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Surgical Oncology

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28 papers 1000+ followers Important papers in Surgical Oncology
By Daniel Tuvin Surgical Oncologist
https://www.readbyqxmd.com/read/29628281/easl-clinical-practice-guidelines-management-of-hepatocellular-carcinoma
#1
(no author information available yet)
No abstract text is available yet for this article.
April 5, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/28684519/origins-of-lymphatic-and-distant-metastases-in-human-colorectal-cancer
#2
Kamila Naxerova, Johannes G Reiter, Elena Brachtel, Jochen K Lennerz, Marc van de Wetering, Andrew Rowan, Tianxi Cai, Hans Clevers, Charles Swanton, Martin A Nowak, Stephen J Elledge, Rakesh K Jain
The spread of cancer cells from primary tumors to regional lymph nodes is often associated with reduced survival. One prevailing model to explain this association posits that fatal, distant metastases are seeded by lymph node metastases. This view provides a mechanistic basis for the TNM staging system and is the rationale for surgical resection of tumor-draining lymph nodes. Here we examine the evolutionary relationship between primary tumor, lymph node, and distant metastases in human colorectal cancer. Studying 213 archival biopsy samples from 17 patients, we used somatic variants in hypermutable DNA regions to reconstruct high-confidence phylogenetic trees...
July 7, 2017: Science
https://www.readbyqxmd.com/read/29620792/risk-reducing-mastectomy-for-the-prevention-of-primary-breast-cancer
#3
REVIEW
Nora E Carbine, Liz Lostumbo, Judi Wallace, Henry Ko
BACKGROUND: Recent progress in understanding the genetic basis of breast cancer and widely publicized reports of celebrities undergoing risk-reducing mastectomy (RRM) have increased interest in RRM as a method of preventing breast cancer. This is an update of a Cochrane Review first published in 2004 and previously updated in 2006 and 2010. OBJECTIVES: (i) To determine whether risk-reducing mastectomy reduces death rates from any cause in women who have never had breast cancer and in women who have a history of breast cancer in one breast, and (ii) to examine the effect of risk-reducing mastectomy on other endpoints, including breast cancer incidence, breast cancer mortality, disease-free survival, physical morbidity, and psychosocial outcomes...
April 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29188499/what-is-a-surgical-oncologist-by-the-editors-of-the-annals-of-surgical-oncology
#4
EDITORIAL
Charles Balch
No abstract text is available yet for this article.
January 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28321554/preoperative-plasma-fibrinogen-is-associated-with-lymph-node-metastasis-and-predicts-prognosis-in-resectable-esophageal-cancer
#5
Kohei Wakatsuki, Sohei Matsumoto, Kazuhiro Migita, Masahiro Ito, Tomohiro Kunishige, Hiroshi Nakade, Mitsuhiro Nakatani, Mutsuko Kitano, Masayuki Sho
BACKGROUND: Although it is well known that patients with malignant tumors have abnormal blood coagulation, its clinical significance has not been studied. We investigated the clinicopathological and prognostic impact of plasma fibrinogen, which is the major factor of the coagulation system, in patients with esophageal cancer. METHODS: From February 1995 to December 2006, 100 patients with esophageal cancer who had their plasma fibrinogen measured were enrolled. The associations between plasma fibrinogen, clinicopathological factors, and prognosis were analyzed...
August 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28877609/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-the-treatment-of-advanced-epithelial-and-recurrent-ovarian-carcinoma-a-single-center-experience
#6
Maja J Pavlov, Miljan S Ceranic, Stojan M Latincic, Predrag V Sabljak, Dragutin M Kecmanovic, Paul H Sugarbaker
BACKGROUND: With standard treatment of epithelial ovarian cancer (EOC), prognosis is very poor. The aim of this study is to show early and late results in patients who underwent cytoreductive surgery and intraperitoneal chemotherapy. PATIENTS AND METHODS: This was a retrospective single centre study. All patients with advanced and recurrent ovarian cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) or modified early postoperative intraperitoneal chemotherapy (EPIC) were included in the study...
September 7, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28597320/diagnostic-laparoscopy-prior-to-neoadjuvant-therapy-in-pancreatic-cancer-is-high-yield-an-analysis-of-outcomes-and-costs
#7
June S Peng, Jeffrey Mino, Rosebel Monteiro, Gareth Morris-Stiff, Noaman S Ali, Jane Wey, Kevin M El-Hayek, R Matthew Walsh, Sricharan Chalikonda
BACKGROUND: There is currently no standardized regimen for management of borderline resectable pancreatic cancer (BRPC), and treatment includes varying sequences of surgery, chemotherapy, and/or radiation. This study examines the diagnostic yield and cost of performing staging diagnostic laparoscopy (SDL) prior to neoadjuvant therapy (NAT) in BRPC. METHODS: Sequential patients treated for BRPC between January 2010 and October 2013 were included. SDL was adopted in a staged fashion due to surgeon preference, and included biopsy of visible lesions and washings for cytology...
September 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28411351/simultaneous-resection-for-synchronous-colorectal-liver-metastasis-the-new-standard-of-care
#8
Jonathan S Abelson, Fabrizio Michelassi, Tianyi Sun, Jialin Mao, Jeffrey Milsom, Benjamin Samstein, Art Sedrakyan, Heather L Yeo
BACKGROUND: Optimal surgical management for patients with synchronous colorectal cancer liver metastasis is controversial. We provide an analysis of surgical utilization and outcomes for patients presenting with synchronous colon and rectal cancer liver metastasis between simultaneous and staged approaches. METHODS: SPARCS database was used to follow patients undergoing surgery for colorectal cancer with liver metastases from 2005 to 2014. Using International Classification of Diseases, Ninth Revision codes, we identified patients undergoing staged and simultaneous resection...
June 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28383294/roux-en-y-or-billroth-ii-reconstruction-after-radical-distal-gastrectomy-for-gastric-cancer-a-multicenter-randomized-controlled-trial
#9
Jimmy Bok-Yan So, Jaideepraj Rao, Andrew Siang-Yih Wong, Yiong-Huak Chan, Ning Qi Pang, Amy Yuh Ling Tay, Man Yee Yung, Zheng Su, Janelle Niam Sin Phua, Asim Shabbir, Enders Kwok Wai Ng
OBJECTIVE: The aim of the study was to compare the clinical symptoms between Billroth II (B-II) and Roux-en-Y (R-Y) reconstruction after distal subtotal gastrectomy (DG) for gastric cancer. BACKGROUND: Surgery is the mainstay of curative treatment for gastric cancer. The technique for reconstruction after DG remains controversial. Both B-II and R-Y are popular methods. METHODS: This is a prospective multicenter randomized controlled trial...
February 2018: Annals of Surgery
https://www.readbyqxmd.com/read/28317592/long-term-prognostic-value-of-preoperative-anemia-in-patients-with-colorectal-cancer-a-systematic-review-and-meta-analysis
#10
REVIEW
M J Wilson, M van Haaren, J J Harlaar, Hee Chul Park, H J Bonjer, J Jeekel, J J Zwaginga, M Schipperus
OBJECTIVE: To evaluate the long-term prognostic factor of preoperative anemia in colorectal cancer patients. BACKGROUND: Anemia is frequently observed in colorectal cancer patients, with a case incidence of 30 to 67 percent. Besides an indicator of tumor-induced blood loss and inflammation, anemia in cancer is also suggested to be a cause of inferior outcome, possibly via worsening of tumor hypoxia. As surgery is likely to enhance anemia, the long-term prognostic value of preoperative anemia seems most interesting...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28318008/meta-analysis-of-prophylactic-abdominal-drainage-in-pancreatic-surgery
#11
REVIEW
F J Hüttner, P Probst, P Knebel, O Strobel, T Hackert, A Ulrich, M W Büchler, M K Diener
BACKGROUND: Intra-abdominal drains are frequently used after pancreatic surgery whereas their benefit in other gastrointestinal operations has been questioned. The objective of this meta-analysis was to compare abdominal drainage with no drainage after pancreatic surgery. METHODS: PubMed, the Cochrane Library and Web of Science electronic databases were searched systematically to identify RCTs comparing abdominal drainage with no drainage after pancreatic surgery...
May 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28088321/surgeon-pathologist-and-hospital-level-variation-in-suboptimal-lymph-node-examination-after-colectomy-compartmentalizing-quality-improvement-strategies
#12
Adan Z Becerra, Christopher T Aquina, Mariana Berho, Francis P Boscoe, Maria J Schymura, Katia Noyes, John R Monson, Fergal J Fleming
BACKGROUND: The goals of this study were to characterize the variation in suboptimal lymph node examination for patients with colon cancer across individual surgeons, pathologists, and hospitals and to examine if this variation affects 5-year, disease-specific survival. METHODS: A retrospective cohort study was conducted by merging the New York State Cancer Registry with the Statewide Planning & Research Cooperative System, Medicaid, and Medicare claims to identify resections for stages I-III colon cancer from 2004-2011...
May 2017: Surgery
https://www.readbyqxmd.com/read/28130846/aasld-guidelines-for-the-treatment-of-hepatocellular-carcinoma
#13
Julie K Heimbach, Laura M Kulik, Richard S Finn, Claude B Sirlin, Michael M Abecassis, Lewis R Roberts, Andrew X Zhu, M Hassan Murad, Jorge A Marrero
No abstract text is available yet for this article.
January 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27785449/hepatocellular-carcinoma-a-review
#14
REVIEW
Julius Balogh, David Victor, Emad H Asham, Sherilyn Gordon Burroughs, Maha Boktour, Ashish Saharia, Xian Li, R Mark Ghobrial, Howard P Monsour
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. In the United States, HCC is the ninth leading cause of cancer deaths. Despite advances in prevention techniques, screening, and new technologies in both diagnosis and treatment, incidence and mortality continue to rise. Cirrhosis remains the most important risk factor for the development of HCC regardless of etiology. Hepatitis B and C are independent risk factors for the development of cirrhosis...
2016: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/28062931/fewer-reoperations-after-lumpectomy-for-breast-cancer-with-neoadjuvant-rather-than-adjuvant-chemotherapy-a-report-from-the-national-cancer-database
#15
Jeffrey Landercasper, Barbara Bennie, Benjamin M Parsons, Leah L Dietrich, Caprice C Greenberg, Lee G Wilke, Jared H Linebarger
BACKGROUND: Reoperations occur frequently after initial lumpectomy for breast cancer. The authors hypothesized that the receipt of neoadjuvant chemotherapy (NAC) is associated with fewer reoperations. METHODS: The association between timing of chemotherapy and reoperation rates (ROR) after lumpectomy was investigated for patients with stages 1-3 breast cancer in the National Cancer Database (NCDB) from 2010 to 2013 by multivariable logistic regression modeling. Then propensity score-matching was performed...
June 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27770344/when-and-when-not-to-perform-a-right-colon-resection-with-mucinous-appendiceal-neoplasms
#16
Paul H Sugarbaker
BACKGROUND: Mucinous appendiceal neoplasms (MAN) with peritoneal dissemination is treated as a standard of care using cytoreductive surgery and hyperthermic perioperative chemotherapy. The extent of the resection of peritoneal surfaces and visceral structures is generally well defined. Exception to this consensus regarding structures to be removed are the right colon and adjacent ileocolic lymph nodes. METHODS: From a prospectively maintained database, all patients with a histologic diagnosis of peritoneal mucinous carcinoma (PMCA) who underwent complete cytoreductive surgery were assessed for the presence versus absence of adenocarcinoma in lymph nodes within the appendiceal mesentery and/or in the lymph nodes of the ileocolic group...
March 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27664260/gastric-cancer-esmo-clinical-practice-guidelines-for-diagnosis-treatment-and-follow-up
#17
E C Smyth, M Verheij, W Allum, D Cunningham, A Cervantes, D Arnold
No abstract text is available yet for this article.
September 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27380959/esmo-consensus-guidelines-for-the-management-of-patients-with-metastatic-colorectal-cancer
#18
E Van Cutsem, A Cervantes, R Adam, A Sobrero, J H Van Krieken, D Aderka, E Aranda Aguilar, A Bardelli, A Benson, G Bodoky, F Ciardiello, A D'Hoore, E Diaz-Rubio, J-Y Douillard, M Ducreux, A Falcone, A Grothey, T Gruenberger, K Haustermans, V Heinemann, P Hoff, C-H Köhne, R Labianca, P Laurent-Puig, B Ma, T Maughan, K Muro, N Normanno, P Österlund, W J G Oyen, D Papamichael, G Pentheroudakis, P Pfeiffer, T J Price, C Punt, J Ricke, A Roth, R Salazar, W Scheithauer, H J Schmoll, J Tabernero, J Taïeb, S Tejpar, H Wasan, T Yoshino, A Zaanan, D Arnold
Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers...
August 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/9849736/perioperative-outcomes-of-major-hepatic-resections-under-low-central-venous-pressure-anesthesia-blood-loss-blood-transfusion-and-the-risk-of-postoperative-renal-dysfunction
#19
J A Melendez, V Arslan, M E Fischer, D Wuest, W R Jarnagin, Y Fong, L H Blumgart
BACKGROUND: We have previously demonstrated that maintenance of a low central venous pressure (LCVP) combined with extrahepatic control of venous outflow reduced the overall blood loss during major hepatic resections. This study examined the overall outcomes and, in particular, renal morbidity associated with a large series of consecutive major liver resections performed with this approach. In addition, the rationale for the anesthetic management to maintain LCVP was carefully reviewed...
December 1998: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27156933/gastric-cancer
#20
REVIEW
Eric Van Cutsem, Xavier Sagaert, Baki Topal, Karin Haustermans, Hans Prenen
Gastric cancer is one of the leading causes of cancer-related death worldwide. Many patients have inoperable disease at diagnosis or have recurrent disease after resection with curative intent. Gastric cancer is separated anatomically into true gastric adenocarcinomas and gastro-oesophageal-junction adenocarcinomas, and histologically into diffuse and intestinal types. Gastric cancer should be treated by teams of experts from different disciplines. Surgery is the only curative treatment. For locally advanced disease, adjuvant or neoadjuvant therapy is usually implemented in combination with surgery...
November 26, 2016: Lancet
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