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Journal of the American Association for Laboratory Animal Science: JAALAS

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https://www.readbyqxmd.com/read/28903831/abstracts-of-scientific-papers-2017-aalas-national-meeting
#1
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903830/an-efficient-simple-and-noninvasive-procedure-for-genotyping-aquatic-and-nonaquatic-laboratory-animals
#2
Morihiro Okada, Thomas C Miller, Julia Roediger, Yun-Bo Shi, Joseph Mat Schech
Various animal models are indispensible in biomedical research. Increasing awareness and regulations have prompted the adaptation of more humane approaches in the use of laboratory animals. With the development of easier and faster methodologies to generate genetically altered animals, convenient and humane methods to genotype these animals are important for research involving such animals. Here, we report skin swabbing as a simple and noninvasive method for extracting genomic DNA from mice and frogs for genotyping...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903829/quantification-of-induced-hypothermia-from-aseptic-scrub-applications-during-rodent-surgery-preparation
#3
Anna M Skorupski, Jingyi Zhang, Danielle Ferguson, Frank Lawrence, F Claire Hankenson
Laboratory mice (Mus musculus) are prone to develop hypothermia during anesthesia for surgery, thus potentially impeding anesthetic recovery, wound healing, and future health. The core body temperatures of isoflurane-anesthetized mice are influenced by the choice of supplemental heat sources; however, the contribution of various surgical scrubs on the body temperatures of mice under gas anesthesia has not been assessed. We sought to quantify the effect of using alcohol (70% isopropyl alcohol [IPA]) compared with saline to rinse away surgical scrub on the progression of hypothermia in anesthetized mice (n = 47)...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903828/pharmacokinetics-of-single-bolus-subcutaneous-cefovecin-in-c57bl-6-mice
#4
Kevin L Sanders, Esperanza Bas, Sherry K Cox, Daniel E Rothen
Because of its extended half-life, cefovecin is a broad-spectrum cephalosporin antibiotic commonly used to treat dermatitis in dogs and cats. A single injection in dogs can yield an effective plasma concentration for as long as 14 d, depending on the strain of Staphylococcus and for as long as 7 d in cats for the treatment of Pasteurella multocida. In the laboratory animal setting, C57BL/6 mice are commonly affected with dermatologic conditions that make these animals unsuitable for experiments. Therefore, we performed this pharmacokinetic study to determine whether cefovecin would be of benefit in mice...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903827/pharmacokinetics-of-a-transdermal-fentanyl-solution-in-suffolk-sheep-ovis-aries
#5
Kimberly Y Jen, Melissa C Dyson, Patrick A Lester, Jean A Nemzek
Sheep used as surgical models require appropriate pain management, and the commonly used transdermal fentanyl patches require a long predosing period to achieve adequate plasma concentrations. The aim of this study was to assess the pharmacokinetic parameters of an FDA-approved transdermal fentanyl solution (TFS) that has yet to be tested in sheep. In this study, we compared TFS at 2.7 mg/kg (n = 2), 1.7 mg/kg (n = 3), and 0.5 mg/kg (n = 3) with the control fentanyl patch at 2 μg/kg/h (n = 1); both products were applied topically to the intrascapular region...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903826/comparison-of-6-injectable-anesthetic-regimens-and-isoflurane-in-gray-short-tailed-opossums-monodelphis-domestica
#6
Grace J Barnett, Ian J Barnett, Steven R Wilson, Peter C Smith
Gray short-tailed opossums are used in a wide variety of research in the areas of developmental biology, oncology, immunology, and comparative biology. Despite many frequent experimental manipulations of these animals under anesthesia, few studies to date have characterized the effects of anesthesia in this species. Our aim was to identify safe and effective injectable anesthetic combinations using ketamine and xylazine or ketamine and dexmedetomidine at doses of 40 mg/kg to 100 mg/kg for ketamine, 5 mg/kg to 10 mg/kg for xylazine, and 0...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903825/pharmacokinetics-of-single-dose-subcutaneous-meloxicam-injections-in-black-tailed-prairie-dogs-cynomys-ludovicianus
#7
Thomas L Wright, David Eshar, Christina McCullough, Matt Warner, Butch Kukanich
This study evaluated the pharmacokinetic profile of a single dose of meloxicam (1.0 mg/kg) administered subcutaneously (n = 6) or intravenously (n = 2) to black-tailed prairie dogs (Cynomys ludovicianus). Blood was collected immediately before (time 0) and at 0.5, 1, 2, 4, 8, 12 and 24 h after drug administration. Plasma meloxicam concentrations were quantified with HPLC-mass spectrometry, and noncompartmental pharmacokinetic analysis was performed. The peak plasma concentrations, time to peak plasma concentration, and terminal half-life of meloxicam after subcutaneous administration (median [minimum-maximum]) were 4...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903824/pharmacokinetic-profiles-of-nalbuphine-after-intraperitoneal-and-subcutaneous-administration-to-c57bl-6-mice
#8
Brenda L Kick, Pan Shu, Bo Wen, Duxin Sun, Douglas K Taylor
Mice undergo a variety of procedures that necessitate the use of analgesic agents. Opioids are often essential to successful pain management plans, but most are controlled substances, and their use requires appropriate federal and state registrations. Nalbuphine is a potentially effective opioid analgesic for mice that is not currently classified as a controlled substance. This compound has received little attention as an analgesic for mice, and standard dosage regimens have not been developed. Here we compared the pharmacokinetic profiles of 10 mg/kg nalbuphine in male C57BL/6 mice subcutaneous or intraperitoneal administration...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903823/results-of-survey-regarding-prevalence-of-adventitial-infections-in-mice-and-rats-at-biomedical-research-facilities
#9
James O Marx, Diane J Gaertner, Abigail L Smith
Control of rodent adventitial infections in biomedical research facilities is of extreme importance in assuring both animal welfare and high-quality research results. Sixty-three U.S. institutions participated in a survey reporting the methods used to detect and control these infections and the prevalence of outbreaks from 1 January 2014 through 31 December 2015. These results were then compared with the results of 2 similar surveys published in 1998 and 2008. The results of the current survey demonstrated that the rate of viral outbreaks in mouse colonies was decreasing, particularly in barrier facilities, whereas the prevalence of parasitic outbreaks has remained constant...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903822/evaluation-of-a-zinc-gluconate-neutralized-with-arginine-product-as-a-nonsurgical-method-for-sterilization-of-rhesus-macaques-macaca-mulatta
#10
Kacie N Woodward, Rebekah I Keesler, J Rachel Reader, Kari L Christe
Because rhesus macaques (Macaca mulatta) are prolific breeders, overpopulation can be problematic in both research and feral populations. Currently, the most effective contraceptive methods are hormonal control in female macaques and vasectomies in males. These methods each come with innate challenges, the foremost being the alteration of necessary hormonal patterns. In this study, we assessed the use of zinc gluconate neutralized with arginine as a novel, nonsurgical alternative to male contraception in 12 rhesus macaques...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903821/age-and-sex-associated-differences-in-phenotypic-and-functional-characteristics-of-peripheral-blood-lymphocytes-in-chimpanzees-pan-troglodytes
#11
Pramod N Nehete, Elizabeth R Magden, Bharti P Nehete, Lawrence E Williams, Christian R Abee, K Jagannadha Sastry
Chimpanzees are the closest phylogenetic relatives to humans, sharing more than 98% genetic sequence identity. These genetic similarities prompted the belief that chimpanzees can serve as an ideal model for human disease conditions and vaccine development. However, in light of the recent NIH decision to phase out biomedical research in chimpanzees and retire NIH-supported chimpanzees, data from the present study will continue to provide value for the care of aged and sick chimpanzees located in zoos, sanctuaries, and primate centers...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903820/considerations-when-writing-and-reviewing-a-higher-education-teaching-protocol-involving-animals
#12
Tracy H Vemulapalli, Shawn S Donkin, Timothy B Lescun, Peggy A O'Neil, Patrick A Zollner
The targeted use of animals in teaching at institutions of higher learning is fundamental to educating the next generation of professionals in the biologic and animal sciences. As with animal research, universities and colleges that use animals in teaching are subject to regulatory oversight. Instructors must receive approval from their IACUC before using animals in their teaching. However, the questions asked on many institutions' animal care and use protocol (ACUP) are often geared more toward the use of animals for research...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903819/review-of-co%C3%A2-as-a-euthanasia-agent-for-laboratory-rats-and-mice
#13
Gregory P Boivin, Debra L Hickman, Michelle A Creamer-Hente, Kathleen R Pritchett-Corning, Natalie A Bratcher
Selecting an appropriate, effective euthanasia agent is controversial. Several recent publications provide clarity on the use of CO2 in laboratory rats and mice. This review examines previous studies on CO2 euthanasia and presents the current body of knowledge on the subject. Potential areas for further investigation and recommendations are provided.
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903818/responses-to-drs-perkins-and-lipman-s-letter-to-the-editor
#14
Ida Washington, Mark Payton
No abstract text is available yet for this article.
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903817/properly-describing-individually-ventilated-caging-systems-in-scientific-manuscripts
#15
Scott E Perkins, Neil S Lipman
No abstract text is available yet for this article.
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903816/publication-of-negative-data-contributes-to-sound-science
#16
Linda A Toth, Nicole E Duffee
No abstract text is available yet for this article.
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28726600/age-and-sex-associated-differences-in-phenotypic-and-functional-characteristics-of-peripheral-blood-lymphocytes-in-chimpanzees-pan-troglodytes
#17
Pramod Nehete, Elizabeth Magden, Bharti Nehete, Lawrence Williams, Christian Abee, K Sastry
Chimpanzees are the closest phylogenetic relatives to humans, sharing more than 98% genetic sequence identity. Thesegenetic similarities prompted the belief that chimpanzees can serve as an ideal model for human disease conditions andvaccine development. However, in light of the recent NIH decision to phase out biomedical research in chimpanzees and retire NIH-supported chimpanzees, data from the present study will continue to provide value for the care of aged and sick chimpanzees located in zoos, sanctuaries, and primate centers...
July 19, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28675139/an-efficient-simple-and-noninvasive-procedure-for-genotyping-aquatic-and-nonaquatic-laboratory-animals
#18
Morihiro Okada, Thomas C Miller, Julia Roediger, Yun-Bo Shi, Joseph M Schech
Various animal models are indispensible in biomedical research. Increasing awareness and regulations have prompted theadaptation of more humane approaches in the use of laboratory animals. With the development of easier and faster methodologies to generate genetically altered animals, convenient and humane methods to genotype these animals are important for research involving such animals. Here, we report skin swabbing as a simple and noninvasive method for extracting genomic DNA from mice and frogs for genotyping...
July 3, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28728613/echocardiographic-parameters-of-clinically-normal-geriatric-rhesus-macaques-macacamulatta
#19
Yu Ueda, Catherine T Gunther-Harrington, Christina L Cruzen, Jeffrey A Roberts, Joshua A Stern
The goal of this study was to generate reference intervals for echocardiographic variables in a population of clinically normal geriatric rhesus macaques (Macaca mulatta). To do this, we studied 51 animals (age, 18-29 y; weight, 5.24-17.04 kg). The normal values for cardiac indices, including geometry and systolic and diastolic function, were determined by 2D, M-mode, spectral Doppler, and tissue Doppler echocardiography under ketamine hydrochloride sedation. Statistical correlations between the echocardiographic parameters and age, body weight, sex, and heart rate were investigated...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28724497/a-redesign-approach-for-improving-animal-care-services-for-researchers
#20
Orighomisan Okpe, Jamison V Kovach
Because a research institution's animal care and use program oversees the provision of services specified in approved protocols designed by researchers, the effective provision of services within these programs is paramount to ensuring the humane care and treatment of research animals in accordance with federal, state, and local regulations and institutional policies. To improve the services provided to researchers through animal care and use programs, we investigated the relationship between the researchers who conduct these types of studies and the veterinary operations that provide care and treatment for research animals...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
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