Ke Nan, Ziwen Zhong, Ying Yue, Wenchang Zhou, Xingfeng Sun, Yang Shen, Mengdi Qu, Zhaoyuan Chen, Jiahui Gu, Caihong Sun, Xun Sun, Lihong Lu, Jie Zhang, Changhong Miao, Minli Sun
BACKGROUND: HSK3486 (ciprofol), a new candidate drug similar to propofol, exerts sedative and hypnotic effects through gamma-aminobutyric acid type A receptors; however, its potential role in colorectal cancer is currently unknown. AIMS: This study aimed to evaluate the effects of HSK3486 on colorectal cancer cell proliferation. METHODS: Imaging was performed to detect reactive oxygen species and mitochondrial membrane potential. Western blotting was used to determine the expression of target signals...
February 20, 2024: Digestive Diseases and Sciences