered heteronuclear polarization transfer efficiency and enables the acquisition of ultraselective 13C and 1H-13C correlation NMR subspectra with hertz-level signal selectivity in both dimensions...

Jewelry identification and evaluation are limited owing to interference from the surrounding metal mount and adjacent gemstones. To maintain transparency in the jewelry market, this study proposes imaging-assisted Raman and photoluminescence spectroscopy for jewelry measurement. The system can automatically measure multiple gemstones on a jewelry piece sequentially, using the image as a reference for alignment. The experimental prototype demonstrates the capability of noninvasive measurement for separating natural diamonds from their laboratory-grown counterparts and diamond simulants...

An ultra-selective 1D NMR experiment - GEMSTONE-ROESY - enables clear, unambiguous assignment of ROE signals in the not uncommon situation that traditional selective methods fail. Its usefulness is demonstrated in the analysis of the natural products cyclosporin and lacto- N -difucohexaose I, providing detailed insight into the structures and conformations of these molecules.

Despite technology advances that have enabled routine acquisition of functional MRI data with sub-millimeter resolution, the inferences that cognitive neuroscientists must make to link fMRI data to behavior are complicated. Thus, a single dataset subjected to different analyses can be interpreted in different ways. This article presents two optical analogies that can be useful for framing fMRI analyses in a way that allows for multiple interpretations of fMRI data to be valid simultaneously without undermining each other...

Background and objective: Non-small cell lung cancer (NSCLC) is one of the most malignant cancer types that causes substantial economic burden in China. This study aimed to evaluate the cost-effectiveness of five first-line anti-PD-(L)1 treatments, including sintilimab, camrelizumab, atezolizumab, pembrolizumab and sugemalimab with each combined with chemotherapy, for treating advanced non-squamous NSCLC (nsq-NSCLC) from Chinese healthcare system perspective. Methods: Clinical data were obtained from the following clinical trials, namely, ORIENT-11, CameL, IMpower132, KEYNOTE-189 and GEMSTONE-302...

PURPOSE: Relapsed or refractory extranodal natural killer/T-cell lymphoma (R/R ENKTL) is a rare and aggressive type of non-Hodgkin lymphoma with limited treatment options. This phase II study evaluated the efficacy and safety of sugemalimab, an anti-PD-L1 monoclonal antibody, in R/R ENKTL. METHODS: Eligible patients received sugemalimab 1,200 mg intravenously once every 3 weeks for up to 24 months or until progression, death, or study withdrawal. The primary end point was objective response rate (ORR) assessed by an independent radiologic review committee...

INTRODUCTION: The formation of color in plants is significantly dependent on anthocyaninpigments. Grape species vary in color due to the differences in anthocyanin accumulation. It is widely recognized that both biotic and abiotic conditions may have an impact on anthocyanin synthesis in plants. The underlying molecular mechanisms by which external application of hyperoside impacts anthocyanin formation in grapes, however, have received little attention. METHODS: In the current study,the transcriptome of Gemstone seedless grape was examined using high-throughput RNA sequencing at various developmental stages reply to both control and hyperoside treatments...

BACKGROUND: Sugemalimab is a newly developed inhibitor of programmed death ligand 1 (PD-L1). As a first-line treatment for metastatic non-small-cell lung cancer (NSCLC), sugemalimab plus chemotherapy (Sugema-Chemo) has been proven effective. Still, its cost-effectiveness has not yet been determined. The objective of this study was to assess the cost-effectiveness of Sugema-Chemo from a health care perspective in China. METHODS: A partitioned survival model was used...

BACKGROUND: Gemstone spectral contrast-enhanced CT with virtual noncontrast (VNC) images and iodine maps can potentially reduce the number of required CT scans for thyroid lesions. However, data regarding the clinical utility of VNC images and iodine maps in characterizing thyroid lesions and distinguishing thyroid papillary carcinoma from nodular goiter are still limited. PURPOSE: To determine whether VNC images and iodine density could reliably aid in characterizing thyroid lesions and distinguishing thyroid papillary carcinoma from nodular goiter compared with true noncontrast (TNC) images...

Diamond is a promising material for the biomedical field, mainly due to its set of characteristics such as biocompatibility, strength, and electrical conductivity. Diamond can be synthesised in the laboratory by different methods, is available in the form of plates or films deposited on foreign substrates, and its morphology varies from microcrystalline diamond to ultrananocrystalline diamond. In this review, we summarise some of the most relevant studies regarding the adhesion of cells onto diamond surfaces, the consequent cell growth, and, in some very interesting cases, the differentiation of cells into neurons and oligodendrocytes...

This retrospective study aimed to predict the injury time of rib fractures in distinguishing fresh (30 days) or old (90 days) rib fractures. We enrolled 111 patients with chest trauma who had been scanned for rib fractures at our hospital between January 2018 and December 2018 using gemstone spectral imaging (GSI). The volume of interest of each broken end of the rib fractures was segmented using calcium-based material decomposition images derived from the GSI scans. The training and testing sets were randomly assigned in a 7:3 ratio...

PURPOSE: To conduct a comparative study of image quality, radiation dose, and iodine intake in hepatic computed tomographic angiography (CTA) of overweight patients with different Gemstone Spectral Imaging (GSI) noise indexes combined with different concentrations of contrast medium. MATERIALS AND METHODS: Ninety patients with a body mass index of ≥ 25 kg/m2 were divided into three groups (A, B and C), each with 30 patients. The three groups underwent hepatic CTA with different NI of 7, 11 and 15, respectively, and were injected with different iodine concentrations of 370, 350 and 320 mgI/mL, respectively...

OBJECTIVE: To evaluate the economics of sugemalimab plus chemotherapy in the first-line treatment of metastatic non-small cell lung cancer, and to provide a reference for the formulation of relevant medical insurance policies and rational drug use. METHODS: From the perspective of the Chinese health system, a three-state partitioned survival model was constructed based on data from a phase III randomized clinical trial (GEMSTONE 302) to evaluate the cost-utility of sugemalimab plus chemotherapy compared with chemotherapy in first-line treatment of metastatic non-small cell lung cancer...

Heavy metal contamination in raw materials has spread widely in the United States. The high increased number of recalls in consumer products and the lack of stricter regulations in the raw materials to be used in the jewelry industry have raised concerns among consumers. Studies in low-cost jewelry have shown the presence and high content of heavy metals; this environmental problem led to a child's death after swallowing a charm containing elevated levels of lead (Pb). Exposure to heavy metals, through inhalation, mouth, and skin contact, causes adverse health effects in children and adults...

The elemental composition, mineral phases, and crystalline structure of nephrite jade were investigated using calibration-free laser-induced breakdown spectroscopy (CF-LIBS), Raman spectroscopy, and X-ray diffraction (XRD). For compositional analysis, the laser-induced plasma was generated on the surface of nephrite jade. The plasma emissions were then acquired and analyzed, which revealed several elements in the sample, including Si, Mg, Ca, Li, Fe, Al, Na, K, and Ni. The plasma temperature was extracted from the Boltzmann plot before and after two-step self-absorption correction, and used in CF-LIBS calculations to get the elemental concentration...

INTRODUCTION: Because of its low immunogenicity and associated risk of toxicity, sugemalimab is expected to reshape the first-line treatment landscape for non-small cell lung cancer (NSCLC) in China. However, it remains unclear whether the use of expensive sugemalimab is cost-effective in this population. METHODS: A Markov model was constructed based on the GEMSTONE-302 study to assess the efficacy of sugemalimab in combination with chemotherapy for first-line treatment of metastatic NSCLC...

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OBJECTIVE: The purpose of this study was to estimate the cost-effectiveness of sugemalimab plus chemotherapy (SC) vs. placebo plus chemotherapy (PC), as the first-line treatment for patients with non-small cell lung cancer (NSCLC) in China. MATERIAL AND METHODS: A three-state Markov model with a cycle of 3 weeks was built to assess the incremental cost-effectiveness ratio (ICER) of SC vs. PC as first-line treatment for patients with NSCLC over a 10-year horizon from Chinese health care perspective...

Garnets that common constituent of skarn type iron deposits are wide ranges of chemical compositions, and they are also important as a semi-gemstone mineral. This study has been investigated garnets and inclusions of its formed in contacts of Pertek granitoid and Keban marble by using a combination of multiple techniques including Raman spectrum, electron microprobe, petrography and LA-ICP-MS. The main mineral assemblage observed in the skarn formation is diopside, garnet, quartz, magnetite, calcite and pyrite...

Imitation gemstone glass has numerous characteristics, including low cost, rich colour, stable colouring, and the formation of colour-changing effects that can meet the jewellery market demand for beautiful gemstones of middle and low grades. In this study, four types of gem-imitating glass were prepared by the elemental substitution of praseodymium, neodymium and chromium elements based on rare earth glass and examined by combining refractive index, density, spectral characteristics and colour parameters. Sample 1 contained only Pr6 O11 and showed a golden-yellow colour like chrysoberyl...