Louis B DeRidder, Kyle A Hare, Aaron Lopes, Josh Jenkins, Nina Fitzgerald, Emmeline MacPherson, Niora Fabian, Josh Morimoto, Jacqueline N Chu, Ameya R Kirtane, Wiam Madani, Keiko Ishida, Johannes L P Kuosmanen, Naomi Zecharias, Christopher M Colangelo, Hen-Wei Huang, Makaya Chilekwa, Nikhil B Lal, Shriya S Srinivasan, Alison M Hayward, Brian M Wolpin, David Trumper, Troy Quast, Douglas A Rubinson, Robert Langer, Giovanni Traverso
BACKGROUND: Dosing of chemotherapies is often calculated according to the weight and/or height of the patient or equations derived from these, such as body surface area (BSA). Such calculations fail to capture intra- and interindividual pharmacokinetic variation, which can lead to order of magnitude variations in systemic chemotherapy levels and thus under- or overdosing of patients. METHODS: We designed and developed a closed-loop drug delivery system that can dynamically adjust its infusion rate to the patient to reach and maintain the drug's target concentration, regardless of a patient's pharmacokinetics (PK)...
April 23, 2024: Med