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Apoptosis and anesthesia

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https://www.readbyqxmd.com/read/29770794/ursodeoxycholic-acid-protects-interstitial-cajal-like-cells-in-the-gallbladder-from-undergoing-apoptosis-by-inhibiting-tnf-%C3%AE-expression
#1
Jiang-Fan Wan, Shi-Feng Chu, Xin Zhou, Yue-Ting Li, Wen-Bin He, Feng Tan, Piao Luo, Qi-di Ai, Qi Wang, Nai-Hong Chen
Hypomotility is a common symptom of gallstone disease, which is accompanied by a loss of interstitial Cajal-like cells (ICLCs) in the gallbladder. Ursodeoxycholic acid (UDCA) is widely used in treating gallstone disease, and has shown anti-apoptotic and anti-inflammatory effects apart from its ability to dissolve gallstones. In this study, we investigated the anti-apoptotic and anti-inflammatory effects of UDCA on ICLCs in guinea pigs with gallstones. Guinea pigs were fed a high-cholesterol diet for 8 weeks to induce the formation of gallstones...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29749446/anesthetic-effects-of-isoflurane-and-the-molecular-mechanism-underlying-isoflurane%C3%A2-inhibited-aggressiveness-of-hepatic-carcinoma
#2
Jing Hu, Jingli Hu, Hongmei Jiao, Qingguo Li
Anesthesia is produced by drugs or other methods, and refers to the attenuation of pain via reversible suppression of neuronal transmission in the central and peripheral nervous systems, during surgery. Clinical investigations have indicated that the anesthetic action of isoflurane is efficient to alleviate pain during tumor resection clinical trials. In addition, it has been reported that isoflurane can induce caspase‑3 activation and is associated with apoptosis of tumor cells. The present study investigated the anesthetic effects and molecular mechanisms underlying isoflurane‑induced apoptosis in patients with hepatic carcinoma...
May 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29684861/inhibition-of-gastric-cancer-by-local-anesthetic-bupivacaine-through-multiple-mechanisms-independent-of-sodium-channel-blockade
#3
Jiapeng Dan, Xiaodan Gong, Dezhan Li, Guanhua Zhu, Lishen Wang, Fang Li
BACKGROUND: Retrospective studies of patients undergoing cancer surgery suggest the use of local anesthesia may decrease tumor recurrence and improve survival. The mechanisms on the benefits of local anesthesia on cancer recurrence are complex and remain to be elucidated. METHODS: This study investigated the effects of bupivacaine on various cellular activities of gastric cancer using proliferation, migration, apoptosis assay. The underlying mechanism was analyzed focusing on mitochondrial functions and the activities of Rho family members...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29593226/caffeine-augments-anesthesia-neurotoxicity-in-the-fetal-macaque-brain
#4
Kevin K Noguchi, Stephen A Johnson, Francesca M Manzella, Kobe L Masuoka, Sasha L Williams, Lauren D Martin, Gregory A Dissen, Chrysanthy Ikonomidou, Katie J Schenning, John W Olney, Ansgar M Brambrink
Caffeine is the most frequently used medication in premature infants. It is the respiratory stimulant of choice for apnea associated with prematurity and has been called the silver bullet in neonatology because of many proven benefits and few known risks. Research has revealed that sedative/anesthetic drugs trigger apoptotic death of neurons and oligodendrocytes in developing mammalian brains. Here we evaluated the influence of caffeine on the neurotoxicity of anesthesia in developing nonhuman primate brains...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29578002/inhibition-of-microrna-34a-protects-against-propofol-anesthesia-induced-neurotoxicity-and-cognitive-dysfunction-via-the-mapk-erk-signaling-pathway
#5
Guang Feng Li, Su Jing Zhuang, Guang Cai Li
AIM: To investigate the protective effect of microRNA-34a (miR-34a) on propofol-induced neurotoxicity and cognitive dysfunction. METHODS: After SH-SY5Y cells were treated with propofol to induce neurotoxicity, microRNA-34a mimics and inhibitors were transfected into the cells. The expression of apoptosis-related genes and the proteins were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot. Sprague-Dawley (SD) rats received intraperitoneal injections of propofol, and were treated with microRNA-34a mimics and lentivirus-mediated microRNA-34a inhibitors...
March 22, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29545833/microrna-383-upregulation-protects-against-propofol-induced-hippocampal-neuron-apoptosis-and-cognitive-impairment
#6
Xinlei Wang, Guoyou Ding, Wei Lai, Shiwen Liu, Jun Shuai
Anesthesia-induced cognitive impairment is a recognized clinical phenomenon. The present study aimed to investigate the effect of microRNA-383 (miR-383) expression on propofol-induced learning and memory impairment. In total, 48 male Sprague-Dawley rats (weight, 250±10 g) were randomly divided into four groups (n=12 each): Control group, and three groups of rats that were anesthetized with propofol for 6 h and untreated (propofol model group), treated with a constructed lentivirus vector expressing miR-383 mimics (mimic + propofol group), or treated with miR-383 scramble (scramble + propofol group)...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29541166/mechanism-of-gastrodin-in-cell-apoptosis-in-rat-hippocampus-tissue-induced-by-desflurane
#7
Luping Wang, Hushan Wang, Zongsheng Duan, Jian Zhang, Wenwen Zhang
This study investigated the protective effect ofgastrodin on cell apoptosis in rats hippocampus tissues induced by desflurane to explore its mechanism. A total of 36 rats were randomly divided into three groups: Blank control group (C group, n=12), desflurane anesthesia group (DF group, n=12) and gastrodin treatment group (GT group, n=12). Rats in DF group were treated with anesthesia using desflurane. Rats in GT group were treated with gavage using gastrodin and the same treatment as DF group. After the experiment, novel object recognition test and water maze test were performed...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29539279/variant-intestinal-cell-kinase-in-juvenile-myoclonic-epilepsy
#8
Julia N Bailey, Laurence de Nijs, Dongsheng Bai, Toshimitsu Suzuki, Hiroyuki Miyamoto, Miyabi Tanaka, Christopher Patterson, Yu-Chen Lin, Marco T Medina, María E Alonso, José M Serratosa, Reyna M Durón, Viet H Nguyen, Jenny E Wight, Iris E Martínez-Juárez, Adriana Ochoa, Aurelio Jara-Prado, Laura Guilhoto, Yolly Molina, Elsa M Yacubian, Minerva López-Ruiz, Yushi Inoue, Sunao Kaneko, Shinichi Hirose, Makiko Osawa, Hirokazu Oguni, Shinji Fujimoto, Thierry M Grisar, John M Stern, Kazuhiro Yamakawa, Bernard Lakaye, Antonio V Delgado-Escueta
BACKGROUND: In juvenile myoclonic epilepsy, data are limited on the genetic basis of networks promoting convulsions with diffuse polyspikes on electroencephalography (EEG) and the subtle microscopic brain dysplasia called microdysgenesis. METHODS: Using Sanger sequencing, we sequenced the exomes of six members of a large family affected with juvenile myoclonic epilepsy and confirmed cosegregation in all 37 family members. We screened an additional 310 patients with this disorder for variants on DNA melting-curve analysis and targeted real-time DNA sequencing of the gene encoding intestinal-cell kinase ( ICK)...
March 15, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29488606/isoflurane-reduces-pain-and-inhibits-apoptosis-of-myocardial-cells-through-the-phosphoinositide-3-kinase-protein-kinase-b-signaling-pathway-in-mice-during-cardiac-surgery
#9
Zhibing Pi, Hai Lin, Jianping Yang
Heart bypass surgery is the most common treatment for myocardial ischemia. Clinical investigations have revealed that isoflurane anesthesia is efficient to alleviate pain during cardiac surgery, including heart bypass surgery. Previous studies have revealed the protective effects of isoflurane on myocardial cells of patients with myocardial ischemia during the perioperative period. The present study aimed to investigate the mechanism underlying the protective effects of isoflurane on myocardial cells in mice with myocardial ischemia...
May 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29456493/administration-of-ketamine-causes-autophagy-and-apoptosis-in-the-rat-fetal-hippocampus-and-in-pc12-cells
#10
Xinran Li, Yanan Li, Jinghua Zhao, Lina Li, Yuxin Wang, Yiming Zhang, Yue Li, Yu Chen, Wenhan Liu, Li Gao
Drug abuse during pregnancy is a serious problem. Like alcohol, anticonvulsants, sedatives, and anesthetics, such as ketamine, can pass through the placental barrier and affect the growing fetus. However, the mechanism by which ketamine causes damage to fetal rats is not well understood. Therefore, in this study, we anesthetized pregnant rats with ketamine and evaluated the Total Antioxidant Capacity (T-AOC), Reactive Oxygen Species (ROS), and Malondialdehyde (MDA). Moreover, we determined changes in the levels of Cleaved-Caspase-3 (C-Caspase-3), Beclin-1, B-cell lymphoma-2 (Bcl-2), Bcl-2 Associated X Protein (Bax), Autophagy-related gene 4 (Atg4), Atg5, p62 (SQSTM1), and marker of autophagy Light Chain 3 (LC3)...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29447230/propofol-induces-a-metabolic-switch-to-glycolysis-and-cell-death-in-a-mitochondrial-electron-transport-chain-dependent-manner
#11
Chisato Sumi, Akihisa Okamoto, Hiromasa Tanaka, Kenichiro Nishi, Munenori Kusunoki, Tomohiro Shoji, Takeo Uba, Yoshiyuki Matsuo, Takehiko Adachi, Jun-Ichi Hayashi, Keizo Takenaga, Kiichi Hirota
The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia and sedation in critical patient care. However, the rare but severe complication propofol infusion syndrome (PRIS) can occur, especially in patients receiving high doses of propofol for prolonged periods. In vivo and in vitro evidence suggests that the propofol toxicity is related to the impaired mitochondrial function. However, underlying molecular mechanisms remain unknown. Therefore, we investigated effects of propofol on cell metabolism and death using a series of established cell lines of various origins, including neurons, myocytes, and trans-mitochondrial cybrids, with defined mitochondrial DNA deficits...
2018: PloS One
https://www.readbyqxmd.com/read/29441990/the-autophagy-inhibitor-3-methyladenine-restores-sevoflurane-anesthesiainduced-cognitive-dysfunction-and-neurons-apoptosis
#12
Xiaoyu Xiao, Yingxian Zhu, Juyuan Bu, Guowei Li, Zibin Liang, Lukun Yang, Bingzong Hou
This study was designed to explore the effect of 3-methyladenine (3-MA) on sevoflurane anesthesia-induced cognitive dysfunction. A total of 60 C57BL/6 (5-8 months old) mice were randomly arranged into 3 groups: Control, sevoflurane (Sev) and Sev+3-MA group with 3-MA administration was performed during Sev administration. Morris water maze and Y-maze test were performed to examine the behavioral disorders. Moreover, hippocampal neuronal cell apoptosis and expression of autophagy related genes were detected. Sevoflurane induced cognitive dysfunction in mice showing significant longer escape latency, lower number of correct response, higher apoptotic neurons, and higher expression of autophagy related genes...
April 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29438409/the-effect-of-transient-oxygenation-on-stem-cell-mobilization-and-ischemia-reperfusion-heart-injury
#13
Rintaro Yano, Chiaki Inadomi, Lan Luo, Shinji Goto, Tetsuya Hara, Tao-Sheng Li
For general anesthesia, pre-oxygenation is routinely performed prior to intubation. It is well-known that ischemic/hypoxic preconditioning induces stem cell mobilization and protects against ischemia/reperfusion (I/R) injury. In this study, we investigated the effect of transient oxygenation on stem cell mobilization and I/R injury of the heart. Mice were exposed to 100% oxygen for 5 or 20 minutes. We evaluated the number of c-kit+ stem/progenitor cells and the levels of SDF-1α and VEGF in peripheral blood at 1, 3, 6, and 24 hours after oxygenation...
2018: PloS One
https://www.readbyqxmd.com/read/29416797/hydrogen-protects-against-liver-injury-during-co-2-pneumoperitoneum-in-rats
#14
Mingzi Chen, Lihong Jiang, Yue Li, Ge Bai, Jinghua Zhao, Ming Zhang, Jiantao Zhang
The aim of the current study was to identify the protective effect of hydrogen gas against liver injury during CO2 pneumoperitoneum. Rats were randomly divided into three groups: control group (C group), pneumoperitoneum group (P15 group) and hydrogen group (H2 group). Rats in the C group were subjected to anesthesia for 90 min. Rats in the P15 group received an abdominal insufflation of CO2 for 90 min at an intra-abdominal pressure of 15 mmHg. Rats in the H2 group received a hypodermic injection of hydrogen gas (0...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29412077/transient-effects-of-anesthesia-on-leukocyte-apoptosis-and-monocyte-cytokine-stimulation-a-clinical-study
#15
Paraskevi Matsota, Georgia Kostopanagiotou, Konstantinos Kalimeris, Ageliki Pandazi, Antigone Kotsaki, Styliani Kontogiannopoulou, Evangelos J Giamarellos-Bourboulis
The effects of anesthetics on immune cell apoptosis and cytokine stimulation were studied in a prospective study. American Society of Anesthesiologists I/II patients underwent elective inguinal hernia repair or varicose veins stripping surgery and were randomized to either epidural anesthesia (n = 14) or general anesthesia with sevoflurane (n = 19) or propofol (n = 15). Blood was sampled before anesthesia induction (T0), at the end of surgery (T1), and 6 h later (T2). Apoptosis was determined by ANNEXIN-V staining of white blood cells; monocytes were isolated and stimulated for cytokine production...
May 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29382532/cordycepin-rescues-lidocaine-induced-neurotoxicity-in-dorsal-root-ganglion-by-interacting-with-inflammatory-signaling-pathway-mmp3
#16
Hongli Kan, Yang Wang, Dongxin Wang, Hong Sun, Shu Zhou, Huaiwu Wang, Jian Guan, Ming Li
Application of local anesthetic reagents, such as lidocaine (Lid), could cause significant neurotoxicity in spinal cord dorsal root ganglia neurons (DRGNs). In this study, we investigated the potential rescuing effect of cordycepin (CDC) in an in vitro explant model of lidocaine-induced apoptosis in DRGNs. Explant of rat neonatal DRGNs was prepared, and treated with Lid in vitro to induce neuronal apoptosis. Prior to Lid treatment, DRGN explant was pre-incubated with various concentrations of CDC to evaluate its rescuing effect on Lid-induced apoptosis...
May 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29379356/effect-of-sevoflurane-and-halothane-anesthesia-on-cognitive-function-and-immune-function-in-young-rats
#17
Jian-Hua Qin, Xue-Rong Zhang, Liang He, Jun Zhu, Qing-Jun Ma
In the current study, we scrutinized the effect of sevoflurane and halothane on cognitive and immune function in young rats. The rats were divided into following groups: sevoflurane, halothane and sevoflurane + halothane groups, respectively. The rats were regularly treated with the pre-determined treatment. We also scrutinized the serum proinflammatory cytokines including IL-10, IL-4 and IL-2; brain level IL-1β; hippocampal neuronal apoptosis concentration were estimated. The water maze test was performed in rats for the estimation of cognitive ability...
January 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29375720/propofol-promotes-apoptosis-and-suppresses-the-hotair-mediated-mtor-p70s6k-signaling-pathway-in-melanoma-cells
#18
Zhiwei Shang, Haixia Feng, Lisha Cui, Weiping Wang, Hongwei Fu
Propofol is an intravenous anesthetic, which is widely used in clinical anesthesia induction and maintenance and is critical in the sedation of patients. However, the functions and mechanisms of propofol on apoptosis of melanoma cells remain unclear. The present study investigated whether propofol promotes cell apoptosis and suppresses the HOX transcript antisense RNA (HOTAIR)-mediated mechanistic target of rapamycin (mTOR) pathway in melanoma cells. B16F10 cells were cultured with different concentrations (0-10 µM) of propofol for 24 or 48 h...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29347949/effects-of-surgery-and-anesthetic-choice-on-immunosuppression-and-cancer-recurrence
#19
REVIEW
Ryungsa Kim
BACKGROUND: The relationship between surgery and anesthetic-induced immunosuppression and cancer recurrence remains unresolved. Surgery and anesthesia stimulate the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) to cause immunosuppression through several tumor-derived soluble factors. The potential impact of surgery and anesthesia on cancer recurrence was reviewed to provide guidance for cancer surgical treatment. METHODS: PubMed was searched up to December 31, 2016 using search terms such as, "anesthetic technique and cancer recurrence," "regional anesthesia and cancer recurrence," "local anesthesia and cancer recurrence," "anesthetic technique and immunosuppression," and "anesthetic technique and oncologic surgery...
January 18, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29246852/lin28b-and-sox2-regulate-anesthesia-induced-neural-degeneration-in-neural-stem-cell-derived-neurons
#20
Fangfang Zhang, Shiping Wang, Chen Lv, Mei Zhang, Liuying Yang, Xiaowen Guo
Ketamine, a commonly used anesthetic compound, may cause neurotoxicity in immature or developing brains. In this study, we indented to understand the molecular expression and functional role of Lin-28 Homolog B (lin28b) in regulating ketamine-induced neurotoxicity in neural stem cells (NSCs)-differentiated neurons. NSCs from embryonic rat brains were cultured in vitro, and induced toward neuronal differentiation. NSCs-differentiated neurons were treated with various concentrations of ketamine for 24h to evaluate the concentration-dependent effect of ketamine on endogenous lin28b mRNA level...
February 5, 2018: European Journal of Pharmacology
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