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Urologic Oncology

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https://www.readbyqxmd.com/read/28533151/low-rates-of-androgen-deprivation-therapy-use-with-salvage-radiation-therapy-in-patients-with-prostate-cancer-after-radical-prostatectomy
#1
David D Yang, Vinayak Muralidhar, Brandon A Mahal, Michelle D Nezolosky, Shelby A Labe, Marie E Vastola, Ninjin Boldbaatar, Martin T King, Neil E Martin, Peter F Orio, Tni K Choueiri, Quoc-Dien Trinh, Robert B Den, Daniel E Spratt, Karen E Hoffman, Felix Y Feng, Paul L Nguyen
OBJECTIVE: The RTOG 9601 and GETUG-AFU 16 randomized controlled trials demonstrated that the addition of androgen deprivation therapy (ADT) to salvage radiation therapy (SRT) improves progression-free and, for RTOG 9601, overall survival. We examined national trends in the use of ADT with SRT. MATERIALS AND METHODS: Of the 484,009 patients in the National Cancer Database from 2004 to 2012 with localized or locally advanced prostate cancer treated with radical prostatectomy (RP), 4,200 men received SRT (≥6mo after surgery)...
May 19, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28527622/genome-wide-copy-number-analysis-reveals-candidate-gene-loci-that-confer-susceptibility-to-high-grade-prostate-cancer
#2
Prevathe Poniah, Shamsul Mohd Zain, Azad Hassan Abdul Razack, Shanggar Kuppusamy, Shankar Karuppayah, Hooi Sian Eng, Zahurin Mohamed
BACKGROUND: Two key issues in prostate cancer (PCa) that demand attention currently are the need for a more precise and minimally invasive screening test owing to the inaccuracy of prostate-specific antigen and differential diagnosis to distinguish advanced vs. indolent cancers. This continues to pose a tremendous challenge in diagnosis and prognosis of PCa and could potentially lead to overdiagnosis and overtreatment complications. Copy number variations (CNVs) in the human genome have been linked to various carcinomas including PCa...
May 17, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28527621/physical-activity-patterns-and-associations-with-health-related-quality-of-life-in-bladder-cancer-survivors
#3
Ajay Gopalakrishna, Thomas A Longo, Joseph J Fantony, Michael R Harrison, Brant A Inman
INTRODUCTION: Physical activity has been shown to significantly improve health-related quality of life (HRQOL) and survivorship in a variety of patients with cancer . However, little is known about the physical activity patterns of bladder cancer survivors and how these are related to HRQOL in the United States. Our objective was to describe self-reported physical activity patterns and HRQOL and examine the association between these measures in a large cohort of bladder cancer survivors...
May 17, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28506596/advances-in-medical-imaging-for-the-diagnosis-and-management-of-common-genitourinary-cancers
#4
REVIEW
Mohammad H Bagheri, Mark A Ahlman, Liza Lindenberg, Baris Turkbey, Jeffrey Lin, Ali Cahid Civelek, Ashkan A Malayeri, Piyush K Agarwal, Peter L Choyke, Les R Folio, Andrea B Apolo
Medical imaging of the 3 most common genitourinary (GU) cancers-prostate adenocarcinoma, renal cell carcinoma, and urothelial carcinoma of the bladder-has evolved significantly during the last decades. The most commonly used imaging modalities for the diagnosis, staging, and follow-up of GU cancers are computed tomography, magnetic resonance imaging (MRI), and positron emission tomography (PET). Multiplanar multidetector computed tomography and multiparametric MRI with diffusion-weighted imaging are the main imaging modalities for renal cell carcinoma and urothelial carcinoma, and although multiparametric MRI is rapidly becoming the main imaging tool in the evaluation of prostate adenocarcinoma, biopsy is still required for diagnosis...
May 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28501565/prostate-zonal-anatomy-correlates-with-the-detection-of-prostate-cancer-on-multiparametric-magnetic-resonance-imaging-ultrasound-fusion-targeted-biopsy-in-patients-with-a-solitary-pi-rads-v2-scored-lesion
#5
Jamil S Syed, Kevin A Nguyen, Cayce B Nawaf, Ansh M Bhagat, Steffen Huber, Angelique Levi, Peter Humphrey, Jeffrey C Weinreb, Peter G Schulam, Preston C Sprenkle
PURPOSE: To evaluate the positive predictive value (PPV) of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) assessment method in patients with a single suspicious finding on prostate multiparametric magnetic resonance imaging (mpMRI). PATIENTS AND METHODS: A total of 176 patients underwent MRI/ultrasound fusion-targeted prostate biopsy after the detection of a single suspicious finding on mpMRI. The PPV for cancer detection was determined based on PI-RADS v2 assessment score and location...
May 10, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28501564/wntless-promotes-bladder-cancer-growth-and-acts-synergistically-as-a-molecular-target-in-combination-with-cisplatin
#6
Sebastian C Schmid, Anuja Sathe, Ferdinand Guerth, Anna-Katharina Seitz, Matthias M Heck, Tobias Maurer, Sarah M Schwarzenböck, Bernd J Krause, Wolfgang A Schulz, Robert Stoehr, Jürgen E Gschwend, Margitta Retz, Roman Nawroth
PURPOSE: To analyze the contribution of Wnt signaling pathway to bladder cancer growth in order to identify suitable target molecules for therapy. MATERIAL AND METHODS: Expression of Wnt 2/4/7, LRP5/6, TCF1/2/4, LEF-1, and β-actin was detected by reverse transcription polymerase chain reaction in a panel of 9 and for Wntless (WLS) in 17 bladder cancer cell lines. Protein expression of WLS was detected in 6 cell lines. Wnt/β-catenin activity was analyzed using the TOPflash/FOPflash luciferase reporter assay...
May 10, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28499734/preoperative-controlling-nutritional-status-conut-score-as-a-novel-predictive-biomarker-of-survival-in-patients-with-localized-urothelial-carcinoma-of-the-upper-urinary-tract-treated-with-radical-nephroureterectomy
#7
Hiroki Ishihara, Tsunenori Kondo, Kazuhiko Yoshida, Kenji Omae, Toshio Takagi, Junpei Iizuka, Kazunari Tanabe
OBJECTIVE: The purpose of this study was to investigate the correlation between the controlling nutritional status (CONUT) score and survival of patients with localized urothelial carcinoma of the upper urinary tract treated with radical nephroureterectomy (RNU). METHODS AND MATERIALS: We retrospectively enrolled 107 patients. CONUT score was calculated based on the serum albumin concentration, lymphocyte count, and total cholesterol concentration. Patients were classified into 2 groups based on CONUT score...
May 9, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28495555/oncological-and-functional-outcomes-of-sexual-function-preserving-cystectomy-compared-with-standard-radical-cystectomy-in-men-a-systematic-review
#8
Virginia Hernández, Estefania Linares Espinos, James Dunn, Steven MacLennan, Thomas Lam, Yuhong Yuan, Eva Compérat, Nigel C Cowan, Georgios Gakis, Thierry Lebrét, Antoine G van der Heijden, Johannes Alfred Witjes, Maria J Ribal
INTRODUCTION: Different sexual function-preserving surgical techniques aimed at improving voiding and sexual function in patients undergoing radical cystectomy for bladder cancer have been described. The objective of this systematic review is to determine the effect of sexual function-preserving cystectomy (SPC) on functional and oncological outcomes. MATERIALS AND METHODS: Relevant databases were searched covering the time frame 2000 to 2015. All publications presenting data on any type of SPC reporting oncological or functional outcomes with a minimum follow-up of 1 year were identified...
May 8, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28495554/collecting-duct-carcinoma-of-the-kidney-disease-characteristics-and-treatment-outcomes-from-the-national-cancer-database
#9
Wilson Sui, Justin T Matulay, Dennis J Robins, Maxwell B James, Ifeanyi C Onyeji, Arindam RoyChoudhury, Sven Wenske, Guarionex Joel DeCastro
OBJECTIVE: To use a large population-level database to assess survival outcomes for collecting duct renal cell carcinoma (CDRCC). MATERIALS AND METHODS: The National Cancer Database was queried for all cases of CDRCC and clear cell renal cell carcinoma (CCRCC) from 2004 to 2013. After removing patients with other cancer diagnoses, the analytic cohort was composed of 201,686 CCRCC and 577 CDRCC cases. Kaplan-Meier and cox proportional hazards analysis were employed to model survival...
May 8, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28495553/the-expanding-repertoire-of-targets-for-immune-checkpoint-inhibition-in-bladder-cancer-what-lies-beneath-the-tip-of-the-iceberg-pd-l1
#10
REVIEW
Alexander Sankin, Deepa Narasimhulu, Peter John, Benjamin Gartrell, Mark Schoenberg, Xingxing Zang
Over the last decade, a new understanding of tumor-immune system interplay has been ushered in, lead in large part by the discovery of immune checkpoints mediated through B7-CD28 family interactions. Therapeutic blockade of the PD-L1 immune checkpoint pathway has already shown great success as a cancer immunotherapy for advanced urothelial carcinoma, leading to durable clinical remissions in an otherwise incurable disease. There are newly described members of the B7-CD28 family including B7-H3, B7x, and HHLA2...
May 8, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28483476/prognostic-significance-of-erythrocyte-protein-band-4-1-like5-expression-in-upper-urinary-tract-urothelial-carcinoma
#11
Tatsuaki Daimon, Takeo Kosaka, Eiji Kikuchi, Shuji Mikami, Yasumasa Miyazaki, Ari Hashimoto, Shigeru Hashimoto, Ryuichi Mizuno, Akira Miyajima, Yasunori Okada, Hisataka Sabe, Mototsugu Oya
OBJECTIVES: The erythrocyte protein band 4.1-like5 (EPB4.1L5) regulates E-cadherin in cancer invasion and metastasis inducing epithelial-to-mesenchymal transition. This study aimed to investigate the biological significance of EPB4.1L5 in upper urinary tract urothelial carcinoma (UTUC). METHODS: Retrospective analysis of the clinical records of 165 patients with UTUC (Ta-4N0M0) subjected to radical nephroureterectomy and immunohistochemical examination of EPB4.1L5 expression in those tissues...
May 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28479117/health-care-services-utilization-during-the-last-6-months-of-life-among-patients-with-bladder-cancer-who-underwent-radical-cystectomy-in-quebec-canada
#12
Ahmed S Zakaria, Fabiano Santos, Alice Dragomir, Wassim Kassouf, Simon Tanguay, Armen Aprikian
INTRODUCTION AND OBJECTIVES: Management of bladder cancer imposes a great economic challenge on the health care system; with the greatest share of this burden attributed to radical cystectomy (RC) and prolonged postoperative follow-up. Our aim was to characterize health care services utilization and evaluate associated cost predictors during the last 6 months of life in patients who had RC. METHODS: We conducted a retrospective study within a cohort of 2,988 patients who had RC from 2000 to 2009...
May 4, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28476530/enriching-gene-expression-profiles-will-help-personalize-prostate-cancer-management-for-african-americans-a-perspective
#13
REVIEW
Srinivasan Vijayakumar, John C Henegan, Xu Zhang, Wanmei Wang, William A Day, Vani Vijayakumar, Carlos S Moreno, Christian R Gomez
Prostate cancer (PCa) remains the most common form of cancer affecting men in the Western Hemisphere. Mortality rate is 130% higher among African-American men (AAM) than Caucasian-American men. As this trend is not new nor changing, there is an urgent need to identify markers with the ability to specifically distinguish aggressive PCa in the context of race. Gene expression patterns have been used as a tool to identify prognostic biomarkers for PCa to help reduce this disparity. Gene expression profiles reveal molecular mechanisms useful in understanding the biologic basis of tumorigenesis...
May 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28476529/is-suspicious-upstaging-on-multiparametric-magnetic-resonance-imaging-useful-in-improving-the-reliability-of-prostate-cancer-research-international-active-surveillance-prias-criteria-use-of-the-k-cap-registry
#14
Sagnjun Yoo, Jun Hyuk Hong, Seok-Soo Byun, Ji Youl Lee, Byung Ha Chung, Choung-Soo Kim
BACKGROUND AND OBJECTIVE: To evaluate the clinical effects of suspicious upstaging on multiparametric magnetic resonance imaging (mpMRI) for improving the quality of Prostate Cancer Research International Active Surveillance (PRIAS) criteria. MATERIAL AND METHODS: A total of 363 patients with low-risk prostate cancer (PCa) were selected from the K-CaP registry (the multicenter Korean PCa Database). Patients were divided into 2 groups according to the results of mpMRI (with or without suspicious upstaging)...
May 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28476528/prognostic-heterogeneity-in-t3an0m0-renal-cell-carcinoma-according-to-the-site-of-invasion
#15
Myungchan Park, Myungsun Shim, Myong Kim, Cheryn Song, Choung-Soo Kim, Hanjong Ahn
PURPOSE: We investigated the influence of the site of invasion on recurrence and survival in patients with pT3aN0M0 renal cell carcinoma (RCC). MATERIALS AND METHODS: We reviewed the data of 266 patients with pT3aN0M0 RCC who underwent nephrectomy and divided them into the following 5 groups according to the site of invasion: perinephric invasion (PNI), sinus fat invasion (SFI), PNI and SFI without renal vein invasion (RVI) (i.e., PNI+SFI), RVI, and RVI with PNI and/or SFI (RVI+PNI±SFI)...
May 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28476527/hypoxia-and-renal-cell-carcinoma-the-influence-of-hif1a-1772c-t-functional-genetic-polymorphism-on-prognosis
#16
Marta Ferreira, Ana Teixeira, Joaquina Maurício, Francisco Lobo, António Morais, Rui Medeiros
OBJECTIVES: Hypoxia-inducible factor (HIF-1) is a key regulator of the genes involved in the cellular response to hypoxia. Overexpression of HIF-1 has been implicated in the pathogenesis of renal cell carcinoma (RCC), and functional polymorphisms of the HIF1A gene may confer susceptibility to RCC. Our purpose was to assess the influence of HIF1A+1772C/T (rs11549465) polymorphism on RCC prognosis. MATERIAL AND METHODS: This study evaluated the associations of the HIF1A+1772C/T (rs11549465) polymorphism with clinicopathologic prognostic factors, recurrence/progression, and survival in a cohort of 179 patients with RCC treated at Portuguese Oncology Institute of Porto...
May 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28476526/restrictive-transfusion-in-radical-cystectomy-is-safe
#17
Sumeet Syan-Bhanvadia, Siri Drangsholt, Swar Shah, Jie Cai, Gus Miranda, Hooman Djaladat, Siamak Daneshmand
INTRODUCTION AND OBJECTIVE: Perioperative blood transfusion (PBT) is commonplace in radical cystectomy (RC) and has been linked to poorer oncologic outcomes. Limiting PBT in this largely elderly and comorbid population has not been studied. Herein, we first investigate the safety of a restrictive transfusion protocol (RTP) in patients undergoing RC for urothelial carcinoma and then compare oncologic outcomes between patients who did and did not receive PBT. METHODS: Outcomes for 173 consecutive patients meeting inclusion criteria undergoing RC for urothelial carcinoma from April 2010 to June 2014 by a single surgeon employing RTP were analyzed from an institutional review board-approved, prospectively collected database...
May 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28460801/obesity-is-associated-with-biochemical-recurrence-after-radical-prostatectomy-a-multi-institutional-extended-validation-study
#18
Agnes B Maj-Hes, Romain Mathieu, Mehmet Özsoy, Francesco Soria, Marco Moschini, Mohammad Abufaraj, Alberto Briganti, Morgan Roupret, Pierre I Karakiewicz, Tobias Klatte, Shahrokh F Shariat
BACKGROUND: There are no clear data regarding the association between body mass index (BMI) and outcomes after radical prostatectomy (RP). This study aimed to investigate the association between BMI and biochemical recurrence (BCR) after RP in a large international contemporary cohort of patients with prostate cancer. METHODS: We retrospectively analyzed data from 6,519 patients who underwent RP at 5 institutions. BMI was analyzed as both a continuous and categorical variable (<25kg/m(2), 25-29...
April 28, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28460800/the-role-of-enhanced-recovery-in-open-or-robotic-cystectomy
#19
LETTER
Sanchia Shanika Goonewardene, Raj Persad, David Gillatt
No abstract text is available yet for this article.
April 28, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28457651/prevalence-and-correlates-of-mental-health-problems-in-prostate-cancer-survivors-a-case-control-study-comparing-survivors-with-general-population-peers
#20
Marie-Anne van Stam, Henk G van der Poel, J L H Ruud Bosch, Corinne N Tillier, Simon Horenblas, Floor Mols, Neil K Aaronson
OBJECTIVE: The purpose of this study was to identify factors associated with mental health (MH) problems in prostate cancer (PC) survivors. Toward this end, we evaluated (1) differences in the prevalence of MH problems between PC survivors and age-matched men from the general population (GenPop) and (2) correlates of MH in PC survivors and the GenPop. METHODS AND MATERIALS: In this observational case-control study, we age-matched PC survivors (n = 644, alive≥5y after diagnosis of a stage I-IV carcinoma) recruited from Dutch community hospitals (Patient Reported Outcomes Following Initial treatment and Long-term Evaluation of Survivorship registry) with GenPop peers (n = 644) selected from a population-based sample recruited in general practices (NIVEL)...
April 27, 2017: Urologic Oncology
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