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https://www.readbyqxmd.com/read/28110183/noncovalent-interaction-assisted-fullerene-for-the-transportation-of-some-brain-anticancer-drugs-a-theoretical-study
#1
Pabitra Narayan Samanta, Kalyan Kumar Das
The treatment of brain cancer like glioblastoma multiforme often uses chemotherapeutic drugs like temozolomide, procarbazine, carmustine, and lomustine. Fullerene loaded with these drugs help to cross the blood brain barriers. The adsorptions of the four drug molecules on the surface of the fullerene are studied mostly by using density functional theory (DFT) based method at the M06-2X/6-31G(d) level of calculations. In all four cases, the estimated interactions are noncovalent type and the average adsorption energy lies in between -5 and -11kcal/mol in the gas phase...
January 8, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28109434/application-of-a-thioredoxin-trapping-mutant-for-analysis-of-the-cellular-nitrosoproteome
#2
M Benhar
Nitric oxide influences a wide range of cellular functions through S-nitrosylation, a redox-dependent posttranslational protein modification that involves attachment of a nitroso moiety to a reactive thiol group. Over the past two decades, S-nitrosylation has emerged as a ubiquitous mechanism for controlling the activity, subcellular localization, and molecular interactions of proteins, thereby influencing many cellular processes. In addition, recent studies have indicated that aberrant S-nitrosylation may lead to cellular dysfunction and damage...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28088449/the-role-of-sumoylation-in-ageing-and-senescent-decline
#3
REVIEW
Andrea Princz, Nektarios Tavernarakis
Posttranslational protein modifications are playing crucial roles in essential cellular mechanisms. SUMOylation is a reversible posttranslational modification of specific target proteins by the attachment of a small ubiquitin-like protein. Although the mechanism of conjugation of SUMO to proteins is analogous to ubiquitination, it requires its own, specific set of enzymes. The consequences of SUMOylation are widely variable, depending on the physiological state of the cell and the attached SUMO isoform. Accumulating recent findings have revealed a prominent role of SUMOylation in molecular pathways that govern senescence and ageing...
January 11, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28081539/regulation-of-anoikis-resistance-by-nadph-oxidase-4-and-epidermal-growth-factor-receptor
#4
Hyeryeong Kim, Jee Young Sung, Eun-Kyung Park, Seongho Kho, Kyung Hee Koo, Seog-Yun Park, Sung-Ho Goh, Yoon Kyung Jeon, Sekyung Oh, Byung-Kiu Park, Yong-Keun Jung, Yong-Nyun Kim
BACKGROUND: Normal cells are sensitive to anoikis, which is a cell detachment-induced apoptosis. However, cancer cells acquire anoikis resistance that is essential for successful metastasis. This study aimed to demonstrate the function and potential mechanism of NADPH oxidase 4 (NOX4) and EGFR activation in regulating anoikis resistance in lung cancer. METHODS: Cells were cultured either in the attached or suspended condition. Cell viability was measured by cell counting and live and dead cell staining...
January 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28078594/exploration-of-fas-s-nitrosylation-by-the-biotin-switch-assay
#5
Ali Bettaieb, Catherine Paul, Stéphanie Plenchette
S-nitrosylation is the covalent attachment of nitric oxide radical to the thiol side chain of cysteine. The death receptor Fas/CD95 can be S-nitrosylated in cancer cell lines by NO donors or iNOS activation. This posttranslational modification (PTM) induces Fas aggregation into lipid rafts and enhances FasL-mediated signaling and apoptosis. In this report, we describe the detection of Fas S-nitrosylation by the most commonly used method, the biotin switch assay (BSA) technique, that allows the detection of this very labile covalent modification in cells or tissues...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28075364/a-social-potential-fields-approach-for-self-deployment-and-self-healing-in-hierarchical-mobile-wireless-sensor-networks
#6
Eva González-Parada, Jose Cano-García, Francisco Aguilera, Francisco Sandoval, Cristina Urdiales
Autonomous mobile nodes in mobile wireless sensor networks (MWSN) allow self-deployment and self-healing. In both cases, the goals are: (i) to achieve adequate coverage; and (ii) to extend network life. In dynamic environments, nodes may use reactive algorithms so that each node locally decides when and where to move. This paper presents a behavior-based deployment and self-healing algorithm based on the social potential fields algorithm. In the proposed algorithm, nodes are attached to low cost robots to autonomously navigate in the coverage area...
January 9, 2017: Sensors
https://www.readbyqxmd.com/read/28069233/a-facile-sonochemical-synthesis-of-shell-stabilized-reactive-microbubbles-using-surface-thiolated-bovine-serum-albumin-with-the-traut-s-reagent
#7
Xiaochen Ma, Adrien Bussonniere, Qingxia Liu
The short lifetime of proteinaceous microbubbles produced using conventional sonication method has hindered their applications in drug delivery and metal removal from wastewater. In this study, we aimed to synthesize stable proteinaceous microbubbles and to demonstrate their reactivity. Our model protein, bovine serum albumin (BSA) was treated with 2-iminothiolane hydrochloride (Traut's reagent) to convert primary amines to thiols before the synthesis of microbubbles. Microbubbles produced with the Traut's reagent-treated BSA (BSA-SH MBs) were initially concentrated at median sizes of 0...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28069217/facile-high-yield-ultrasound-mediated-protocol-for-zno-hierarchical-structures-synthesis-formation-mechanism-optical-and-photocatalytic-properties
#8
Oana Carp, Alina Tirsoaga, Ramona Ene, Adelina Ianculescu, Raluca F Negrea, Paul Chesler, Gabriela Ionita, Ruxandra Birjega
Hierarchical flowers-like zinc oxide structures have been successfully obtained by a simple and fast ultrasound-assisted method performed in a ordinary ultrasonic bath using an ammonia solution and zinc acetate, in the absence of any surfactant or template. The composition, structure, crystallinity, morphology and optical properties of the materials obtained at different ultrasound irradiation times were characterized by infrared, UV-Vis and photoluminescence spectroscopy, X-ray diffraction, scanning and transmission electron microscopy investigations...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28068671/high-spatial-resolution-mapping-of-catalytic-reactions-on-single-particles
#9
Chung-Yeh Wu, William J Wolf, Yehonatan Levartovsky, Hans A Bechtel, Michael C Martin, F Dean Toste, Elad Gross
The critical role in surface reactions and heterogeneous catalysis of metal atoms with low coordination numbers, such as found at atomic steps and surface defects, is firmly established. But despite the growing availability of tools that enable detailed in situ characterization, so far it has not been possible to document this role directly. Surface properties can be mapped with high spatial resolution, and catalytic conversion can be tracked with a clear chemical signature; however, the combination of the two, which would enable high-spatial-resolution detection of reactions on catalytic surfaces, has rarely been achieved...
January 11, 2017: Nature
https://www.readbyqxmd.com/read/28067486/photo-cross-linkable-polymer-dots-with-stable-sensitizer-loading-and-amplified-singlet-oxygen-generation-for-photodynamic-therapy
#10
Ying Tang, Haobin Chen, Kaiwen Chang, Zhihe Liu, Yu Wang, Songnan Qu, Hong Xu, Changfeng Wu
Photodynamic therapy (PDT) is a promising treatment modality for clinical cancer therapy. However, the therapeutic effect of PDT is strongly dependent on the property of photosensitizer. Here, we developed photo-cross-linkable semiconductor polymer dots doped with photosensitizer Chlorin e6 (Ce6) to construct a nanoparticle platform for photodynamic therapy. Photoreactive oxetane groups were attached to the side chains of the semiconductor polymer. After photo-cross-linking reaction, the Ce6-doped Pdots formed an interpenetrated structure to prevent Ce6 leaching out from the Pdot matrix...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28044157/bis-amidinate-ligands-in-early-lanthanide-chemistry-synthesis-structures-and-hydroamination-catalysis
#11
Neda Kazeminejad, Denise Munzel, Michael T Gamer, Peter W Roesky
Bis(amidinate) ligands attached to rigid dibenzofuran and phenanthrene backbones have been introduced into lanthanide chemistry for the first time. Depending on the ligand and on the lanthanide source, either bi- and tetra-metallic macrocycles or monometallic complexes were obtained. The mono- and bi-metallic systems were compared in terms of their reactivity in the intramolecular hydroamination reaction. Depending on the catalyst used (mono vs. bimetallic) different rate laws were observed.
January 3, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28043901/mother-child-language-style-matching-predicts-children-s-and-mothers-emotion-reactivity
#12
Hannah F Rasmussen, Jessica L Borelli, Patricia A Smiley, Chloe Cohen, Ryan Cheuk Ming Cheung, Schuyler Fox, Matthew Marvin, Betsy Blackard
Co-regulation of behavior occurring within parent-child attachment relationships is thought to be the primary means through which children develop the capacity to regulate emotion, an ability that is protective across development. Existing research on parent-child co-regulation focuses predominantly on parent-infant dyads, and operationalizes co-regulation as the matching of facial expressions; however, matching can occur on other behaviors, including vocal tone, body movement, and language. Studies with young children find that greater matching is associated with children's lower emotion reactivity, but with unknown impacts on parents...
December 30, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/28038956/penicillin-acylase-and-o-aryloxycarbonyl-hydroxamates-two-acyl-enzymes-one-leading-to-hydrolysis-the-other-to-inactivation
#13
S A Adediran, R F Pratt
O-Aryloxycarbonyl hydroxamates have previously been shown to covalently inactivate serine/amine amidohydrolases such as class C β-lactamases and a N-terminal hydrolase, the proteasome. We report here reactions between O-aryloxycarbonyl hydroxamates and another N-terminal hydrolase, penicillin acylase. O-Aryloxycarbonyl hydroxamates, as non-symmetric carbonates, have two different leaving groups attached to the reactive central carbonyl group. We propose that these compounds can bind to the active site in either of two orientations and that either leaving group can be displaced from either orientation...
January 15, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28032259/role-of-the-nad-p-h-quinone-oxidoreductase-nqr-and-the-cytochrome-b-air12-in-controlling-superoxide-generation-at-the-plasma-membrane
#14
Catherine Biniek, Eiri Heyno, Jerzy Kruk, Francesca Sparla, Paolo Trost, Anja Krieger-Liszkay
The quinone reductase NQR and the b-type cytochrome AIR12 of the plasma membrane are important for the control of reactive oxygen species in the apoplast. AIR12 and NQR are two proteins attached to the plant plasma membrane which may be important for generating and controlling levels of reactive oxygen species in the apoplast. AIR12 (Auxin Induced in Root culture) is a single gene of Arabidopsis that codes for a mono-heme cytochrome b. The NADPH quinone oxidoreductase NQR is a two-electron-transferring flavoenzyme that contributes to the generation of O 2(•-) in isolated plasma membranes...
December 28, 2016: Planta
https://www.readbyqxmd.com/read/28029038/dual-electrochemiluminescence-signal-system-for-in-situ-and-simultaneous-evaluation-of-multiple-cell-surface-receptors
#15
Bin Zhou, Youyi Qiu, Qingqing Wen, Mingyao Zhu, Peihui Yang
A mutiplex cytosensor based on a dual electrochemiluminescence (ECL) signal system was fabricated for in situ and simultaneous detection of the expression levels of multiple cell-surface receptors, mannose and epidermal growth factor receptor (EGFR), using luminol-capped gold nanoparticles (Au@luminol) and CdS quantum dots (CdS QDs) as potential-resolved ECL nanoprobes. Two spatially resolved areas on indium tin oxide (ITO) electrodes were modified with polyaniline (PANI) by electropolymerization, on which gold nanoparticles (AuNPs) were attached to strengthen conductivity and stability of the sensing interface...
January 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28018270/psychological-effects-of-a-1-month-meditation-retreat-on-experienced-meditators-the-role-of-non-attachment
#16
Jesus Montero-Marin, Marta Puebla-Guedea, Paola Herrera-Mercadal, Ausias Cebolla, Joaquim Soler, Marcelo Demarzo, Carmelo Vazquez, Fernando Rodríguez-Bornaetxea, Javier García-Campayo
Background: There are few studies devoted to assessing the impact of meditation-intensive retreats on the well-being, positive psychology, and personality of experienced meditators. We aimed to assess whether a 1-month Vipassana retreat: (a) would increase mindfulness and well-being; (b) would increase prosocial personality traits; and (c) whether psychological changes would be mediated and/or moderated by non-attachment. Method: A controlled, non-randomized, pre-post-intervention trial was used. The intervention group was a convenience sample (n = 19) of experienced meditators who participated in a 1-month Vipassana meditation retreat...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/28011363/significant-changes-in-the-photo-reactivity-of-tio2-in-the-presence-of-a-capped-natural-dissolved-organic-matter-layer
#17
Hong Peng, Yuan Chen, Lu Mao, Xu Zhang
Natural dissolved organic matter (NDOM) in surface waters has a high sorption affinity for TiO2 during long contact. An attached NDOM layer can act as a conduction band electron and/or valance band hole acceptor, and NDOM can also decrease the concentration of hydroxyl radicals (OH) in the bulk phase. Therefore, the degradation kinetics and mechanism for degradation of acetaminophen on NDOM capped TiO2 (NDOM-TiO2) are significantly different from those on raw TiO2. Quantum calculation results suggest that hydroxylation to the ortho position in relation to the acetamide group is more favorable...
December 18, 2016: Water Research
https://www.readbyqxmd.com/read/28007960/prendb-a-substrate-prediction-database-to-enable-biocatalytic-use-of-prenyltransferases
#18
Jakub Gunera, Florian Kindinger, Shu-Ming Li, Peter Kolb
Prenyltransferases of the dimethylallyltryptophan synthase (DMATS 1 ) superfamily catalyze the attachment of prenyl or prenyl-like moieties to diverse acceptor compounds. These acceptor molecules are generally aromatic in nature and mostly indole or indole-like. Their catalytical transformation represent a major skeletal diversification step in the biosynthesis of secondary metabolites including the indole alkaloids. DMATS enzymes thus contribute significantly to the biological and pharmacological diversity of small molecule metabolites...
December 22, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28007575/the-mechanism-of-formation-structure-and-physiological-relevance-of-covalent-hemoglobin-attachment-to-the-erythrocyte-membrane
#19
Elizabeth M Welbourn, Michael T Wilson, Ashril Yusof, Metodi V Metodiev, Chris E Cooper
Covalent hemoglobin binding to membranes leads to band 3 (AE1) clustering and the removal of erythrocytes from the circulation; it is also implicated in blood storage lesions. Damaged hemoglobin, with the heme being in a redox and oxygen-binding inactive hemichrome form, has been implicated as the binding species. However, previous studies used strong non-physiological oxidants. In vivo hemoglobin is constantly being oxidised to methemoglobin (ferric), with around 1% of hemoglobin being in this form at any one time...
December 20, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27997174/lithium-enolates-in-the-enantioselective-construction-of-tetrasubstituted-carbon-centers-with-chiral-lithium-amides-as-noncovalent-stereodirecting-auxiliaries
#20
Kai Yu, Ping Lu, Jeffrey J Jackson, Thuy-Ai D Nguyen, Joseph Alvarado, Craig E Stivala, Yun Ma, Kyle A Mack, Trevor W Hayton, David B Collum, Armen Zakarian
Lithium enolates derived from carboxylic acids are ubiquitous intermediates in organic synthesis. Asymmetric transformations with these intermediates, a central goal of organic synthesis, are typically carried out with covalently attached chiral auxiliaries. An alternative approach is to utilize chiral reagents that form discrete, well-defined aggregates with lithium enolates, providing a chiral environment conducive of asymmetric bond formation. These reagents effectively act as noncovalent, or traceless, chiral auxiliaries...
December 20, 2016: Journal of the American Chemical Society
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