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Urologic Oncology

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https://www.readbyqxmd.com/read/28935185/impact-of-hospital-case-volume-on-testicular-cancer-outcomes-and-practice-patterns
#1
Solomon L Woldu, Justin T Matulay, Timothy N Clinton, Nirmish Singla, Laura-Maria Krabbe, Ryan C Hutchinson, Arthur Sagalowsky, Yair Lotan, Vitaly Margulis, Aditya Bagrodia
BACKGROUND: Given the rarity of testicular germ cell tumors (TGCTs) and the complex aspects of management, we evaluate the effect of hospital TGCT case volume on overall survival outcomes and practice patterns. MATERIALS AND METHODS: The National Cancer Database was queried for patients diagnosed with seminoma or nonseminomatous germ cell tumor (NSGCT). Hospitals were classified by case volume as high (99th percentile, ≥26.1 cases annually), high-intermediate (95-99th percentile, 14...
September 18, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28935184/differential-expression-of-the-sirtuin-family-in-renal-cell-carcinoma-aspects-of-carcinogenesis-and-prognostic-significance
#2
Seong Uk Jeh, Jung Je Park, Jong Sil Lee, Dong Chul Kim, Jungmo Do, Sin Woo Lee, See Min Choi, Jae Seog Hyun, Deok Ha Seo, Chunwoo Lee, Sung Chul Kam, Ky Hyun Chung, Jeong Seok Hwa
OBJECTIVES: Sirtuins (1-7) are evolutionarily conserved NAD-dependent deacetylases that play an important role in carcinogenesis. However, their role in renal cell carcinoma (RCC) remains unclear. The objective of the present study was to examine the role of SIRTs in RCC carcinogenesis and prognosis. MATERIALS AND METHODS: Paraffin-embedded specimens from 102 patients who underwent extirpative renal surgeries for renal masses between January 2004 and December 2010 were examined...
September 18, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28927783/surgical-resection-of-locally-recurrent-renal-cell-carcinoma-after-nephrectomy-oncological-outcome-and-predictors-of-survival
#3
Roman Herout, Johannes Graff, Angelika Borkowetz, Stefan Zastrow, Steffen Leike, Rainer Koch, Desiree-Louise Draeger, Chris Protzel, Oliver W Hakenberg, Manfred P Wirth, Michael Froehner
OBJECTIVE: To describe the course of disease of patients surgically treated for locally recurrent renal cell carcinoma (LRRCC) after nephrectomy and to identify potential predictive factors for long-term survival. PATIENTS AND METHODS: We, retrospectively, identified 54 patients who underwent surgical resection of LRRCC after open nephrectomy for localized kidney cancer. The median age at time of surgery for LRRCC was 65 years. Survival rates were determined with the Kaplan-Meier method...
September 15, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28927782/development-and-internal-validation-of-prediction-models-for-biochemical-failure-and-composite-failure-after-focal-salvage-high-intensity-focused-ultrasound-for-local-radiorecurrent-prostate-cancer-presentation-of-risk-scores-for-individual-patient-prognoses
#4
Max Peters, Abi Kanthabalan, Taimur T Shah, Neil McCartan, Caroline M Moore, Manit Arya, Jochem R van der Voort van Zyp, Marinus A Moerland, Richard G Hindley, Mark Emberton, Hashim U Ahmed
PURPOSE: Patient selection for focal salvage remains difficult. Therefore, we developed and internally validated prediction models for biochemical failure (BF) and a composite endpoint (CE) following focal salvage high intensity focused ultrasound (HIFU) for radiorecurrent prostate cancer. MATERIALS AND METHODS: A prospective HIFU registry identified 150 cases (November 2006-August 2015). Recurrence was assessed with multiparametric magnetic resonance imaging (MRI) combined with template prostate mapping biopsies, targeted biopsies, or systematic transrectal ultrasound-guided biopsies...
September 15, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28919182/population-based-study-of-the-incidence-and-survival-for-intraductal-carcinoma-of-the-prostate
#5
Brian F Dinerman, Francesca Khani, Ron Golan, Adrien N Bernstein, Michael F Cosiano, Daniel J Margolis, Jim C Hu
PURPOSE: The degree to which intraductal carcinoma of the prostate (IDC-P) affects clinical course remains poorly understood owing to small sample sizes from single-center studies. We sought to determine prognostic factors and outcomes associated with IDC-P in radical prostatectomy (RP) specimens. MATERIALS AND METHODS: This is a retrospective study of RP during 2004 to 2013 using Surveillance, Epidemiology, and End Results to compare IDC-P with non-IDC-P. The effect of IDC-P on overall and disease-specific survival was assessed using Cox regression with a median follow-up of 4...
September 14, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28919181/lymphadenectomy-in-gleason-7-prostate-cancer-adherence-to-guidelines-and-effect-on-clinical-outcomes
#6
Thenappan Chandrasekar, Hanan Goldberg, Zachary Klaassen, Rashid K Sayyid, Robert J Hamilton, Neil E Fleshner, Girish S Kulkarni
BACKGROUND: To examine usage trends, guideline adherence, and survival data for patients undergoing lymphadenectomy (LND) at the time of radical prostatectomy (RP) for Gleason 7 prostate cancer (PCa). METHODS: The SEER database was queried for all patients with nonmetastatic biopsy Gleason 7 PCa from 2004 to 2013. Distribution and trends of LND were analyzed. The Memorial-Sloan Kettering Cancer Center nomogram was applied to stratify patients based on risk of nodal disease at time of RP (<5% risk or ≥5% risk)...
September 14, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28918166/high-expression-of-cxc-chemokine-receptor-6-associates-with-poor-prognosis-in-patients-with-clear-cell-renal-cell-carcinoma
#7
Yuan Chang, Lin Zhou, Le Xu, Qiang Fu, Yuanfeng Yang, Zongming Lin, Jiejie Xu
PURPOSE: Accumulating evidence indicates that CXC chemokine receptor 6 (CXCR6) has a crucial role in cancer development and progression, however, its role in clear cell renal cell carcinoma (ccRCC) remains obscure. The aim of this study is to investigate the prognostic value of CXCR6 expression in patients with ccRCC following surgery. MATERIALS AND METHODS: This study retrospectively included 239 patients with ccRCC who underwent nephrectomy and had paraffin tissue available at a single center...
September 13, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28916150/use-of-cylindrical-coordinates-to-localize-prostate-cancers-on-mri-and-prostatectomy-pathology
#8
Devin N Patel, Christopher Nguyen, Deepika Sirohi, Vida Falahatian, Rola Saouf, Daniel Luthringer, Debiao Li, Hyung L Kim
PURPOSE: To describe and test a quantitative system for designating prostate tumor location on magnetic resonance imaging (MRI) and prostatectomy. A system for describing tumor location will facilitate research correlating MRI and pathology. MATERIALS AND METHODS: The prostate cylindrical coordinate (PCC) system was developed for locating prostate tumors using 3 coordinate values. The 3 coordinate values include the angular location centered on the urethra, the radial distance to the periphery and the long axis from apex to base...
September 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28911924/sialyl-tn-identifies-muscle-invasive-bladder-cancer-basal-and-luminal-subtypes-facing-decreased-survival-being-expressed-by-circulating-tumor-cells-and-metastases
#9
Luís Lima, Manuel Neves, Marta I Oliveira, Lorena Dieguez, Rui Freitas, Rita Azevedo, Cristiana Gaiteiro, Janine Soares, Dylan Ferreira, Andreia Peixoto, Elisabete Fernandes, Diana Montezuma, Ana Tavares, Ricardo Ribeiro, Ana Castro, Manuel Oliveira, Avelino Fraga, Celso A Reis, Lúcio Lara Santos, José Alexandre Ferreira
OBJECTIVES: To evaluate the potential of sialyl-Tn (STn), a cancer-associated glycan antigen present in membrane glycoproteins, to improve a recent molecular model for stratification and prognostication of advanced stage bladder tumors based on keratins (KRT14, 5, and 20) expression. In addition, determine the association between STn and disease dissemination based on the evaluation of circulating tumor cells (CTCs) and the metastasis, which is a critical matter to improve patient management...
September 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28911923/secondary-data-sources-for-health-services-research-in-urologic-oncology
#10
REVIEW
Alexander P Cole, David F Friedlander, Quoc-Dien Trinh
BACKGROUND: Though secondary data analyses of large datasets may reduce logistical and financial barriers required to perform significant and innovative work, such research requires specialized skills in data handling and statistical techniques as well as thorough and detailed knowledge of the data sources being used. OBJECTIVES: To provide an overview of several common types of secondary data, focusing on strengths, weaknesses and examples of how these data may be used for health services research...
September 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28911922/neoadjuvant-sorafenib-gemcitabine-and-cisplatin-administration-preceding-cystectomy-in-patients-with-muscle-invasive-urothelial-bladder-carcinoma-an-open-label-single-arm-single-center-phase-2-study
#11
Andrea Necchi, Salvatore Lo Vullo, Daniele Raggi, Federica Perrone, Patrizia Giannatempo, Giuseppina Calareso, Elena Togliardi, Nicola Nicolai, Luigi Piva, Davide Biasoni, Mario Catanzaro, Tullio Torelli, Silvia Stagni, Maurizio Colecchia, Adele Busico, Marzia Pennati, Nadia Zaffaroni, Luigi Mariani, Roberto Salvioni
BACKGROUND: Outcomes of neoadjuvant chemotherapy in patients with muscle-invasive urothelial bladder carcinoma (MIUBC) should be improved. Sorafenib was combined with gemcitabine and cisplatin chemotherapy (SGC) in an open-label, single-arm, phase 2 trial (NCT01222676). PATIENTS AND METHODS: After transurethral resection of the bladder, T2-T4a N0 patients received four cycles of SGC followed by cystectomy. Sorafenib 400mg q12h daily, continuously, was added to standard GC chemotherapy...
September 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28889922/the-effect-of-ab0-and-rhesus-blood-grouping-systems-on-oncological-outcome-in-patients-undergoing-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma
#12
Michael Rink, Oliver Engel, Georgios Gakis, Hans Martin Fritsche, Malte W Vetterlein, Armin Soave, Sven Peine, Atiqullah Aziz, Roland Dahlem, Arnulf Stenzl, Maximilian Burger, Shahrokh F Shariat, Margit Fisch, Philipp Gild
OBJECTIVES: To investigate the effect of AB0 and Rhesus factor expression blood group systems on outcomes of upper tract urothelial carcinoma patients treated with radical nephroureterectomy. PATIENTS AND METHODS: We analyzed data from 271 patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy at 3 German academic institutions. Cox and logistic regression models assessed the association of AB0 blood group antigen and Rhesus factor expression with tumor biologic features and outcomes, respectively...
September 7, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28889921/pd-1-checkpoint-inhibition-toxicities-and-management
#13
REVIEW
Andrew W Hahn, David M Gill, Neeraj Agarwal, Benjamin L Maughan
PURPOSE: With the recent approval of 5 PD-1/PD-L1 inhibitors for a number of malignancies, PD-1 axis inhibition is drastically changing the treatment landscape of immunotherapy in cancer. As PD-1/PD-L1 are involved in peripheral immune tolerance, inhibition of this immune checkpoint has led to novel immune-related adverse events including colitis, hepatitis, pneumonitis, rash, and endocrinopathies among many others. MATERIALS AND METHODS: In this seminar, we will analyze the incidence of immune-related adverse events for nivolumab, pembrolizumab, atezolizumab, durvalumab, and avelumab...
September 7, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28889920/the-incidence-of-unsuccessful-partial-nephrectomy-within-the-united-states-a-nationwide-population-based-analysis-from-2003-to-2015
#14
Yash S Khandwala, In Gab Jeong, Jae Heon Kim, Deok Hyun Han, Shufeng Li, Ye Wang, Steven L Chang, Benjamin I Chung
PURPOSE: Partial nephrectomy (PN) remains underutilized within the United States and few reports have attempted to explain this trend. The aim of this study is to evaluate the nationwide incidence of unsuccessful PN and factors that predict its occurrence. METHODS: Using the Premier Healthcare Database, we retrospectively analyzed a weighted sample of 66,432 patients undergoing curative surgery for renal mass between 2003 and 2015. PN intent was denoted by presence of insurance claims for the administration of mannitol...
September 7, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28889919/emerging-immunotherapy-in-advanced-renal-cell-carcinoma
#15
REVIEW
Prateek Mendiratta, Brian I Rini, Moshe C Ornstein
Immunotherapy has recently catapulted to the forefront of treatments for patients with solid tumors. Given its inherent immunogenic properties, renal cell carcinoma (RCC) has historically responded to immunotherapy and remains primed for further development. Although immunotherapy with high-dose interleukin 2 was a primary treatment for advanced RCC (aRCC), recent discoveries of key molecular and immunological alterations have led to the FDA-approval of nivolumab, an antiprogrammed cell death inhibitor, which has demonstrated an overall survival in patients with previously treated aRCC...
September 7, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28888400/characterization-of-inflammasome-related-genes-in-urine-sediments-of-patients-receiving-intravesical-bcg-therapy
#16
Giulia Poli, Giovanni Cochetti, Andrea Boni, Maria Giulia Egidi, Stefano Brancorsini, Ettore Mearini
BACKGROUND: Nowadays, the intravesical Bacillus Calmette-Guérin (BCG) instillation is the method of choice for the postsurgical treatment of high-grade nonmuscle-invasive bladder cancer , to reduce both recurrence rate and risk of progression. BCG is hypothesized to correct the immune system disequilibrium occurring during carcinogenesis, through an immunostimulation with detrimental effects for tumoral cells. Inflammation plays a crucial role in tumor progression. The deregulation of inflammasomes upon carcinogenesis underlines its importance both in physiologic and pathologic human conditions...
September 6, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28887097/second-line-systemic-therapy-in-metastatic-renal-cell-carcinoma-a-review
#17
REVIEW
Rohit K Jain, Shipra Gandhi, Saby George
Treatment in metastatic renal-cell carcinoma (mRCC) has evolved tremendously in the last decade. The development of newer targeted agents, like vascular endothelial growth factor inhibitors and immunotherapy have changed the treatment paradigm in mRCC patients. Axitinib and everolimus have been used extensively in patients who progressed on prior antiangiogenic therapy. The newer agents including nivolumab, cabozantinib, and lenvatinib in combination with everolimus have all demonstrated overall survival benefit over everolimus...
September 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28887096/predicting-local-failure-after-radical-cystectomy-in-patients-with-bladder-cancer-implications-for-the-selection-of-candidates-at-adjuvant-radiation-therapy
#18
Marco Moschini, Shahrokh F Shariat, Mohammad Abufaraj, Beat Foerster, David D Andrea, Francesco Soria, Paolo Dell Oglio, Agostino Mattei, Francesco Montorsi, Renzo Colombo, Alberto Briganti, Andrea Gallina
OBJECTIVE: To evaluate incidence and predictors of local failure (LF) after radical cystectomy (RC) due to bladder cancer. METHODS: We focused on 1,112 patients treated with RC, between 1990 and 2012, at a single center. LF was defined as imaging evidence of recurrence in the pelvic soft tissues or nodes below the aortic bifurcation at least 3 months before the detection of distant metastases. Competing risk analyses tested the relationship between clinical and pathological factors and the risk to develop LF...
September 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28887095/psychological-distress-in-patients-undergoing-surgery-for-urological-cancer-a-single-centre-cross-sectional-study
#19
Antonio Luigi Pastore, Ana Mir, Serena Maruccia, Giovanni Palleschi, Antonio Carbone, Cristina Lopez, Nuria Camps, Joan Palou
PURPOSE: Interest in the disease-specific psychological well-being of patients with cancer has increased, and it has been estimated that less than half of all patients with cancer are properly identified and subsequently treated for anxiety or depression. The aim of this study is to evaluate psychological distress in uro-oncological patients undergoing different surgeries: radical cystectomy, radical prostatectomy, radical nephrectomy, or transurethral resection (TUR) before the surgery...
September 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28882673/predictive-factors-for-local-recurrence-after-glansectomy-and-neoglans-reconstruction-for-penile-squamous-cell-carcinoma
#20
Maarten Albersen, Arie Parnham, Steven Joniau, Varun Sahdev, Michelle Christodoulidou, Fabio Castiglione, Raj Nigam, Peter Malone, Alex Freeman, Charles Jameson, Suks Minhas, David J Ralph, Asif Muneer
OBJECTIVES: To investigate predictive pathological factors for local recurrence (LR) after glansectomy for penile squamous cell carcinoma (SCC) and to develop a risk score for prediction of LR after glansectomy. PATIENTS AND METHODS: In this retrospective study, we analyzed 117 patients operated between February 2005 and January 2016 in a supraregional penile cancer center in the UK for LR after glansectomy and glans reconstruction. Univariate and multivariate Cox proportional hazards regression was used to identify 4 prognostic indicators for LR...
September 4, 2017: Urologic Oncology
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