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Fahad alsaif's collection

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93 papers 0 to 25 followers
https://www.readbyqxmd.com/read/29733229/healthcare-resource-utilization-costs-of-care-and-treatment-of-mycosis-fungoides-cutaneous-t-cell-lymphoma-patterns-in-a-large-managed-care-population-a-retrospective-us-claims-based-analysis
#1
Yuen Tsang, Tao Gu, Gaurav Sharma, Susan Raspa, Bill Drake, Hiangkiat Tan
PURPOSE: To evaluate health care utilization, treatment patterns and costs among patients with mycosis fungoides-cutaneous T-cell lymphoma (MF-CTCL). METHODS: This retrospective cohort study queried the HealthCore Integrated Research Database to identify patients ≥18 years with ≥2 diagnoses of MF-CTCL (ICD-9-CM code 202.1x, 202.2x) between 07 January 2006 and 07 January 2013. Index date was defined as first MF-CTCL diagnosis. Patients were continuously enrolled ≥6 months before and ≥12 months after index date...
May 7, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29750467/chronic-urticaria-what-does-the-new-guideline-tell-us
#2
Marcus Maurer, Torsten Zuberbier, Frank Siebenhaar, Karoline Krause
Patients with chronic urticaria experience significant impairment, and require an effective treatment. Such treatment is preceded by a thorough diagnostic workup and measurement of disease activity, disease burden and disease control using well--established tools. Treatment is subsequently adjusted according to patient needs and therapeutic response, based on the tenet "as much as necessary, as little as possible" (in that order). Once disease control has been achieved, it is recommended that intermittent attempts at medication withdrawal be made in order to identify spontaneous disease remission...
May 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29943217/topical-ivermectin-in-the-treatment-of-papulopustular-rosacea-a-systematic-review-of-evidence-and-clinical-guideline-recommendations
#3
REVIEW
Chiel Cristiano F Ebbelaar, Aalt W Venema, Maria R Van Dijk
INTRODUCTION: Rosacea is a chronic inflammatory skin disease with different phenotypes. There is accumulating evidence that the commensal Demodex mite is linked to papulopustular rosacea. Established treatment options, including topical metronidazole, azelaic acid, and tetracyclines, are thought to work through their anti-inflammatory effects. However, none of these therapies have been shown to be curative and are associated with frequent relapses. Therefore, new and improved treatment options are needed...
June 25, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29974453/nonclinical-and-human-pharmacology-of-the-potent-and-selective-topical-retinoic-acid-receptor-%C3%AE-agonist-trifarotene
#4
J Aubert, D Piwnica, B Bertino, S Blanchet-Réthoré, I Carlavan, S Déret, B Dreno, B Gamboa, A Jomard, A P Luzy, P Mauvais, C Mounier, J Pascau, I Pelisson, T Portal, M Rivier, P Rossio, E Thoreau, E Vial, J J Voegel
BACKGROUND: First- and third-generation retinoids are the main treatment for acne. Even though efficacious, they lack full selectivity for retinoic acid receptor (RAR) γ, expressed in the epidermis and infundibulum. OBJECTIVES: To characterize the in vitro metabolism and the pharmacology of the novel retinoid trifarotene. MATERIALS AND METHODS: In vitro assays determined efficacy, potency and selectivity on RARs, as well as the activity on the expression of retinoid target genes in human keratinocytes and ex vivo cultured skin...
July 4, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29657671/dermoscopy-in-the-diagnosis-of-inflammatory-dermatoses-systematic-review-findings-reported-for-psoriasis-lupus-and-lichen-planus
#5
REVIEW
Lauren C Cook, Courtney Hanna, Galen T Foulke, Elizabeth V Seiverling
Background: Dermoscopy is well established as a tool to improve the detection of cancerous skin growths. Published data suggest that dermoscopy might be useful in evaluating inflammatory dermatoses and in distinguishing between rashes and skin cancer. Objective: The authors sought to review the published literature regarding use of dermoscopy in the evaluation of inflammatory skin conditions. Methods: Using a systematic approach, the authors performed a literature search using the names of 146 inflammatory dermatoses and pairing each one separately with the search terms dermoscopy, dermatoscopy, and epiluminescence microscopy...
April 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29357600/british-association-of-dermatologists-guidelines-for-the-investigation-and-management-of-generalized-pruritus-in-adults-without-an-underlying-dermatosis-2018
#6
G W M Millington, A Collins, C R Lovell, T A Leslie, A S W Yong, J D Morgan, T Ajithkumar, M J Andrews, S M Rushbook, R R Coelho, S J Catten, K Y C Lee, A M Skellett, A G Affleck, L S Exton, M F Mohd Mustapa, N J Levell
No abstract text is available yet for this article.
January 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29692619/personalized-skincare-from-molecular-basis-to-clinical-and-commercial-applications
#7
REVIEW
Ewa Markiewicz, Olusola Clement Idowu
Individual responses of human skin to the environmental stress are determined by differences in the anatomy and physiology that are closely linked to the genetic characteristics such as pigmentation. Ethnic skin phenotypes can be distinguished based on defined genotypic traits, structural organization and compartmentalized sensitivity to distinct extrinsic aging factors. These differences are not only responsible for the variation in skin performance after exposure to damaging conditions, but can also affect the mechanisms of drug absorption, sensitization and other longer term effects...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29695554/total-skin-electron-beam-therapy-with-rotary-dual-technique-as-palliative-treatment-for-mycosis-fungoides
#8
Tomasz Piotrowski, Magdalena Fundowicz, Mariola Pawlaczyk
BACKGROUND/AIM: The aim of the study was to retrospectively assess the efficacy and toxicity of total skin electron beam therapy (TSEBT) in patients with primary cutaneous T-cell lymphoma (MF, mycosis fungoides) at various stages of development. PATIENTS AND METHODS: Treatment results of 40 patients with MF stage IB-III, treated between 2001 and 2015, were reviewed. Median total dose was 32 Gy, delivered to the entire skin surface. Median follow-up was 60 months...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29409107/indications-and-use-of-isotretinoin-in-facial-plastic-surgery
#9
Markus V Heppt, Michael C Kirchberger, Thomas Ruzicka, Carola Berking, Werner J Heppt
Isotretinoin is a first generation retinoid with pleiotropic effects on keratinocyte differentiation, proliferation, and activity of sebaceous glands. For years, there has been intense debate on whether the use of isotretinoin combined with cosmetic or surgical procedures is safe and potentially more efficient than either therapy alone. Due to delays in wound healing and keloid formation, conservative recommendations were not to combine isotretinoin with any plastic surgery or local treatment at 6 to 12 months after discontinuation of the drug...
February 2018: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29409915/withdrawn-efficacy-and-safety-of-topical-oxymetazoline-cream-1-0-for-treatment-of-persistent-facial-erythema-associated-with-rosacea-findings-from-the-2-phase-3-29-day-randomized-controlled-reveal-trials
#10
Linda Stein-Gold, Leon H Kircik, Zoe Diane Draelos, Philip Werschler, Janet DuBois, Edward Lain, Leslie Baumann, David J Goldberg, Joely Kaufman, Emil A Tanghetti, Nancy Alvandi, Emily Weng, David R Berk, Gurpreet Ahluwalia
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
January 31, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29305643/treatment-of-soft-tissue-filler-complications-expert-consensus-recommendations
#11
REVIEW
Fernando Urdiales-Gálvez, Nuria Escoda Delgado, Vitor Figueiredo, José V Lajo-Plaza, Mar Mira, Antonio Moreno, Francisco Ortíz-Martí, Rosa Del Rio-Reyes, Nazaret Romero-Álvarez, Sofía Ruiz Del Cueto, María A Segurado, Cristina Villanueva Rebenaque
BACKGROUND: Dermal fillers have been increasingly used in minimally invasive facial esthetic procedures. This widespread use has led to a rise in reports of associated complications. The aim of this expert consensus report is to describe potential adverse events associated with dermal fillers and to provide guidance on their treatment and avoidance. METHODS: A multidisciplinary group of experts in esthetic treatments convened to discuss the management of the complications associated with dermal fillers use...
April 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29282672/successful-treatment-of-refractory-vitiligo-with-a-combination-of-khellin-and-308-nm-excimer-lamp-an-open-label-1-year-prospective-study
#12
Samy Fenniche, Anissa Zaouak, Azima Ben Tanfous, Meriem Jrad, Houda Hammami
INTRODUCTION: Phototherapy is the cornerstone of treatment of vitiligo. The 308-nm excimer lamp (EL) induces T cell apoptosis and the stimulation of melanocyte proliferation. Khellin is a furanochromone with a chemical structure close to psoralens. The objective of the study was to evaluate the safety and efficacy of 1-year treatment of recalcitrant vitiligo with a combination of 308-nm EL and khellin. METHODS: Twenty patients with resistant vitiligo were included...
March 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29271481/systemic-pharmacological-treatments-for-chronic-plaque-psoriasis-a-network-meta-analysis
#13
REVIEW
Emilie Sbidian, Anna Chaimani, Ignacio Garcia-Doval, Giao Do, Camille Hua, Canelle Mazaud, Catherine Droitcourt, Carolyn Hughes, John R Ingram, Luigi Naldi, Olivier Chosidow, Laurence Le Cleach
BACKGROUND: Psoriasis is an immune-mediated disease for which some people have a genetic predisposition. The condition manifests in inflammatory effects on either the skin or joints, or both, and it has a major impact on quality of life. Although there is currently no cure for psoriasis, various treatment strategies allow sustained control of disease signs and symptoms. Several randomised controlled trials (RCTs) have compared the efficacy of the different systemic treatments in psoriasis against placebo...
December 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29214107/diet-and-rosacea-the-role-of-dietary-change-in-the-management-of-rosacea
#14
REVIEW
Emma Weiss, Rajani Katta
Dietary change may play a role in the therapy of rosacea. Certain foods and beverages may act as "triggers" for rosacea exacerbations. These may be divided into heat-related, alcohol-related, capsaicin-related, and cinnamaldehyde-related. One potential pathogenic mechanism may be via the activation of transient receptor potential cation channels, which result in neurogenic vasodilatation. Further research is needed on the role of the gut skin connection in rosacea. Epidemiologic studies suggest that patients with rosacea have a higher prevalence of gastrointestinal disease, and one study reported improvement in rosacea following successful treatment of small intestinal bacterial overgrowth...
October 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29178034/pharmacotherapy-for-neuropathic-pain-a-review
#15
REVIEW
Diego Fornasari
Neuropathic pain, comprising a range of heterogeneous conditions, is often severe and difficult to manage, and this may result in a chronic condition that negatively affects the overall functioning and quality of life in patients. The pharmacotherapy of neuropathic pain is challenging and for many patients effective treatment is lacking; therefore, evidence-based recommendations are essential. Currently, there is general agreement on which drugs are appropriate for the first-line treatment of neuropathic pain, whereas debate continues regarding second- and third-line treatments...
December 2017: Pain and Therapy
https://www.readbyqxmd.com/read/29122851/guidelines-on-the-management-of-abnormal-liver-blood-tests
#16
Philip N Newsome, Rob Cramb, Suzanne M Davison, John F Dillon, Mark Foulerton, Edmund M Godfrey, Richard Hall, Ulrike Harrower, Mark Hudson, Andrew Langford, Anne Mackie, Robert Mitchell-Thain, Karen Sennett, Nicholas C Sheron, Julia Verne, Martine Walmsley, Andrew Yeoman
These updated guidelines on the management of abnormal liver blood tests have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines, which this document supersedes, were written in 2000 and have undergone extensive revision by members of the Guidelines Development Group (GDG). The GDG comprises representatives from patient/carer groups (British Liver Trust, Liver4life, PBC Foundation and PSC Support), elected members of the BSG liver section (including representatives from Scotland and Wales), British Association for the Study of the Liver (BASL), Specialist Advisory Committee in Clinical Biochemistry/Royal College of Pathology and Association for Clinical Biochemistry, British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN), Public Health England (implementation and screening), Royal College of General Practice, British Society of Gastrointestinal and Abdominal Radiologists (BSGAR) and Society of Acute Medicine...
January 2018: Gut
https://www.readbyqxmd.com/read/29216643/emerging-treatment-options-in-atopic-dermatitis-topical-therapies
#17
Uffe Nygaard, Mette Deleuran, Christian Vestergaard
Atopic dermatitis is a chronic inflammatory skin disorder affecting children and adults, with the majority presenting mild to moderate disease severity. The use of topical corticosteroids (TCSs) in combination with emollients has been the mainstay for treating mild to moderate atopic dermatitis since the 1950s, and as a supplement to systemic treatment in severe disease. However, while very effective, TCSs are often accompanied by poor adherence due to corticophobia (fear of using corticosteroids in patients or doctors), unwanted side effects, and in some cases insufficient clinical response...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28957311/ten-simple-rules-for-structuring-papers
#18
EDITORIAL
Brett Mensh, Konrad Kording
No abstract text is available yet for this article.
September 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29036256/pharmacokinetic-comparison-of-once-daily-topical-minocycline-foam-4-vs-oral-minocycline-for-moderate-to-severe-acne
#19
COMPARATIVE STUDY
Terry M Jones, Herman Ellman, Tina deVries
OBJECTIVE: To characterize minocycline pharmacokinetics and relative bioavailability following multiple-dose topical administration of minocycline hydrochloride (HCl) foam 4% (FMX101 4%) as compared with single-dose oral administration of minocycline HCl extended-release tablets (Solodyn®) in subjects with moderate-to-severe acne. METHODS: A Phase 1, single-center, nonrandomized, open-label, active-controlled, 2-period, 2-treatment crossover clinical study. The study included 30 healthy adults (mean age, 22...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29045820/five-year-results-of-a-randomized-controlled-trial-comparing-effectiveness-of-photodynamic-therapy-topical-imiquimod-and-topical-5-fluorouracil-in-patients-with-superficial-basal-cell-carcinoma
#20
Maud H E Jansen, Klara Mosterd, Aimee H M M Arits, Marieke H Roozeboom, Anja Sommer, Brigitte A B Essers, Han P A van Pelt, Patricia J F Quaedvlieg, Peter M Steijlen, Patty J Nelemans, Nicole W J Kelleners-Smeets
For the treatment of superficial basal cell carcinoma, a prospective, noninferiority, randomized controlled multicenter trial with 601 patients showed that 5% imiquimod cream was superior and 5-fluorouracil cream not inferior to methyl aminolevulinate photodynamic therapy (MAL-PDT) at 1 and 3 years after treatment. No definite conclusion could be drawn regarding the superiority of imiquimod over 5-fluorouracil. We now present the 5-year follow-up results according to the intention-to-treat analysis. Five years after treatment, the probability of tumor-free survival was 62...
March 2018: Journal of Investigative Dermatology
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