Jamary Oliveira-Filho, Ana C P Ornellas, Cathy R Zhang, Luciana M B Oliveira, Théo Araújo-Santos, Valeria M Borges, Laís M G B Ventura, Francisco J F B Reis, Roque Aras, André M Fernandes, Jonathan Rosand, Steven M Greenberg, Karen L Furie, Natalia S Rost
BACKGROUND: To investigate the effect of COX-2 polymorphism and its product, prostaglandin E2 (PGE2), on stroke risk in an endemic area for Chagas disease. In a separate cohort, to investigate the effect of COX-2 polymorphisms on the total burden of cerebral white matter disease. METHODS: Cases were outpatients with ischemic stroke; controls were stroke-free subjects from 2 outpatient clinics (heart failure and caregivers of a movement disorders clinic). We extracted DNA from total blood to investigate the rs20417 COX-2 polymorphism...
August 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association