Read by QxMD icon Read


shared collection
12 papers 0 to 25 followers johnny
By Li Li
Andrea Calcagno, Lorena Baietto, Nicole Pagani, Marco Simiele, Sabrina Audagnotto, Antonio D'Avolio, Francesco Giuseppe De Rosa, Giovanni Di Perri, Stefano Bonora
AIM: To investigate the pharmacokinetics of voriconazole when administered to HIV-positive patients receiving treatment with atazanavir-containing therapies according to CYP2C19 genotype. MATERIALS & METHODS: We describe four HIV-positive patients with pulmonary aspergillosis treated with voriconazole and atazanavir-based regimens (with or without ritonavir). They were managed by assessing their CYP2C19 genotype (CYP2C19*2, rs4244285, G>A, real-time PCR) and therapeutic drug monitoring (HPLC-based validation methods)...
July 2014: Pharmacogenomics
Yanjun Hong, Yvonne Mei Fen Chia, Ray Hng Yeo, Gopalakrishnan Venkatesan, Siew Kwan Koh, Christina Li Lin Chai, Lei Zhou, Pipin Kojodjojo, Eric Chun Yong Chan
Dronedarone is an antiarrhythmic agent approved in 2009 for the treatment of atrial fibrillation. An in-house preliminary study demonstrated that dronedarone inhibits cytochrome P450 (CYP) 3A4 and 3A5 in a time-dependent manner. This study aimed to investigate the inactivation of CYP450 by dronedarone. We demonstrated for the first time that both dronedarone and its main metabolite N-desbutyl dronedarone (NDBD) inactivate CYP3A4 and CYP3A5 in a time-, concentration-, and NADPH-dependent manner. For the inactivation of CYP3A4, the inactivator concentration at the half-maximum rate of inactivation and inactivation rate constant at an infinite inactivator concentration are 0...
January 2016: Molecular Pharmacology
Amanda K Bolles, Rina Fujiwara, Erran D Briggs, Amin A Nomeir, Laura Lowe Furge
Human cytochrome P450 3A4 (CYP3A4) is responsible for the metabolism of more than half of pharmaceutic drugs, and inactivation of CYP3A4 can lead to adverse drug-drug interactions. The substituted imidazole compounds 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine (SCH 66712) and 1-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methyl]-4-[4-(trifluoromethyl)-2-pyridinyl]piperazine (EMTPP) have been previously identified as mechanism-based inactivators (MBI) of CYP2D6. The present study shows that both SCH 66712 and EMTPP are also MBIs of CYP3A4...
December 2014: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Hyun Kang, Sushruta Koppula
CONTEXT: Houttuynia cordata Thunb. (Saururaceae) is used traditionally in Asian countries to treat various disease symptoms. OBJECTIVE: To study the effect of H. cordata ethyl acetate (HC-EA) extract on high-fat diet (HFD)-induced hepatic steatosis. MATERIALS AND METHODS: HFD fed rats were orally dosed with HC-EA (100, 200, or 300 mg/kg) once daily for 8 weeks and the lipid profiles and protein expressions in hepatocytes were evaluated. RESULTS: HFD rats showed an increase (p < 0...
March 2015: Pharmaceutical Biology
Manish Kumar, Satyendra K Prasad, S Hemalatha
The present review is an attempt to put an insight into a medicinal plant Houttuynia cordata Thunb, which is indigenous to North-East India and China. It is an aromatic medicinal herb belonging to family Saururaceae and is restricted to specialized moist habitats. The review provides detailed information regarding the morphology, distribution, phytochemistry, ethnopharmacological uses and also describes various pharmacological activities reported on the plant H. cordata. The review describes therapeutic efficacy of the whole plant and its extracts, fractions and isolated compounds in different diseased condition...
January 2014: Pharmacognosy Reviews
Zhan-nan Yang, Yi-ming Sun, Shi-qiong Luo, Jin-wu Chen, Jin-wu Chen, Zheng-wen Yu, Min Sun
A new, validated method, developed for the simultaneous determination of 16 phenolics (chlorogenic acid, scopoletin, vitexin, rutin, afzelin, isoquercitrin, narirutin, kaempferitrin, quercitrin, quercetin, kaempferol, chrysosplenol D, vitexicarpin, 5-hydroxy-3,3',4',7-tetramethoxy flavonoids, 5-hydroxy-3,4',6,7-tetramethoxy flavonoids and kaempferol-3,7,4'-trimethyl ether) in Houttuynia cordata Thunb. was successfully applied to 35 batches of samples collected from different regions or at different times and their total antioxidant activities (TAAs) were investigated...
March 2014: Pakistan Journal of Pharmaceutical Sciences
Hye Hyun Yoo, Sun-A Kim, In Sook Kim, Seong-Gyu Ko
In the present study, the effect of CP-001, a standardized herbal mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus, on cytochrome P450 (CYP) enzyme-mediated drug metabolism was investigated in vitro to evaluate the potential for herb-drug interactions. CP-001 was tested at concentrations of 1, 3, 10, 30, and 100  μ g/mL. A CYP-specific substrate mixture was incubated with CP-001 in human liver microsomes, and the metabolites generated by each CYP-specific metabolic reaction were measured by liquid chromatography-tandem mass spectrometry...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
Xueqin Xu, Hongzhi Ye, Wei Wang, Lishuang Yu, Guonan Chen
Four flavonoids (rutin, hyperoside, quercitrin and quercetin) in Houttuynia cordata Thunb. and Saururus chinensis (Lour.) Bail. were determined by capillary electrophoresis with wall-jet amperometric detection. The working electrode was a 500 microm diameter carbon disc electrode and the detection potential was +0.95 V (versus Ag/AgCl). Effects of several important factors, such as the running buffer and its corresponding pH and concentration, separation voltage, injection time were investigated to acquire the optimum conditions for separation of these four flavonoids...
January 15, 2006: Talanta
Cheng-Jian Xu, Yi-Zeng Liang, Foo-Tim Chau
Starting with Biller-Biemann's work [J.E. Biller, K. Biemann, Anal. Lett. 7 (1974) 515], various kinds of approaches have been proposed to extract GC/MS data to obtain pure components responses. In this paper, an integrated chemometric approach is proposed, which combine four sequential steps, data pretreatment, component perception, resolution and component identification, and then the proposed approach is manipulated to analyze the essential oils of a herbal medicine named Houttuynia cordata (HC). On the basis of the selective information obtained from both chromatograms and mass spectra, the proposed integrated chemometric approach can resolve the two-way GC/MS responses matrix into pure chromatograms and mass spectra without any model assumption on the peak shape...
November 15, 2005: Talanta
Jiang Meng, Kelvin Sze-Yin Leung, Zhihong Jiang, Xiaoping Dong, Zhongzhen Zhao, Li-Jia Xu
A HPLC-DAD-MS fingerprint method of fresh Houttuynia cordata THUNB. was developed basing on the consistent chromatographic features among 11 batches of authentic samples. Major chemical components including phenolic compounds, flavones and alkaloids were simultaneously analyzed. Eleven common peaks in the fingerprint were chosen and identified by comparing their UV and ESI-MS data with the authentic compounds. The unique properties of this HPLC-DAD-MS fingerprint were successfully applied to analyze and differentiate samples from different geographical origins, processing methods and various medicinal parts of H...
December 2005: Chemical & Pharmaceutical Bulletin
Ya-Yen Chen, Chiao-Ming Chen, Pi-Yu Chao, Tsan-Ju Chang, Jen-Fang Liu
AIM: To evaluate the effects of frying oil and Houttuynia cordata Thunb (H. cordata), a vegetable traditionally consumed in Taiwan, on the xenobiotic-metabolizing enzyme system of rodents. METHODS: Forty-eight Sprague-Dawley rats were fed with a diet containing 0%, 2% or 5% H. cordata powder and 15% fresh soybean oil or 24-h oxidized frying oil (OFO) for 28 d respectively. The level of microsomal protein, total cytochrome 450 content (CYP450) and enzyme activities including NADPH reductase, ethoxyresorufin O-deethylase (EROD), pentoxyresorufin O-dealkylase (PROD), aniline hydroxylase (ANH), aminopyrine demethylase (AMD), and quinone reductase (QR) were determined...
January 21, 2005: World Journal of Gastroenterology: WJG
J W Budzinski, B C Foster, S Vandenhoek, J T Arnason
Serial dilutions of 21 commercial ethanolic herbal extracts and tinctures, and 13 related pure plant compounds have been analyzed for their in vitro cytochrome P450 3A4 (CYP3A4) inhibitory capability via a fluorometric microtitre plate assay. Roughly 75% of the commercial products and 50% of the pure compounds showed significant inhibition of CYP3A4 metabolite formation. For each herbal product and pure compound exhibiting dose-dependency, the inhibition values were used to generate median inhibitory concentration (IC50) curves using linear regression...
July 2000: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"