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Reactive Attachment

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https://www.readbyqxmd.com/read/28210728/self-initiation-of-uv-photopolymerization-reactions-using-tetrahalogenated-bisphenol-a-meth-acrylates
#1
Théophile Pelras, Wolfgang Knolle, Sergej Naumov, Katja Heymann, Olesya Daikos, Tom Scherzer
The potential of tetrachlorinated and tetrabrominated bisphenol A diacrylates and dimethacrylates for self-initiation of a radical photopolymerization was investigated. The kinetics of the photopolymerization of an acrylic model varnish containing halogenated monomers was studied by real-time FTIR spectroscopy, whereas the formation of reactive species and secondary products was elucidated by laser flash photolysis and product analysis by GC-MS after steady-state photolysis. The interpretation of the experimental data and the analysis of possible reaction pathways were assisted by quantum chemical calculations...
February 17, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28202687/oxidized-phagosomal-nox2-is-replenished-from-lysosomes
#2
Ilse Dingjan, Peter T A Linders, Luuk van den Bekerom, Maksim V Baranov, Partho Halder, Martin Ter Beest, Geert van den Bogaart
In dendritic cells, the NADPH oxidase 2 (NOX2) is recruited to the phagosomal membrane during antigen uptake. NOX2 produces reactive oxygen species (ROS) in the lumen of the phagosome which kill ingested pathogens, delay antigen breakdown and alter the peptide repertoire for presentation to T cells. How the integral membrane component of NOX2, cytochrome b558, traffics to phagosomes is incompletely understood. In this study, we show in dendritic cells derived from human blood-isolated monocytes that cytochrome b558 is initially recruited to the phagosome from the plasma membrane during phagosome formation...
February 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28202646/mussel-adhesion-essential-footwork
#3
REVIEW
J Herbert Waite
Robust adhesion to wet, salt-encrusted, corroded and slimy surfaces has been an essential adaptation in the life histories of sessile marine organisms for hundreds of millions of years, but it remains a major impasse for technology. Mussel adhesion has served as one of many model systems providing a fundamental understanding of what is required for attachment to wet surfaces. Most polymer engineers have focused on the use of 3,4-dihydroxyphenyl-l-alanine (Dopa), a peculiar but abundant catecholic amino acid in mussel adhesive proteins...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28199142/dc-stamp-is-an-osteoclast-fusogen-engaged-in-periodontal-bone-resorption
#4
W Wisitrasameewong, M Kajiya, A Movila, S Rittling, T Ishii, M Suzuki, S Matsuda, Y Mazda, M R Torruella, M M Azuma, K Egashira, M O Freire, H Sasaki, C Y Wang, X Han, M A Taubman, T Kawai
Dendritic cell-specific transmembrane protein (DC-STAMP) plays a key role in the induction of osteoclast (OC) cell fusion, as well as DC-mediated immune regulation. While DC-STAMP gene expression is upregulated in the gingival tissue with periodontitis, its pathophysiological roles in periodontitis remain unclear. To evaluate the effects of DC-STAMP in periodontitis, anti-DC-STAMP-monoclonal antibody (mAb) was tested in a mouse model of ligature-induced periodontitis ( n = 6-7/group) where Pasteurella pneumotropica ( Pp)-reactive immune response activated T cells to produce receptor activator of nuclear factor kappa-B ligand (RANKL), which, in turn, promotes the periodontal bone loss via upregulation of osteoclastogenesis...
February 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28195731/nucleophilic-aromatic-substitution-reactions-described-by-the-local-electron-attachment-energy
#5
Joakim Halldin Stenlid, Tore Brinck
A local multi-orbital electrophilicity descriptor, the local electron attachment energy [E(r)], is used to study the nucleophilic aromatic substitution reactions of SNAr and VNS (vicarious nucleophilic substitution). The E(r) considers all virtual orbitals below the free electron limit and is determined on the molecular isodensity contour of 0.004 a.u. Good (R2=0.83) to excellent (R2=0.98) correlations are found between descriptor values and experimental reactivity data for six series of electron-deficient arenes...
February 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28192960/rational-design-of-a-red-emissive-fluorophore-with-aie-and-esipt-characteristics-and-its-application-in-light-up-sensing-of-esterase
#6
Lu Peng, Shidang Xu, Xiaokun Zheng, Xiamin Cheng, Ruoyu Zhang, Jie Liu, Bin Liu, Aijun Tong
The development of red fluorophores with efficient solid-state emission is still challenging. Herein, a red fluorophore 1 with aggregation-induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) characteristics is rationally designed and facilely synthesized by attaching an electron-donor diethylamine and an electron-acceptor maleonitrile group to salicyladazine. In contrast to many red fluorophores which undergo serious aggregation-caused quenching (ACQ), compound 1 emits bright red fluorescence (λem = 650 nm, ΦF = 24...
February 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28187387/permeable-bio-reactive-barriers-to-address-petroleum-hydrocarbon-contamination-at-subantarctic-macquarie-island
#7
Benjamin L Freidman, Deborah Terry, Dan Wilkins, Tim Spedding, Sally L Gras, Ian Snape, Geoffrey W Stevens, Kathryn A Mumford
A reliance on diesel generated power and a history of imperfect fuel management have created a legacy of petroleum hydrocarbon contamination at subantarctic Macquarie Island. Increasing environmental awareness and advances in contaminant characterisation and remediation technology have fostered an impetus to reduce the environmental risk associated with legacy sites. A funnel and gate permeable bio-reactive barrier (PRB) was installed in 2014 to address the migration of Special Antarctic Blend diesel from a spill that occurred in 2002, as well as older spills and residual contaminants in the soil at the Main Power House...
January 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/28179303/sirna-based-analysis-of-the-abrogation-of-the-protective-function-of-membrane-associated-catalase-of-tumor-cells
#8
Georg Bauer
Tumor cells, in contrast to non-malignant cells, show sustained expression of membrane-associated NADPH oxidase-1 and therefore generate extracellular superoxide anions and their dismutation product H2O2 In order to prevent intercellular reactive oxygen species/reactive nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling, tumor cells need to express membrane-associated catalase that interferes with HOCl and nitric oxide/peroxynitrite signaling. Catalase is attached to tumor cells through the activity of transglutaminase-2 and is prevented from superoxide anion-dependent inhibition through coexpression of membrane-associated superoxide dismutase...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28170217/multifunctional-theranostics-for-dual-modal-photodynamic-synergistic-therapy-via-stepwise-water-splitting
#9
Dan Yang, Guixin Yang, Shili Gai, Fei He, Chunxia Li, Piaoping Yang
Combined therapy using multiple approaches has been demonstrated to be a promising route for cancer therapy. To achieve enhanced antiproliferation efficacy under hypoxic condition, here we report a novel hybrid system by integrating dual-model photodynamic therapies (dual-PDT) in one system. First, we attached core-shell structured up-conversion nanoparticles (UCNPs, NaGdF4:Yb,Tm@NaGdF4) on graphitic-phase carbon nitride (g-C3N4) nanosheets (one photosensitizer). Then, the as-fabricated nanocomposite and carbon dots (another photosensitizer) were assembled in ZIF-8 metal-organic frameworks through an in situ growth process, realizing the dual-photosensitizer hybrid system employed for PDT via stepwise water splitting...
February 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28159413/broad-spectrum-anti-infective-properties-of-benzisothiazolones-and-the-parallels-in-their-anti-bacterial-and-anti-fungal-effects
#10
P Gopinath, R K Yadav, P K Shukla, K Srivastava, S K Puri, K M Muraleedharan
Various mono- and bis-benzisothiazolone derivatives were synthesized and screened against different strains of bacteria and fungi in order to understand the effect of multiple electrophilic sulfur atoms and substitution pattern in the immediate vicinity of reactive sulfur. Staphyllococcus aureus-ATCC 7000699, MRSA and S. aureus-ATCC 29213 (Quality Control strain) were more susceptible to this class of compounds, and the most potent derivative 1.15 had MIC50 of 0.4μg/mL (cf. Gentamicin=0.78μg/mL). CLogP value, optimally in the range of 2...
January 12, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28148272/dose-dependent-induction-of-astrocyte-activation-and-reactive-astrogliosis-in-mouse-brain-following-maternal-exposure-to-carbon-black-nanoparticle
#11
Atsuto Onoda, Ken Takeda, Masakazu Umezawa
BACKGROUND: Recent studies indicate that maternal exposure to ambient ultrafine particles and nanoparticles has adverse effects of on the central nervous system. Quantitative dose-response data is required to better understand the developmental neurotoxicity of nanoparticles. The present study investigated dose-dependent effects of maternal exposure to carbon black nanoparticle (CB-NP) on astrocyte in the brains of mouse offspring. METHODS: A CB-NP suspension (2...
2, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28143999/3d-hydrogel-based-microwell-arrays-as-a-tumor-microenvironment-model-to-study-breast-cancer-growth
#12
John Casey, Xiaoshan Yue, DungTrung Nguyen, Aylin Acun, Victoria Zellmer, Siyuan Zhang, Pinar Zorlutuna
The tumor microenvironment (TME) is distinctly heterogeneous and is involved in tumor growth, metastasis, and drug resistance. Mimicking this diverse microenvironment is essential for understanding tumor growth and metastasis. Despite the substantial scientific progress made with traditional cell culture methods, microfabricated three-dimensional (3D) cell cultures that can be precisely controlled to mimic the changes occur in the TME over tumor progression are necessary for simulating organ-specific TME in vitro...
February 1, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28141706/attached-to-a-diagnosis-the-quandary-of-social-deficits-and-reactive-attachment-disorder
#13
Randall Phelps, Debra Eisert, Susan Schulz, Marilyn Augustyn
Alex is a 9-year-old boy brought to you, his primary care provider, for a "fifth opinion." You have cared for Alex since he was adopted from a Romanian orphanage at 3 years of age. He has been physically healthy with normal growth parameters and no evidence of fetal alcohol syndrome. Alex has long-standing history of social difficulties, impulsivity, lying, controlling, manipulative behaviors, violent outbursts at home with subsequent lack of remorse, and excessive chatter. You referred Alex to an interdisciplinary child development clinic 2 years ago, where he was diagnosed with reactive attachment disorder (RAD) and attention deficit hyperactivity disorder (ADHD)...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28139803/synthesis-of-tri-functionalized-mmp2-fret-probes-using-a-chemo-selective-and-late-stage-modification-of-unprotected-peptides
#14
Sean Oriana, Ye Cai, Jeffrey W Bode, Yoko Yamakoshi
A polymeric FRET probe for the detection of MMP2 was prepared using a new N-hydroxylamine derivative of lysine (1), which was successfully incorporated into the natural peptide sequence by solid phase peptide synthesis (SPPS). Following the attachment of a PEG group to the N-terminus, a peptide was cleaved from the resin. The fully-deprotected peptide-PEG conjugate was subsequently subjected to the α-ketoacid-hydroxylamine (KAHA) ligation and Michael addition of FRET donor (MCA) and acceptor (DNP) moieties, respectively...
January 31, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28128681/impact-of-periodontitis-case-criteria-a-cross-sectional-study-of-lifestyle
#15
Johanne Kongstad, Christian Enevold, Lisa Bøge Christensen, Nils-Erik Fiehn, Palle Holmstrup
BACKGROUND: Associations of risk factors/indicators with periodontitis may depend on the included case criterion. The objective was to evaluate differences in outcome by applying five periodontitis case definitions for cross-sectional associations with lifestyle factors among participants of The Danish Health Examination Survey (DANHES). METHODS: A total of 4,402 adults aged 18-96 years from the general health examination of DANHES had a periodontal examination consisting of half-mouth registration at 6 sites per tooth including probing pocket depth (PPD) and clinical attachment level (CAL)...
January 27, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28128060/proteoglycans-and-diabetes
#16
Linda Hiebert
BACKGROUND: Most proteoglycans are heterogeneous molecules composed of a protein core with glycosaminoglycans (GAGs) attached. GAGs are highly negatively charged molecules that readily bind to enzymes, growth factors, cytokines etc. and as such have many functions. The role played by proteoglycans in diabetes has only recently been investigated. METHODS: The importance of proteoglycans and the effects of diabetes on proteoglycans are discussed. Possible strategies for reducing diabetic complications associated with preventing proteoglycan destruction are examined...
January 25, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28126657/a-study-of-attachment-disorders-in-young-offenders-attending-specialist-services
#17
Kate Moran, Jennifer McDonald, Alison Jackson, Sue Turnbull, Helen Minnis
Attachment disorders, specifically Reactive Attachment Disorder (RAD) and Disinhibited Social Engagement Disorder (DSED) are disorders associated with neglect and abuse in which people have significant difficulties relating to others. This study aims to explore Attachment Disorder symptoms and diagnoses in young offenders and factors that may be associated with them such as mental health problems. A cross-sectional design was used with 29 young people who were known to Intensive Services, aged 12-17 (M=16.2, SD=1...
January 23, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28126350/peptostreptococcus-anaerobius-induces-intracellular-cholesterol-biosynthesis-in-colon-cells-to-induce-proliferation-and-causes-dysplasia-in-mice
#18
Ho Tsoi, Eagle Sh Chu, Xiang Zhang, Jianqiu Sheng, Daniel Nakatsu, Siew C Ng, Anthony Wh Chan, Francis Kl Chan, Joseph Jy Sung, Jun Yu
BACKGROUND & AIMS: Stool samples from patients with colorectal cancer (CRC) have a higher abundance of Peptostreptococcus anaerobius than stool from individuals without CRC, based on metagenome sequencing. We investigated whether P anaerobius contributes to colon tumor formation in mice and its possible mechanisms of carcinogenesis. METHODS: We performed quantitative PCR analyses to measure P anaerobius in 112 stool samples and 255 colon biopsies from patients with CRC or advanced adenoma and from healthy individuals (controls) undergoing colonoscopy examination at hospitals in Hong Kong and Beijing...
January 23, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28124705/responsive-mesoporous-silica-nanoparticles-for-sensing-of-hydrogen-peroxide-and-simultaneous-treatment-toward-heart-failure
#19
Si Yu Tan, Cathleen Teh, Chung Yen Ang, Menghuan Li, Peizhou Li, Vladimir Korzh, Yanli Zhao
Chronic heart failure is often characterized by the elevated amounts of reactive oxygen species such as hydrogen peroxide (H2O2) in the heart. Thus, it is of importance that selective release of therapeutic drugs occurs at the heart failure site to maximize therapeutic effects. In this work, functional mesoporous silica nanoparticles (MSNPs) were developed for detection of H2O2, selective drug release and controlled treatment toward heart failure. The H2O2-sensitive probe was attached to the surface of the MSNPs, and a therapeutic drug of heart failure, captopril, was loaded within the pores of the MSNPs and retained by the binding of α-cyclodextrin to the probe...
January 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28112235/nanoscale-topography-on-black-titanium-imparts-multi-biofunctional-properties-for-orthopedic-applications
#20
Jafar Hasan, Shubham Jain, Kaushik Chatterjee
We have developed a chlorine based reactive ion etching process to yield randomly oriented anisotropic nanostructures that render the titanium metal surface 'black' similar to that of black silicon. The surface appears black due to the nanostructures in contrast to the conventional shiny surface of titanium. The nanostructures were found to kill bacteria on contact by mechanically rupturing the cells as has been observed previously on wings of certain insects. The etching was optimized to yield nanostructures of ≈1 μm height for maximal bactericidal efficiency without compromising cytocompatibility...
January 23, 2017: Scientific Reports
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