collection
https://read.qxmd.com/read/36581395/optimising-intravenous-salbutamol-in-children-a-phase-2-study
#1
JOURNAL ARTICLE
Sandra Walsh, Shan Pan, Yucheng Sheng, Frank Kloprogge, Joe F Standing, Brian J Anderson, Padmanabhan Ramnarayan
OBJECTIVE: The β2-agonists such as salbutamol are the mainstay of asthma management. Pharmacokinetic-pharmacodynamic (PKPD) models to guide paediatric dosing are lacking. We explored the relationship between salbutamol dose, serum concentration, effectiveness and adverse effects in children by developing a PKPD model. DESIGN: A prospective cohort study of children admitted to hospital with acute asthma, who received intravenous salbutamol. SETTING: Children were recruited in two cohorts: the emergency departments of two London hospitals or those retrieved by the Children's Acute Transport Service to three London paediatric intensive care units...
April 2023: Archives of Disease in Childhood
https://read.qxmd.com/read/35944965/safe-and-effective-use-of-score-based-continuous-albuterol-therapy-in-a-pathway-for-treatment-of-pediatric-asthma-exacerbation
#2
JOURNAL ARTICLE
L Denise Willis, Nikki P Danner, Tera L Lloyd, Naisha L Carper, Ariel Berlinski
BACKGROUND: Standardized acute asthma management with score-based, respiratory therapist (RT)-driven pathways and protocols improves outcomes including decreased length of stay (LOS) and time on continuous albuterol therapy. Limited data are available for the safety of continuous albuterol used outside of pediatric ICU (PICU). We use a modified pediatric asthma score (PAS) for the asthma pathway at our institution. The safety and effectiveness of using PAS to initiate/stop continuous albuterol as part of a score-based, RT-driven asthma pathway were evaluated...
November 2022: Respiratory Care
https://read.qxmd.com/read/35648708/another-rescue-therapy-option-for-patients-with-moderate-to-severe-asthma
#3
EDITORIAL
Michael Schatz
New England Journal of Medicine, Volume 386, Issue 22, Page 2139-2140, June 2022.
June 2, 2022: New England Journal of Medicine
https://read.qxmd.com/read/34271233/early-versus-delayed-administration-of-intravenous-magnesium-sulfate-for-pediatric-asthma
#4
JOURNAL ARTICLE
Amy M DeLaroche, Fabrice I Mowbray, Maryam Bohsaghcheghazel, Kristina Zalewski, Katherine Obudzinski
OBJECTIVE: This study aims to describe and examine the factors associated with the early administration of intravenous magnesium sulfate (IV Mg) in children presenting to the pediatric emergency department (ED) for an asthma exacerbation. METHODS: Retrospective cohort study of children aged 5-11 years who received IV Mg in the pediatric ED between September 1, 2018 and August 31, 2019 for management of an asthma exacerbation. Primary outcome was administration of IV Mg in ≤60 min from ED triage ('early administration')...
December 2021: American Journal of Emergency Medicine
https://read.qxmd.com/read/34861100/pulmonary-specialist-involvement-in-critical-asthma-in-the-pediatric-intensive-care-unit-a-retrospective-review
#5
JOURNAL ARTICLE
Janaki Paskaradevan, Mackenzie Zier, Brian Rissmiller, Julie P Katkin, Jorge A Coss-Bu, M Carolina Gazzaneo
INTRODUCTION: Asthma is one of the most common chronic diseases of childhood. There is a scarcity of published literature on critical asthma, considered acute asthma requiring pediatric intensive care unit (PICU) admission. The goal of this study was to describe the clinical care of children with critical asthma admitted to a single center PICU and to determine whether pulmonary medicine consultation during admission impacted outcomes. METHODS: Retrospective chart review of known asthma patients aged 4-18 years admitted to a quaternary PICU between 01/2013 and 07/2019 for management of critical asthma...
February 2022: Pediatric Pulmonology
https://read.qxmd.com/read/34862766/the-efficacy-and-safety-of-azithromycin-in-treatment-for-childhood-asthma-a-systematic-review-and-meta-analysis
#6
JOURNAL ARTICLE
Xiangcheng Pan, Yan Liu, Jiefeng Luo, Siyu Li, Sha Diao, Hailong Li, Liang Huang, Zhijun Jia, Lina Chen, Guo Cheng, Hanmin Liu, Lingli Zhang
BACKGROUND: Azithromycin (AZI) is increasingly used for childhood asthma despite limited and inconsistent data. We aimed to evaluate the efficacy and safety of AZI in childhood asthma. METHODS: We searched seven databases to include randomized controlled trials (RCTs) of AZI in the treatment of childhood asthma. Four reviewers independently screened the records. Risk of Bias 2 was used to assess the quality of RCTs. Risk ratios with 95% confidence interval (CI) from dichotomous outcomes, and mean difference (MD) with 95% CI from continuous outcomes were pooled...
March 2022: Pediatric Pulmonology
https://read.qxmd.com/read/34279646/association-between-intravenous-magnesium-therapy-in-the-emergency-department-and-subsequent-hospitalization-among-pediatric-patients-with-refractory-acute-asthma-secondary-analysis-of-a-randomized-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
Suzanne Schuh, Stephen B Freedman, Roger Zemek, Amy C Plint, David W Johnson, Francine Ducharme, Jocelyn Gravel, Graham Thompson, Sarah Curtis, Derek Stephens, Allan L Coates, Karen J Black, Darcy Beer, Judy Sweeney, Maggie Rumantir, Yaron Finkelstein
IMPORTANCE: Despite guidelines recommending administration of intravenous (IV) magnesium sulfate for refractory pediatric asthma, the number of asthma-related hospitalizations has remained stable, and IV magnesium therapy is independently associated with hospitalization. OBJECTIVE: To examine the association between IV magnesium therapy administered in the emergency department (ED) and subsequent hospitalization among pediatric patients with refractory acute asthma after adjustment for patient-level variables...
July 1, 2021: JAMA Network Open
https://read.qxmd.com/read/34078003/pediatric-pulmonology-2020-year-in-review-asthma
#8
REVIEW
Andrew T Barber, Ceila E Loughlin
Pediatric asthma is a heterogeneous and common chronic condition with significant morbidity and burden on the healthcare system. Despite advances in the field, the disease has proven to be increasingly complex to diagnose and management strategies are constantly evolving. Studies from 2020 have advanced the field even further, particularly with regard to new methods of diagnosis and monitoring, treatment of severe asthma, modifiable risk factors like exercise and obesity, aerosol delivery, and viral respiratory infections contributing to the development of asthma...
August 2021: Pediatric Pulmonology
https://read.qxmd.com/read/34002877/pediatric-problematic-severe-asthma-recent-advances-in-management
#9
REVIEW
Elizabeth Scotney, Saskia Burchett, Thomas Goddard, Sejal Saglani
Problematic severe asthma remains a significant challenge to manage, accounting for the majority of healthcare utilization among children with asthma. The heterogeneity is recognized and the clinical phenotypes of "difficult-to-treat" asthma (DA) and "severe therapy-resistant asthma" (STRA) help to guide management. Recent evidence supports molecular distinctions between these phenotypes and shows poor correlations between peripheral and airway markers of inflammation, especially in STRA. Airway neutrophils in the context of childhood severe asthma have been explored, but their role in disease causation, protection, or as bystanders remain unknown, and thus, treatment implications are unclear...
October 2021: Pediatric Allergy and Immunology
https://read.qxmd.com/read/33773928/initiating-home-spirometry-for-children-during-the-covid-19-pandemic-a-practical-guide
#10
REVIEW
C H Richardson, N J Orr, S L Ollosson, S J Irving, I M Balfour-Lynn, S B Carr
The COVID-19 pandemic has led to a rapid escalation in use of home monitoring and video consultations in children with a variety of chronic respiratory conditions. Our department set up a home spirometry service from scratch once it became evident that we needed to keep patients away from hospital clinics whenever possible. We faced a number of challenges but now have around 400 children using home spirometers. There are a number of portable spirometers available, some with online platforms. The technology, particularly the software/apps interface, has been improved by the companies in response to issues that have arisen...
June 2022: Paediatric Respiratory Reviews
https://read.qxmd.com/read/33771473/high-flow-nasal-cannula-in-children-with-asthma-exacerbation-a-review-of-current-evidence
#11
REVIEW
Ke-Yun Chao, Yu-Hsuan Chien, Shu-Chi Mu
Asthma is the commonest obstructive airway disease and the leading cause of morbidity in children. In the pediatric population, acute exacerbations of asthma are a frequent cause of presentations and hospital admissions. An acute asthma exacerbation is potentially life-threatening; it is predominantly treated using conventional oxygen therapy with bronchodilators and systemic corticosteroids. The treatment of those who do not respond to conventional therapy is escalated to noninvasive positive pressure ventilation (NIPPV) before invasive ventilation...
December 2021: Paediatric Respiratory Reviews
https://read.qxmd.com/read/33380248/methylprednisolone-dexamethasone-or-hydrocortisone-for-acute-severe-pediatric-asthma-does-it-matter
#12
RANDOMIZED CONTROLLED TRIAL
Sule Doymaz, Youssef E Ahmed, Densley Francois, Rohit Pinto, Ramon Gist, Miriam Steinberg, Clara Giambruno
OBJECTIVE: Various intravenous (IV) corticosteroids are available for acute severe asthma (ASA) treatment. The choice of IV corticosteroids varies broadly and depends on institution, country, or physician preferences. In this study, we compared the efficacy of IV methylprednisolone, hydrocortisone and dexamethasone in ASA treatment during pediatric intensive care unit (PICU) admission. METHODS: The study was a prospective randomized clinical trial. We enrolled patients of 1-21 years after they were admitted to the PICU requiring continuous beta-2 agonist treatment...
March 2022: Journal of Asthma
https://read.qxmd.com/read/33169215/how-to-ventilate-obstructive-and-asthmatic-patients
#13
REVIEW
Alexandre Demoule, Laurent Brochard, Martin Dres, Leo Heunks, Amal Jubran, Franco Laghi, Armand Mekontso-Dessap, Stefano Nava, Lamia Ouanes-Besbes, Oscar Peñuelas, Lise Piquilloud, Theodoros Vassilakopoulos, Jordi Mancebo
Exacerbations are part of the natural history of chronic obstructive pulmonary disease and asthma. Severe exacerbations can cause acute respiratory failure, which may ultimately require mechanical ventilation. This review summarizes practical ventilator strategies for the management of patients with obstructive airway disease. Such strategies include non-invasive mechanical ventilation to prevent intubation, invasive mechanical ventilation, from the time of intubation to weaning, and strategies intended to prevent post-extubation acute respiratory failure...
December 2020: Intensive Care Medicine
https://read.qxmd.com/read/32940961/metered-dose-inhalers-versus-nebulization-for-the-delivery-of-albuterol-for-acute-exacerbations-of-wheezing-or-asthma-in-children-a-systematic-review-with-meta-analysis
#14
COMPARATIVE STUDY
Laura Payares-Salamanca, Sandra Contreras-Arrieta, Victor Florez-García, Alexander Barrios-Sanjuanelo, Ivan Stand-Niño, Carlos E Rodriguez-Martinez
OBJECTIVES: The benefits of metered-dose inhalers with a spacer (MDI+S) have increasingly been recognized as an alternative method of albuterol administration for treating pediatric asthma exacerbations. The aim of this systematic review was to compare the response to albuterol delivered through nebulization (NEB) with albuterol delivered through MDI+S in pediatric patients with asthma exacerbations. METHODS: We conducted an electronic search in MEDLINE/PubMed, EMBASE, Ovid, and ClinicalTrials...
December 2020: Pediatric Pulmonology
https://read.qxmd.com/read/32686927/an-update-on-biological-therapies-for-pediatric-allergic-diseases
#15
REVIEW
Riccardo Castagnoli, Maria De Filippo, Martina Votto, Alessia Marseglia, Lorenza Montagna, Gian Luigi Marseglia, Amelia Licari
Allergic diseases represent a global health burden. Patients with allergic diseases may experience disability, reduced quality of life and productivity, emotional distress, and social restrictions, especially in the most severe cases. Current advances in unveiling the pathogenesis of allergic disorders have paved the way for the development of novel therapeutic strategies. Biological drugs have been widely studied in pediatric allergic asthma, with strong evidence of efficacy and safety. Moreover, promising results derive from studies on other conditions such as atopic dermatitis, chronic spontaneous urticaria, and food allergy...
October 2020: Minerva Pediatrica
https://read.qxmd.com/read/32653467/rational-use-of-mucoactive-medications-to-treat-pediatric-airway-disease
#16
REVIEW
R S N Linssen, J Ma, R A Bem, B K Rubin
Many airway diseases in children, notably bronchiolitis, cystic fibrosis (CF), non-CF bronchiectasis including primary ciliary dyskinesia, pneumonia, and severe asthma are associated with retention of airway secretions. Medications to improve secretions clearance, the mucoactive medications, are employed to treat these diseases with varying degrees of success. This manuscript reviews evidence for the use of these medications and future directions of study.
November 2020: Paediatric Respiratory Reviews
https://read.qxmd.com/read/32558360/asthma-and-covid-19-in-children-a-systematic-review-and-call-for-data
#17
JOURNAL ARTICLE
Jose A Castro-Rodriguez, Erick Forno
RATIONALE: Whether asthma constitutes a risk factor for coronavirus disease-2019 (COVID-19) is unclear. Here, we aimed to assess whether asthma, the most common chronic disease in children, is associated with higher COVID-19 risk or severity in pediatric populations. METHODS: We performed a systematic literature search in three stages: first, we reviewed PubMed, EMBASE, and CINAHL for systematic reviews of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 in pediatric populations, and reviewed their primary articles; second, we searched PubMed for studies on COVID-19 or SARS-CoV-2 and asthma/wheeze, and evaluated whether the resulting studies included pediatric populations; third, we repeated the second search in BioRxiv...
September 2020: Pediatric Pulmonology
https://read.qxmd.com/read/32217526/assessing-pulsus-paradoxus-in-severe-exacerbations-of-asthma
#18
EDITORIAL
Roona Aniapravan, Colin Powell
No abstract text is available yet for this article.
June 2020: Archives of Disease in Childhood
https://read.qxmd.com/read/32147221/intravenous-magnesium-in-asthma-pharmacotherapy-variability-in-use-in-the-pecarn-registry
#19
MULTICENTER STUDY
Michael D Johnson, Joseph J Zorc, Douglas S Nelson, Theron Charles Casper, Lawrence J Cook, Yaron Finkelstein, Lynn Babcock, Lalit Bajaj, James M Chamberlain, Robert W Grundmeier, Michael Webb, Elizabeth R Alpern
OBJECTIVE: To examine the use, efficacy, and safety of intravenous magnesium sulfate (IVMg) in children with asthma whose emergency department (ED) management is recorded in the Pediatric Emergency Care Applied Research Network (PECARN) Registry. STUDY DESIGN: This multicenter retrospective cohort study analyzed clinical data from 7 EDs from 2012 to 2017. We described use of IVMg in children aged 2-17 years treated for acute asthma and its effect on blood pressure...
May 2020: Journal of Pediatrics
https://read.qxmd.com/read/30854887/dexamethasone-associated-with-significantly-shorter-length-of-hospital-stay-compared-with-a-prednisolone-based-regimen-in-pediatric-patients-with-mild-to-moderate-acute-asthma-exacerbations
#20
COMPARATIVE STUDY
Kristin Bohannon, Ronda Machen, Carolyn Ragsdale, Eimeira Padilla-Tolentino, Patricia Cervenka
A retrospective chart review was done to evaluate the efficacy of a course of dexamethasone for pediatric patients hospitalized with a mild to moderate acute asthma exacerbation compared with a prednisone-based regimen. Patients were identified based on International Classification of Diseases (ICD-9 and ICD-10) discharge diagnosis codes for asthma and cross-referenced with pharmacy dispense reports during the study period of June 2011 to January 2016. Baseline characteristics were similar among the 2 groups...
May 2019: Clinical Pediatrics
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