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26 papers 0 to 25 followers
Vivian Isaac, Chia-Yi Wu, Chun-Ta Huang, Bernhard T Baune, Chia-Lin Tseng, Craig S McLachlan
Neutrophil to lymphocyte ratio (NLR) is an easy measurable laboratory marker used to evaluate systemic inflammation. Elevated NLR is associated with poor survival and increased morbidity in cancer and cardiovascular disease. However, the usefulness of NLR to predict morbidity and mortality in a hospital setting for patients with multiple chronic conditions has not been previously examined. In this study, we investigate the association between NLR and mortality in multimorbid medical inpatients. Two hundred thirty medical in-patients with chronic conditions were selected from a single academic medical center in Taiwan...
June 2016: Medicine (Baltimore)
Hong Hu, Xiajuan Yao, Xiangcheng Xie, Xia Wu, Chuanming Zheng, Wenkai Xia, Shenglin Ma
BACKGROUND: Emerging evidences indicate that inflammation plays a crucial role in carcinogenesis and tumor progression. Inflammatory response biomarkers are recognized as promising prognostic factors for improving predictive accuracy in renal cell carcinoma (RCC). We aimed to evaluate the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR) and serum C-reactive protein (CRP) in RCC...
February 2017: World Journal of Urology
Jun Ho Lee, Sung Won Lee
INTRODUCTION: A recent study investigated the role of testosterone (T) in chronic prostatitis or chronic pelvic pain syndrome (CP/CPPS). However, only a small amount of data is available to date, and the results are inconsistent. AIMS: To evaluate the relation between total T (TT) and CP/CPPS. METHODS: We conducted a propensity-matched study by identifying men with a TT level lower than 3.5 ng/mL among 8,336 men in their 40s and 50s. A control group of men with a TT level of at least 3...
July 2016: Journal of Sexual Medicine
Jihad H Kaouk, Oktay Akca, Homayoun Zargar, Peter Caputo, Daniel Ramirez, Hiury Andrade, Selami Albayrak, Humberto Laydner, Kenneth Angermeier
OBJECTIVE: To minimize technical challenges of radical perineal prostatectomy (RPP), we conceived and applied the robotic approach to this technique in an aim to improve surgical applicability of RPP. Radical prostatectomy via the perineal route, avoiding the intra-abdominal cavity, has been shown to be oncologically safe, with excellent functional outcomes and a short hospital stay. We report our initial results with this novel approach. MATERIALS AND METHODS: We performed the procedure in 4 patients...
August 2016: Urology
Hakmin Lee, Sang Eun Lee, Seok-Soo Byun, Hyeon Hoe Kim, Cheol Kwak, Sung Kyu Hong
OBJECTIVE: To evaluate the associations of preoperative De Ritis ratio (aspartate transaminase [AST]/alanine transaminase [ALT]) with postoperative clinical outcomes after surgical treatment of localized RCC. MATERIALS AND METHODS: We retrospectively reviewed data from 2 965 patients surgically treated for non-metastatic RCC. Propensity scores for high AST/ALT ratio were calculated and 430 patients with a high AST/ALT ratio were matched to 1 117 patients with a low AST/ALT ratio...
February 2017: BJU International
Michele Marchioni, Giulia Primiceri, Manuela Ingrosso, Roberta Filograna, Pietro Castellan, Piergustavo De Francesco, Luigi Schips
The neutrophil to lymphocyte ratio (NLR) is an inflammatory index that has been considered as a potential prognostic factor in human cancer. The aim of this study was to evaluate the available evidence regarding the NLR as a prognostic value in patients affected by urothelial cancer. This literature review, including papers on NLR in urothelial cancers, was done on PubMed/Medline and Cochrane libraries in November 2015. The selection of the articles followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses process...
December 2016: Clinical Genitourinary Cancer
Mihai Dorin Vartolomei, Romain Mathieu, Vitaly Margulis, Jose A Karam, Morgan Rouprêt, Ilaria Lucca, Aurélie Mbeutcha, Christian Seitz, Pierre I Karakiewicz, Harun Fajkovic, Christopher G Wood, Alon Z Weizer, Jay D Raman, Nathalie Rioux-Leclercq, Andrea Haitel, Karim Bensalah, Michael Rink, Alberto Briganti, Evanguelos Xylinas, Shahrokh F Shariat
OBJECTIVE: Several retrospective studies with small cohorts reported neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker in upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU). We aimed at validating the predictive and prognostic role of NLR in a large multi-institutional cohort. METHODS: Preoperative NLR was assessed in a multi-institutional cohort of 2477 patients with UTUC treated with RNU. Altered NLR was defined by a ratio >2...
January 2017: World Journal of Urology
Yoko Maeda, Takashi Kawahara, Mitsuyuki Koizumi, Hiroki Ito, Yohei Kumano, Mari Ohtaka, Takuya Kondo, Taku Mochizuki, Yusuke Hattori, Jun-Ichi Teranishi, Yasushi Yumura, Yasuhide Miyoshi, Masahiro Yao, Hiroshi Miyamoto, Hiroji Uemura
Introduction. The neutrophil-to-lymphocyte ratio (NLR), which can be easily calculated from routine complete blood counts of the peripheral blood, has been suggested to serve as a prognostic factor for some solid malignancies. In the present study, we aimed to determine the relationship between NLR in prostate cancer patients undergoing radical prostatectomy (RP) and their prognosis. Materials and Methods. We assessed NLR in 73 men (patients) who received RP for their prostate cancer. We also performed immunohistochemistry for CD8 and CD66b in a separate set of RP specimens...
2016: BioMed Research International
Kristine H Allin, Stig E Bojesen, Børge G Nordestgaard
Inflammation and cancer are tightly linked. This study tests the hypothesis that an inflammatory score based on plasma levels of C-reactive protein (CRP) and fibrinogen and whole blood leukocyte count is associated with risk of colorectal, lung, breast and prostate cancer. A score ranging from none through three elevated biomarkers was constructed in 84,000 individuals from the Danish general population. During a median follow-up time of 4.8 years, 4,081 incident cancers occurred. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) of incident cancer...
October 1, 2016: International Journal of Cancer. Journal International du Cancer
Yoichi Nakamura, Ryohei Watanabe, Miwa Katagiri, Yoshihisa Saida, Natsuya Katada, Manabu Watanabe, Yasushi Okamoto, Koji Asai, Toshiyuki Enomoto, Takaharu Kiribayashi, Shinya Kusachi
BACKGROUND: Determining prognosis in advanced cancer is of key importance. Various prognostic scores have been developed. However, they are often very complex. In this study, we evaluated the feasibility of neutrophil/lymphocyte ratio (NLR) as an index to estimate survival in terminal cancer patients. METHODS: NLR was calculated retrospectively based on blood tests performed at 3 months, 2 months, 4 weeks, 3 weeks, 2 weeks, 1 week, and within 3 days before death in 160 cancer patients (82 men, 78 women; age range, 33-99 years; mean age, 69...
May 16, 2016: World Journal of Surgical Oncology
Lu Tang, Xintao Li, Baojun Wang, Guoxiong Luo, Liangyou Gu, Luyao Chen, Kan Liu, Yu Gao, Xu Zhang
OBJECTIVE AND BACKGROUND: Increasing evidence suggests that inflammation plays an essential role in cancer development and progression. The inflammation marker neutrophil-lymphocyte ratio (NLR) is correlated with prognosis across a wide variety of tumor types, but its prognostic value in prostate cancer (PCa) remains controversial. In the present meta-analysis, the prognostic value of NLR in PCa patients is investigated. METHODS: We performed a meta-analysis to determine the predictive value of NLR for overall survival (OS), recurrence-free survival (RFS), and clinical features in patients with PCa...
2016: PloS One
Xiaobin Gu, Xianshu Gao, Xiaoying Li, Xin Qi, Mingwei Ma, Shangbin Qin, Hao Yu, Shaoqian Sun, Dong Zhou, Wen Wang
This study was aimed to investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with prostate cancer (PCa). A meta-analysis including 14 publications (15 cohorts) with 16,266 patients was performed to evaluate the association between NLR and overall survival (OS), progression-free survival (PFS)/recurrence-free survival (RFS) in PCa using hazard ratio (HR) and 95% confidence intervals (95% CI). The combining data showed that increased NLR predict poor OS (HR = 1.38, 95%CI: 1...
February 25, 2016: Scientific Reports
Xiaotao Yin, Yi Xiao, Fanglong Li, Siyong Qi, Zhaoyang Yin, Jiangping Gao
Inflammation is increasingly reported to be associated with the prognosis of patients with cancers. And the prognostic role of neutrophil-to-lymphocyte ratio (NLR) in patients with prostate cancer (PCa) remains inconsistent. Therefore, we conducted this systematic review and meta-analysis to obtain a more reliable assessment of prognostic significance of NLR in PCa.A comprehensive literature research regarding the association of NLR and prognosis of PCa was performed through PubMed, Embase, Cochrane Central, and Web of Science...
January 2016: Medicine (Baltimore)
Mehmet Ilker Gokce, Nurullah Hamidi, Evren Suer, Semih Tangal, Adil Huseynov, Arif Ibiş
INTRODUCTION: We evaluate the role of NLR prior to prostate biopsy to predict biopsy histology and Gleason score in patients with prostate cancer. METHODS: In this retrospective study, we evaluated data of patients underwent prostate biopsy between May 2005 and March 2015. We collected the following data: age, prostate-specific antigen (PSA), biopsy histology, Gleason score (GS) in prostate cancer patients, neutrophil counts, and lymphocyte counts. Patients were grouped as benign prostatic hyperplasia (BPH), prostate cancer, and prostatitis...
November 2015: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Jong Jin Oh, Ohsung Kwon, Jung Keun Lee, Seok-Soo Byun, Sang Eun Lee, Sangchul Lee, Sung Kyu Hong
The aim of this study was to determine whether the neutrophil-to-lymphocyte ratio (NLR), a measure of the systemic inflammatory response is associated with the overall prostate cancer detection rate in men who underwent contemporary multi (≥12)-core transrectal ultrasound (TRUS) biopsy. We reviewed the records of 3913 patients with initial prostate-specific antigen (PSA) levels ranging from 4 to 10 ng ml-1 who underwent TRUS-guided prostate biopsy between April 2006 and May 2014. NLR was calculated by prebiopsy neutrophil and lymphocyte counts...
November 2016: Asian Journal of Andrology
Gui-Ming Zhang, Yao Zhu, Xiao-Cheng Ma, Xiao-Jian Qin, Fang-Ning Wan, Bo Dai, Li-Jiang Sun, Ding-Wei Ye
The pretreatment neutrophil-to-lymphocyte ratio (NLR) is reportedly associated with the clinical outcomes of many cancers. However, it has not been widely investigated whether the pretreatment NLR is associated with the pathological characteristics of prostate cancer (PCa) and biochemical recurrence in PCa patients receiving radical prostatectomy (RP).In this cohort study, a total of 1688 PCa patients who had undergone RP were analyzed retrospectively, and a subset of 237 of these patients were evaluated to determine the relationship between pretreatment NLR and biochemical recurrence...
October 2015: Medicine (Baltimore)
Ozgur Haki Yuksel, Ahmet Urkmez, Serkan Akan, Caglar Yldirim, Ayhan Verit
PURPOSE: To predict prostatic carcinoma using a logistic regression model on prebiopsy peripheral blood samples. MATERIALS AND METHODS: Data of a total of 873 patients who consulted Urology Outpatient Clinics of Fatih Sultan Mehmet Training and Research Hospital between February 2008 and April 2014 scheduled for prostate biopsy were screened retrospectively. PSA levels, prostate volumes, prebiopsy whole blood cell counts, neutrophil and platelet counts, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), biopsy results and Gleason scores in patients who had established diagnosis of prostate cancer (PCa) were evaluated...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Takashi Kawahara, Sachi Fukui, Kentaro Sakamaki, Yusuke Ito, Hiroki Ito, Naohito Kobayashi, Koji Izumi, Yumiko Yokomizo, Yasuhide Miyoshi, Kazuhide Makiyama, Noboru Nakaigawa, Takeharu Yamanaka, Masahiro Yao, Hiroshi Miyamoto, Hiroji Uemura
Neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammatory response, has been demonstrated as an independent prognosticator for some solid malignancies, including prostate cancer. In the present study, we evaluated the role of NLR in men who underwent prostate needle biopsy for their initial diagnosis of prostatic carcinoma. Both complete blood counts and free/total (F/T) prostate-specific antigen (PSA) ratio were examined in a total of 3,011 men in our institution. Of these, 1,207 had a PSA level between 4 and 10 ng/mL, and 357 of 810 who subsequently underwent prostate needle biopsy were found to have prostatic adenocarcinoma...
October 13, 2015: Oncotarget
Young Suk Kwon, Christopher Sejong Han, Ji Woong Yu, Sinae Kim, Parth Modi, Rachel Davis, Ji Hae Park, Paul Lee, Yun-Sok Ha, Wun-Jae Kim, Isaac Yi Kim
UNLABELLED: Appropriate patient selection for active surveillance is challenging.Our study of 217 patients demonstrated that the preoperative absolute neutrophil and lymphocyte counts were better predictors of aggressive oncologic features than were the neutrophil-to-lymphocyte ratio in the assessment of low-risk prostate cancer patients. Our findings suggest that routine hematologic workup could be used to further stratify low-risk prostate cancer patients. INTRODUCTION: The neutrophil-to-lymphocyte ratio (NLR) has emerged as a ubiquitous prognostic biomarker in cancer-related inflammation, specifically in patients with metastatic castration-resistant prostate cancer (PCa)...
February 2016: Clinical Genitourinary Cancer
Tanja Langsenlehner, Eva-Maria Thurner, Sabine Krenn-Pilko, Uwe Langsenlehner, Tatjana Stojakovic, Armin Gerger, Martin Pichler
PURPOSE: Recent studies have expanded the concept that the systemic inflammatory response has an important role in the progression of several solid tumors. The neutrophil-to-lymphocyte ratio (NLR), an easily determinable marker of systemic inflammation, has been associated with clinical outcome in various cancer entities. In the present study, we validated the prognostic relevance of an elevated NLR in a cohort of European prostate cancer patients. METHODS: Data from 415 consecutive prostate cancer patients treated with 3D conformal radiotherapy at a single tertiary academic center from 1999 to 2007 were included in this retrospective study...
November 2015: World Journal of Urology
2016-10-13 07:35:38
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