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Asthma

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64 papers 25 to 100 followers
By M KKhan Pediatric Intensivist
https://www.readbyqxmd.com/read/29105540/mechanically-ventilating-the-severe-asthmatic
#1
Abdullah E Laher, Sean K Buchanan
The management of the critically ill patients with asthma can be rather challenging. Potentially devastating complications relating to this presentation include hypoxemia, worsening bronchospasm, pulmonary aspiration, tension pneumothorax, dynamic hyperinflation, hypotension, dysrhythmias, and seizures. In contrast to various other pathologies requiring mechanical ventilation, acute asthma is generally associated with better outcomes. This review serves as a practical guide to the physician managing patients with severe acute asthma requiring mechanical ventilation...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28780506/should-we-use-montelukast-in-wheezy-children
#2
EDITORIAL
Iram Haq, Caroline Harris, Jake Taylor, Michael C McKean, Malcolm Brodlie
No abstract text is available yet for this article.
August 5, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28903951/managing-problematic-severe-asthma-beyond-the-guidelines
#3
REVIEW
Katharine C Pike, Mark L Levy, John Moreiras, Louise Fleming
This review discusses issues related to managing problematic severe asthma in children and young people. A small minority of children have genuinely severe asthma symptoms which are difficult to control. Children with genuinely severe asthma need investigations and treatments beyond those described within conventional guidelines. However, the majority of children with poor symptom control despite high-intensity treatment achieve improvement in their asthma control once attention has been paid to the basics of asthma management...
September 13, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28910134/eosinophilic-and-non-eosinophilic-asthma
#4
Tara F Carr, Amir A Zeki, Monica Kraft
Asthma can be subdivided into eosinophilic or non-eosinophilic phenotypes based on the inflammatory cellular patterns seen in sputum, blood, and airway tissue compartments. However, this level of stratification does not always produce robust clinical phenotypes as there is considerable overlap across these phenotypes when viewed from the perspective of "eosinophilia". Multiple proposed subphenotypes of asthma have instead been described within both the eosinophilic and non-eosinophilic groups. An endotype is the mechanism driving a subphenotype including those associated with eosinophilia such as early-onset allergic asthma, with and without obesity, aspirin sensitive asthma and late-onset eosinophilic asthma, allergic bronchopulmonary mycosis, and exercise-induced asthma...
September 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28957644/effect-of-early-life-geohelminth-infections-on-the-development-of-wheezing-at-5-years-of-age
#5
Philip J Cooper, Martha E Chico, Maritza G Vaca, Carlos A Sandoval, Sofia Loor, Leila Amorim, Laura C Rodrigues, Mauricio L Barreto, David P Strachan
RATIONALE: Exposures to geohelminths during gestation or early childhood may reduce risk of wheezing illness/asthma and atopy during childhood in tropical regions. OBJECTIVES: To investigate the effect of maternal and early childhood geohelminths on development of wheeze/asthma and atopy during the first 5 years of life. METHODS: Cohort of 2,404 neonates followed to 5 years of age in rural District in coastal Ecuador. Data on wheeze collected by questionnaire and atopy measured by allergen skin prick test reactivity to 9 allergens at 5 years...
September 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28869358/the-role-of-respiratory-tract-infections-and-the-microbiome-in-the-development-of-asthma-a-narrative-review
#6
REVIEW
Evelien R van Meel, Vincent W V Jaddoe, Klaus Bønnelykke, Johan C de Jongste, Liesbeth Duijts
Asthma is a common disease in childhood, and might predispose for chronic obstructive respiratory morbidity in adolescence and adulthood. Various early-life risk factors might influence the risk of wheezing, asthma, and lower lung function in childhood. Cohort studies demonstrated that lower respiratory tract infections in the first years of life are associated with an increased risk of wheezing and asthma, while the association with lung function is less clear. Additionally, the gut and airway microbiome might influence the risk of wheezing and asthma...
October 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28910519/trans-nasal-flexible-bronchoscopy-in-wheezing-children-diagnostic-yield-impact-on-therapy-and-prevalence-of-laryngeal-cleft
#7
Richard P Boesch, Julie M Baughn, Shelagh A Cofer, Karthik Balakrishnan
AIM: Persistent or recurrent wheezing is a common indication for flexible bronchoscopy, as anatomic and infectious or inflammatory changes are highly prevalent. We sought to evaluate the prevalence of anatomic, infectious, and inflammatory disease in a cohort of children undergoing flexible bronchoscopy for wheezing or poorly controlled asthma. METHODS: We retrospectively reviewed all children <18 years old who underwent flexible bronchoscopy at our center from October 29, 2012-December 31, 2016 for the primary or secondary indication of wheezing (persistent, frequently recurring, or atypical) or poorly controlled asthma...
September 14, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27842794/clinical-toxicology-and-its-relevance-to-asthma-and-atopy
#8
REVIEW
Rauno Joks, Martin H Bluth
Although both the prevalence of asthma and the prescription drug use, notably the opiate analgesic class, epidemics are increasing, there is a complex interplay between both disorders, with both protective and exacerbating factors involved in the effect of opiates on asthma pathogenesis and clinical severity. This review examines the airway effects, both immunologic and neurologic, of opiates, which may interact and result in protection or exacerbation of asthma.
December 2016: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/27515731/concerns-with-beta2-agonists-in-pediatric-asthma-a-clinical-perspective
#9
REVIEW
Elin T G Kersten, Gerard H Koppelman, Bernard J Thio
Beta2-adrenoreceptor agonists (β2-agonists) are extensively used in the treatment of childhood asthma. However, there have been concerns regarding their adverse effects and safety. In 2005, the FDA commissioned a "Black Box Warning" communicating the potential for an increased risk for serious asthma exacerbations or asthma related deaths, with the regular use of LABAs. In a meta-analysis of controlled clinical trials, the incidence of severe adverse events appeared to be highest in the 4-11 year age group...
January 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27522304/intravenous-magnesium-sulfate-for-treating-children-with-acute-asthma-in-the-emergency-department
#10
REVIEW
Benedict Griffiths, Kayleigh M Kew, Rebecca Normansell
No abstract text is available yet for this article.
September 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28927779/extracorporeal-membrane-oxygenation-ecmo-and-ultraprotective-mechanical-ventilation-for-near-fatal-status-asthmaticus
#11
Y Corcia-Palomo, L Martín-Villén, S Escalona-Rodríguez, A Roldán Reina, A Adsuar-Gómez, R Martín-Bermúdez
No abstract text is available yet for this article.
September 16, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28258535/routine-use-of-budesonide-formoterol-fixed-dose-combination-in-elderly-asthmatic-patients-practical-considerations
#12
REVIEW
Nicola Scichilone, Fulvio Braido, Federico Lavorini, Mark L Levy, Omar S Usmani
Asthma has been demonstrated to be as common in the elderly as in younger age groups. Although no specific recommendations exist to manage the disease differently in older individuals, functional features and clinical presentations may be affected by age per se, and by age-related conditions, such as comorbidities and polypharmacy. In this review article, we aimed to explore the efficacy and safety in elderly asthmatic patients of one of the most currently used inhaled treatments for asthma, that is, the fixed-dose combination of budesonide/formoterol...
May 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28719697/diagnosis-and-management-of-asthma-in-adults-a-review
#13
REVIEW
Jennifer L McCracken, Sreenivas P Veeranki, Bill T Ameredes, William J Calhoun
Importance: Asthma affects about 7.5% of the adult population. Evidence-based diagnosis, monitoring, and treatment can improve functioning and quality of life in adult patients with asthma. Observations: Asthma is a heterogeneous clinical syndrome primarily affecting the lower respiratory tract, characterized by episodic or persistent symptoms of wheezing, dyspnea, and cough. The diagnosis of asthma requires these symptoms and demonstration of reversible airway obstruction using spirometry...
July 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28663322/asthma-and-corticosteroids-time-for-a-more-precise-approach-to-treatment
#14
EDITORIAL
Eleanor M Dunican, John V Fahy
No abstract text is available yet for this article.
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28599066/rhinovirus-and-preschool-wheeze
#15
REVIEW
Katarina Stenberg-Hammar, Gunilla Hedlin, Cilla Söderhäll
Rhinovirus (RV) known as the common cold virus generally only causes a mild upper respiratory infection, but severe lower respiratory symptoms have been associated with RV infections especially in asthmatic individuals. Wheezing is a symptom of airway obstruction, and preschool children wheezing with RV have been associated with increased risk of asthma at school age. There are, however, conflicting opinions as to whether there are differences in response to RV infection or whether wheezing with RV reveals a preexisting impairment that promotes asthma mainly in predisposed children...
September 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28534235/nasal-high-flow-in-management-of-children-with-status-asthmaticus-a-retrospective-observational-study
#16
Florent Baudin, Alexandra Buisson, Blandine Vanel, Bruno Massenavette, Robin Pouyau, Etienne Javouhey
BACKGROUND: Asthma is the most common obstructive airway disease in children and adults. Nasal high flow (NHF) is a recent device that is now used as a primary support for respiratory distress. Several studies have reported use of NHF as a respiratory support in status asthmaticus; however, there are no data to recommend such practice. We therefore conducted this preliminary study to evaluate NHF therapy for children with status asthmaticus admitted to our PICU in order to prepare a multicentre randomized controlled study...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28538609/critical-care-interventions-for-asthmatic-patients-admitted-from-the-emergency-department-to-the-pediatric-intensive-care-unit
#17
Kristen Michelle Cundiff, James M Gerard, Robert G Flood
OBJECTIVES: The aim of this study was to assess the frequency and predictors of critical interventions in asthmatic patients admitted to the pediatric intensive care unit (PICU) at a tertiary-care pediatric hospital. METHODS: We conducted a retrospective chart review of patients admitted from our emergency department (ED) to the PICU for treatment of status asthmaticus between January 1, 2008, and March 31, 2013. Patients with concomitant medical conditions and those who received a critical intervention, other than continuously aerosolized albuterol, in the ED before admission were excluded...
May 23, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28183482/use-of-biological-agents-in-asthma-pharmacoeconomic-lessons-learned-from-omalizumab
#18
EDITORIAL
Steven Draikiwicz, John Oppenheimer
No abstract text is available yet for this article.
February 2017: Chest
https://www.readbyqxmd.com/read/23607855/an-official-american-thoracic-society-workshop-report-optimal-lung-function-tests-for-monitoring-cystic-fibrosis-bronchopulmonary-dysplasia-and-recurrent-wheezing-in-children-less-than-6-years-of-age
#19
REVIEW
Margaret Rosenfeld, Julian Allen, Bert H G M Arets, Paul Aurora, Nicole Beydon, Claudia Calogero, Robert G Castile, Stephanie D Davis, Susanne Fuchs, Monika Gappa, Per M Gustaffson, Graham L Hall, Marcus H Jones, Jane C Kirkby, Richard Kraemer, Enrico Lombardi, Sooky Lum, Oscar H Mayer, Peter Merkus, Kim G Nielsen, Cara Oliver, Ellie Oostveen, Sarath Ranganathan, Clement L Ren, Paul D Robinson, Paul C Seddon, Peter D Sly, Marianna M Sockrider, Samatha Sonnappa, Janet Stocks, Padmaja Subbarao, Robert S Tepper, Daphna Vilozni
Although pulmonary function testing plays a key role in the diagnosis and management of chronic pulmonary conditions in children under 6 years of age, objective physiologic assessment is limited in the clinical care of infants and children less than 6 years old, due to the challenges of measuring lung function in this age range. Ongoing research in lung function testing in infants, toddlers, and preschoolers has resulted in techniques that show promise as safe, feasible, and potentially clinically useful tests...
April 2013: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28235797/inhaled-corticosteroids-and-respiratory-infections-in-children-with-asthma-a-meta-analysis
#20
REVIEW
Cristine Cazeiro, Cristina Silva, Susana Mayer, Vanessa Mariany, Claire Elizabeth Wainwright, Linjie Zhang
CONTEXT: Inhaled corticosteroids (ICS) are associated with an increased risk of pneumonia in adult patients with chronic obstructive pulmonary disease. OBJECTIVE: To assess the association between ICS use and risk of pneumonia and other respiratory infections in children with asthma. DATA SOURCES: We searched PubMed from inception until May 2015. We also searched clinicaltrials.gov and databases of pharmaceutical manufacturers. STUDY SELECTION: We selected randomized trials that compared ICS with placebo for at least 4 weeks in children with asthma...
March 2017: Pediatrics
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