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By Joe Weatherly FM/Hospitalist-CoFounder of QuestioningMedicine and PCRAP contributor.
Andrea Morelli, Christian Ertmer, Martin Westphal, Sebastian Rehberg, Tim Kampmeier, Sandra Ligges, Alessandra Orecchioni, Annalia D'Egidio, Fiorella D'Ippoliti, Cristina Raffone, Mario Venditti, Fabio Guarracino, Massimo Girardis, Luigi Tritapepe, Paolo Pietropaoli, Alexander Mebazaa, Mervyn Singer
IMPORTANCE: β-Blocker therapy may control heart rate and attenuate the deleterious effects of β-adrenergic receptor stimulation in septic shock. However, β-Blockers are not traditionally used for this condition and may worsen cardiovascular decompensation related through negative inotropic and hypotensive effects. OBJECTIVE: To investigate the effect of the short-acting β-blocker esmolol in patients with severe septic shock. DESIGN, SETTING, AND PATIENTS: Open-label, randomized phase 2 study, conducted in a university hospital intensive care unit (ICU) between November 2010 and July 2012, involving patients in septic shock with a heart rate of 95/min or higher requiring high-dose norepinephrine to maintain a mean arterial pressure of 65 mm Hg or higher...
October 23, 2013: JAMA: the Journal of the American Medical Association
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