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MAOIs —monoamine oxidase inhibitors

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3 papers 0 to 25 followers
https://www.readbyqxmd.com/read/26780349/behavioral-and-pharmacokinetic-interactions-between-monoamine-oxidase-inhibitors-and-the-hallucinogen-5-methoxy-n-n-dimethyltryptamine
#1
Adam L Halberstadt
Monoamine oxidase inhibitors (MAOIs) are often ingested together with tryptamine hallucinogens, but relatively little is known about the consequences of their combined use. We have shown previously that monoamine oxidase-A (MAO-A) inhibitors alter the locomotor profile of the hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in rats, and enhance its interaction with 5-HT2A receptors. The goal of the present studies was to investigate the mechanism for the interaction between 5-MeO-DMT and MAOIs, and to determine whether other behavioral responses to 5-MeO-DMT are similarly affected...
April 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/26837935/critical-appraisal-of-selegiline-transdermal-system-for-major-depressive-disorder
#2
REVIEW
Mario A Cristancho, Michael E Thase
INTRODUCTION: Although safer and easier to use antidepressants (ie.,SSRIs/SNRIs) have largely displaced MAOIs, these medications still have a role in difficult to treat conditions. Efforts to improve MAOIs benefit-risk profile resulted on the reversible MAOI and in the first antidepressant patch (selegiline transdermal delivery system-STS). The later had been available in the US since 2006. Thus a review on its safety profile and comparative efficacy is timely. AREAS COVERED: This review provides an overview of STS's clinical pharmacology and summarizes what has been learned across nearly a decade of experience...
2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/26881714/irreversible-lsd1-inhibitors-application-of-tranylcypromine-and-its-derivatives-in-cancer-treatment
#3
REVIEW
Yi C Zheng, Bin Yu, Guo Z Jiang, Xue J Feng, Peng X He, Xiao Y Chu, Wen Zhao, Hong M Liu
Due to the increasing costs and time consuming for new drug discovery, a large number of pharmaceutical firms have chosen to modify the existing drug molecules for repositioning candidates with new or improved properties, especially those with severe adverse effects, thereby accelerating the drug discovery process. Such strategy has witnessed its success with several examples reported. As the first identified histone lysine specific demethylase, lysine specific demethylase 1 (LSD1) is classified as a member of monoamine oxidase (MAO) superfamily, and specifically removes mono- and dimethylated histone 3 lysine 4 (H3K4) and H3 lysine 9 (H3K9)...
2016: Current Topics in Medicinal Chemistry
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