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Urologic Oncology

Ying-En Lee, Ti-Chun Chan, Yu-Feng Tian, Peir-In Liang, Yow-Ling Shiue, Yi-Sheng Chen, Hong-Lin He
BACKGROUND: Metabolic adaptation in cancer cells is important for cancer cell survival. Alternation in cellular metabolism getting more energy to support cell proliferation played a critical role in disease progression. We initially analyzed the public transcriptome of urothelial carcinoma in Gene Expression Omnibus database (GSE31684) with particular focus on genes associated with carbohydrate metabolism, and found that Chitinase 3-like-1 (CHI3L1) was a significantly up-regulated gene associated with advanced disease status...
January 16, 2019: Urologic Oncology
Christophe K Mannaerts, Amir Kajtazovic, Olivia A P Lodeizen, Maudy Gayet, Marc R W Engelbrecht, Gerrit J Jager, Hessel Wijkstra, Theo M de Reijke, Harrie P Beerlage
PURPOSE: Incorporation of multiparametric magnetic resonance imaging (mpMRI) and targeted biopsy (TBx) in the diagnostic pathway for prostate cancer (CaP) is rapidly becoming common practice. In men with a prebiopsy positive mpMRI a TBx only approach, thereby omitting transrectal ultrasound-guided systematic biopsy (SBx), has been postulated. In this study we evaluated the additional clinical relevance of SBx in men with a positive prebiopsy mpMRI (Prostate Imaging Reporting and Data System [PI-RADS] ≥ 3) undergoing TBx for CaP detection, Gleason grading and CaP localization...
January 16, 2019: Urologic Oncology
David R Lairson, Chi-Fang Wu, Wenyaw Chan, Shuangshuang Fu, Karen E Hoffman, Curtis A Pettaway
PURPOSE: The aims of this study were to estimate the short-term cost of treating newly diagnosed penile cancer and determine the correlates of penile cancer treatment cost in the United States. METHODS: The Truven MarketScan database was used to identify commercially insured patients with penile cancer newly diagnosed during 2011 to 2014. A control group without HPV-related cancer diagnosis was selected by matching to the case group by the propensity score method...
January 16, 2019: Urologic Oncology
Earle F Burgess, Chad Livasy, Aaron Hartman, Myra M Robinson, James Symanowski, Caroline Naso, Shannon Doherty, Renato Guerrieri, Stephen Riggs, Claud M Grigg, Peter E Clark, Derek Raghavan
Immune checkpoint inhibitors (ICI) targeting PD-(L)1 are effective in select patients with advanced urothelial carcinoma (UC). High PD-L1 expression enriches for response to ICIs; however, the predictive value of PD-L1 expression is limited, which may be due in part to dynamic expression of PD-L1 in the tumor environment. We sought to characterize PD-L1 expression in primary UC and paired metastatic lesions to gain insight into the potential discordance of tumor PD-L1 expression during the metastatic process...
January 16, 2019: Urologic Oncology
Sanaa Eissa, Maheera Safwat, Marwa Matboli, Ashraf Zaghloul, Maha El-Sawalhi, Amira Shaheen
OBJECTIVE: To assist in the diagnosis, treatment, and prognostic prediction of bladder cancer, the molecular patterns associated with it should be elucidated. Competing endogenous RNA network: MicroRNA (miRNA), long noncoding RNA (lncRNA), and their target autophagy genes have been strongly implicated in tumor development and metastasis. PATIENTS AND METHODS: Bioinformatics analysis was performed to retrieve a ceRNA: lncRNA-miRNA-mRNA network linked to autophagy and relevant to bladder cancer...
January 14, 2019: Urologic Oncology
Marc A Furrer, Juerg Huesler, Adrian Fellmann, Fiona C Burkhard, George N Thalmann, Patrick Y Wuethrich
OBJECTIVE: To optimize complication reporting in patients undergoing cystectomy and urinary diversion (UD) using the Comprehensive Complication Index (CCI). The original CCI ranging from 0 (no complications) to 100 (death) integrates all complications weighted by severity over time in a single formula. However, due to the large number of complications after cystectomy and UD, the CCI may exceed the upper limit. METHODS: In an observational single-center cohort, 90-day postoperative complications in 1,313 consecutive patients undergoing cystectomy and UD from 2000 to 2017 were evaluated...
January 8, 2019: Urologic Oncology
Gagan Fervaha, Jason P Izard, Dean A Tripp, Selina Rajan, Darryl P Leong, D Robert Siemens
Prostate cancer is the most common malignancy among men. Given its prevalence and relatively low mortality rates, several biopsychosocial survivorship issues have garnered recent attention. This article reviews the literature on the association between depression and prostate cancer, emphasizing key practice points relevant for clinicians. Depression is prevalent among men with prostate cancer, with approximately 1 in 6 patients experiencing clinical depression. Suicidal ideation is also not uncommon in this population and does not always present in those with other depressive symptoms...
January 7, 2019: Urologic Oncology
Naoya Niwa, Kazuhiro Matsumoto, Hiroki Ide
OBJECTIVE: The production of antibody, also referred immunoglobulin, is the principal functions of B cells. Gamma globulin fraction determined by serum protein electrophoresis is composed almost entirely of immunoglobulin. This study aimed to investigate the association between gamma globulin level and oncological outcomes in patients with nonmuscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS: A total of 274 patients with NMIBC who underwent transurethral surgery between 2000 and 2015 were identified...
January 7, 2019: Urologic Oncology
Shuxiong Zeng, Lihe Dai, Jun Yang, Xiaomin Gao, Xiaowen Yu, Qian Ren, Kaijian Wang, Jinshan Xu, Zeyu Yang, Bo Yang, Huiqing Wang, Qing Yang, Huamao Ye, Jianguo Hou, Yue Pan, Zhensheng Zhang, Zhiliang Weng, Yinghao Sun, Chuanliang Xu
OBJECTIVE: To create multivariable models with readily available clinicopathologic variables for predicting the prognosis of upper tract urothelial carcinomas (UTUC). PATIENTS AND METHODS: We retrospectively analyzed patients diagnosed as UTUC and underwent radical nephroureterectomy in 2 high volumes, tertiary care centers. A total of 445 patients and 227 patients met the inclusion criteria were included for constructing the prediction model and external validation, respectively...
January 7, 2019: Urologic Oncology
Leilei Xia, Ruchika Talwar, Benjamin L Taylor, Michael H Shin, Ian B Berger, Colin D Sperling, Raju R Chelluri, Ibardo A Zambrano, Jay D Raman, Thomas J Guzzo
PURPOSE: To investigate national utilization trends of minimally-invasive partial nephrectomy (PN) and minimally-invasive radical nephrectomy (RN), and to identify disparities in the usage of these techniques across different sociodemographic subgroups. MATERIALS AND METHODS: A retrospective cohort study was conducted using the National Cancer Database to identify patients undergoing partial or RN for cT1N0M0 renal cancer diagnosed between 2010 and 2015. Main outcomes of interest were the utilizations of minimally-invasive (robotic and laparoscopic) PN and RN...
January 7, 2019: Urologic Oncology
Timothy A Masterson, Clint Cary, Richard S Foster
The role of surgery in the locoregional management of many solid tumors has long been established. For testicular cancer, the incorporation of lymphadenectomy has played an important part in generating long-term survival outcomes in excess of 90% for germ cell tumor patients. In this review, we address several clinical scenarios in which lymphadenectomy at times is underutilized, and others ill advised.
January 7, 2019: Urologic Oncology
Nishtman Dizeyi, Dorota Trzybulska, Yahia Al-Jebari, Ilpo Huhtaniemi, Yvonne Lundberg Giwercman
INTRODUCTION: Conversion of androgen-responsive prostate cancer (CaP) to castration-resistant CaP) is associated with an acceleration of the disease that often requires treatment modalities other than androgen deprivation therapy only. Recently, follicle-stimulating hormone (FSH) has been shown to play a role in CaP growth, and clinical data showed that high serum concentration of FSH in chemically castrated CaP patients was associated with a shorter time of progression to castration-resistant CaP...
January 2, 2019: Urologic Oncology
Eric M Lo, James M Hotaling, Alexander W Pastuszak
INTRODUCTION: Recent advances in cancer research have highlighted the role of genetics in malignancy. Genetic dysregulation of core cellular functions similarly influences benign conditions. These common genetic factors have led researchers to identify an association between certain urologic conditions and malignancy. The objective of this review is to evaluate the literature linking benign urologic conditions including male infertility, Peyronie's disease, cryptorchidism, and hypospadias, to malignancy...
January 2, 2019: Urologic Oncology
Ming-Dow Tsay, Ming-Ju Hsieh, Shian-Shiang Wang, Wen-Chen Wang, Ya-Yi Chou, Chen-Ho Shih, Shun-Fa Yang, Ying-Erh Chou
OBJECTIVES: Urothelial cell carcinoma (UCC), a major malignancy of the genitourinary tract, is induced through carcinogenic etiological factors. Endothelial nitric oxide synthase (eNOS) is one of the major isoforms of nitric oxide synthase and is involved in various pathophysiologic and physiologic processes. In this study, eNOS single-nucleotide polymorphisms were investigated to evaluate UCC susceptibility and clinicopathological characteristics. MATERIALS AND METHODS: Two single-nucleotide polymorphisms of eNOS in 431 patients with UCC and 862 controls without cancer were analyzed using real-time polymerase chain reaction...
January 2, 2019: Urologic Oncology
Adam B Weiner, Oliver S Ko, Alec Zhu, Daniel E Spratt, Jim C Hu, Edward M Schaeffer
PURPOSE: Controversy surrounds the benefit of pelvic lymph node irradiation (PLN-RT) in localized prostate cancer (CaP). Our objective was to determine the practice patterns and predictors of PLN-RT in a national cohort. MATERIALS AND METHODS: The National Cancer Data Base (2005-2015) was leveraged to obtain men diagnosed with nonmetastatic CaP treated with external beam radiotherapy (n = 197,378). Multivariable logistic regressions were used to assess temporal trends and factors associated with PLN-RT...
January 2, 2019: Urologic Oncology
Mary M Everist, Lauren E Howard, William J Aronson, Christopher J Kane, Christopher L Amling, Matthew R Cooperberg, Martha K Terris, Stephen J Freedland
INTRODUCTION: We previously found racial differences in biochemical recurrence (BCR) after radical prostatectomy (RP) persisted after adjusting for socioeconomic status (SES) while SES did not predict BCR. The impact on long-term prostate cancer (PC) outcomes is unclear. We hypothesized higher SES would associate with better long-term outcomes regardless of race. METHODS: Among 4,787 black and white men undergoing RP from 1988 to 2015 in the SEARCH Database, poverty (primary SES measure) was estimated by linking home ZIP-code to census data...
December 28, 2018: Urologic Oncology
Antonio Gómez-Martín, Luis J Martinez-Gonzalez, Ignacio Puche-Sanz, Jose M Cozar, Jose A Lorente, Antonio F Hernández, Maria J Alvarez-Cubero
BACKGROUND: Many etiological factors have been related to prostate cancer (CaP) development, progression, and survival, such as age, population origin, geographic area, occupational exposures, and nutrition and lifestyle factors. However, physical activity affords health benefits to cancer patients, including those with CaP. Glutathione S-Transferases enzymes have been linked to CaP because of their role in the detoxification of a wide variety of potential carcinogens, steroid hormones and xenobiotics...
December 27, 2018: Urologic Oncology
Thomas Martini, Jakob Heinkele, Roman Mayr, Cleo-Aron Weis, Felix Wezel, Sarah Wahby, Markus Eckstein, Thomas Schnöller, Johannes Breyer, Ralph Wirtz, Manuel Ritter, Christian Bolenz, Philipp Erben
No abstract text is available yet for this article.
December 27, 2018: Urologic Oncology
Ti-Chun Chan, Chien-Feng Li, Hung-Lung Ke, Yu-Ching Wei, Yow-Ling Shiue, Ching-Chia Li, Hsin-Chih Yeh, Hsiang-Ying Lee, Steven-K Huang, Wen-Jeng Wu, Wei-Ming Li
PURPOSE: Inflammatory responses affect each stage of carcinogenesis, from initiation, through invasion, to metastasis. Studies have shown that chronic inflammation induced by environmental and occupational exposures increase the risk of developing urothelial carcinoma (UC). Using a published UC transcriptome (GSE32894), we identified that among genes associated with inflammatory response (GO:0006954), TNFAIP6 was significantly upregulated during UC progression. Therefore, we investigated the association of TNFAIP6 with disease features, metastasis and survival in our well-characterized cohort of UC...
December 27, 2018: Urologic Oncology
Olaf Schoffer, Anne Neumann, Roland Stabenow, Stefanie Schülein, Wolf-Diether Böhm, Andreas Gonsior, Lars-Christian Horn, Christian Kriegel, Jens-Uwe Stolzenburg, Manfred Wirth, Stefanie J Klug
OBJECTIVE: Penile cancer is a rare disease in Europe and North America. Cancer registry data were used to estimate the incidence, mortality, and survival of penile cancer in Saxony, Germany. METHODS: Data on incidence were analyzed for the period 1961 to 2012 and mortality for the period 1990 to 2012. Trend analyses of incidence and mortality were performed using joinpoint regression. Survival rates for primary penile cancer (ICD-10 C60) were estimated; overall, by T stage, UICC stage, and by year of diagnosis for the years 1963 to 2012...
December 27, 2018: Urologic Oncology
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