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Stem Cells

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Anna E Beaudin, Scott W Boyer, Jessica Perez-Cunningham, Gloria E Hernandez, S Christopher Derderian, Chethan Jujjavarapu, Eric Aaserude, Tippi MacKenzie, E Camilla Forsberg
The generation of distinct hematopoietic cell types, including tissue-resident immune cells, distinguishes fetal from adult hematopoiesis. However, the mechanisms underlying differential cell production to generate a layered immune system during hematopoietic development are unclear. Using an irreversible lineage-tracing model, we identify a definitive hematopoietic stem cell (HSC) that supports long-term multilineage reconstitution upon transplantation into adult recipients but does not persist into adulthood in situ...
September 15, 2016: Cell Stem Cell
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