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Spondyloarthritis

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13 papers 0 to 25 followers
https://www.readbyqxmd.com/read/26998860/anti-tnf-discontinuation-and-tapering-strategies-in-patients-with-axial-spondyloarthritis-a-systematic-literature-review
#1
Victoria Navarro-Compán, Chamaida Plasencia-Rodríguez, Eugenio de Miguel, Alejandro Balsa, Emilio Martín-Mola, Daniel Seoane-Mato, Juan D Cañete
OBJECTIVE: The aim was to evaluate whether anti-TNF discontinuation and tapering strategies are efficacious for maintaining remission or low disease activity (LDA) in patients with axial spondyloarthritis. METHODS: A systematic literature review up to September 2014 was performed using Medline, EMBASE and Cochrane databases. Longitudinal studies evaluating the efficacy of discontinuation/tapering of anti-TNF therapy to maintain clinical response achieved after receiving a standard dose of the same drug were included...
July 2016: Rheumatology
https://www.readbyqxmd.com/read/27884254/troponin-testing-for-clinicians
#2
REVIEW
John E Brush, Sanjay Kaul, Harlan M Krumholz
The analytical performance of troponin assays has improved markedly in the last 2 decades. The variety of assays, their evolution over time, and their critical importance in influencing care, mandates the need for skills in their use. There are 3 critical elements necessary for optimal use of troponin testing in clinical care, as follows: 1) the analytical performance of the assay; 2) the clinical sensitivity and specificity of the test result; and 3) the clinical reasoning for ordering and the proper clinical context for interpreting the test result...
November 29, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27913376/axial-disease-in-psoriatic-arthritis-study-defining-the-clinical-and-radiographic-phenotype-of-psoriatic-spondyloarthritis
#3
Deepak R Jadon, Raj Sengupta, Alison Nightingale, Mark Lindsay, Eleanor Korendowych, Graham Robinson, Amelia Jobling, Gavin Shaddick, Jing Bi, Robert Winchester, Jon T Giles, Neil J McHugh
OBJECTIVES: To compare the prevalence, clinical and radiographic characteristics of psoriatic spondyloarthritis (PsSpA) in psoriatic arthritis (PsA), with ankylosing spondylitis (AS). METHODS: A prospective single-centre cross-sectional observational study recruited consecutive PsA and AS cases. Participants completed outcome measures, and underwent clinical examination, axial radiographic scoring and HLA-sequencing. Multivariable analyses are presented. RESULTS: The 402 enrolled cases (201 PsA, 201 AS; fulfilling classification criteria for respective conditions) were reclassified based upon radiographic axial disease and psoriasis, as: 118 PsSpA, 127 peripheral-only PsA (pPsA), and 157 AS without psoriasis (AS) cases...
December 2, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27908311/obesity-decreases-clinical-efficacy-and-levels-of-adalimumab-in-patients-with-ankylosing-spondylitis
#4
José Rosas, Francisca Llinares-Tello, José Miguel Senabre-Gallego, Xavier Barber-Vallés, Gregorio Santos-Soler, Esteban Salas-Heredia, Ana Pons Bas, Catalina Cano Pérez, Mario García-Carrasco
OBJECTIVES: Obesity can be a factor that affects response to anti-TNF drugs. However, studies on patients with ankylosing spondylitis (AS) are rare. We aimed to determine whether obesity affects serum levels of adalimumab (ADL), and immunogenicity and clinical efficacy of the drug in patients with AS. METHODS: A cross-sectional study on 57 patients with axial AS receiving ADL was conducted. They received DMARD per standard of care at their rheumatologist's discretion...
November 13, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27829672/management-of-psoriatic-arthritis-in-2016-a-comparison-of-eular-and-grappa-recommendations
#5
REVIEW
Laure Gossec, Laura C Coates, Maarten de Wit, Arthur Kavanaugh, Sofia Ramiro, Philip J Mease, Christopher T Ritchlin, Désirée van der Heijde, Josef S Smolen
Psoriatic arthritis (PsA) is a heterogeneous, potentially severe disease. Many therapeutic agents are now available for PsA, but treatment decisions are not always straightforward. To assist in this decision making, two sets of recommendations for the management of PsA were published in 2016 by international organizations - the European League Against Rheumatism (EULAR) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). In both sets of recommendations, the heterogeneity of PsA is recognized and the place of various drugs in the therapeutic armamentarium is discussed...
November 10, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27558584/bsr-and-bhpr-guideline-for-the-treatment-of-axial-spondyloarthritis-including-ankylosing-spondylitis-with-biologics
#6
REVIEW
Louise Hamilton, Nick Barkham, Ashok Bhalla, Robin Brittain, Debbie Cook, Gareth Jones, Kirsten Mackay, David Marshall, Helena Marzo-Ortega, Daniel Murphy, Claire Riddell, Raj Sengupta, Stefan Siebert, Liz Van Rossen, Karl Gaffney
No abstract text is available yet for this article.
August 24, 2016: Rheumatology
https://www.readbyqxmd.com/read/27411482/partial-remission-in-ankylosing-spondylitis-and-non-radiographic-axial-spondyloarthritis-in-treatment-with-infliximab-plus-naproxen-or-naproxen-alone-associations-between-partial-remission-and-baseline-disease-characteristics
#7
Joachim Sieper, Martin Rudwaleit, Jan Lenaerts, Jürgen Wollenhaupt, Leysan Myasoutova, Sung-Hwan Park, Yeong W Song, Ruji Yao, Susan Huyck, Marinella Govoni, Denesh Chitkara, Nathan Vastesaeger
OBJECTIVES: To evaluate partial remission during treatment with infliximab (IFX) + naproxen (NPX) vs NPX alone in patients from the two subgroups of SpA and explore baseline predictors of partial remission. METHODS: Infliximab as First Line Therapy in Patients with Early Active Axial Spondyloarthritis Trial was a double-blind, randomised controlled trial of IFX in biologic-naïve patients with early, active axial SpA. Patients were randomised (2:1) to receive 28 weeks of treatment with i...
November 2016: Rheumatology
https://www.readbyqxmd.com/read/27283333/is-ankylosing-spondylitis-a-risk-factor-for-cardiovascular-disease-and-how-do-these-risks-compare-with-those-in-rheumatoid-arthritis
#8
Jonas K Eriksson, Lennart Jacobsson, Karin Bengtsson, Johan Askling
AIMS: To assess and compare the incidence of cardiovascular (CV) events, by CV phenotype, between patients with ankylosing spondylitis (AS), rheumatoid arthritis (RA) and the general population. METHODS: Using linkages of national and population-based registers, we identified one cohort of prevalent patients with AS (n=5358), one with RA (n=37 245) and one with matched general population subjects (n=25 006). These cohorts were identified in 2006 through 2011 and were followed in 31 December 2012, for first ever occurrence of acute coronary syndromes (ACS), deep venous thromboembolism, pulmonary embolism and stroke, respectively...
June 9, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26768408/defining-active-sacroiliitis-on-mri-for-classification-of-axial-spondyloarthritis-update-by-the-asas-mri-working-group
#9
Robert G W Lambert, Pauline A C Bakker, Désirée van der Heijde, Ulrich Weber, Martin Rudwaleit, K G Hermann, Joachim Sieper, Xenofon Baraliakos, Alex Bennett, Jürgen Braun, Rubén Burgos-Vargas, Maxime Dougados, Susanne Juhl Pedersen, Anne Grethe Jurik, Walter P Maksymowych, Helena Marzo-Ortega, Mikkel Østergaard, Denis Poddubnyy, Monique Reijnierse, Filip van den Bosch, Irene van der Horst-Bruinsma, Robert Landewé
OBJECTIVES: To review and update the existing definition of a positive MRI for classification of axial spondyloarthritis (SpA). METHODS: The Assessment in SpondyloArthritis International Society (ASAS) MRI working group conducted a consensus exercise to review the definition of a positive MRI for inclusion in the ASAS classification criteria of axial SpA. Existing definitions and new data relevant to the MRI diagnosis and classification of sacroiliitis and spondylitis in axial SpA, published since the ASAS definition first appeared in print in 2009, were reviewed and discussed...
November 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26663907/progression-of-nonradiographic-axial-spondyloarthritis-to-ankylosing-spondylitis-a-population-based-cohort-study
#10
Runsheng Wang, Sherine E Gabriel, Michael M Ward
OBJECTIVE: The long-term outcome of patients with nonradiographic axial spondyloarthritis (SpA) is unclear, particularly whether few or most progress to ankylosing spondylitis (AS). Our objective was to examine the progression to AS in a population-based inception cohort of patients with nonradiographic axial SpA. METHODS: The Rochester Epidemiology Project (REP) is a longstanding population-based study of health in the residents of Olmsted County, Minnesota. We searched the REP from 1985 to 2010 using diagnostic and procedural codes for back pain, HLA-B27, and magnetic resonance imaging of the pelvis, and we performed detailed chart reviews to identify subjects who fulfilled the Assessment of SpondyloArthritis international Society classification criteria for axial SpA but did not have AS...
June 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26568809/pharmacological-treatment-of-spondyloarthritis-exploring-the-effectiveness-of-nonsteroidal-anti-inflammatory-drugs-traditional-disease-modifying-antirheumatic-drugs-and-biological-therapies
#11
REVIEW
Francesco Caso, Luisa Costa, Antonio Del Puente, Matteo Nicola Dario Di Minno, Gelsy Lupoli, Raffaele Scarpa, Rosario Peluso
Spondyloarthritis represents a heterogeneous group of articular inflammatory diseases that share common genetic, clinical and radiological features. The therapy target of spondyloarthritis relies mainly in improving patients' quality of life, controlling articular inflammation, preventing the structural joints damage and preserving the functional abilities, autonomy and social participation of patients. Among these, traditional disease-modifying antirheumatic drugs have been demonstrated to be effective in the management of peripheral arthritis; moreover, in the last decade, biological therapies have improved the approach to spondyloarthritis...
November 2015: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/26242443/effect-of-continuous-versus-on-demand-treatment-of-ankylosing-spondylitis-with-diclofenac-over-2%C3%A2-years-on-radiographic-progression-of-the-spine-results-from-a-randomised-multicentre-trial-enradas
#12
Joachim Sieper, Joachim Listing, Denis Poddubnyy, In-Ho Song, Kay-Geert Hermann, Johanna Callhoff, Uta Syrbe, Jürgen Braun, Martin Rudwaleit
BACKGROUND: To date, only a single controlled trial provided evidence that non-steroidal anti-inflammatory drugs (NSAIDs) given continuously reduce radiographic progression compared with an on-demand therapy over 2 years in patients with ankylosing spondylitis (AS). In the current study, we tested whether such an effect of NSAIDs could be confirmed in another randomised trial. METHODS: Patients with AS were randomised for treatment with either continuous (150 mg/day) or on-demand diclofenac for 2 years...
August 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/25837448/eular-recommendations-for-the-use-of-imaging-in-the-diagnosis-and-management-of-spondyloarthritis-in-clinical-practice
#13
P Mandl, V Navarro-Compán, L Terslev, P Aegerter, D van der Heijde, M A D'Agostino, X Baraliakos, S J Pedersen, A G Jurik, E Naredo, C Schueller-Weidekamm, U Weber, M C Wick, P A C Bakker, E Filippucci, P G Conaghan, M Rudwaleit, G Schett, J Sieper, S Tarp, H Marzo-Ortega, M Østergaard
A taskforce comprised of an expert group of 21 rheumatologists, radiologists and methodologists from 11 countries developed evidence-based recommendations on the use of imaging in the clinical management of both axial and peripheral spondyloarthritis (SpA). Twelve key questions on the role of imaging in SpA were generated using a process of discussion and consensus. Imaging modalities included conventional radiography, ultrasound, magnetic resonance imaging, computed tomography (CT), positron emission tomography, single photon emission CT, dual-emission x-ray absorptiometry and scintigraphy...
July 2015: Annals of the Rheumatic Diseases
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