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https://www.readbyqxmd.com/read/28930445/thermo-responsive-and-active-functional-fiber-mats-for-cultured-cell-recovery
#1
Wilaiporn Graisuwan, Songchan Puthong, Hui Zhao, Suda Kiatkamjornwong, Patrick Theato, Voravee P Hoven
Thermo-responsive and active functional fiber mats were prepared from random copolymer of poly(pentafluorophenyl acrylate-co-N-isopropylacrylamide) (P(PFPA-co-NIPAM)), which was synthesized by a controlled radical polymerization process based on reversible addition-fragmentation chain transfer (RAFT). As reactive sites, pentafluorophenyl ester (PFP) groups were incorporated in the copolymer to allow for a multiple post-polymerization modification. UV-crosslinkable moieties were first introduced by partially reacting PFP groups in the copolymer with ortho-nitrobenzyl (ONB)-protected diamine...
September 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28922007/attachment-based-family-therapy-and-individual-emotion-focused-therapy-for-unresolved-anger-qualitative-analysis-of-treatment-outcomes-and-change-processes
#2
Ravit Steinmann, Inbal Gat, Ofir Nir-Gottlieb, Ben Shahar, Gary M Diamond
Twenty-six clients who received 10 sessions of either attachment-based family therapy (ABFT) or individual emotion-focused therapy (EFT) for unresolved anger toward a parent were interviewed 6 months after completing treatment. Interviews were analyzed using the consensual qualitative research approach. Clients in both conditions reported improved relationships with parents, gaining a new perspective of their parent, increased compassion toward parent, less reactivity to anger, feeling cleaned-out, and acquiring new coping strategies...
September 2017: Psychotherapy
https://www.readbyqxmd.com/read/28921442/preparation-of-immunoliposomes-by-direct-coupling-of-antibodies-based-on-a-thioether-bond
#3
Raquel Petrilli, Josimar O Eloy, Robert J Lee, Renata F V Lopez
Drug delivery is of paramount importance, since the drug needs to be delivered to a specific site, in adequate concentration, avoiding degradation in order to provide therapeutic efficacy. Different nanocarriers have been used over the years for this purpose and liposomes are well-established systems due to the high biocompatibility and the possibility to vehiculate both hydrophilic and lipophilic drugs. In order to circumvent the rapid clearance by the reticuloendothelial system and to avoid the healthy cells exposure to the drug, long circulating liposomes containing polyethyleneglycol (PEG) and functionalized liposomes for targeted delivery have been developed...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28918125/iodinated-chlorin-p6-copper-complex-induces-anti-proliferative-effect-in-oral-cancer-cells-through-elevation-of-intracellular-reactive-oxygen-species
#4
Paromita Sarbadhikary, Alok Dube
We investigated the anticancer chemotoxicity of previously reported iodinated chlorin p6 copper complex (ICp6-Cu), a novel chlorophyll derivative in which copper is attached to the side chain carboxylate groups via coordination. Human oral carcinoma cells NT8e, 4451 and the non-cancerous keratinocyte HaCaT cells were treated with ICp6-Cu for 48 h in dark and cell viability, proliferation and morphological alterations were examined. ICp6-Cu showed pronounced cytotoxicity in cancer cells with IC50 ∼40 μM, whereas, the viability of HaCaT cells was not affected...
September 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28917845/influence-of-binding-mechanism-on-labeling-efficiency-and-luminous-properties-of-fluorescent-cellulose-nanocrystals
#5
Qijun Ding, Jinsong Zeng, Bin Wang, Wenhua Gao, Kefu Chen, Zhe Yuan, Jun Xu
Cellulose nanocrystals (CNCs) have excellent properties, such as reproducibility, low biodegradability and a large amount of reactive hydroxyl groups on the surface. This study focused on the labeling efficiency and fluorescent properties of the fluorescent labeling of CNCs by means of electrostatic adsorption and covalent bonding. The CNCs in the sample were approximately 94.76% successfully labeled with dyes, and the number of dye molecules adsorbed by per CNC was approximately 208 by electrostatic adsorption...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28910418/the-effect-of-s-substitution-at-the-o6-guanine-site-on-the-structure-and-dynamics-of-a-dna-oligomer-containing-a-g-t-mismatch
#6
Elaine Ann Moore, Yao-Zhong Xu
The effect of S-substitution on the O6 guanine site of a 13-mer DNA duplex containing a G:T mismatch is studied using molecular dynamics. The structure, dynamic evolution and hydration of the S-substituted duplex are compared with those of a normal duplex, a duplex with S-substitution on guanine, but no mismatch and a duplex with just a G:T mismatch. The S-substituted mismatch leads to cell death rather than repair. One suggestion is that the G:T mismatch recognition protein recognises the S-substituted mismatch (GS:T) as G:T...
2017: PloS One
https://www.readbyqxmd.com/read/28910242/how-does-the-social-get-under-the-gums-the-role-of-socio-economic-position-in-the-oral-systemic-health-link
#7
Noha Gomaa, Belinda Nicolau, Arjumand Siddiqi, Howard Tenenbaum, Michael Glogauer, Carlos Quiñonez
OBJECTIVES: To evaluate the extent of association between systemic inflammation and periodontal disease in American adults, and to assess whether socio-economic position mediated this relationship. METHODS: We used data from the National Health and Nutrition Examination Survey (NHANES IV) (2001-2010). Systemic inflammation was defined by individual and aggregate (cumulative inflammatory load) biomarkers (C-reactive protein, white blood cell counts, neutrophil counts, and neutrophil:lymphocyte ratio)...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28905618/functionalization-of-reduced-graphene-oxide-via-thiol-maleimide-click-chemistry-facile-fabrication-of-targeted-drug-delivery-vehicles
#8
Yavuz Oz, Alexandre Barras, Rana Sanyal, Rabah Boukherroub, Sabine Szunerits, Amitav Sanyal
Materials based on reduced graphene oxide (rGO) have shown to be amenable to noncovalent functionalization through hydrophobic interactions. The scaffold, however, does not provide sufficient covalent linkage given the low number of reactive carboxyl and alcohol groups typically available on the rGO. The integration of clickable groups, particularly the ones that can undergo efficient conjugation without any metal catalyst, would allow facile functionalization of these materials. This study reports on the noncovalent association of a maleimide-containing catechol (dopa-MAL) surface anchor onto the rGO...
September 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28904021/bap-exposure-causes-oocyte-meiotic-arrest-and-fertilization-failure-to-weaken-female-fertility
#9
Mianqun Zhang, Yilong Miao, Qian Chen, Meng Cai, Wenkang Dong, Xiaoxin Dai, Yajuan Lu, Changyin Zhou, Zhaokang Cui, Bo Xiong
Benzo[a]pyrene (BaP) is a ubiquitous environmental pollutant and carcinogen that is frequently found in particulate matter, with a diameter of ≤2.5 μm (PM2.5). It has been reported to interrupt the normal reproductive system, but the exact molecular basis has not been clearly defined. To understand the underlying mechanisms regarding how BaP exposure disrupts female fertility, we evaluated oocyte quality by assessing the critical regulators and events during oocyte meiotic maturation and fertilization. We found that BaP exposure compromised the mouse oocyte meiotic progression by disrupting normal spindle assembly, chromosome alignment, and kinetochore-microtubule attachment, consequently leading to the generation of aneuploid eggs...
September 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28902851/redox-mediated-quorum-sensing-in-plants
#10
Alexandra W Fuller, Phoebe Young, B Daniel Pierce, Jamie Kitson-Finuff, Purvi Jain, Karl Schneider, Stephen Lazar, Olga Taran, Andrew G Palmer, David G Lynn
The rhizosphere, the narrow zone of soil around plant roots, is a complex network of interactions between plants, bacteria, and a variety of other organisms. The absolute dependence on host-derived signals, or xenognosins, to regulate critical developmental checkpoints for host commitment in the obligate parasitic plants provides a window into the rhizosphere's chemical dynamics. These sessile intruders use H2O2 in a process known as semagenesis to chemically modify the mature root surfaces of proximal host plants and generate p-benzoquinones (BQs)...
2017: PloS One
https://www.readbyqxmd.com/read/28898995/uncovering-the-arrhythmogenic-potential-of-trpm4-activation-in-atrial-derived-hl-1-cells-using-novel-recording-and-numerical-approaches
#11
Yaopeng Hu, Yubin Duan, Ayako Takeuchi, Lin Hai-Kurahara, Jun Ichikawa, Keizo Hiraishi, Tomohiro Numata, Hiroki Ohara, Gentaro Iribe, Michio Nakaya, Masayuki X Mori, Satoshi Matsuoka, Genshan Ma, Ryuji Inoue
Aims: Transient receptor potential cation channel subfamily melastatin member 4 (TRPM4), a Ca2+-activated nonselective cation channel abundantly expressed in the heart, has been implicated in conduction block and other arrhythmic propensities associated with cardiac remodelling and injury. The present study aimed to quantitatively evaluate the arrhythmogenic potential of TRPM4. Methods and results: Patch clamp and biochemical analyses were performed using expression system and an immortalized atrial cardiomyocyte cell line (HL-1), and numerical model simulation was employed...
August 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28891668/visual-attention-and-emotional-reactions-to-negative-stimuli-the-role-of-age-and-cognitive-reappraisal
#12
Maria Wirth, Derek M Isaacowitz, Ute Kunzmann
Prominent life span theories of emotion propose that older adults attend less to negative emotional information and report less negative emotional reactions to the same information than younger adults do. Although parallel age differences in affective information processing and age differences in emotional reactivity have been proposed, they have rarely been investigated within the same study. In this eye-tracking study, we tested age differences in visual attention and emotional reactivity, using standardized emotionally negative stimuli...
September 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28891389/bioactive-zwitterionic-polymer-brushes-grafted-from-silicon-wafers-via-si-atrp-for-enhancement-of-antifouling-properties-and-endothelial-cell-selectivity
#13
Yu Wei, Jingxun Zhang, Xiantao Feng, Dongyin Liu
Zwitterionic copolymers keep good resistance to platelet adhesion and nonspecific protein adsorption. In this study, A block copolymer brushes consisting of carboxybetaine methacrylate (CBMA) and glycidyl methacrylate (GMA) were grafted from silicon wafers via surface-initiated atom transfer radical polymerization (SI-ATRP),and then the Arg-Glu-Asp-Val (REDV) peptide was attached to the polymer brush via an reactive epoxy group of the P(GMA) unit to improve endothelial cells (ECs) selectivity. These modified surfaces were evaluated with scanning electron microscopy (SEM), atomic force microscopy (AFM), attenuated total reflectance-Fourier transform infrared spectra (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and static water contact angle measurement (WCA)...
September 11, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28888136/activating-attachment-representations-during-memory-retrieval-modulates-intrusive-traumatic-memories
#14
Richard A Bryant, Iris Chan
Although priming mental representations of attachment security reduces arousal, research has not examined the effect of attachment on the retrieval of emotionally arousing memories. This study investigated the effect of priming attachment security on the retrieval of emotional memories. Seventy-five participants viewed negative and neutral images, and two days later received either an attachment prime or a control prime immediately prior to free recall of the images. Two days later, participants reported how frequently they experienced intrusions of the negative images...
September 6, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28887999/preferential-killing-of-bacterial-cells-by-hybrid-carbon-nanotube-mno2-nanocomposite-synthesized-by-novel-microwave-assisted-processing
#15
D Sivaraj, K Vijayalakshmi
We present a comprehensive study on the enhanced effect of CNT addition on the structural, optical, morphological and antibacterial properties of CNT-MnO2 nanocomposite synthesized by microwave assisted processing. X-ray diffraction pattern of the hybrid CNT/MnO2 nanocomposite revealed the shifting of highly oriented MnO2 preferential planes. SEM images show porous MnO2 nanospheres uniformly and discretely attached on the walls of carbon nanotube network. Significant variation in the peak shape and IR absorption intensity with CNT addition, indicate the interaction of CNT ions with MnO2 nanoparticles...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28885012/the-impact-of-the-major-baltic-inflow-of-december-2014-on-the-mercury-species-distribution-in-the-baltic-sea
#16
Joachim Kuss, Florian Cordes, Volker Mohrholz, Günther Nausch, Michael Naumann, Siegfried Krüger, Detlef Eckart Schulz-Bull
The Baltic Sea is a marginal sea characterized by stagnation periods of several years. Oxygen consumption in its deep waters leads to the build-up of sulfide from sulfate reduction. Some of the microorganisms responsible for these processes also transform reactive ionic mercury to neurotoxic methylmercury. Episodic inflows of oxygenated saline water from the North Sea temporally re-establish oxic life in deep waters of the Baltic Sea. Thus, this sea is an especially important region to better understand mercury species distributions in connection with variable redox conditions...
September 8, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28879678/a-diversity-oriented-library-of-fluorophore-modified-receptors-constructed-from-a-chemical-library-of-synthetic-fluorophores
#17
Shun Nakano, Tomoki Tamura, Raj Kumar Das, Eiji Nakata, Young-Tae Chang, Takashi Morii
One of the key determinants to successfully obtain a useful biosensor is wide variation of fluorophores attached to a given receptor. Thus, use of a larger fluorophore-modified receptor library provides a higher probability of obtaining a practically useful biosensor. However, no effective method has yet been developed for constructing such a diverse library of fluorophore-modified receptors. Herein, we report a method for constructing fluorophore-modified receptors using a chemical library of synthetic fluorophores with a thiol-reactive group...
September 6, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28879249/gingival-fluid-inflammatory-biomarkers-and-hypertension-in-african-americans
#18
A Khocht, T Rogers, M N Janal, M Brown
Hypertension and periodontitis are highly prevalent among African Americans. This cross-sectional study investigated the relationships among inflammatory biomarkers in the gingival fluid, periodontitis, and blood pressure in these individuals. Twenty-one subjects who reported a diagnosis of hypertension and a comparison group of 26 nonhypertensive participants were enrolled. All were African Americans, non-cigarette smoking, and free from other systemic illness. Blood pressure and body mass index were assessed...
July 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28877406/integration-of-bromine-and-cyanogen-bromide-generators-for-the-telescoped-continuous-synthesis-of-cyclic-guanidines
#19
Gabriel Glotz, Rene Lebl, Doris Dallinger, C Oliver Kappe
A continuous flow process for the in-situ on-demand generation of cyanogen bromide (BrCN) from bromine and potassium cyanide utilizing membrane separation technology is described. In order to circumvent handling, storage and transportation of elemental bromine, a continuous bromine generator using bromate-bromide synproportionation can optionally be attached upstream. Monitoring and quantification of BrCN generation was enabled by implementation of in-line FTIR technology. With the Br2 and BrCN generators connected in series 0...
September 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28862259/lateral-canthotomy-orbitotomy-a-rapid-approach-to-the-orbit
#20
S Hamed-Azzam, D H Verity, G E Rose
PurposeThe lateral compartment of the orbit can readily be accessed through a horizontal lateral canthotomy without the need to swing the lid or remove bone. In this paper the technique, accessible orbital territory, and duration of surgery are presented.Patients and methodsRetrospective, non-interventional descriptive case series for patients who underwent a lateral canthotomy to access pathology within the lateral orbit.ResultsA series of 18 patients are included, all presenting with pathology lateral to, or within, the optic nerve...
September 1, 2017: Eye
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