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Catherine M Biggs, Sevgi Keles, Talal A Chatila
Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending beyond recurrent infections to include atopy, autoimmunity and cancer. It is caused by loss of function mutations in DOCK8, encoding a guanine nucleotide exchange factor highly expressed in lymphocytes that regulates the actin cytoskeleton. Additional roles of DOCK8 have also emerged, including regulating MyD88-dependent Toll-like receptor signaling and the activation of the transcription factor STAT3...
August 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Katarzyna Nazimek, Krzysztof Bryniarski, Philip W Askenase
Extracellular vesicles, such as exosomes, are newly recognized intercellular conveyors of functional molecular mechanisms. Notably, they transfer RNAs and proteins between different cells that can then participate in the complex pathogenesis of allergic and related hypersensitivity responses and disease mechanisms, as described herein. This review highlights this important new appreciation of the in vivo participation of such extracellular vesicles in the interactions between allergy-mediating cells. We take into account paracrine epigenetic exchanges mediated by surrounding stromal cells and the endocrine receipt of exosomes from distant cells via the circulation...
2016: International Archives of Allergy and Immunology
Mübeccel Akdis, Alar Aab, Can Altunbulakli, Kursat Azkur, Rita A Costa, Reto Crameri, Su Duan, Thomas Eiwegger, Andrzej Eljaszewicz, Ruth Ferstl, Remo Frei, Mattia Garbani, Anna Globinska, Lena Hess, Carly Huitema, Terufumi Kubo, Zsolt Komlosi, Patricia Konieczna, Nora Kovacs, Umut C Kucuksezer, Norbert Meyer, Hideaki Morita, Judith Olzhausen, Liam O'Mahony, Marija Pezer, Moira Prati, Ana Rebane, Claudio Rhyner, Arturo Rinaldi, Milena Sokolowska, Barbara Stanic, Kazunari Sugita, Angela Treis, Willem van de Veen, Kerstin Wanke, Marcin Wawrzyniak, Paulina Wawrzyniak, Oliver F Wirz, Josefina Sierra Zakzuk, Cezmi A Akdis
There have been extensive developments on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections during the last few years. Better understanding the functions, reciprocal regulation, and counterbalance of subsets of immune and inflammatory cells that interact through interleukins, interferons, TNF-α, and TGF-β offer opportunities for immune interventions and novel treatment modalities in the era of development of biological immune response modifiers particularly targeting these molecules or their receptors...
October 2016: Journal of Allergy and Clinical Immunology
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