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multiparametric magnetic resonance imaging

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https://www.readbyqxmd.com/read/29770848/imaging-biomarkers-from-multiparametric-magnetic-resonance-imaging-are-associated-with-survival-outcomes-in-patients-with-brain-metastases-from-breast-cancer
#1
Bang-Bin Chen, Yen-Shen Lu, Chih-Wei Yu, Ching-Hung Lin, Tom Wei-Wu Chen, Shwu-Yuan Wei, Ann-Lii Cheng, Tiffany Ting-Fang Shih
OBJECTIVES: The aim of this study is to investigate the correlation of survival outcomes with imaging biomarkers from multiparametric magnetic resonance imaging (MRI) in patients with brain metastases from breast cancer (BMBC). METHODS: This study was approved by the institutional review board. Twenty-two patients with BMBC who underwent treatment involving bevacizumab on day 1, etoposide on days 2-4, and cisplatin on day 2 in 21-day cycles were prospectively enrolled for a phase II study...
May 16, 2018: European Radiology
https://www.readbyqxmd.com/read/29770311/-super-active-surveillance-mri-ultrasound-fusion-biopsy-and-ablation-for-less-invasive-management-of-prostate-cancer
#2
REVIEW
Jonathan B Bloom, Samuel A Gold, Graham R Hale, Kareem N Rayn, Vikram K Sabarwal, Ivane Bakhutashvili, Vladimir Valera, Baris Turkbey, Peter A Pinto, Bradford J Wood
Multiparametric magnetic resonance imaging (mpMRI) of the prostate has allowed clinicians to better visualize and target suspicious lesions during biopsy. Targeted prostate biopsies give a more accurate representation of the true cancer volume and stage so that appropriate treatment or active surveillance can be selected. Advances in technology have led to the development of MRI and ultrasound fusion platforms used for targeted biopsies, monitoring cancer progression, and more recently for the application of focal therapy...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29770305/the-prostate-cancer-focal-therapy
#3
REVIEW
Filippo Pesapane, Francesca Patella, Enrico Maria Fumarola, Edoardo Zanchetta, Chiara Floridi, Gianpaolo Carrafiello, Chloë Standaert
Despite prostate cancer (PCa) is the leading form of non-cutaneous cancer in men, most patients with PCa die with disease rather than of the disease. Therefore, the risk of overtreatment should be considered by clinicians who have to distinguish between patients with high risk PCa (who would benefit from radical treatment) and patients who may be managed more conservatively, such as through active surveillance or emerging focal therapy (FT). The aim of FT is to eradicate clinically significant disease while protecting key genito-urinary structures and function from injury...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29755006/multiparametric-magnetic-resonance-imaging-for-bladder-cancer-development-of-vi-rads-vesical-imaging-reporting-and-data-system
#4
REVIEW
Valeria Panebianco, Yoshifumi Narumi, Ersan Altun, Bernard H Bochner, Jason A Efstathiou, Shaista Hafeez, Robert Huddart, Steve Kennish, Seth Lerner, Rodolfo Montironi, Valdair F Muglia, Georg Salomon, Stephen Thomas, Hebert Alberto Vargas, J Alfred Witjes, Mitsuru Takeuchi, Jelle Barentsz, James W F Catto
CONTEXT: Management of bladder cancer (BC) is primarily driven by stage, grade, and biological potential. Knowledge of each is derived using clinical, histopathological, and radiological investigations. This multimodal approach reduces the risk of error from one particular test, but may present a staging dilemma when results conflict. Multiparametric magnetic resonance imaging (mpMRI) may improve patient care through imaging of the bladder with better resolution of the tissue planes than computed tomography and without radiation exposure...
May 10, 2018: European Urology
https://www.readbyqxmd.com/read/29753548/fusion-prostate-biopsy-outperforms-12-core-systematic-prostate-biopsy-in-patients-with-prior-negative-systematic-biopsy-a-multi-institutional-analysis
#5
Abhinav Sidana, Matthew J Watson, Arvin K George, Ardeshir R Rastinehad, Srinivas Vourganti, Soroush Rais-Bahrami, Akhil Muthigi, Mahir Maruf, Jennifer B Gordetsky, Jeffrey W Nix, Maria J Merino, Baris Turkbey, Peter L Choyke, Bradford J Wood, Peter A Pinto
INTRODUCTION AND OBJECTIVES: Patients with persistently elevated prostate specific antigen (PSA) and prior negative 12-core TRUS prostate biopsy (or biopsies) (systematic biopsy-SBx) are a diagnostic challenge. Repeat SBx or saturation biopsy in this cohort has been shown to have an even lower yield. The aim of our study is to compare the prostate cancer yield of magnetic resonance imaging (MRI) fusion biopsy (FBx) to SBx in a multi-institutional cohort comprised of patients with prior negative biopsies...
May 9, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29752647/multiparametric-magnetic-resonance-imaging-versus-partin-tables-and-the-memorial-sloan-kettering-cancer-center-nomogram-in-risk-stratification-of-patients-with-prostate-cancer-referred-to-external-beam-radiation-therapy
#6
Rossano Girometti, Martina Pancot, Marco Andrea Signor, Martina Urbani, Luca Balestreri, Chiara Zuiani
PURPOSE: To evaluate the agreement between multiparametric Magnetic Resonance Imaging (mpMRI), Partin tables (PT) and the Memorial Sloan Kettering Cancer Center nomogram (MSKCCn) in assessing risk category in prostate cancer (PCa) patients referred to External Beam Radiotherapy (EBRT). MATERIALS AND METHODS: In this bicentric study, we prospectively enrolled 80 PCa patients who underwent pre-EBRT mpMRI on a 3.0T magnet with a multiparametric protocol including high-resolution, multiplanar T2-weighted sequences, diffusion-weighted imaging and dynamic contrast-enhanced imaging...
May 12, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29734177/multiparametric-magnetic-resonance-to-confirm-eligibility-to-an-active-surveillance-program-for-low-risk-prostate-cancer-intermediate-time-results-of-a-third-referral-high-volume-centre-active-surveillance-protocol
#7
Stefano Luzzago, Gennaro Musi, Michele Catellani, Andrea Russo, Ettore Di Trapani, Francesco Alessandro Mistretta, Roberto Bianchi, Gabriele Cozzi, Andrea Conti, Paola Pricolo, Matteo Ferro, Deliu-Victor Matei, Vincenzo Mirone, Giuseppe Petralia, Ottavio de Cobelli
BACKGROUND: To evaluate the role of confirmatory multiparametric magnetic resonance imaging (mpMRI) of the prostate at the time of Active Surveillance (AS) enrollment to reduce disease misclassification. MATERIALS: From 2012 to 2016, 383 patients with low-risk disease respecting Prostate Cancer Research International AS criteria underwent confirmatory 1.5-T mpMRI. AS was proposed to patients with Prostate Imaging and Report and Data System (PI-RADS) score ≤3 and no extraprostatic extension (EPE), whereas patients with PI-RADS score ≥4 and/or EPE were treated actively...
May 7, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29733838/validation-of-pi-rads-version-2-for-the-detection-of-prostate-cancer
#8
Sebastian L Hofbauer, Beatrice Kittner, Andreas Maxeiner, Robin Heckmann, Maximillian Reimann, Laura Wiemer, Patrick Asbach, Matthias Haas, Tobias Penzkofer, Carsten Stephan, Frank Friedersdorff, Florian Fuller, Kurt Miller, Hannes Cash
PURPOSE: The second version of the Prostate Imaging Reporting and Data System (PI-RADSv2) was introduced in 2015 to standardize the interpretation and reporting of multiparametric prostate magnetic resonance imaging (mpMRI). Recently, low cancer detection rates (CDR) for PI-RADSv2 category 4 lesions were reported. Therefore the aim of the study was to evaluate the CDR of PI-RADSv2 in a large prospective cohort. METHODS: The study included 704 consecutive men with primary or prior negative biopsies who underwent MRI/ultrasound fusion-guided targeted biopsy (TB) and 10-core systematic prostate biopsy (SB) between September 2015 and May 2017...
May 4, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29733790/pi-rads-v2-current-standing-and-future-outlook
#9
REVIEW
Clayton P Smith, Barış Türkbey
The Prostate Imaging-Reporting and Data System (PI-RADS) was created in 2012 to establish standardization in prostate multiparametric magnetic resonance imaging (mpMRI) acquisition, interpretation, and reporting. In hopes of improving upon some of the PI-RADS v1 shortcomings, the PI-RADS Steering Committee released PI-RADS v2 in 2015. This paper reviews the accuracy, interobserver agreement, and clinical outcomes of PI-RADS v2 and comments on the limitations of the current literature. Overall, PI-RADS v2 shows improved sensitivity and similar specificity compared to PI-RADS v1...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29732281/imaging-for-the-selection-and-monitoring-of-men-on-active-surveillance-for-prostate-cancer
#10
REVIEW
Maria C Velasquez, Nachiketh Soodana Prakash, Vivek Venkatramani, Bruno Nahar, Sanoj Punnen
Traditional prostate imaging is fairly limited, and only a few imaging modalities have been used for this purpose. Until today, grey scale ultrasound was the most widely used method for the characterization of the prostatic gland, however its limitations for prostate cancer (PCa) detection are well known and hence ultrasound is primarily used to localize the prostate and facilitate template prostate biopsies. In the past decade, multiparametric magnetic resonance imaging (mpMRI) of the prostate has emerged as a promising tool for the detection of PCa...
April 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29732280/expanded-criteria-for-active-surveillance-in-prostate-cancer-a-review-of-the-current-data
#11
REVIEW
Cameron Jones, Mina M Fam, Benjamin J Davies
Over the last ten years, active surveillance (AS) has become increasingly utilized for patients with low-risk prostate cancer. Appropriately selected AS patients have a 10-year prostate cancer-specific mortality (PCSM) approaching 99%. Therefore, some institutions have expanded the inclusion criteria for AS to avoid the unnecessary morbidity associated with overtreatment. In this review, data from several high-quality studies were compiled to demonstrate how AS inclusion criteria may be safely expanded. Although AS criteria, data reporting, and statistical methods were heterogeneous across studies, several findings were consistent and provided insight for clinical practice...
April 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29718792/a-younger-man-with-localized-prostate-cancer-asks-which-type-of-radiation-is-right-for-me
#12
Justin E Bekelman
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
May 2, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29715138/comparing-image-guided-targeted-biopsies-to-radical-prostatectomy-specimens-for-accurate-characterization-of-the-index-tumor-in-prostate-cancer
#13
Francesco Porpiglia, Stefano DE Luca, Enrico Checcucci, Diletta Garrou, Matteo Manfredi, Fabrizio Mele, Angela Pecoraro, Roberto Passera, Enrico Bollito, Cristian Fiori
AIM: To evaluate the accuracy of multiparametric magnetic resonance-transrectal ultrasound fusion targeted biopsy (TBx) in the characterization of the index tumor, as confirmed by association with radical prostatectomy (RP) specimens. PATIENTS AND METHODS: A total of 152 patients with TBx-confirmed prostate cancer (PCa) underwent robot-assisted RP. Stained whole-mount histological sections were used as the reference standard. All lesions with a volume >0.5 ml and/or pathological Gleason score (GS) >6 were defined as clinically significant PCa...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29712696/cardiovascular-magnetic-resonance-in-acute-st-segment-elevation-myocardial-infarction-recent-advances-controversies-and-future-directions
#14
REVIEW
Heerajnarain Bulluck, Rohan Dharmakumar, Andrew E Arai, Colin Berry, Derek J Hausenloy
Although mortality after ST-segment elevation myocardial infarction (MI) is on the decline, the number of patients developing heart failure as a result of MI is on the rise. Apart from timely reperfusion by primary percutaneous coronary intervention, there is currently no established therapy for reducing MI size. Thus, new cardioprotective therapies are required to improve clinical outcomes after ST-segment-elevation MI. Cardiovascular magnetic resonance has emerged as an important imaging modality for assessing the efficacy of novel therapies for reducing MI size and preventing subsequent adverse left ventricular remodeling...
May 1, 2018: Circulation
https://www.readbyqxmd.com/read/29705281/a-multireader-exploratory-evaluation-of-individual-pulse-sequence-cancer-detection-on-prostate-multiparametric-magnetic-resonance-imaging-mri
#15
Sonia Gaur, Stephanie Harmon, Rajan T Gupta, Daniel J Margolis, Nathan Lay, Sherif Mehralivand, Maria J Merino, Bradford J Wood, Peter A Pinto, Joanna H Shih, Peter L Choyke, Baris Turkbey
RATIONALE AND OBJECTIVES: To determine independent contribution of each prostate multiparametric magnetic resonance imaging (mpMRI) sequence to cancer detection when read in isolation. MATERIALS AND METHODS: Prostate mpMRI at 3-Tesla with endorectal coil from 45 patients (n = 30 prostatectomy cases, n = 15 controls with negative magnetic resonance imaging [MRI] or biopsy) were retrospectively interpreted. Sequences (T2-weighted [T2W] MRI, diffusion-weighted imaging [DWI], and dynamic contrast-enhanced [DCE] MRI; N = 135) were separately distributed to three radiologists at different institutions...
April 25, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29698083/voxel-wise-prostate-cell-density-prediction-using-multiparametric-magnetic-resonance-imaging-and-machine-learning
#16
Yu Sun, Hayley M Reynolds, Darren Wraith, Scott Williams, Mary E Finnegan, Catherine Mitchell, Declan Murphy, Annette Haworth
BACKGROUND: There are currently no methods to estimate cell density in the prostate. This study aimed to develop predictive models to estimate prostate cell density from multiparametric magnetic resonance imaging (mpMRI) data at a voxel level using machine learning techniques. MATERIAL AND METHODS: In vivo mpMRI data were collected from 30 patients before radical prostatectomy. Sequences included T2-weighted imaging, diffusion-weighted imaging and dynamic contrast-enhanced imaging...
April 26, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29692375/comparison-thigh-skeletal-muscles-between-snowboarding-halfpipe-athletes-and-healthy-volunteers-using-quantitative-multi-parameter-magnetic-resonance-imaging-at-rest
#17
He Sun, Meng-Tao Xu, Xiao-Qi Wang, Meng-Hu Wang, Bao-Heng Wang, Feng-Zhe Wang, Shi-Nong Pan
Background: Magnetic resonance (MR) imaging provides a unique, noninvasive diagnostic platform to quantify the physiological and biochemical variables of skeletal muscle at rest. This study was to investigate the difference in thigh skeletal muscles between snowboarding halfpipe athletes and healthy volunteers via multiparametric MR imaging. Methods: A comparative study was conducted between 12 healthy volunteers and 14 snowboarding halfpipe athletes. MR scanning targeted the left leg at the level of the proximal thigh on a 3...
May 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29685613/cognitive-versus-software-assisted-registration-development-of-a-new-nomogram-predicting-prostate-cancer-at-mri-targeted-biopsies
#18
Sascha Kaufmann, Giorgio I Russo, Wolfgang Thaiss, Mike Notohamiprodjo, Fabian Bamberg, Jens Bedke, Giuseppe Morgia, Konstantin Nikolaou, Arnulf Stenzl, Stephan Kruck
INTRODUCTION: Multiparametric magnetic resonance imaging (mpMRI) is gaining acceptance to guide targeted biopsy (TB) in prostate cancer (PC) diagnosis. We aimed to compare the detection rate of software-assisted fusion TB (SA-TB) versus cognitive fusion TB (COG-TB) for PC and to evaluate potential clinical features in detecting PC and clinically significant PC (csPC) at TB. PATIENTS AND METHODS: This was a retrospective cohort study of patients with rising and/or persistently elevated prostate-specific antigen (PSA) undergoing mpMRI followed by either transperineal SA-TB or transrectal COG-TB...
April 3, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29685521/prospective-evaluation-of-fluciclovine-18-f-pet-ct-and-mri-in-detection-of-recurrent-prostate-cancer-in-non-prostatectomy-patients
#19
Oladunni Akin-Akintayo, Funmilayo Tade, Pardeep Mittal, Courtney Moreno, Peter T Nieh, Peter Rossi, Dattatraya Patil, Raghuveer Halkar, Baowei Fei, Viraj Master, Ashesh B Jani, Hiroumi Kitajima, Adeboye O Osunkoya, Claudia Ormenisan-Gherasim, Mark M Goodman, David M Schuster
PURPOSE: To investigate the disease detection rate, diagnostic performance and interobserver agreement of fluciclovine (18 F) PET-CT and multiparametric magnetic resonance imaging (mpMR) in recurrent prostate cancer. METHODS: Twenty-four patients with biochemical failure after non-prostatectomy definitive therapy, 16/24 of whom had undergone brachytherapy, underwent fluciclovine PET-CT and mpMR with interpretation by expert readers blinded to patient history, PSA and other imaging results...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29680356/influence-of-myocardial-hemorrhage-on-staging-of-reperfused-myocardial-infarctions-with-t-2-cardiac-magnetic-resonance-imaging-insights-into-the-dependence-on-infarction-type-with-ex-vivo-validation
#20
Guan Wang, Hsin-Jung Yang, Avinash Kali, Ivan Cokic, Richard Tang, Guoxi Xie, Qi Yang, Joseph Francis, Songbai Li, Rohan Dharmakumar
OBJECTIVES: This study sought to determine whether T2 cardiac magnetic resonance (CMR) can stage both hemorrhagic and nonhemorrhagic myocardial infarctions (MIs). BACKGROUND: CMR-based staging of MI with or without contrast agents relies on the resolution of T2 elevations in the chronic phase, but whether this approach can be used to stage both hemorrhagic and nonhemorrhagic MIs is unclear. METHODS: Hemorrhagic (n = 15) and nonhemorrhagic (n = 9) MIs were created in dogs...
April 14, 2018: JACC. Cardiovascular Imaging
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