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https://www.readbyqxmd.com/read/28534601/management-of-psoriatic-arthritis-psa-among-cutaneous-psoriasis-from-pathogenesis-to-therapy
#1
Pauline Hoelt, Cyrille Confavreux, Denis Jullien, Axel P Villani
Psoriatic arthritis (PsA) is an inflammatory rheumatism belonging to spondylarthritis family and which occurs in about 30% of patients with psoriasis. The pathogenesis entails a genetic predisposition, environmental and immunologic factors. Most of the time, cutaneous lesions precede apparition of articular manifestations and dermatologists who treat psoriatic patients have to regularly screen for early PsA, especially in patients with risk factors (notably nail psoriasis). Early detection greatly increases the chances for successful treatment and can prevent slow joint destruction...
May 23, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28501804/exercise-and-other-non-pharmaceutical-interventions-for-cancer-related-fatigue-in-patients-during-or-after-cancer-treatment-a-systematic-review-incorporating-an-indirect-comparisons-meta-analysis
#2
REVIEW
Roger Hilfiker, Andre Meichtry, Manuela Eicher, Balfe Lina Nilsson, Ruud H Knols, Martin L Verra, Jan Taeymans
AIM: To assess the relative effects of different types of exercise and other non-pharmaceutical interventions on cancer-related fatigue (CRF) in patients during and after cancer treatment. DESIGN: Systematic review and indirect-comparisons meta-analysis. DATA SOURCES: Articles were searched in PubMed, Cochrane CENTRAL and published meta-analyses. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised studies published up to January 2017 evaluating different types of exercise or other non-pharmaceutical interventions to reduce CRF in any cancer type during or after treatment...
May 13, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28501048/systematic-review-of-evidence-underpinning-non-pharmacological-therapies-in-dementia
#3
Richard Olley, Andrea Morales
Objective Dementia is one of the most common illnesses worldwide, and is one of the most important causes of disability in older people. Currently, dementia affects over 35million people around the globe. It is expected that this number will increase to 65.7million by 2030. Early detection, diagnosis and treatment to control the principal behaviour symptoms may help reduce these numbers and delay the progression to more advanced and dangerous stages of this disorder with resultant increase quality of life for those affected...
May 15, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28441894/self-directed-exercise-in-multiple-sclerosis-evaluation-of-a-home-automated-tele-management-system
#4
Susan S Conroy, Min Zhan, William J Culpepper, Walter Royal, Mitchell T Wallin
Introduction Physical rehabilitation is one of the few non-pharmaceutical therapies for maintaining or improving walking ability for patients with multiple sclerosis. However, travel distance to rehabilitation clinics, neurological disability and insurance coverage often limit access to specialised rehabilitation services. To address these issues, we utilised a web-based system to support a home-based self-directed exercise programme. Methods Patients ( n = 24) were randomised to either routine home rehabilitation or to the multiple sclerosis home automated tele-management system for a six-month period...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28416027/pharmacological-and-non-pharmacological-treatment-preferences-of-healthcare-professionals-and-proxies-for-challenging-behaviors-in-patients-with-dementia
#5
Sarah I Janus, Jeannette G van Manen, Janine A van Til, Sytse U Zuidema, Maarten J IJzerman
BACKGROUND: Prescribing antipsychotics to patients with neuropsychiatric symptoms is a matter of concern. Physicians have to make treatment decisions for patients with dementia together with proxies and/or nurses. However, it is unknown whether physicians, nurses, and proxies' treatment preferences are aligned; hence this study. METHODS: Sixteen treatment attributes were selected to elicit the preferences of physicians and nurses. Ten of these attributes were used for the proxies...
April 18, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28393216/cancer-induced-cardiac-cachexia-pathogenesis-and-impact-of-physical-activity-review
#6
Yassine Belloum, Françoise Rannou-Bekono, François B Favier
Cachexia is a wasting syndrome observed in many patients suffering from several chronic diseases including cancer. In addition to the progressive loss of skeletal muscle mass, cancer cachexia results in cardiac function impairment. During the severe stage of the disease, patients as well as animals bearing cancer cells display cardiac atrophy. Cardiac energy metabolism is also impeded with disruption of mitochondrial homeostasis and reduced oxidative capacity, although the available data remain equivocal. The release of inflammatory cytokines by tumor is a key mechanism in the initiation of heart failure...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28300617/sex-and-gender-related-prevalence-cardiovascular-risk-and-therapeutic-approach-in-metabolic-syndrome-a-review-of-the-literature
#7
REVIEW
Giacomo Pucci, Riccardo Alcidi, Lisanne Tap, Francesca Battista, Francesco Mattace-Raso, Giuseppe Schillaci
Metabolic syndrome (MS), a cluster of metabolic abnormalities linked to insulin-resistance and abdominal obesity, is associated with an increased risk of Type II diabetes mellitus (DM) and cardiovascular (CV) disease. Its prevalence is high, affecting 20%-30% of the general population, and increases with age in a sex-specific manner: in fact, while below 50 years it is slightly higher in men, it reverses after 50 years. The pronounced age-related increase in the prevalence of MS in women occurs as the result of several factors, which may be classified into sex- and gender-related factors...
June 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28247580/analysis-of-non-pharmacological-interventions-attempted-prior-to-pro-re-nata-medication-use
#8
Krystle Martin, Vinita Arora, Ilan Fischler, Renee Tremblay
The aim of the present study was to elucidate what non-pharmacological interventions are applied by nursing staff prior to the administration of psychotropic pro re nata (PRN) medication. Best practices would instruct clinical staff to provide non-pharmacological strategies, such as de-escalation and skills coaching, as the first response to patient distress, anxiety, or agitation. Non-pharmacological strategies might be safer for patients, promote more collaborative relationships, and facilitate greater skills development for managing symptoms...
March 1, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28162355/-547-chronic-pain-refectory-to-opioids-treated-with-non-pharmaceutical-measures-using-an-interdisciplinary-inpatient-team
#9
C Reeves, J Standley, L Kelleher, J Murphy, E Galang, A Patel, J Frye
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28155101/intermittent-hypoxia-revisited-a-promising-non-pharmaceutical-strategy-to-reduce-cardio-metabolic-risk-factors
#10
Guillaume Costalat, Frederic Lemaitre, Barbara Tobin, Gillian Renshaw
PURPOSE: The study aims to investigate the effects of moderate intermittent hypoxia (IH) on key cardio-metabolic risk factors in overweight and obese subjects. METHODS: Six subjects were exposed to 10 sessions of moderate IH over 2 weeks (based on [Formula: see text]; ~70 min per session). Measures were made of blood glucose (GLU) and lactate (La(-)); high (HDLc) and low-density lipoproteins (LDLc); triglycerides (TRG), systolic (SBP), and diastolic blood pressure (DBP); and cardiac autonomic indices [root mean square of successive R-R interval differences (RMSSD) and short-term fractal scaling exponent (DFAα1)]...
February 2, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28110588/neuroprotective-effects-of-adjunctive-treatments-for-acute-stroke-thrombolysis-a-review-of-clinical-evidence
#11
Hongxing Zhou, Suyun Huang, Gavin Sunnassee, Weiyu Guo, Jian Chen, Yang Guo, Sheng Tan
The narrow therapeutic time window and risk of intracranial hemorrhage largely restrict the clinical application of thrombolysis in acute ischemic stroke. Adjunctive treatments added to rt-PA may be beneficial to improve the capacity of neural cell to withstand ischemia, and to reduce the hemorrhage risk as well. This review aims to evaluate the neuroprotective effects of adjunctive treatments in combination with thrombolytic therapy for acute ischemic stroke. Relevant studies were searched in the PubMed, Web of Science and EMBASE database...
February 7, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28068563/a-review-fentanyl-and-non-pharmaceutical-fentanyls
#12
REVIEW
Joji Suzuki, Saria El-Haddad
BACKGROUND: Fentanyl and non-pharmaceutical fentanyls (NPFs) have been responsible for numerous outbreaks of overdoses all over the United States since the 1970s. However, there has been a growing concern in recent years that NPFs are contributing to an alarming rise in the number of opioid-related overdoses. METHODS: The authors conducted a narrative review of the published and grey literature on fentanyl and NPFs in PubMed, Google Scholar, and Google using the following search terms: "fentanyl", "non-pharmaceutical fentanyl", "fentanyl analogs", "fentanyl laced heroin" and "fentanyl overdose"...
February 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28042768/blood-serum-atherogenicity-cellular-test-for-the-development-of-anti-atherosclerotic-therapy
#13
Veronika A Myasoedova, Galina A Ivashinnikova, Igor A Sobenin, Ekaterina A Ivanova, Alexander N Orekhov
Atherosclerosis is one of the main problems in modern medical practice. This multifactorial disease can remain asymptomatic for a long time before manifesting itself in cardiovascular disorders, causing ischemic heart disease, myocardial infarction and even sudden death. Many synthetic drugs have been developed to reduce the symptoms of atherosclerosis, however, their efficacy in terms of reduction of atherosclerotic lesions progression is a matter of debate. Adverse effects of the exiting therapy should also be taken into account...
January 2, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27995830/mechanisms-responsible-for-the-hypocholesterolaemic-effect-of-regular-consumption-of-probiotics
#14
S A Reis, L L Conceição, D D Rosa, N P Siqueira, M C G Peluzio
CVD affect a large proportion of the world's population, with dyslipidaemia as the major risk factor. The regular consumption of both probiotic bacteria and yeast has been associated with improvement in the serum lipid profile. Thus, the present review aims to describe and discuss the potential mechanisms responsible for the hypocholesterolaemic effect of regular consumption of probiotic bacteria and yeast. Regarding the hypocholesterolaemic effect of probiotic bacteria, the potential mechanisms responsible include: deconjugation of bile salts; modulation of lipid metabolism; and decreased absorption of intestinal cholesterol through co-precipitation of intestinal cholesterol with the deconjugated bile salts, incorporation and assimilation of cholesterol in the cell membrane of the probiotics, intestinal conversion of cholesterol in coprostanol, and inhibition of the expression of the intestinal cholesterol transporter Niemann-Pick C1 like 1 (NPC1L1) in the enterocytes...
December 20, 2016: Nutrition Research Reviews
https://www.readbyqxmd.com/read/27994443/relationship-between-patients-knowledge-and-medication-adherence-among-patients-with-hypertension
#15
Beata Jankowska-Polańska, Izabella Uchmanowicz, Krzysztof Dudek, Grzegorz Mazur
OBJECTIVE: The purpose of this study was to investigate the relationship between knowledge on arterial hypertension (AH) and its management, and adherence to pharmaceutical treatment. METHODS: The study included 233 patients diagnosed with AH and treated with hypotensive drugs for at least 1 year. The 8-item © Morisky Medication Adherence Scale (MMAS-8) and the Hypertension Knowledge-Level Scale (HK-LS) were used. RESULTS: Sixty-three percent of the patients had a low level of knowledge on AH, with the smallest proportion of correct answers provided for items related to non-pharmaceutical treatment, diet, hypertension definition, and drug adherence...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27981021/effectiveness-of-vaccination-and-wearing-masks-on-seasonal-influenza-in-matsumoto-city-japan-in-the-2014-2015-season-an-observational-study-among-all-elementary-schoolchildren
#16
Mitsuo Uchida, Minoru Kaneko, Yoshihiko Hidaka, Hiroshi Yamamoto, Takayuki Honda, Shouhei Takeuchi, Masaya Saito, Shigeyuki Kawa
Measures of seasonal influenza control are generally divided into two categories: pharmaceutical and non-pharmaceutical interventions. The effectiveness of these measures remains unclear, because of insufficient study sample size and/or differences in study settings. This observational epidemiological study involved all elementary schoolchildren in Matsumoto City, Japan, with seasonal influenza during the 2014/2015 season. Questionnaires, including experiences with influenza diagnosis and socio-demographic factors, were distributed to all 29 public elementary schools, involving 13,217 children, at the end of February 2015...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27890574/modeling-the-role-of-information-and-limited-optimal-treatment-on-disease-prevalence
#17
Anuj Kumar, Prashant K Srivastava, Yasuhiro Takeuchi
Disease outbreaks induce behavioural changes in healthy individuals to avoid contracting infection. We first propose a compartmental model which accounts for the effect of individual's behavioural response due to information of the disease prevalence. It is assumed that the information is growing as a function of infective population density that saturates at higher density of infective population and depends on active educational and social programmes. Model analysis has been performed and the global stability of equilibrium points is established...
November 25, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27801865/herbal-products-in-italy-the-thin-line-between-phytotherapy-nutrition-and-parapharmaceuticals-a-normative-overview-of-the-fastest-growing-market-in-europe
#18
REVIEW
Marco Biagi, Rita Pecorari, Giovanni Appendino, Elisabetta Miraldi, Anna Rosa Magnano, Paolo Governa, Giulia Cettolin, Daniela Giachetti
The Italian herbal products market is the most prosperous in Europe. The proof is represented by the use of these products in several marketing categories, ranging from medicine to nutrition and cosmetics. Market and legislation in Italy are at the same time cause and consequence of this peculiar situation. In fact, the legislation on botanical food supplements in Italy is very permissive and at the same time the market shows an overall satisfaction of users and strong feedback in terms of consumption, which brings a widening use of medicinal plants, formerly the prerogative of pharmaceuticals, to other fields such as nutrition...
October 29, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27768704/a-meta-analysis-of-the-association-between-gender-and-protective-behaviors-in-response-to-respiratory-epidemics-and-pandemics
#19
Kelly R Moran, Sara Y Del Valle
Respiratory infectious disease epidemics and pandemics are recurring events that levy a high cost on individuals and society. The health-protective behavioral response of the public plays an important role in limiting respiratory infectious disease spread. Health-protective behaviors take several forms. Behaviors can be categorized as pharmaceutical (e.g., vaccination uptake, antiviral use) or non-pharmaceutical (e.g., hand washing, face mask use, avoidance of public transport). Due to the limitations of pharmaceutical interventions during respiratory epidemics and pandemics, public health campaigns aimed at limiting disease spread often emphasize both non-pharmaceutical and pharmaceutical behavioral interventions...
2016: PloS One
https://www.readbyqxmd.com/read/27752251/direct-to-consumer-drug-advertisements-can-paradoxically-increase-intentions-to-adopt-lifestyle-changes
#20
Maya B Mathur, Michael Gould, Nayer Khazeni
Background: Direct-to-consumer (DTC) prescription drug advertisements are thought to induce "boomerang effects," meaning they reduce the perceived effectiveness of a potential alternative option: non-pharmaceutical treatment via lifestyle change. Past research has observed such effects using artificially created, text-only advertisements that may not adequate capture the complex, conflicting portrayal of lifestyle change in real television advertisements. In other risk domains, individual "problem status" often moderates boomerang effects, such that subjects who currently engage in the risky behavior exhibit the strongest boomerang effects...
2016: Frontiers in Psychology
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