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David Cyranoski, Heidi Ledford
No abstract text is available yet for this article.
November 2018: Nature
#2
Heidi Ledford
No abstract text is available yet for this article.
February 15, 2017: Nature
#3
David Cyranoski
No abstract text is available yet for this article.
November 24, 2016: Nature
#4
JOURNAL ARTICLE
Puping Liang, Yanwen Xu, Xiya Zhang, Chenhui Ding, Rui Huang, Zhen Zhang, Jie Lv, Xiaowei Xie, Yuxi Chen, Yujing Li, Ying Sun, Yaofu Bai, Zhou Songyang, Wenbin Ma, Canquan Zhou, Junjiu Huang
Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious knowledge gap remains in our understanding of DNA repair mechanisms in human early embryos, and in the efficiency and potential off-target effects of using technologies such as CRISPR/Cas9 in human pre-implantation embryos...
May 2015: Protein & Cell
#5
JOURNAL ARTICLE
David Baltimore, Paul Berg, Michael Botchan, Dana Carroll, R Alta Charo, George Church, Jacob E Corn, George Q Daley, Jennifer A Doudna, Marsha Fenner, Henry T Greely, Martin Jinek, G Steven Martin, Edward Penhoet, Jennifer Puck, Samuel H Sternberg, Jonathan S Weissman, Keith R Yamamoto
No abstract text is available yet for this article.
April 3, 2015: Science
#6
JOURNAL ARTICLE
Andrew Hammond, Roberto Galizi, Kyros Kyrou, Alekos Simoni, Carla Siniscalchi, Dimitris Katsanos, Matthew Gribble, Dean Baker, Eric Marois, Steven Russell, Austin Burt, Nikolai Windbichler, Andrea Crisanti, Tony Nolan
Gene drive systems that enable super-Mendelian inheritance of a transgene have the potential to modify insect populations over a timeframe of a few years. We describe CRISPR-Cas9 endonuclease constructs that function as gene drive systems in Anopheles gambiae, the main vector for malaria. We identified three genes (AGAP005958, AGAP011377 and AGAP007280) that confer a recessive female-sterility phenotype upon disruption, and inserted into each locus CRISPR-Cas9 gene drive constructs designed to target and edit each gene...
January 2016: Nature Biotechnology
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