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Journal of the American Association for Laboratory Animal Science: JAALAS

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https://www.readbyqxmd.com/read/30107866/contaminated-shipping-materials-identified-as-the-source-of-rotaviral-infection-of-exported-mice
#1
Krista E Lindstrom, Kenneth S Henderson, Melinda S Mayorga, Veronica A Kuiper, James D Wilkerson
Over a 4-wk period in 2017, we received notification from 7 different institutions that mice exported from our SPF barrierfacilities had tested positive for mouse rotavirus (MRV). The exports originated from several different buildings acrossmultiple campuses. Our institution excludes MRV in all of our barrier facilities and has historically been free of this virus.Extensive testing of our rooms from which the exported mice originated did not detect the presence of rotavirus. The singlecommonality among the 7 shipments was the use of shipping boxes acquired from one vendor...
August 14, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/30092857/pcr-testing-of-filter-material-from-ivc-lids-for-microbial-monitoring-of-mouse-colonies
#2
Ariana R Dubelko, Metanuj Zuwannin, Samantha C McIntee, Robert S Livingston, Patricia L Foley
Testing sentinel animals exposed to soiled bedding from colony animals is the most common method used for health monitoringin rodent facilities. Although environmental sampling is being explored-and, in many cases, has been implemented-asan alternative, exhaust plenum sampling is not effective for all ventilated rack designs. This study evaluated PCR testing offilter paper from sentinel cages on ventilated racks. We hypothesized that testing filter paper from cages containing soiledbedding would be as effective as testing sentinel mice and that periodic shaking of cages would generate sufficient particulatemovement to substitute for the presence of live animals...
August 9, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/30092855/evaluation-of-analgesic-efficacy-of-meloxicam-and-2-formulations-of-buprenorphine-after-laparotomy-in-female-sprague-dawley-rats
#3
Elizabeth A Nunamaker, Julia L Goldman, Cynthia R Adams, Jeffrey D Fortman
Managing postoperative pain in rodents is an important part of any animal care and use program, and identifying an optimalanalgesic plan for a surgical procedure is critical to providing for animal welfare. Opioids and NSAID are commonly used in rodents, but few studies have evaluated their efficacy in surgical models. The current study aimed to evaluate thetherapeutic efficacy of clinically relevant doses of buprenorphine (2 formulations) or meloxicam used in combination with ketamine and xylazine anesthesia in a Sprague-Dawley rat ovariohysterectomy surgical model...
August 9, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/30075826/improving-the-patency-of-jugular-vein-catheters-in-sprague-dawley-rats-by-using-an-antiseptic-nitrocellulose-coating
#4
Thomas De Luca, Keely L Szilágyi, Katherine A Hargreaves, Kimberly S Collins, Eric A Benson
Preclinical studies in animals often require frequent blood sampling over prolonged periods. A preferred method in ratsis the implantation of a polyurethane catheter into the jugular vein, with heparinized glycerol as a lock solution. However,analysis of various biologic compounds (for example, microRNA) precludes the use of heparin. We used sodium citrate as an alternative to heparin but observed more frequent loss of catheter patency. We hypothesized that this effect was due toevaporation of lock solution at the exteriorized portion of the catheter, subsequent blood infiltration into the catheter, andultimately clot formation within the catheter...
August 3, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/30060780/vibration-induced-behavioral-responses-and-response-threshold-in-female-c57bl-6-mice
#5
Angela M Garner, John N Norton, Will L Kinard, Grace E Kissling, Randall P Reynolds
Despite documented adverse effects, limits for rodent exposure to vibration in the laboratory animal facility have not beenestablished. This study used female C57BL/6 mice to determine the frequencies of vibration at which mice were most sensitiveto behavioral changes, the highest magnitude of vibration that would not cause behavioral changes, the behavioral changesthat occur in response to vibration, and the extent to which mice habituate to vibration. Mice were exposed to frequenciesof vibration between 20 and 190 Hz at accelerations of 0...
July 30, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/30021671/hepatic-vitamin-a-concentrations-in-vervets-chlorocebus-aethiops-supplemented-with-carotenoids-derived-from-oil-palm
#6
Stephanie J Mondloch, Sherry A Tanumihardjo, Christopher R Davis, Paul J van Jaarsveld
Commonly used in biomedical research, vervets (Chlorocebus aethiops) are omnivorous but primarily meet their vitaminA requirements from provitamin A carotenoids. Hypervitaminosis A has occurred in vervets that consume feed high in preformedvitamin A. We investigated the vitamin A status of vervets supplemented daily with various antioxidants derived from palm oil. Male vervets (n = 40) were placed for 23 wk on a high-fat diet (34.9% energy) containing 645 μg retinol activity equivalents (RAE), with 515 μg RAE from preformed vitamin A...
July 18, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/30012240/effects-of-3-rodent-beddings-on-biochemical-measures-in-rats-and-mice
#7
Ayman S Mohamed, Sohair R Fahmy, Amel M Soliman, Khadiga M Gaafar
Components of bedding might interact with experimental treatments and affect the outcome of various experiments. Herewe studied the biochemical effects of 3 rodent bedding materials that are commonly used in Egypt. Male and female rats and mice were assigned randomly into 4 single-sex and single-species groups (10 animals per group). Three types of bedding-rice straw, wheat straw, and pine wood shavings-were evaluated. After 4 wk, animals were euthanized, and biochemical parameterswere measured. In male and female rats given wood shavings, serum ALT activity and malondialdehyde concentration increased whereas catalase activity decreased compared with levels in the wheat straw group...
July 16, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/30005716/facility-wide-eradication-of-corynebacterium-bovis-by-using-pcr-validated-vaporized-hydrogen-peroxide
#8
Emily L Miedel, Natalie H Ragland, Robert W Engelman
Facility-wide Corynebacterium bovis eradication was established using vaporized hydrogen peroxide (VHP) decontaminationguided by C. bovis PCR surveillance. Prior attempts limited to culling PCR-positive mice and decontaminating affectedrooms were ineffective in preventing recurrence. Because research aims often require trafficking to and use of proceduralcores, a 12-mo facility-wide C. bovis PCR surveillance of 2064 specimens was performed and documented that, despite thepresence of few clinically hyperkeratotic mice, 35% of the murine housing and use space was contaminated by C...
July 13, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29933765/effect-of-continuous-trio-breeding-compared-with-continuous-pair-breeding-in-shoebox-caging-on-measures-of-reproductive-performance-in-estrogen-receptor-knockout-mice
#9
Tom T Chatkupt, Nicole L Libal, Sarah L Mader, Stephanie J Murphy, Kim E Saunders
Some performance standards for continuous trio breeding in 'shoebox' cages for inbred stocks and outbred strains ofmice challenge the minimum floor space recommendations in the 8th edition of the Guide for the Care and Use of LaboratoryAnimals. In our study, we evaluated whether continuous trio breeding could be successfully applied to a breeding colonyof genetically engineered mice housed in shoebox cages with a floor area of 67.6 in2. Mice heterozygous for genetically engineered mutations to estrogen receptors and their wildtype counterparts were continuously bred as trios or pairs...
June 22, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/30049297/effect-of-continuous-trio-breeding-compared-with-continuous-pair-breeding-in-shoebox-caging-on-measures-of-reproductive-performance-in-estrogen-receptor-knockout-mice
#10
Tom T Chatkupt, Nicole L Libal, Sarah L Mader, Stephanie J Murphy, Kim E Saunders
Some performance standards for continuous trio breeding in 'shoebox' cages for inbred stocks and outbred strains of mice challenge the minimum floor space recommendations in the 8th edition of the Guide for the Care and Use of Laboratory Animals. In our study, we evaluated whether continuous trio breeding could be successfully applied to a breeding colony of genetically engineered mice housed in shoebox cages with a floor area of 67.6 in2. Mice heterozygous for genetically engineered mutations to estrogen receptors and their wildtype counterparts were continuously bred as trios or pairs...
July 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/30049296/the-race-to-publish
#11
Virginia Dawson
No abstract text is available yet for this article.
July 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29976274/effects-of-nesting-material-on-the-toxicologic-assessment-of-cyclophosphamide-in-crl-cd1-icr-mice
#12
Catherine P Brochu, Christina L Winnicker, Anne L Provencher, Elaine Debien, Sebastien Gariépy, Brianna N Gaskill
The provision of nesting material benefits mice by reducing cold stress, improving feed conversion, increasing litter size, and improving adaptive immunity. The effects of toxins are sensitive to environmental changes, and the introduction of novel items can alter results in some toxicologic studies. We hypothesized that nesting material would reduce stress and positively alter immunologic parameters in Crl:CD1(ICR) mice, thus changing typical results from a well-studied immunomodulating drug, cyclophosphamide...
July 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29970215/comparison-of-aqueous-and-alcohol-based-agents-for-presurgical-skin-preparation-methods-in-mice
#13
Jacquelyn M Del Valle, Elizabeth A Fisk, Erica L Noland, Daewoo Pak, Jingyi Zhang, Marcus J Crim, Frank R Lawrence, F Claire Hankenson
Preparing the skin of rodents for surgery often involves multiple applications of antiseptic agents. However, fewer applications may achieve the same antiseptic outcome. We evaluated the antimicrobial efficacy and effects on intraoperative body temperature of various surgical scrub agents, including novel waterless alcohol-based (WAB) options. Prior to ventral laparotomy, female C57BL/6 mice were treated with 0.9% saline (control); 70% ethanol; 10% povidone-iodine alternated with saline or 70% ethanol; 2% chlorhexidine digluconate alternated with saline or 70% ethanol; or 1 of 3 WAB products-commercial surgical scrub A, commercial surgical scrub B, or a common commercial hand sanitizer...
July 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29966544/behavioral-assessment-of-vision-in-pigs
#14
Francesca Barone, Eleonora Nannoni, Alberto Elmi, Carlotta Lambertini, Diana Gerardi Scorpio, Domenico Ventrella, Marika Vitali, José F Maya-Vetencourt, Giovanna Martelli, Fabio Benfenati, Maria L Bacci
Swine (Sus scrofa) are often the 'gold standard' laboratory animal for ophthalmology research due to the anatomic and physiologic similarities between the porcine and human eye and retina. Despite the importance of this model, few tools for behavioral vision assessment in pigs are available. The aim of this study was to identify and validate a feasible and reproducible behavioral test to assess vision in a pig model of photoreceptor degeneration. In addition, a robust behavioral test will reduce stress and enhance enrichment by allowing animals opportunities for environmental exploration and by reducing the number of invasive experimental procedures...
July 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29950249/effects-of-various-cleaning-agents-on-the-performance-of-mice-in-behavioral-assays-of-anxiety
#15
John D Hershey, Janace J Gifford, Lauren J Zizza, Darya A Pavlenko, George C Wagner, Shoreh Miller
Cleaning behavioral equipment between rodent subjects is important to prevent disease transmission and reduce odor cues from previous subjects. However, the reporting regarding the cleansing procedures used during such experiments is sporadic and often incomplete. In addition, some investigators are reluctant to clean devices between subjects because they are concerned that animals will react negatively to the smell of the cleansing agents. We hypothesized that mice tested on an elevated plus maze (EPM) soiled with excretions from conspecifics would test as being more stressed than mice tested on the same apparatus that was cleaned between animals...
July 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29933766/cardiopulmonary-effects-of-a-partial-intravenous-anesthesia-technique-for-laboratory-swine
#16
Justin D Duval, Jessica M Pang, Søren R Boysen, Nigel A Caulkett
Various anesthetic protocols are used in laboratory swine, each with specific advantages and disadvantages. Partial intravenous anesthetic techniques (PIVA) help minimize dose-dependent cardiopulmonary effects of inhalant drugs. The aim of this study was to determine the cardiopulmonary effects of a PIVA in laboratory swine. In a prospective, nonrandomized clinical study, 8 healthy juvenile Landrace-White pigs were premedicated with azaperone (0.20 ± 0.20 mg/kg IM), dexmedetomidine (0.02 ± 0.002 mg/kg IM), and alfaxalone (2...
July 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29933764/use-of-air-activated-thermal-devices-during-recovery-after-surgery-in-mice
#17
Corinna N Beale, Michael Y Esmail, Ariel M Aguiar, Lily Coughlin, Anne L Merley, Tania M Alarcon Falconi, Scott E Perkins
Laboratory mice (Mus musculus) are susceptible to hypothermia, especially during anesthetic events, disease states, and exposure to environmental stressors. Thermal support devices for small mammals are numerous, but often require a power source and may be impractical to use for cages on a rack. Air-activated thermal devices (AATD) are mixtures of chemicals that cause an exothermic reaction. In this study, we examined the environmental effects of AATD on internal cage temperatures without the use of additional equipment as well as the physiologic effects of AATD as postoperative thermal support in mice...
July 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29907166/comparison-of-serial-blood-collection-by-facial-vein-and-retrobulbar-methods-in-c57bl-6-mice
#18
Jennifer R Frohlich, Christina N Alarcón, Camille R Toarmino, Anna K Sunseri, Tyler M Hockman
Many biomedical research protocols for mouse models involve serial blood collection and analysis. Two common techniques for serial blood collection in this species are the retrobulbar (RB, also called retroorbital) and facial vein (FV) methods. However, previous studies comparing these methods typically evaluated collection at a maximum of 2 time points. Here we compared hematologic values, adverse clinical effects, and histopathologic lesions in mice bled either once or serially (6 times) by using the FV or RB method...
July 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29871714/analgesic-efficacy-of-subcutaneous-oral-dosage-of-tramadol-after-surgery-in-c57bl-6j-mice
#19
Rocio Evangelista-Vaz, Alessandra Bergadano, Margarete Arras, Paulin D Jirkof
This study investigated the analgesic activity of tramadol in female C57BL/6J mice by using a single subcutaneous injection (25 mg/kg) of tramadol combined with the same dose given in drinking water for 24 h. We then evaluated the pharmacokinetics of tramadol and its active metabolite O-demethyltramadol (M1). To evaluate pain and analgesic efficacy, we performed clinical and behavioral assessment, burrowing tests, and activity analysis and measured body weight, food and water intake in mice that were untreated (control) or underwent analgesia only (T); anesthesia and surgery (AS); or anesthesia, surgery, and analgesia (AS+T)...
July 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29764539/effect-of-chronic-social-stress-on-prenatal-transfer-of-antitetanus-immunity-in-captive-breeding-rhesus-macaques-macaca-mulatta
#20
Rachelle L Stammen, Joyce K Cohen, Tracy L Meeker, Maria M Crane, Rama R Amara, Sakeenah L Hicks, Jerrold S Meyer, Kelly F Ethun
Because tetanus can cause significant morbidity and mortality in NHP, colonywide vaccination with tetanus toxoid is recommended for outdoor breeding colonies of rhesus macaques, with primary immunizations commonly given to infants at 6 mo of age followed by booster vaccines every 10 y. Maternal antibodies are thought to offer protective immunity to infants younger than 6 mo. However, historical colony data from the Yerkes National Primate Research Center show a higher incidence of tetanus among infants (≤ 6 mo old) born to subordinate dams...
July 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
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