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Anaphylaxis

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14 papers 0 to 25 followers
https://www.readbyqxmd.com/read/29524997/exercise-lowers-threshold-and-increases-severity-but-wheat-dependent-exercise-induced-anaphylaxis-can-be-elicited-at-rest
#1
Morten J Christensen, Esben Eller, Charlotte G Mortz, Knut Brockow, Carsten Bindslev-Jensen
BACKGROUND: Wheat-dependent, exercise-induced anaphylaxis (WDEIA) is a severe form of allergy in which exercise is being considered as mandatory. The diagnosis is often complex and the clinical reproducibility low. OBJECTIVE: The aims of this study were to establish a standardized challenge method for the diagnosis of WDEIA and to investigate whether exercise is an essential trigger factor or alternatively an augmentation factor able to lower threshold and increase severity...
March 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29018449/mechanisms-cofactors-and-augmenting-factors-involved-in-anaphylaxis
#2
REVIEW
Rosa Muñoz-Cano, Mariona Pascal, Giovanna Araujo, M J Goikoetxea, Antonio L Valero, Cesar Picado, Joan Bartra
Anaphylaxis is an acute and life-threatening systemic reaction. Many triggers have been described, including food, drug, and hymenoptera allergens, which are the most frequently involved. The mechanisms described in anaphylactic reactions are complex and implicate a diversity of pathways. Some of these mechanisms may be key to the development of the anaphylactic reaction, while others may only modify its severity. Although specific IgE, mast cells, and basophils are considered the principal players in anaphylaxis, alternative mechanisms have been proposed in non-IgE anaphylactic reactions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28888247/fatal-anaphylaxis-mortality-rate-and-risk-factors
#3
REVIEW
Paul J Turner, Elina Jerschow, Thisanayagam Umasunthar, Robert Lin, Dianne E Campbell, Robert J Boyle
Up to 5% of the US population has suffered anaphylaxis. Fatal outcome is rare, such that even for people with known venom or food allergy, fatal anaphylaxis constitutes less than 1% of total mortality risk. The incidence of fatal anaphylaxis has not increased in line with hospital admissions for anaphylaxis. Fatal drug anaphylaxis may be increasing, but rates of fatal anaphylaxis to venom and food are stable. Risk factors for fatal anaphylaxis vary according to cause. For fatal drug anaphylaxis, previous cardiovascular morbidity and older age are risk factors, with beta-lactam antibiotics, general anesthetic agents, and radiocontrast injections the commonest triggers...
September 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28780941/the-pathophysiology-of-anaphylaxis
#4
REVIEW
Laurent L Reber, Joseph D Hernandez, Stephen J Galli
Anaphylaxis is a severe systemic hypersensitivity reaction that is rapid in onset; characterized by life-threatening airway, breathing, and/or circulatory problems; and usually associated with skin and mucosal changes. Because it can be triggered in some persons by minute amounts of antigen (eg, certain foods or single insect stings), anaphylaxis can be considered the most aberrant example of an imbalance between the cost and benefit of an immune response. This review will describe current understanding of the immunopathogenesis and pathophysiology of anaphylaxis, focusing on the roles of IgE and IgG antibodies, immune effector cells, and mediators thought to contribute to examples of the disorder...
August 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28780942/mast-cell-activation-syndromes
#5
REVIEW
Cem Akin
Mast cell activation is common and possibly necessary for maintenance of survival. Disordered mast cell activation occurs when mast cells are pathologically overproduced or if their activation is out of proportion to the perceived threat to homeostasis. Mast cell activation syndrome refers to a group of disorders with diverse causes presenting with episodic multisystem symptoms as the result of mast cell mediator release. Despite introduction of diagnostic criteria and some advances in treatment in the last decade, many areas of mast cell activation syndrome are in need of research...
August 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28552379/are-ace-inhibitors-and-beta-blockers-dangerous-in-patients-at-risk-for-anaphylaxis
#6
Christopher A Coop, Rebecca S Schapira, Theodore M Freeman
The objective of this article is to review the available studies regarding angiotensin converting enzyme (ACE) inhibitors and beta-blockers and their effect on patients at risk for anaphylaxis. A literature search was conducted in PUBMED to identify peer-reviewed articles using the following keywords: anaphylaxis, ACE inhibitor, beta-blocker, food allergy, radiocontrast media, venom allergy, skin testing, and immunotherapy. Some studies show an increased risk of anaphylaxis in patients who are taking ACE inhibitors and beta-blockers, whereas others studies do not show an increased risk...
September 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28302183/reaching-multidisciplinary-consensus-on-classification-of-anaphylaxis-for-the-eleventh-revision-of-the-world-health-organization-s-who-international-classification-of-diseases-icd-11
#7
Luciana Kase Tanno, Robert J G Chalmers, Moises A Calderon, Ségolène Aymé, Pascal Demoly
BACKGROUND: Although currently misclassified in the International Classification of Diseases (ICD) and still not officially listed as a rare disease, anaphylaxis is a well-known clinical emergency. Anaphylaxis is now one of the principal headings in the "Allergic and hypersensitivity conditions" section recently compiled for the forthcoming 11th Revision of ICD (ICD-11). We here report the building process used for the pioneering "Anaphylaxis" subsection of ICD-11 in which we aimed for transparency as recommended in the ICD-11 revision guidelines...
March 16, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28138352/anaphylaxis-in-a-4-year-old-male-caused-by-contact-with-grasses-a-case-report
#8
Germán Darío Ramón, Victor H Croce, Iván Chérrez Ojeda
BACKGROUND: Acute urticaria is the presence of urticaria for <6 weeks, and it is the most common type of urticaria in children. Sometimes, it may be associated with anaphylaxis, a life-threatening condition. Urticaria must be differentiated from anaphylaxis because the latter may require emergency treatment. We describe a child with anaphylaxis exposed to grasses on two occasions. CASE PRESENTATION: We described a 4-year-old male child with anaphylaxis exposed to grasses...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27886904/mastocytosis-and-anaphylaxis
#9
REVIEW
Anna Schuch, Knut Brockow
This article updates current knowledge on epidemiology, risk factors, triggers, and management of anaphylaxis in patients with mastocytosis. Hyperactive mast cells and higher number of effector mast cells are speculated to facilitate anaphylaxis in this condition. In children, increased risk is limited to those with extensive skin involvement and high tryptase. In adults, manifestations of anaphylaxis are severe with high frequency of cardiovascular symptoms. Hymenoptera stings are the most common triggers for these reactions; however, idiopathic anaphylaxis and reactions to food or drugs occur...
February 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/27864089/anaphylaxis-induced-by-ingested-molds
#10
Ricardo Moreno-Borque, Teresa Collazo-Lorduy, Mariangélica Bermúdez-Martínez, Pilar Gajate-Fernández, Paula Sánchez-López, María Moreno-Geada, Nuria Plaza-Sánchez
No abstract text is available yet for this article.
January 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27822074/diagnosis-of-exercise-induced-anaphylaxis-current-insights
#11
REVIEW
Valerio Pravettoni, Cristoforo Incorvaia
Exercise-induced anaphylaxis (EIAn) is defined as the occurrence of anaphylactic symptoms (skin, respiratory, gastrointestinal, and cardiovascular symptoms) after physical activity. In about a third of cases, cofactors, such as food intake, temperature (warm or cold), and drugs (especially nonsteroidal anti-inflammatory drugs) can be identified. When the associated cofactor is food ingestion, the correct diagnosis is food-dependent EIAn (FDEIAn). The literature describes numerous reports of FDEIAn after intake of very different foods, from vegetables and nuts to meats and seafood...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27788890/rye-dependent-exercise-induced-anaphylaxis
#12
Jesús Miguel García-Menaya, Gian Marco Chiarella, Concepción Cordobés-Durán, Alba Catherine Mahecha, Pedro Bobadilla-González
No abstract text is available yet for this article.
November 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27765461/anaphylaxis-conundrum-a-trojan-horse-phenomenon
#13
REVIEW
Ann Esquivel, William W Busse
Anaphylaxis is a serious and potentially life-threatening allergic reaction that may follow the ingestion of foods. Although these reactions usually follow a common clinical pattern and often demonstrate IgE sensitization to the antigen in question, both the clinical presentation and causative allergen may be atypical, surprising, and difficult to identify. Failure to identify the actual cause of the reaction can compromise treatment and complicate long-term care. Here, we present a patient who had symptoms of anaphylaxis after eating salmon, but confirmation of the causative allergen was not readily apparent...
March 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27743592/the-risk-of-recurrent-anaphylaxis
#14
Andrew O'Keefe, Ann Clarke, Yvan St Pierre, Jennifer Mill, Yuka Asai, Harley Eisman, Sebastien La Vieille, Reza Alizadehfar, Lawrence Joseph, Judy Morris, Jocelyn Gravel, Moshe Ben-Shoshan
OBJECTIVES: To determine the recurrence rate of anaphylaxis in children medically attended in an emergency department (ED), we performed a prospective cohort study to evaluate prehospital and ED management of children with recurrent anaphylaxis and to assess factors associated with recurrent anaphylaxis. STUDY DESIGN: As part of the Cross-Canada Anaphylaxis Registry, parents of children with anaphylaxis identified prospectively in 3 EDs and through an emergency medical response service were contacted annually after presentation and queried on subsequent reactions...
January 2017: Journal of Pediatrics
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