journal
MENU ▼
Read by QxMD icon Read
search

Toxicology Letters

journal
https://www.readbyqxmd.com/read/28438492/metabolism-of-14-c-octamethylcyclotetrasiloxane-14-c-d4-or-14-c-decamethylcyclopentasiloxane-14-c-d5-orally-gavaged-in-rainbow-trout-oncorhynchus-mykiss
#1
Jeanne Y Domoradzki, Jacob M Sushynski, Lisa M Thackery, Timothy A Springer, Timothy L Ross, Kent B Woodburn, Jeremy A Durham, Debra A McNett
Critical factors (uptake, distribution, metabolism and elimination) for understanding the bioaccumulation/biomagnification potential of Octamethylcyclotetrasiloxane (D4) and Decamethylcyclopentasiloxane (D5) siloxanes in fish were investigated to address whether these chemicals meet the "B" criteria of the Persistent, Bioaccumulative, and Toxic (PBT) classification. A metabolism study was conducted in rainbow trout whereby a 15mg [(14)C]D4 /kg bw or [(14)C]D5/kg bw as a single bolus oral dose was administered via gavage...
April 21, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28435131/repression-of-acetaminophen-induced-hepatotoxicity-by-a-combination-of-celastrol-and-brilliant-blue-g
#2
Heba A Abdelaziz, Mohamed E Shaker, Mohamed F Hamed, Nariman M Gameil
The sterile inflammatory response is an eminent contributor to acetaminophen (APAP)-hepatotoxicity in humans. Recent advances unraveled an axial role of the NLRP3-inflammasome in APAP-post injury inflammation. Nevertheless, the role of signaling events preceded the NLRP3-inflammasome activation, like the transcription factor NF-κB and the purinergic receptor P2×7, is still unclear and needs further elucidation. Here, we investigated the pharmacological inhibition of these upstream signaling molecules by celastrol and brilliant blue G (BBG) (separately or simultaneously) in APAP-hepatotoxicity in mice...
April 20, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28428138/pregnane-x-receptor-regulates-the-ahr-cyp1a1-pathway-and-protects-liver-cells-from-benzo-%C3%AE-pyrene-induced-dna-damage
#3
Hongmei Cui, Xinsheng Gu, Jingshu Chen, Ying Xie, Sui Ke, Jing Wu, Andrei Golovko, Benjamin Morpurgo, Chunhong Yan, Timothy D Phillips, Wen Xie, Jianyuan Luo, Zhijun Zhou, Yanan Tian
Pregnane X receptor (PXR) plays an important role in protecting cells from mutagenic DNA damages induced by endogenous and exogenous toxicants. This protective function is often attributed to the PXR-regulated metabolic detoxification. Here we report a novel potential mechanism that PXR reduces benzo-[α]-pyrene(BaP)-induced DNA damage through inhibiting the transcriptional activity of aryl hydrocarbon receptor (AhR) which plays a pivotal role in the bioactivation of BaP. We have utilized three well-characterized cell lines, i...
April 17, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28428137/jwa-antagonizes-paraquat-induced-neurotoxicity-via-activation-of-nrf2
#4
Xue Zhao, Rihua Wang, Jianping Xiong, Donglin Yan, Aiping Li, Shouyu Wang, Jin Xu, Jianwei Zhou
Paraquat (PQ), a widely used environmental toxin in agriculture, contributes to the onset and progression of Parkinson's disease (PD) by damaging neurons. The JWA gene, also known as ARL6IP5, exerts a protective effect on degenerating dopamine (DA) neurons. However, the roles of JWA in PQ-induced neuronal damage are still unknown. In our study, two neuronal cell lines (HT-22 and SH-SY5Y) and neuron-specific JWA knockout (JWA-nKO) and age-matched wild-type (JWA-nWT) mice were subjected to PQ treatment. The results indicate that PQ administration triggers the upregulation of JWA...
April 17, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28428136/hesperetin-derivative-14-alleviates-inflammation-by-activating-ppar-%C3%AE-in-mice-with-ccl4-induced-acute-liver-injury-and-lps-treated-raw264-7-cells
#5
Xin Chen, Hai-Wen Ding, Hai-Di Li, Hui-Min Huang, Xiao-Feng Li, Yang Yang, Yi-Long Zhang, Xue-Yin Pan, Cheng Huang, Xiao-Ming Meng, Jun Li
Hesperetin is a flavanone glycoside compound naturally occurring in the fruit peel of Citrusaurantium L. (Rutaceae). Previous studies revealed that hesperetin possesses various pharmacological effects, including anti-inflammation, anti-tumor, anti-oxidant and neuroprotective properties. Hesperetin derivative-14 (HD-14) is a derivative of hesperetin improved in water solubility and bioavailability. In this study, we indicated that HD-14 (2μM) significantly attenuated inflammation in LPS-treated RAW264.7 cells and had hepato-protective effects and anti-inflammatory effects (100mg/kg) on C57BL/6J mice with CCl4-induced acute liver injury...
April 17, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28428135/the-immunotoxicological-pattern-of-subchronic-and-chronic-benzene-exposure-in-rats
#6
Alexander V Karaulov, Irina V Mikhaylova, Alexander I Smolyagin, Viktor M Boev, Alexandra Kalogeraki, Aristides M Tsatsakis, Ayse Basak Engin
Exposure to benzene and its inevitable metabolites can result in deleterious effects on human health, including lymphocytopenia, hematotoxicity and cancer. However, the duration of exposure might alter the effects including immune consequences. The aim of this study was to determine whether benzene could modulate lymphocyte proliferation induced by the T cell mitogen concanavalin A, in rats, at different exposure durations. 386 Wistar rats were assigned into control and treatment groups which was subdivided into groups for 45, 90 and 135days for 0,6mL/kg of drinking water mixed benzene treatment...
April 17, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28419832/dihydromyricetin-modulates-p62-and-autophagy-crosstalk-with-the-keap-1-nrf2-pathway-to-alleviate-ethanol-induced-hepatic-injury
#7
Ping Qiu, Yu Dong, Bo Li, Xian-Jie Kang, Chao Gu, Tao Zhu, Yun-Yun Luo, Min-Xia Pang, Wei-Feng Du, Wei-Hong Ge
Increasing evidence has demonstrated that dihydromyricetin (DMY) contains highly effective antioxidative, anti-inflammatory, anti-microbial and anti-diabetic properties. Nevertheless, the underlying hepatoprotective mechanisms of DMY have infrequently been reported thus far. In the present study, C57BL/6 mice were fed with the Lieber-DeCarli diet containing alcohol or isocaloric maltose dextrin as a control diet with or without DMY (75 and 150mg/kg/d bw) for 6 weeks. DMY significantly attenuated hepatic enzyme release, hepatic lipid peroxidation and triglyceride deposition induced by chronic alcohol exposure...
April 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28412454/new-insights-into-the-toxicity-of-mineral-fibres-a-combined-in-situ-synchrotron-%C3%AE-xrd-and-hr-tem-study-of-chrysotile-crocidolite-and-erionite-fibres-found-in-the-tissues-of-sprague-dawley-rats
#8
Alessandro F Gualtieri, Nicola Bursi Gandolfi, Simone Pollastri, Manfred Burghammer, Eva Tibaldi, Fiorella Belpoggi, Kilian Pollok, Falko Langenhorst, Ruggero Vigliaturo, Goran Dražić
Along the line of the recent research topic aimed at understanding the in vivo activity of mineral fibres and their mechanisms of toxicity, this work describes the morpho-chemical characteristics of the mineral fibres found in the tissues of Sprague-Dawley rats subjected to intraperitoneal/intrapleural injection of UICC chrysotile, UICC crocidolite and erionite-Na from Nevada (USA). The fibres are studied with in situ synchrotron powder diffraction and high resolution transmission electron microscopy to improve our understanding of the mechanisms of toxicity of these mineral fibres...
April 12, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28412453/in-vitro-mercaptopyruvate-sulfurtransferase-species-comparison-in-humans-and-common-laboratory-animals
#9
Bryant M Moeller, Daune L Crankshaw, Jacquie Briggs, Herbert Nagasawa, Steven E Patterson
Cyanide is a metabolic poison that inhibits cytochrome c oxidase. Its broad applications in manufacturing and history as an agent of warfare/terror highlight the limitations in approved cyanide antidotes for mass casualties. Sulfanegen, a pre-clinical antidote for cyanide poisoning, exploits an endogenous detoxification pathway and should be amenable to mass-casualty scenarios. Because human studies are unethical, determination of appropriate animal species as models in translational studies for FDA approval under the "Animal Rule" are critical...
April 12, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28408153/refinement-of-the-oral-exposure-description-in-the-cyclic-siloxane-pbpk-model-for-rats-and-humans-implications-for-exposure-assessment
#10
Jerry L Campbell, Melvin E Andersen, Cynthia Van Landingham, Robinan Gentry, Elke Jensen, Jean Y Domoradzki, Harvey J Clewell
The multi-compound, and multi-dose (MC-MD) route physiologically based pharmacokinetic (PBPK) model for cyclic siloxanes reported by McMullin et al. (2016) brought together the series of models for octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in rat and human into a unified code structure that would allow simulation of both compounds following the inhalation and dermal routes of exposure. The refined MC-MD PBPK model presented here expands upon this effort to include representation of rat kinetic data in plasma, tissues and exhaled breath for the parent compounds after oral bolus administration...
April 10, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28400208/diesel-exhaust-particles-dep-pre-exposure-contributes-to-the-anti-oxidant-response-impairment-in-hcmec-d3-during-post-oxygen-and-glucose-deprivation-damage
#11
Francesca Farina, Elena Lonati, Anna Brambilla, Roberta Dal Magro, Chiara Milani, Laura Botto, Giulio Sancini, Paola Palestini, Alessandra Bulbarelli
Recently, air pollution has been identified as a significant modifiable risk factor to the increasing stroke burden. Diesel exhaust particles, characterized by high polycyclic aromatic hydrocarbons content, constitute an important component of outdoor air pollution and is known to cause oxidative stress, and could therefore contribute to and exacerbate the effects of ROS in post-ischemic injury. hCMEC/D3 cells have been submitted to 48h treatment with diesel exhaust particles (25μg/ml and 50μg/ml, DEP50) or alternatively to 3h of oxygen and glucose deprivation, followed by 1h of oxygen and glucose restoration...
April 8, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28389379/exposure-to-welding-fumes-activates-dna-damage-response-and-redox-sensitive-transcription-factor-signalling-in-sprague-dawley-rats
#12
Jayaraman Krishnaraj, Jaganathan Kowshik, Robin Sebastian, Sathees C Raghavan, Siddavaram Nagini
BACKGROUND: Occupational exposure to welding fumes containing a complex mixture of genotoxic heavy metals, radiation, gases and nanoparticles poses a serious health hazard to welders. Since their categorization as possible carcinogens, welding fumes have gained increasing attention as high priority agents for risk assessment. OBJECTIVE: The present study was undertaken to investigate the effects of welding fume inhalation on oxidative stress, DNA damage response (DDR), and nuclear factor erythroid 2-related factor-2 (Nrf2) and nuclear factor kappa B (NFκB) signalling in the lung tissues of male Sprague-Dawley rats...
April 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28366735/regulator-of-g-protein-signaling-1-modulates-paraquat-induced-oxidative-stress-and-longevity-via-the-insulin-like-signaling-pathway-in-caenorhabditis-elegans
#13
Mingyu Wu, Xin Kang, Qiang Wang, Chunyu Zhou, Chandra Mohan, Ai Peng
Insulin or insulin like signaling (IIS) pathway is a crucial pathway in Caenorhabditis elegans associated with mediating longevity, and stress resistance. Regulators of G protein signaling (RGS) also modulate stress resistance and longevity in multiple in vitro and in vivo models. However, the mechanism underlying RGS mediating stress resistance and longevity remains largely unclear. Here we report that rgs-1, an important member of rgs family, is a novel modulator of IIS pathway in C. elegans. We found that the loss of rgs-1 dramatically promoted paraquat resistance in C...
March 31, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28366736/lncrna-linc00341-mediates-pm2-5-induced-cell-cycle-arrest-in-human-bronchial-epithelial-cells
#14
Yiqin Xu, Jianjun Wu, Xiaowu Peng, Ti Yang, Meiling Liu, Lijian Chen, Xin Dai, Zhishan Wang, Chengfeng Yang, Bing Yan, Yiguo Jiang
Fine particulate matter (PM2.5) could adhere to many toxic substances and cause respiratory diseases.However, the associated pathogenic mechanism remains unclear. In this study, we investigated the effects of PM2.5 on cell cycle progression in human bronchial epithelial cells (16HBE) and the underlying mechanism mediated by lncRNAs. PM2.5 treatment inhibited cell proliferation in 16HBE cells in a dose-dependent manner. The results of flow cytometry assay (FCM) showed that PM2.5 induced cell apoptosis and cell cycle arrest at G2/M phase...
March 30, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28359802/low-level-arsenite-exposures-suppress-the-development-of-bone-marrow-erythroid-progenitors-and-result-in-anemia-in-adult-male-mice
#15
Sebastian Medina, Huan Xu, Shu Chun Wang, Fredine T Lauer, Ke Jian Liu, Scott W Burchiel
Epidemiological studies report an association between chronic arsenic (As) exposure and anemia in men, and women who are predisposed to anemia. The purpose of these studies was to determine whether a 60 d drinking water exposure of adult male C57BL/6J mice to 0, 100, and 500ppb arsenite (As(+3)) results in anemia due to alterations in erythroid progenitor cell development in the bone marrow. Exposure to 500ppb As(+3) for 60 d resulted in a reduction of mean corpuscular hemoglobin (MCH) levels, but did not significantly alter red blood cell (RBC) counts, hemoglobin (Hgb) levels, mean corpuscular Hgb concentrations (MCHC), or mean corpuscular volumes (MCV)...
March 27, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28359801/hybrid-optimal-descriptors-as-a-tool-to-predict-skin-sensitization-in-accordance-to-oecd-principles
#16
Alla P Toropova, Andrey A Toropov
Skin sensitization (allergic contact dermatitis) is a widespread problem arising from the contact of chemicals with the skin. The detection of molecular features with undesired effect for skin is complex task owing to unclear biochemical mechanisms and unclearness of conditions of action of chemicals to skin. The development of computational methods for estimation of this endpoint in order to reduce animal testing is recommended (Cosmetics Directive EC regulation 1907/2006; EU Regulation, Regulation, 1223/2009)...
March 27, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28356238/hepatic-effects-of-tartrazine-e-102-after-systemic-exposure-are-independent-of-oestrogen-receptor-interactions-in-the-mouse
#17
Stephanie K Meyer, Philip M E Probert, Anne F Lakey, Andrew R Axon, Alistair C Leitch, Faith M Williams, Paul A Jowsey, Peter G Blain, George E N Kass, Matthew C Wright
Tartrazine is a food colour that activates the transcriptional function of the human oestrogen receptor alpha in an in vitro cell model. Since oestrogens are cholestatic, we hypothesised tartrazine will cause periportal injury to the liver in vivo. To test this hypothesis, tartrazine was initially administered systemically to mice resulting in a periportal recruitment of inflammatory cells, increased serum alkaline phosphatase activity and mild periportal fibrosis. To determine whether an oestrogenic effect may be a key event in this response, tartrazine, sulphonated metabolites and a food additive contaminant were screened for their ability to interact with murine oestrogen receptors...
March 27, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28347839/cellular-response-to-star-shaped-polyacids-solution-behavior-and-conjugation-advantages
#18
Anna Mielańczyk, Magdalena Skonieczna, Dorota Neugebauer
The nanosized (∼10nm in 0.01M PBS and 210nm in water) star-shaped polymethacrylates with various content of pendant carboxyl groups were characterized via basic physicochemical and biological properties toward their use as drug carriers for intravenous administration. The carboxyl groups in polymer were employed to conjugate fluorescein (FA) or doxorubicin (DOX) via amide bond formation. In case of DOX, the conjugation efficiency was higher (4.0-16.0%) than of FA conjugation (1.5-4.5%) for corresponding copolymers...
March 24, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28343895/pharmacokinetic-profile-of-promising-acetylcholinesterase-reactivators-k027-and-k203-in-experimental-pigs
#19
Jana Zdarova Karasova, Jaroslav Kvetina, Ilja Tacheci, Vera Radochova, Kamil Musilek, Kamil Kuca, Jan Bures
Standard treatment of organophosphorus compounds (OPs) poisoning includes administration of an anti-muscarinic (atropine), anticonvulsive (diazepam) and acetylcholinesterase reactivator (oxime). From a wide group of newly synthesized oximes, oxime K027 and oxime K203 seem to be perspective compounds in some specific OPs intoxication. The available in vitro and in vivo preclinical data indicate that both oximes may be considered for potential human use. The main aim of this study was to establish plasmatic concentration curves of both oximes after intramuscular (i...
March 23, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28343894/-1-9-n%C3%AE-c-crourorb-a1-isolated-from-croton-urucurana-latex-induces-g2-m-cell-cycle-arrest-and-apoptosis-in-human-hepatocarcinoma-cells
#20
Priscila de Matos Cândido-Bacani, Frédéric Ezan, Patrícia de Oliveira Figueiredo, Maria de Fátima Cepa Matos, Fernanda Rodrigues Garcez, Walmir Silva Garcez, Georges Baffet
[1-9-NαC]-crourorb A1 is a cyclic peptide isolated from Croton urucurana Baillon latex, found in midwestern Brazil, that has been shown to exert cytotoxic effects against a panel of cancer cell lines. However, the underlying mechanisms responsible for the crourorb A1-induced cytotoxicity in cancer cells remain unknown. In this study, the effects of crourorb A1 on the viability, apoptosis, cell cycle and migration of Huh-7 (human hepatocarcinoma) cells were investigated. We evaluated the viability of Huh-7 cells treated with crourorb A1 in 2D and 3D collagen cultures and found that cells in 3D culture exhibited increased resistance to crourorb A1 compared to cells in 2D culture (IC50: 62μg/ml versus 35...
March 23, 2017: Toxicology Letters
journal
journal
27195
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"