Jan Wernerman, Kenneth B Christopher, Djillali Annane, Michael P Casaer, Craig M Coopersmith, Adam M Deane, Elisabeth De Waele, Gunnar Elke, Carole Ichai, Constantine J Karvellas, Stephen A McClave, Heleen M Oudemans-van Straaten, Olav Rooyackers, Renee D Stapleton, Jukka Takala, Arthur R H van Zanten, Paul E Wischmeyer, Jean-Charles Preiser, Jean-Louis Vincent
Metabolic alterations in the critically ill have been studied for more than a century, but the heterogeneity of the critically ill patient population, the varying duration and severity of the acute phase of illness, and the many confounding factors have hindered progress in the field. These factors may explain why management of metabolic alterations and related conditions in critically ill patients has for many years been guided by recommendations based essentially on expert opinion. Over the last decade, a number of randomized controlled trials have been conducted, providing us with important population-level evidence that refutes several longstanding paradigms...
September 18, 2019: Critical Care: the Official Journal of the Critical Care Forum