Rebecca L Prentiss, Brooke L Bollinger, Katherine A Lamont, Kimberly N Gaston, Craig A Fletcher, Morika D Williams, Hannah M Atkins, Ilana A Galex
Blood collection is frequently used for neonatal and juvenile mice in toxicology, developmental, and immunology studies and is often a terminal procedure. However, the use of nonterminal blood collection techniques, including the submandibular and the submental collection techniques described for adult mice, may offer opportunities to reduce animal numbers and refine current methods. The use of the submental technique has not been described for neonatal or juvenile mice. In this study, we compared the submental and submandibular blood collection techniques to determine their suitability for use in neonatal and juvenile mice...
March 21, 2024: Journal of the American Association for Laboratory Animal Science: JAALAS