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Journal of the American Association for Laboratory Animal Science: JAALAS

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https://www.readbyqxmd.com/read/28534468/effect-of-wearing-a-telemetry-jacket-on-behavioral-and-physiologic-parameters-of-dogs-in-the-open%C3%A2-field-test
#1
Richard E Fish, Melanie L Foster, Margaret E Gruen, Barbara L Sherman, David C Dorman
Safety pharmacology studies in dogs often integrate behavioral assessments made using video recording with physiologicmeasurements collected by telemetry. However, whether merely wearing the telemetry vest affects canine behavior and otherparameters has not been evaluated. This pilot study assessed the effect of a telemetry vest on behavioral and physiologic responses to an environmental stressor, the sounds of a thunderstorm, in Labrador retrievers. Dogs were assigned to one of 2 experimental groups (Vest and No-Vest, n = 8 dogs per group) by using a matched pairs design, with a previously determined,sound-associated anxiety score as the blocking variable...
May 22, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28524022/minimum-alveolar-concentration-and-cardiopulmonary-effects-of-isoflurane-in-ring-tailed-lemurs-lemur-catta
#2
Sathya K Chinnadurai, Julie A Balko, Cathy V Williams
The goal of this study was to determine the minimum alveolar concentration (MAC) and cardiopulmonary effects of isofluranein ring-tailed lemurs (Lemur catta). The MAC of isoflurane was determined by using a tail-clamp stimulus in adultring-tailed lemurs (6 male, 4 female). Once MAC was determined, another group of 10 adult ring-tailed lemurs (5 male, 5female) were anesthetized and instrumented similarly as the previous group and maintained at 0.5, 1, 1.5, and 2 times MACfor 15 min each with no external stimulation...
May 18, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28516834/comparison-of-antemortem-and-environmental-samples-for-zebrafish-health-monitoring-and-quarantine
#3
Marcus J Crim, Christian Lawrence, Robert S Livingston, Andrei Rakitin, Shane J Hurley, Lela K Riley
Molecular diagnostic assays offer both exquisite sensitivity and the ability to test a wide variety of sample types. Varioustypes of environmental sample, such as detritus and concentrated water, might provide a useful adjunct to sentinels in routinezebrafish health monitoring. Similarly, antemortem sampling would be advantageous for expediting zebrafish quarantine,without euthanasia of valuable fish. We evaluated the detection of Mycobacterium chelonae, M. fortuitum, M. peregrinum,Pseudocapillaria tomentosa, and Pseudoloma neurophilia in zebrafish, detritus, pooled feces, and filter membranes after filtration of 1000-, 500-, and 150-mL water samples by real-time PCR analysis...
May 17, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28497727/using-white-tailed-deer-odocoileus-virginianus-in-infectious-disease-research
#4
Mitchell Palmer, Rebecca J Cox, W Ray Waters, Tyler C Thacker, Diana L Whipple
Between 1940 and 2004, more than 335 emerging infectious disease events were reported in the scientific literature. Themajority (60%) of these events involved zoonoses, most of which (72%) were of wildlife origin or had an epidemiologically important wildlife host. Because this trend of increasing emerging diseases likely will continue, understanding the pathogenesis, transmission, and diagnosis of these diseases in the relevant wildlife host is paramount. Achieving this goal often requires using wild animals as research subjects, which are vastly different from the traditional livestock or laboratory animals used by most universities and institutions...
May 11, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28455889/effects-of-water-bottle-materials-and-filtration-on-bisphenol-a-content-in-laboratory-animal-drinking-water
#5
Jennifer A Honeycutt, Jenny Q T Nguyen, Amanda C Kentner, Heather C Brenhouse
Bisphenol A (BPA) is widely used in the polycarbonate plastics and epoxy resins that are found in laboratory animal husbandrymaterials including cages and water bottles. Concerns about BPA exposure in humans has led to investigations that suggest physiologic health risks including disruptions to the endocrine system and CNS. However, the extent of exposure of laboratory animals to BPA in drinking water is unclear. In the first study, we compared the amount of BPA contamination in water stored in plastic bottles used in research settings with that in glass bottles...
April 28, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28455888/helicobacter-infection-significantly-alters-pregnancy-success-in-laboratory-mice
#6
Tara C Bracken, Caitlin A Cooper, Zil Ali, Ha Truong, Julie M Moore
Helicobacter spp. are gram-negative, helically shaped bacteria that cause gastric and enterohepatic infections in mammalianspecies. Although Helicobacter infection frequently is implicated to interfere with reproductive success, few experimentaldata support these claims. We therefore retrospectively investigated the effect of Helicobacter infection on murine pregnancy outcome after the identification of endemic Helicobacter infection in an animal research facility. Multiplex conventional PCR analysis was used to characterize Helicobacter infection status in one inbred and 2 transgenic strains of mice in 2 self-contained rooms assigned to the same investigator...
April 28, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28443538/iohexol-clearance-for-determination-of-glomerular-filtration-rate-in-cynomolgus-monkeys-macaca-fascicularis
#7
Changqing Zhang, Shanshan Ding, Yupeng Fang, Li Zhang, Weimin Hu, Jinlian Lu, Tao Jing, Yi Tao, Xin Zhang
The purpose of this study was to validate a method for determine the glomerular filtration rate (GFR) in healthy cynomolgus monkeys by using iohexol. Eighteen healthy cynomolgus macaque monkeys (age, 4 to 6 y [mean, 5 y]; weight, 2 to 6 kg [mean, 4 kg]) were randomly entered into 3 different doses groups (3 male and 3 female macaques per group) of 30, 60, 90 mg I/kg to receive an intravenous bolus injection of iohexol. Serum iohexol concentrations were determined by using liquid chromatography-tandem mass spectrometry, and clearance rate were determined by using WinNonlin software...
April 25, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28443536/effects-of-nesting-material-on-energy-homeostasis-in-balb-canncrl-c57bl-6ncrl-and-crl-cd1-icr-mice-housed-at-20-%C3%A2-c
#8
Daniel Taylor, Angela Green, Brianna Gaskill
Discrepancies exist between the preferred temperature range for mice (26 to 32 °C) and current recommendations (20 to26 °C), which may alter metabolism and negatively affect studies using mice. Previous research indicates that nesting materialcan alleviate cold stress in mice; therefore, we sought to determine the effects of the amount of nesting material provided(0, 6, or 12 g) on heat energy loss and energy balance in 3 mouse strains housed at currently recommended temperatures duringthe daytime, a period of presumed inactivity...
April 25, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28432759/anesthetic-and-postanesthetic-effects-of-alfaxalone-butorphanol-compared-with-dexmedetomidine-ketamine-in-chinchillas-chinchilla-lanigera
#9
Lily Parkinson, Christoph Mans
Effective and safe anesthetic protocols are required for a variety of surgical and diagnostic procedures in chinchillas.Alfaxalone, a new anesthetic agent in the United States, can be administered intramuscularly and subcutaneously and is therefore potentially useful as an anesthetic induction agent in chinchillas. This study compared the anesthetic efficacy andpostanesthetic effects on food intake and fecal output of a combination of intramuscular alfaxalone (5 mg/kg) and butorphanol(0.5 mg/kg; AB anesthesia) with a combination of dexmedetomidine (0...
April 21, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28429678/intraperitoneal-administration-of-ethanol-as-a-means-of-euthanasia-for-neonatal-mice-mus-musculus
#10
Cecilia de Souza Dyer Angela K Brice And James O Marx
The humane euthanasia of animals in research is of paramount importance. Neonatal mice frequently respond differentlyto euthanasia agents when compared with adults. The AVMA's Guidelines for the Euthanasia of Animals includes intraperitonealinjection of ethanol as "acceptable with conditions," and recent work confirmed that this method is appropriate for euthanizing adult mice, but neonatal mice have not been tested. To explore this method in neonatal mice, mouse pups(C57BL/6 and CD1, 162 total) were injected with 100% ethanol, a pentobarbital-phenytoin combination, or saline at 7, 14, 21, 28, or 35 d of age...
April 20, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28425395/comparing-phlebotomy-by-tail-tip-amputation-facial-vein-puncture-and-tail-vein-incision-in-c57bl-6-mice-by-using-physiologic-and-behavioral-metrics-of-pain-and-distress
#11
Elizabeth S Moore Thomas A Cleland Wendy O Williams Christine M Peterson Bhupinder Singh Teresa L Southard Bret Pasch Rachael N Labitt And Erin K Daugherity
Tail tip amputation with minimal restraint is not widely used for mouse phlebotomy. In part, this infrequency may reflectpolicies influenced by tail tip amputation procedures for genotyping, which involve greater handling and tissue removal. Toassess tail tip amputation with minimal restraint as a phlebotomy technique, we compared it with 2 more common methods:scruffing with facial vein puncture and lateral tail vein incision with minimal restraint. Blood glucose levels, audible and ultrasonic vocalizations, postphlebotomy activity and grooming behavior, open field and elevated plus maze behaviors,nest-building scores, and histologic changes at the phlebotomy site were evaluated...
April 19, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28425390/sterility-and-stability-of-diluted-carprofen-in-a-multidose-vial-in-the-laboratory-animal-setting
#12
Gregory D Simonek Gwendolyne G Alarcio And Laurie L Brignolo
Using compounded multidose vials (cMDV) is a common practice in the laboratory animal setting, where medications oftenare diluted to provide appropriate doses to rodents. However, bacterial contamination of MDV has been well establishedin both the human and veterinary medical literature. For this study, we created 14 cMDV by diluting carprofen into sterilewater (dilution, 1:10) and stored 6 cMDV each at 5 and 24 °C. The stoppers of the cMDV were not cleaned with alcohol, andall were punctured twice daily for 28 d...
April 19, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28417829/comparison-of-3-methods-for-preventing-perianesthetic-hypothermia-in-callimicos-callimico-goeldii
#13
Sathya K Chinnadurai James G Johnson Iii And Jennifer N Langan
Perianesthetic hypothermia is one of the most common complications in veterinary anesthesia, especially in small patients with a large body surface area to mass ratio. During anesthesia, body heat can be lost through 4 mechanisms-radiation, convection,conduction, and evaporation-but anesthetists frequently address only one mechanism at a time. Here we sought to evaluate 3 methods of preventing perianesthetic hypothermia in callimicos (Callimico goeldii). In our experience, these smallNHP routinely become hypothermic under even brief inhalant anesthesia...
April 17, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28409549/elo-rating-for-tracking-rank-fluctuations-after-demographic-changes-involving-semi-free-ranging-rhesus-macaques-macaca-mulatta
#14
Lauren J Wooddell Stefano Sk Kaburu Stephen J Suomi And Amanda M Dettmer
Rhesus macaques (Macaca mulatta) are gregarious primates that form despotic societies characterized by frequent andintense aggression. Within long-term social groups, demographic changes may influence hierarchical stability, potentiallyresulting in conflict and violently abrupt hierarchical changes. This conflict can result in serious implications for animalwelfare, and thus, predictive tools would be invaluable to captive managers in determining social instabilities. Using themethod Elo-rating to track rank changes and dominance stability, we predicted that demographic changes to a populationof semi-free ranging rhesus macaques would result in changes in hierarchical stability...
April 13, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28378704/uses-and-doses-of-local-anesthetics-in-fish-amphibians-and-reptiles
#15
Frederic Chatigny Collins Kamunde Catherine M Creighton And E Don Stevens
Local anesthetics are an integral part of routine pain management in mammals, yet their use is relatively limited in fish,amphibians and reptiles. These animals frequently undergo potentially painful surgical procedures and therefore couldpossibly benefit from those drugs. Some recommendations are currently available in the literature concerning analgesic usein these animals. However the pharmacological properties, safety and often efficacy of local anesthetic drugs have not beeninvestigated yet in fish, amphibians, or reptiles...
April 4, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28374666/uses-and-doses-of-local-anesthetics-in-fish-amphibians-and-reptiles
#16
Frederic Chatigny Collins Kamunde Catherine M Creighton And E Don Stevens
Local anesthetics are an integral part of routine pain management in mammals, yet their use is relatively limited in fish,amphibians and reptiles. These animals frequently undergo potentially painful surgical procedures and therefore couldpossibly benefit from those drugs. Some recommendations are currently available in the literature concerning analgesic usein these animals. However the pharmacological properties, safety and often efficacy of local anesthetic drugs have not beeninvestigated yet in fish, amphibians, or reptiles...
April 3, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28256188/effects-of-human-management-events-on-conspecific-aggression-in-captive-rhesus-macaques-macaca-mulatta
#17
Jacob H Theil Brianne A Beisner Ashley E Hill And Brenda McCowan
Conspecific aggression in outdoor-housed rhesus macaques (Macaca mulatta) at primate research facilities is a leadingsource of trauma and can potentially influence animal wellbeing and research quality. Although aggression between macaquesis a normal part of daily social interactions, human presence might affect the frequency of various behaviors and instigateincreases in conspecific aggression. We sought to determine how and which human management events affect conspecificaggression both immediately after an event and throughout the course of a day...
March 2, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28256186/comparison-of-saliva-collection-methods-for-the-determination-of-salivary-cortisol-levels-in-rhesus-macaques-macaca-mulatta-cynomolgus-macaques-macaca-fascicularis-and-african-green-monkeys-chlorocebus-aethiops
#18
Kamala J Rapp-Santos Louis A Altamura Sarah L Norris Luis A Lugo-Roman Pedro J Rico And Christian C Hofer
The ability to quickly and accurately determine cortisol as a biomarker for stress is a valuable tool in assessing thewellbeing of NHP. In this study, 2 methods of collecting saliva (a commercial collection device and passive drool) and the resulting free salivary cortisol levels were compared with total serum cortisol concentration in rhesus macaques (Macaca mulatta),cynomolgus macaques (Macaca fascicularis) and African green monkeys (Chlorocebus aethiops) at 2 collection time points.Serum and salivary cortisol levels were determined using a competitive quantitative ELISA...
March 2, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28535869/erratum
#19
(no author information available yet)
No abstract text is available yet for this article.
May 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28535868/helicobacter-infection-significantly-alters-pregnancy-success-in-laboratory-mice
#20
Tara C Bracken, Caitlin A Cooper, Zil Ali, Ha Truong, Julie M Moore
Helicobacter spp. are gram-negative, helically shaped bacteria that cause gastric and enterohepatic infections in mammalian species. Although Helicobacter infection frequently is implicated to interfere with reproductive success, few experimental data support these claims. We therefore retrospectively investigated the effect of Helicobacter infection on murine pregnancy outcome after the identification of endemic Helicobacter infection in an animal research facility. Multiplex conventional PCR analysis was used to characterize Helicobacter infection status in one inbred and 2 transgenic strains of mice in 2 self-contained rooms assigned to the same investigator...
May 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
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