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Blood products

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9 papers 0 to 25 followers
Alan D Murdock, Olle Berséus, Tor Hervig, Geir Strandenes, Turid Helen Lunde
Toward the end of World War I and during World War II, whole-blood transfusions were the primary agent in the treatment of military traumatic hemorrhage. However, after World War II, the fractionation of whole blood into its components became widely accepted and replaced whole-blood transfusion to better accommodate specific blood deficiencies, logistics, and financial reasons. This transition occurred with very few clinical trials to determine which patient populations or scenarios would or would not benefit from the change...
May 2014: Shock
Philip C Spinella, Heather F Pidcoke, Geir Strandenes, Tor Hervig, Andrew Fisher, Donald Jenkins, Mark Yazer, James Stubbs, Alan Murdock, Anne Sailliol, Paul M Ness, Andrew P Cap
Recent combat experience reignited interest in transfusing whole blood (WB) for patients with life-threatening bleeding. US Army data indicate that WB transfusion is associated with improved or comparable survival compared to resuscitation with blood components. These data complement randomized controlled trials that indicate that platelet (PLT)-containing blood products stored at 4°C have superior hemostatic function, based on reduced bleeding and improved functional measures of hemostasis, compared to PLT-containing blood products at 22°C...
April 2016: Transfusion
Philip C Spinella, Andrew P Cap
PURPOSE OF REVIEW: We present data comparing whole blood with blood components and summarize the data that support increased availability of whole blood for patients with life-threatening bleeding. RECENT FINDINGS: Recent data indicate that whole-blood transfusion is associated with improved or comparable survival compared with resuscitation with blood components. These data complement randomized controlled trials indicating that platelet-containing blood products stored at 4 °C have superior hemostatic function, compared with platelet-containing blood products at 22 °C...
November 2016: Current Opinion in Hematology
Philbert Y Van, John B Holcomb, Martin A Schreiber
PURPOSE OF REVIEW: Traumatic injuries are a major cause of mortality worldwide. Damage control resuscitation or balanced transfusion of plasma, platelets, and red blood cells for the management of exsanguinating hemorrhage after trauma has become the standard of care. We review the literature regarding the use of alternatives to achieve the desired 1 : 1:1 ratio as availability of plasma and platelets can be problematic in some environments. RECENT FINDINGS: Liquid and freeze dried plasma (FDP) are logistically easier to use and may be superior to fresh frozen plasma...
December 2017: Current Opinion in Critical Care
Nicholas Warner, Jackson Zheng, Greg Nix, Andrew D Fisher, Jeffery C Johnson, John E Williams, D Marc Northern, John S Hellums
The military's use of whole-blood transfusions is not new but has recently received new emphasis by the Tactical Combat Casualty Care Committee. US Army units are implementing a systematic approach to obtain and use whole blood on the battlefield. This case report reviews the care of the first patient to receive low titer group O whole blood (LTOWB) transfusion, using a new protocol.
December 0: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Ashley C McGinity, Caroline S Zhu, Leslie Greebon, Elly Xenakis, Elizabeth Waltman, Eric Epley, Danielle Cobb, Rachelle Jonas, Susannah E Nicholson, Brian J Eastridge, Ronald M Stewart, Donald H Jenkins
The mortality from hemorrhage in trauma patients remains high. Early balanced resuscitation improves survival. These truths, balanced with the availability of local resources and our goals for positive regional impact, were the foundation for the development of our prehospital whole blood initiative-using low-titer cold-stored O RhD-positive whole blood. The main concern with use of RhD-positive blood is the potential development of isoimmunization in RhD-negative patients. We used our retrospective massive transfusion protocol (MTP) data to analyze the anticipated risk of this change in practice...
June 2018: Journal of Trauma and Acute Care Surgery
Jansen N Seheult, Marshall Bahr, Vincent Anto, Louis H Alarcon, Alain Corcos, Jason L Sperry, Darrell J Triulzi, Mark H Yazer
BACKGROUND: The use of cold-stored low-titer group O whole blood (LTOWB) for civilian trauma patients is gaining popularity. However, hemolysis might occur among non-group O recipients. This study evaluated the serologic safety of transfusing up to 4 units of LTOWB. STUDY DESIGN AND METHODS: Hypotensive male and at least 50-year-old female trauma patients who received leukoreduced, uncrossmatched, group O+, low-titer (<50 anti-A and anti-B), platelet-replete whole blood during initial resuscitation were included in this prospective, observational study...
May 25, 2018: Transfusion
Daniel Bodnar, Stephen Rashford, Catherine Hurn, Jamie Quinn, Lachlan Parker, Katherine Isoardi, Sue Williams
OBJECTIVE: To describe the characteristics, clinical interventions and the outcomes of patients administered packed red blood cells (pRBCs) by a metropolitan, road based, doctor-paramedic trauma response team (TRT). METHODS: A retrospective cohort study examining 18 months of historical data collated by the Queensland Ambulance Service TRT, the Pathology Queensland Central Transfusion Laboratory, the Royal Brisbane and Women's Hospital and the Princess Alexandra Hospital Trauma Services was undertaken...
July 2014: Emergency Medicine Journal: EMJ
Daniel Bodnar, Stephen Rashford, Sue Williams, Emma Enraght-Moony, Lachlan Parker, Benjamin Clarke
OBJECTIVE: To evaluate the feasibility, limitations and costs involved in providing prehospital trauma teams with packed red blood cells (pRBCs) for use in the prehospital setting. METHODS: A retrospective cohort study, examining 18 months of historical data collated by the Queensland Ambulance Service Trauma Response Team (TRT) and the Pathology Queensland Central Transfusion Laboratory was undertaken. RESULTS: Over an 18-month period (1 January 2011-30 June 2012), of 500 pRBC units provided to the TRT, 130 (26%) were administered to patients in the prehospital environment...
February 2014: Emergency Medicine Journal: EMJ
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