journal
MENU ▼
Read by QxMD icon Read
search

Yale Journal of Biology and Medicine

journal
https://www.readbyqxmd.com/read/29599661/on-the-opioid-crisis-and-the-future-of-pain-treatment-an-interview-with-bertha-k-madras-phd
#1
Lisa M Ogawa
No abstract text is available yet for this article.
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29599660/a-career-in-addiction-medicine-an-interview-with-patrick-g-o-connor-md-mph-facp
#2
Corey Horien
No abstract text is available yet for this article.
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29599659/beyond-sensation-exploring-the-molecular-and-genetic-basis-for-pain-an-interview-with-stephen-waxman-md-phd
#3
Erin K DeNardo
No abstract text is available yet for this article.
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29599658/sensory-disruption-in-modern-living-and-the-emergence-of-sensory-inequities
#4
REVIEW
Kara C Hoover
Modern lifestyles are disrupting the human senses-primarily sight, sound, and smell. Noise-induced hearing loss has been noted for centuries and increasing over time following the industrial era. From the mid-20th century, the numbers of individuals with myopia (the leading visual impairment) have been increasing globally. Historical evidence for olfactory dysfunction is not known but its etiological links to pollution suggest it increased following industrialization. Clinical interventions for sight and sound loss include preventative and corrective measures but none exist for olfactory dysfunction...
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29599657/phototransduction-in-retinal-ganglion-cells
#5
REVIEW
Peter B Detwiler
The mammalian retina contains a small number of retinal ganglion cells that express melanopsin, a retinal based visual pigment, and generate a depolarizing response to light in the absence of rod and cone driven synaptic input; hence they are referred to as intrinsically photosensitive retinal ganglion cells (ipRGCs). They have been shown to be comprised of a number of sub-types and to provide luminance information that participates primarily in a variety of non-imaging forming visual functions. Here I review what is currently known about the cascade of events that couple the photoisomerization of melanopsin to the opening of a non-selective cation channel...
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29599656/degenerative-cervical-myelopathy-a-clinical-review
#6
REVIEW
Justin Gibson, Aria Nouri, Bryan Krueger, Nikita Lakomkin, Rani Nasser, David Gimbel, Joseph Cheng
Degenerative Cervical Myelopathy (DCM) is the most common form of spinal cord impairment in adults and results in disability and reduced quality of life. DCM can present with a wide set of clinical and imaging findings, including: 1) pain and reduced range of motion of the neck, and motor and sensory deficits on clinical exam, and 2) cord compression due to static and dynamic injury mechanisms resulting from degenerative changes of the bone, ligaments, and intervertebral discs on MRI. The incidence and prevalence of DCM has been estimated at a minimum of 4...
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29599655/dark-matters-challenges-of-nocturnal-communication-between-plants-and-animals-in-delivery-of-pollination-services
#7
REVIEW
Renee M Borges
The night is a special niche characterized by dim light, lower temperatures, and higher humidity compared to the day. Several animals have made the transition from the day into the night and have acquired unique adaptations to cope with the challenges of performing nocturnal activities. Several plant species have opted to bloom at night, possibly as a response to aridity to prevent excessive water loss through evapotranspiration since flowering is often a water-demanding process, or to protect pollen from heat stress...
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29599654/serotonergic-modulation-of-olfaction-in-rodents-and-insects
#8
REVIEW
Quentin Gaudry
Recent advances in genetic tools and optical imaging technology have allowed rodent and Drosophila researchers to explore the relationship between serotonergic modulation and olfactory processing at a mechanistic level previously unfeasible. Here, I review the basic organization of olfactory and serotonergic systems in both rodents and Drosophila and draw comparisons where similarities exist. I discuss circuit level models that explain many of serotonin's effects on olfactory responses in the olfactory system's inputs and outputs...
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29599653/corneal-innervation-and-sensation-the-eye-and-beyond
#9
REVIEW
Alina Y Yang, Jessica Chow, Ji Liu
The cornea is one of the most densely innervated and sensitive tissues in the body. In addition to their important sensory functions, corneal nerves induce reflex tear production, blinking, and the release of trophic factors - all of which combined help to maintain the structural and functional integrity of the surface of the eye. Consequently, damage to corneal nerves as a result of disease, surgery, or trauma can lead to diminished corneal sensitivity, epithelial defects, and possible blindness. In this review, we describe commonly used tools that have provided considerable new information on corneal architecture and sensation in healthy and diseased corneas, with special emphasis on changes seen in herpes zoster ophthalmicus, corneal and other therapeutic ocular procedures, antiglaucoma medical therapy, aging, and diabetes...
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29599652/the-utility-of-lumbar-puncture-after-a-negative-head-ct-in-the-emergency-department-evaluation-of-subarachnoid-hemorrhage
#10
Harman Singh Gill, Evie Grace Marcolini, Douglas Barber, Charles R Wira
Background: American College of Emergency Physicians (ACEP) [1] recommends that patients presenting with acute non-traumatic headache concerning for subarachnoid hemorrhage (SAH) undergo lumbar puncture (LP) when non-contrast head computed tomography (CT) is negative. The diagnostic yield of this approach is unknown. Objective: Evaluate the diagnostic yield, lengths of stay and complication rates of LPs in patients undergoing Emergency Department (ED) evaluation for aneurysmal SAH. Methods: Multi-center, retrospective, hypothesis-blinded, explicit chart review of patients undergoing ED-based lumbar puncture between 2007 and 2012...
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29259533/regulatory-considerations-for-gene-therapy-products-in-the-us-eu-and-japan
#11
Celine-Lea Halioua-Haubold, James G Peyer, James A Smith, Zeeshaan Arshad, Matthew Scholz, David A Brindley, Robert E MacLaren
Developers of gene therapy products (GTPs) must adhere to additional regulation beyond that of traditional small-molecule therapeutics, due to the unique mechanism-of-action of GTPs and the subsequent novel risks arisen. We have provided herein a summary of the regulatory structure under which GTPs fall in the United States, the European Union, and Japan, and a comprehensive overview of the regulatory guidance applicable to the developer of GTP. Understanding the regulatory requirements for seeking GTP market approval in these major jurisdictions is crucial for an effective and expedient path to market...
December 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29259532/gene-editing-in-humans-towards-a-global-and-inclusive-debate-for-responsible-research
#12
Itziar de Lecuona, María Casado, Gemma Marfany, Manuel Lopez Baroni, Mar Escarrabill
In December 2016, the Opinion Group of the Bioethics and Law Observatory (OBD) of the University of Barcelona launched a Declaration on Bioethics and Gene Editing in Humans analyzing the use of genome editing techniques and their social, ethical, and legal implications through a multidisciplinary approach. It focuses on CRISPR/Cas9, a genome modification technique that enables researchers to edit specific sections of the DNA sequence of humans and other living beings. This technique has generated expectations and worries that deserve an interdisciplinary analysis and an informed social debate...
December 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29259531/crispr-patents-and-the-public-health
#13
Jacob S Sherkow
Patent issues surrounding CRISPR, the revolutionary genetic editing technology, may have important implications for the public health. Patents maintain high prices for novel therapies, limiting patient access. Relatedly, insurance coverage for expensive therapies is waning. Patents also misallocate research and development resources to profitable disease indications rather than those that necessarily impinge on the public health. And it is unclear how CRISPR therapies will figure into the current regulatory framework for biosimilars...
December 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29259530/an-appreciation-of-the-gene-an-intimate-history-by-siddhartha-mukherjee-and-a-call-for-expanded-training-in-the-responsible-conduct-of-research
#14
REVIEW
Evan D Morris
The Gene: An Intimate History by Siddhartha Mukherjee, first published in 2016, is a comprehensive and fascinating recounting of the discovery of the gene and genetics research from wrinkled peas to CRISPR/Cas9 and all the details in between. In Mukherjee's sweeping history, the science is clearly depicted but also tightly integrated into the political movements and world events that it spawned, both hopeful and detestable. Two stories from The Gene are the central focuses of this article. One story is driven by the desire of Eugenicists in early 20th century America to rid the population of defective traits...
December 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29259529/genome-editing-past-present-and-future
#15
REVIEW
Dana Carroll
The CRISPR-Cas genome editing tools have been adopted rapidly in the research community, and they are quickly finding applications in the commercial sector as well. Lest we lose track of the broader context, this Perspective presents a brief review of the history of the genome editing platforms and considers a few current technological issues. It then takes a very limited view into the future of this technology and highlights some of the societal issues that require examination and discussion.
December 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29259528/yeast-still-a-beast-diverse-applications-of-crispr-cas-editing-technology-in-s-cerevisiae
#16
REVIEW
Rachael M Giersch, Gregory C Finnigan
The recent discovery and use of CRISPR/Cas9 gene editing technology has provided new opportunities for scientific research in many fields of study including agriculture, genetic disorders, human disease, biotechnology, and basic biological research. The ability to precisely target DNA sequences and either remove, modify, or replace genetic sequences provides a new level of control in nearly all eukaryotic organisms, including budding yeast. Given the many discoveries made in Saccharomyces cerevisiae over the past decades spanning genetics, cell biology, and biochemistry, as well as the development of new technologies that have allowed high throughput screening, robotic automation, and a platform for synthetic genome engineering, the yeast community has also started to recognize the utility and complementary nature of CRISPR-based methodologies...
December 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29259527/potential-of-gene-editing-and-induced-pluripotent-stem-cells-ipscs-in-treatment-of-retinal-diseases
#17
REVIEW
Katherine Chuang, Mark A Fields, Lucian V Del Priore
The advent of gene editing has introduced the ability to make changes to the genome of cells, thus allowing for correction of genetic mutations in patients with monogenic diseases. Retinal diseases are particularly suitable for the application of this new technology because many retinal diseases, such as Stargardt disease, retinitis pigmentosa (RP), and Leber congenital amaurosis (LCA), are monogenic. Moreover, gene delivery techniques such as the use of adeno-associated virus (AAV) vectors have been optimized for intraocular use, and phase III trials are well underway to treat LCA, a severe form of inherited retinal degeneration, with gene therapy...
December 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29259526/science-and-bioethics-of-crispr-cas9-gene-editing-an-analysis-towards-separating-facts-and-fiction
#18
REVIEW
Adam P Cribbs, Sumeth M W Perera
Since its emergence in 2012, the genome editing technique known as CRISPR-Cas9 and its scientific use have rapidly expanded globally within a very short period of time. The technique consists of using an RNA guide molecule to bind to complementary DNA sequences, which simultaneously recruits the endonuclease Cas9 to introduce double-stranded breaks in the target DNA. The resulting double-stranded break is then repaired, allowing modification or removal of specific DNA bases. The technique has gained momentum in the laboratory because it is cheap, quick, and easy to use...
December 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29259525/adeno-associated-virus-aav-dual-vector-strategies-for-gene-therapy-encoding-large-transgenes
#19
REVIEW
Michelle E McClements, Robert E MacLaren
The use of adeno-associated viral (AAV) vectors for gene therapy treatments of inherited disorders has accelerated over the past decade with multiple clinical trials ongoing in varying tissue types and new ones initiating every year. These vectors are exhibiting low-immunogenicity across the clinical trials in addition to showing evidence of efficacy, making it clear they are the current standard vector for any potential gene therapy treatment. However, AAV vectors do have a limitation in their packaging capacity, being capable of holding no more than ~5kb of DNA and in a therapeutic transgene scenario, this length of DNA would need to include genetic control elements in addition to the gene coding sequence (CDS) of interest...
December 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29259524/genetic-code-expansion-and-optoproteomics
#20
REVIEW
Yuting Chen, Linjie Lu, Shixin Ye
Nature has invented photoreceptor proteins that are involved in sensing and response to light in living organisms. Genetic code expansion (GCE) technology has provided new tools to transform light insensitive proteins into novel photoreceptor proteins. It is achieved by the site-specific incorporation of unnatural amino acids (Uaas) that carry light sensitive moieties serving as "pigments" that react to light via photo-decaging, cross-linking, or isomerization. Over the last two decades, various proteins including ion channels, GPCRs, transporters, and kinases have been successfully rendered light responsive owing to the functionalities of Uaas...
December 2017: Yale Journal of Biology and Medicine
journal
journal
24848
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"