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MAOIs —monoamine oxidase inhibitors

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Yi C Zheng, Bin Yu, Guo Z Jiang, Xue J Feng, Peng X He, Xiao Y Chu, Wen Zhao, Hong M Liu
Due to the increasing costs and time consuming for new drug discovery, a large number of pharmaceutical firms have chosen to modify the existing drug molecules for repositioning candidates with new or improved properties, especially those with severe adverse effects, thereby accelerating the drug discovery process. Such strategy has witnessed its success with several examples reported. As the first identified histone lysine specific demethylase, lysine specific demethylase 1 (LSD1) is classified as a member of monoamine oxidase (MAO) superfamily, and specifically removes mono- and dimethylated histone 3 lysine 4 (H3K4) and H3 lysine 9 (H3K9)...
2016: Current Topics in Medicinal Chemistry
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