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Journal of the American Association for Laboratory Animal Science: JAALAS

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https://www.readbyqxmd.com/read/29907166/comparison-of-serial-blood-collection-by-facial-vein-and-retrobulbar-methods-in-c57bl-6-mice
#1
Jennifer R Frohlich, Christina N Alarcón, Camille R Toarmino, Anna K Sunseri, Tyler M Hockman
Many biomedical research protocols for mouse models involve serial blood collection and analysis. Two common techniquesfor serial blood collection in this species are the retrobulbar (RB, also called retroorbital) and facial vein (FV) methods. However, previous studies comparing these methods typically evaluated collection at a maximum of 2 time points. Here we compared hematologic values, adverse clinical effects, and histopathologic lesions in mice bled either once or serially (6 times) by using the FV or RB method...
June 15, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29871714/analgesic-efficacy-of-subcutaneous-oral-dosage-of-tramadol-after-surgery-in-c57bl-6j-mice
#2
Rocio Evangelista-Vaz, Alessandra Bergadano, Margarete Arras, Paulin D Jirkof
This study investigated the analgesic activity of tramadol in female C57BL/6J mice by using a single subcutaneous injection(25 mg/kg) of tramadol combined with the same dose given in drinking water for 24 h. We then evaluated the pharmacokineticsof tramadol and its active metabolite O-demethyltramadol (M1). To evaluate pain and analgesic efficacy, we performed clinical and behavioral assessment, burrowing tests, and activity analysis and measured body weight, food and water intake in mice that were untreated (control) or underwent analgesia only (T); anesthesia and surgery (AS); or anesthesia, surgery, and analgesia (AS+T)...
June 5, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29764539/effect-of-chronic-social-stress-on-prenatal-transfer-of-antitetanus-immunity-in-captive-breeding-rhesus-macaques-macaca-mulatta
#3
Rachelle L Stammen, Joyce K Cohen, Tracy L Meeker, Maria M Crane, Rama R Amara, Sakeenah L Hicks, Jerrold S Meyer, Kelly F Ethun
Because tetanus can cause significant morbidity and mortality in NHP, colonywide vaccination with tetanus toxoid is recommendedfor outdoor breeding colonies of rhesus macaques, with primary immunizations commonly given to infants at 6 mo of age followed by booster vaccines every 10 y. Maternal antibodies are thought to offer protective immunity to infants younger than 6 mo. However, historical colony data from the Yerkes National Primate Research Center show a higher incidence of tetanus among infants (≤ 6 mo old) born to subordinate dams...
May 15, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29720295/methods-for-investigating-the-motivation-of-mice-to-explore-and-access-food-rewards
#4
Elin M F Spangenberg, Anette Wichman
The emotional state of domestic animals is an essential component of the assessment of their welfare. In addition, sensitivity to various rewards can be a valuable indicator when investigating these states. We aimed to design an exploration test and a contrast test that did not evoke fear and anxiety in C57BL/6N mice but that instead were perceived as positive experiences and that might be used to assess sensitivity to various rewards. The exploratory arena had a larger central area and 8 smaller sections containing various objects...
May 2, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29695313/effects-of-ketamine-compared-with-urethane-anesthesia-on-vestibular-sensory-evoked-potentials-and-systemic-physiology-in-mice
#5
Choongheon Lee, Timothy A Jones
The injectable anesthetic mixture ketamine-xylazine is commonly used for electrophysiologic experiments in laboratory animals, especially rodents. General anesthesia can induce significant changes in systemic physiology, including those that compromise neural function, thus introducing research confounds. The extent of such concerns varies by agent. Here in mice, we compared the effects of ketamine-xylazine and urethane-xylazine anesthesia on systemic physiologic parameters and the vestibular sensory evoked potential (VsEP), a tool used commonly to assess peripheral vestibular function...
April 25, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29690955/analgesic-efficacy-and-safety-of-buprenorphine-in-chinchillas-chinchilla-lanigera
#6
Lana Fox, Christoph Mans
Buprenorphine is routinely used in chinchillas at reported doses of 0.01 to 0.1 mg/kg IM or SC. However, these dose recommendations are based on anecdotal reports or extrapolation from studies in other species. Therefore, the purpose of thisstudy was to evaluate the analgesic efficacy and safety of subcutaneously administered buprenorphine in chinchillas. Using arandomized, blind, controlled, complete crossover design, we evaluated buprenorphine at a single dose of 0.05, 0.1 or 0.2 mg/kg SC (experiment A) and 0...
April 24, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29690952/refinement-of-perioperative-feeding-in-a-mouse-model-of-vertical-sleeve-gastrectomy
#7
Carolyn M Doerning, Lisa A Burlingame, Alfor G Lewis, Andriy Myronovych, Randy J Seeley, Patrick A Lester
Provision of liquid enteral nutrition (LEN) during the perioperative period is standard practice for rodents undergoingbariatric surgery, yet these diets are associated with several challenges, including coagulation of the liquid diet within thedelivery system and decreased postoperative consumption. We investigated the use of a commercially available high-caloriedietary gel supplement (DG) as an alternative food source for mice during the perioperative period. C57BL/6J male mice werefed high-fat diet for 8 to 10 wk prior to surgery...
April 24, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29669621/effect-of-environmental-enrichment-on-aggression-in-balb-cj-and-balb-cbyj-mice-monitored-by-using-an-automated-system
#8
Jareca M Giles, Julia W Whitaker, Sheryl S Moy, Craig A Fletcher
Aggression among mice remains a common undesirable problem in laboratory settings, and animal welfare and scientific outcomes may become compromised depending on the severity of aggression. This study evaluated the effect of cage enrichment comprising a bilevel, mounted 'mezzanine' compared with a cotton square or shelter on intracage male aggression over a 6-wk period. Our first study involved home-cage behavioral challenges to male mice from a high aggression substrain (BALB/cJ) and low-aggression substrain (BALB/cByJ)...
April 18, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29734971/characterization-of-the-correct-mandibular-premolar-region-for-delayed-dental-implantation-in-beagle-dogs
#9
Chenxi Xie, Xiaoming Fu, Ling Xu, Sheng Xu
For delayed dental implantation into the mandible, the implant size should be chosen according to the characteristics of thatbone. This study investigated anatomic features of the mandible in beagle dogs, to develop recommendations regarding the correct implantation region and available bone area for delayed dental implantation surgery. We used 20 healthy male beagle dogs to create delayed dental implantation models. The dogs' mandibles underwent cone beam CT (CBCT) imaging; the locations of the middle mental foramen and canine root apex were measured on CBCT images...
April 12, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29784079/analgesic-efficacy-and-safety-of-hydromorphone-in-chinchillas-chinchilla-lanigera
#10
Emily A Evenson, Christoph Mans
Limited information is available regarding the efficacy of opioid analgesics in chinchillas. Here we sought to evaluate the analgesic efficacy and safety of hydromorphone in chinchillas. In a randomized, controlled, blind, complete crossover design, hydromorphone was administered at 0.5, 1, and 2 mg/kg SC to 16 chinchillas. Analgesic efficacy was determined by measuring hindlimb withdrawal latencies after a thermal noxious stimulus (Hargreaves method) at 0, 1, 2, 4, and 8 h after drug administration. Changes in daily food intake and fecal output after hydromorphone administration were recorded...
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29784078/corticoadrenal-and-cardiorespiratory-responses-to-administration-of-propofol-combined-with-dexmedetomidine-or-ketamine-in-rabbits
#11
Alfredo González-Gil, Rosa Ana Picazo, Paul de Bruyn, Juan Carlos Illera
Anesthetic protocols may influence adrenal function. Effective methods for modulating stress are desirable to minimize secondary effects during the perioperative period. The aim of this study was to evaluate the effects of the administration of propofol with dexmedetomidine or ketamine on corticoadrenal function and heart and respiratory rates. A random treatment-order design was used: each rabbit received all treatments, with at least 14 d between experiments. Rabbits were assigned to 3 treatment groups (10 per group): group 1, 1 mL normal saline solution intravenously; group 2, propofol (3 mg/kg IV) and dexmedetomidine (0...
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29784077/effects-of-ketamine-compared-with-urethane-anesthesia-on-vestibular-sensory-evoked-potentials-and-systemic-physiology-in-mice
#12
Choongheon Lee, Timothy A Jones
The injectable anesthetic mixture ketamine-xylazine is commonly used for electrophysiologic experiments in laboratory animals, especially rodents. General anesthesia can induce significant changes in systemic physiology, including those that compromise neural function, thus introducing research confounds. The extent of such concerns varies by agent. Here in mice, we compared the effects of ketamine-xylazine and urethane-xylazine anesthesia on systemic physiologic parameters and the vestibular sensory evoked potential (VsEP), a tool used commonly to assess peripheral vestibular function...
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29784076/analgesic-efficacy-and-hematologic-effects-of-robenacoxib-in-mice
#13
Jennifer A Beninson, Jennifer L Lofgren, Patrick A Lester, Madeline M Hileman, Daniel J Berkowitz, Daniel D Myers
NSAID analgesics may confound models that require inflammation to mimic disease development in humans. This effect presents a challenge for veterinary staff and investigators, because surgery is often necessary to create mouse models of disease and NSAID are first-line analgesics used to treat postoperative pain. We evaluated robenacoxib, a NSAID highly selective for cyclooxygenase 2, in a carrageenan paw edema (CPE) assay and surgical model of venous thrombosis (VT). We generated a mouse-specific dose-response curve by using the CPE assay for robenacoxib doses of 3...
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29784075/extending-the-use-of-disposable-caging-based-on-results-of-microbiologic-surface-testing
#14
Brian J Smith, Kristin E Killoran, Jiajie J Xu, Jessica D Ayers, Lon V Kendall
Prions are proteinaceous infectious agents that are highly resistant to denaturation. Sterilization of prion-contaminated mouse cages requires chemical agents and increased autoclave temperatures that damage traditional cages, thus increasing facility costs. Disposable cages are a possible alternative that might decrease replacement costs without compromising the environment of the mice. We compared our standard protocol of changing traditional cages and bedding once every 2 wk to an experimental protocol using disposable cages in which only the bedding was changed once every 2 wk over an 8-wk period...
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29784074/effects-of-fenbendazole-impregnated-feed-and-topical-moxidectin-during-quarantine-on-the-gut-microbiota-of-c57bl-6-mice
#15
Scott W Korte, Craig L Franklin, Rebecca A Dorfmeyer, Aaron C Ericsson
To protect the biosecurity of research rodent colonies, research institutions frequently require a quarantine period for live animals transferred into their facilities. Quarantine practices often include antibiotic and antiparasitic treatment with drugs such as fenbendazole and macrolide lactones. The influence of these compounds on the resident gut microbiota of mice is unknown, and any effects might subsequently affect model reproducibility. To test the influence of standard quarantine procedures on the composition of the microbiota, C57BL/6 mice, purchased from 2 different commercial suppliers, were randomly assigned to treatment groups (n = 12) by vendor and treated with fenbendazole-supplemented feed, topical moxidectin, both treatments, or no treatment (control), according to our institution's standard treatment regimen and duration...
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29784073/aaalac-international-and-government-agencies
#16
Javier Guillén, Kathryn Bayne
No abstract text is available yet for this article.
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29673414/influence-of-isoflurane-anesthesia-on-plasma-thyroxine-concentrations-in-black-tailed-prairie-dogs-cynomys-ludovicianus
#17
David Eshar, Sara M Gardhouse, Hugues Beaufrere
Anesthesia can affect measured thyroxine (total T4) concentrations in humans and animals, but its effect in black-tailed prairie dogs (Cynomys ludovicianus) has not yet been studied. We used isoflurane to anesthetize 12 prairie dogs for 60 min. Blood samples were obtained from each animal immediately after anesthesia induction and at 30 and 60 min and used for analysis of plasma T4 concentration. The plasma T4 concentration (mean ± 1 SD) was significantly decreased from baseline (3.49 ± 0.52 μg/dL) at both 30 min (3...
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29555009/comparison-of-etomidate-benzocaine-and-ms222-anesthesia-with-and-without-subsequent-flunixin-meglumine-analgesia-in-african-clawed-frogs-xenopus-laevis
#18
Briony D Smith, Krystal J Vail, Gwendolyn L Carroll, Maggie C Taylor, Nicholas D Jeffery, Tracy H Vemulapalli, James J Elliott
Often few alternative anesthetics for exotic species are available, due to the small numbers of these animals used in research. In this study, we evaluated the depth and duration of anesthesia in Xenopus laevis after their immersion in 3 doses of etomidate (15, 22.5, and 30 mg/L) and in 3 doses of benzocaine (0.1%, 0.5%, and 1%) compared with the 'gold standard,' tricaine methanesulfonate (MS222; 2 g/L). We then chose an optimal dose for each alternative anesthetic according to induction time, duration of surgical plane, and time to complete recovery...
March 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29555008/using-cageside-measures-to-evaluate-analgesic-efficacy-in-mice-mus-musculus-after-surgery
#19
Vanessa L Oliver, Sarah E Thurston, Jennifer L Lofgren
Recent studies have revealed some of the most frequently used analgesics in mice are not effectively treating postoperative pain. Our laboratory sought to compare and assess the validity and reliability of 2 cageside pain assessments that we recently developed for use in mice-nesting consolidation and grooming transfer tests. We then applied these tests to compare the efficacy of commonly used analgesics-buprenorphine (0.1 mg/kg SC every 12 h for 48 h) and carprofen (30 mg/kg in drinking water for 72 h)-alone and in multimodal combination as a refinement for treating postoperative pain in mice...
March 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29555007/comparison-of-diagnostic-methods-and-sampling-sites-for-the-detection-of-demodex-musculi
#20
Melissa A Nashat, Rodolfo J Ricart Arbona, Elyn R Riedel, Olga Francino, Lluis Ferrer, Kerith R Luchins, Neil S Lipman
Demodex mites are microscopic, cigar-shaped, follicular mites often regarded as commensal microfauna in mammals. Although Demodex spp. can cause dermatologic disease in any immunocompromised mammal, they are rarely reported in laboratory mice. Recent identification of Demodex musculi in a colony of immunodeficient mice with dermatitis afforded us the opportunity to investigate the comparative sensitivity of 4 antemortem diagnostic techniques to detect D. musculi-superficial skin scrape (SSS), tape impression (TI), fur pluck (FP), and deep skin scrape (DSS)-which we performed on 4 anatomic sites (face, interscapular region [IS], caudal ventrum [CV], and caudal dorsum [CD]) in 46 mice...
March 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
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